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  1. Book ; Online ; E-Book: Novel Coronavirus 2019

    Kumar, Amit / Saxena, Ajit Kumar / Lee, Gwo Giun (Chris) / Kashyap, Amita / Jyothsna, G.

    In-silico vaccine design and drug discovery

    (SpringerBriefs in applied sciences and technology)

    2020  

    Author's details Amit Kumar, Ajit Kumar Saxena, Gwo Giun (Chris) Lee, Amita Kashyap, G. Jyothsna
    Series title SpringerBriefs in applied sciences and technology
    Keywords Biophysics ; Biological physics ; Chemistry, Physical and theoretical ; Health informatics ; Biomedical engineering ; Bioinformatics ; Chemistry
    Subject code 571.4
    Language English
    Size 1 Online-Ressource (IX, 78 Seiten), Illustrationen
    Publisher Springer
    Publishing place Singapore
    Publishing country Singapore
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT020699766
    ISBN 978-981-15-7918-9 ; 9789811579172 ; 981-15-7918-0 ; 9811579172
    DOI 10.1007/978-981-15-7918-9
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book: Next generation DNA led technologies

    Avadhanam, Sharada / Jyothsna, G / Kashyap, Amita

    (SpringerBriefs in applied sciences and technology,)

    2016  

    Author's details Sharada Avadhanam, G. Jyothsna, Amita Kashyap, editors
    Series title SpringerBriefs in applied sciences and technology,
    MeSH term(s) DNA Fingerprinting ; Industry
    Language English
    Size x, 140 pages :, illustrations (mostly color), portraits.
    Document type Book
    ISBN 9789812876690 ; 9812876693 ; 9789812876706 ; 9812876707
    Database Catalogue of the US National Library of Medicine (NLM)

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  3. Article: Assessment of road traffic behavior using Youth Risk Behavior Survey questionnaire among school-going adolescents of Jaipur city, Rajasthan: An observational analysis.

    Dobhal, Priyanka / Dobhal, Aviral / Kashyap, Amita / Bhadoria, Ajeet Singh

    Journal of family medicine and primary care

    2019  Volume 8, Issue 11, Page(s) 3595–3599

    Abstract: Background: Adolescents are a relatively healthy group, but their developmental stage makes them vulnerable to many risk-taking behaviors. One such major issue is road safety practices and their risk on roads.: Objective: To determine road safety ... ...

    Abstract Background: Adolescents are a relatively healthy group, but their developmental stage makes them vulnerable to many risk-taking behaviors. One such major issue is road safety practices and their risk on roads.
    Objective: To determine road safety risk behavior among school-going adolescents of Jaipur city and factors associated with it.
    Materials and methods: An observational, cross-sectional study was conducted from July 2015 to February 2016. A total of 900 school-going adolescents were enrolled from eight schools of Jaipur city and the Youth Risk Behavior Survey (YRBS) questionnaire was administered.
    Results: Most of the participants (67.56%) were in the age group of 13-16 years. A total of 682 (75%) adolescents were driving one or other type of vehicle to commute. Out of the 682 vehicle-using adolescents, 603 (88%) had risky behavior on roads. Driving under the influence was found more among those using four-wheelers (10%) than two-wheelers (5%). Almost half of drivers used mobile phones while driving a car or two-wheeler. There was statistically significant association between risk on roads with respect to rising education and occupation of parents. A majority (88.41%) of the school-going students were found to be at risk on roads while driving. Safety-belt was not used by 28% of the students while half did not use a helmet. More than 70% of the car drivers and two-wheeler drivers drove without license.
    Conclusion: Majority of the adolescent drivers are at risk on roads. Driving without license and/or helmet and using mobile phone are the main risk factors.
    Language English
    Publishing date 2019-11-15
    Publishing country India
    Document type Journal Article
    ZDB-ID 2735275-4
    ISSN 2278-7135 ; 2249-4863
    ISSN (online) 2278-7135
    ISSN 2249-4863
    DOI 10.4103/jfmpc.jfmpc_494_19
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Successfully Managing Swine Flu (H1N1) 2015 and the Way Ahead: The Rajasthan Model.

    Kashyap, Amita / Rathore, Monika / Panagariya, Ashok

    Annals of neurosciences

    2016  Volume 23, Issue 2, Page(s) 66–67

    Language English
    Publishing date 2016-07-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2576191-2
    ISSN 0976-3260 ; 0972-7531
    ISSN (online) 0976-3260
    ISSN 0972-7531
    DOI 10.1159/000443561
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Book: Bioinformatics of non small cell lung cancer and the Ras proto-oncogene

    Kashyap, Amita / Bujamma, D / M., Naresh Babu

    (Springer Briefs in applied science and technology. Forensic and medical bioinformatics,)

    2015  

    Author's details Amita Kashyap, D. Bujamma, Naresh Babu M
    Series title Springer Briefs in applied science and technology. Forensic and medical bioinformatics,
    MeSH term(s) Carcinoma, Non-Small-Cell Lung/genetics ; Proto-Oncogenes ; Computational Biology/methods
    Language English
    Size vii, 72 pages :, illustrations
    Document type Book
    ISBN 9789814585071 ; 9789814585088 ; 9814585076 ; 9814585084
    Database Catalogue of the US National Library of Medicine (NLM)

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  6. Book ; Online: Bioinformatics of Non Small Cell Lung Cancer and the Ras Proto-Oncogene

    Kashyap, Amita / Babu M, Naresh / Bujamma, D

    (SpringerBriefs in Applied Sciences and Technology)

    2015  

    Abstract: Cancer is initiated by activation of oncogenes or inactivation of tumor suppressor genes. Mutations in the K-ras proto-oncogene are responsible for 10-30% of adenocarcinomas. Clinical Findings point to a wide variety of other cancers contributing to lung ...

    Author's details by Amita Kashyap, D. Bujamma, Naresh Babu M
    Series title SpringerBriefs in Applied Sciences and Technology
    Abstract Cancer is initiated by activation of oncogenes or inactivation of tumor suppressor genes. Mutations in the K-ras proto-oncogene are responsible for 10-30% of adenocarcinomas. Clinical Findings point to a wide variety of other cancers contributing to lung cancer incidence. Such a scenario makes identification of lung cancer difficult and thus identifying its mechanisms can contribute to the society. Identifying unique conserved patterns common to contributing proto-oncogenes may further be a boon to Pharmacogenomics and pharmacoinformatics. This calls for ab initio/de novo drug discovery that in turn will require a comprehensive in silico approach of Sequence, Domain, Phylogenetic and Structural analysis of the receptors, ligand screening and optimization and detailed Docking studies. This brief involves extensive role of the RAS subfamily that includes a set of proteins, which cause an over expression of cancer-causing genes like M-ras and initiate tumour formation in lungs. SNP Studies and Structure based drug discovery will also be undertaken
    Keywords Bioinformatics ; Biomedical engineering ; Engineering ; Engineering mathematics ; Medical records/Data processing ; Oncology
    Language English
    Size Online-Ressource (VII, 72 p. 40 illus., 39 illus. in color), online resource
    Publisher Springer Singapore
    Publishing place Singapore ;s.l
    Document type Book ; Online
    ISBN 9789814585071 ; 9789814585088 ; 9814585076 ; 9814585084
    DOI 10.1007/978-981-4585-08-8
    Database Former special subject collection: coastal and deep sea fishing

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  7. Article: In Search of Novel Coronavirus 19 Therapeutic Targets

    Gundlapally, Jyothsna / Kumar, Amith / Kashyap, Amita / Saxena, Ajit Kumar / Sanyal, Aryasekhar

    Helix

    Abstract: Novel Coronavirus 2019 pandemic has become a nightmare of the year 2019-20 It is affecting both health and wealth across the world It has become a great challenge for the entire human race to protect itself from the viral outbreak This is time for the ... ...

    Abstract Novel Coronavirus 2019 pandemic has become a nightmare of the year 2019-20 It is affecting both health and wealth across the world It has become a great challenge for the entire human race to protect itself from the viral outbreak This is time for the entire Scientific community to come together and undertake studies and contribute in conducting research on CoVID 19 and possible solutions to defeat this killer, million times smaller than humans, as even minute information can also play a very important role in fighting against the Virus The current work is aimed to analyze the genome of CoVID 19 and compare its evolutionary relation with the other species of viruses that are known to cause respiratory disorders Viral membrane proteins and proteins involved in replication of viral genetic material play an integral part in virus-host interactions These classes of protein are often the best candidates for antiviral drug and vaccine targets Disrupting these proteins may be an effective means to inhibit the growth and disintegrate the virus Taking advantage of the recent release of some of the gene sequences and the genome of Novel Coronavirus 2019 by NCBI GenBank and the agility provided by Insilico Bioinformatics tools, the current work aimed to study the evolutionally conserved regions of the genome of the CoVid 19 The comparison of the complete genome and specifically the coding gene sequence for membrane proteins and proteins involved in viral replication of MN908947 3 Severe acute respiratory syndrome coronavirus 2 isolate Wuhan-Hu-1, complete genome-2019 (better known as Covid 19), Isolated from China, was conducted 25 viruses including commonly known respiratory tract pathogen were selected for the current study Sequence similarity analysis and comparative study results revealed that the viral membrane protein, M protein Shares similarity only with the other corona group of viruses and (MERS) and not with HCOV Moreover, the complete genome comparison revealed the presence of a specific conserved gene region shared by MERS and CoVid 19, which was further analyzed Identifying the commonly shared gene regions can immensely aid in identifying druggable target and help in development of appropriate therapy protocol or medication for 2019 novel Coronavirus
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #724573
    Database COVID19

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  8. Article ; Online: Plasma Therapy Towards COVID Treatment

    Kumar, Amit / Saxena, Ajit Kumar / Lee, Gwo Giun (Chris) / Kashyap, Amita / Jyothsna, G.

    Novel Coronavirus 2019

    Abstract: Apart from the drugs used in the treatment of COVID, it is necessary to try several other routes through which the recovery of the victims can be made possible. India has now laid its steps towards implementing the Plasma Therapy as an approach towards ... ...

    Abstract Apart from the drugs used in the treatment of COVID, it is necessary to try several other routes through which the recovery of the victims can be made possible. India has now laid its steps towards implementing the Plasma Therapy as an approach towards the treatment of COVID19. Here the Plasma is collected from the individuals who have recovered from the infection, as they have already developed antibodies against the pathogen. The plasma from these individuals is expected to contain antibodies against COVID which can be used further for treating the patients affected with this pathogen.
    Keywords covid19
    Publisher PMC
    Document type Article ; Online
    DOI 10.1007/978-981-15-7918-9_8
    Database COVID19

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  9. Article ; Online: Evolutionary and Structural Studies of NCoV and SARS CoV-Spike proteins and their association with ACE2 Receptor

    Kumar, Amit / Saxena, Ajit Kumar / Lee, Gwo Giun (Chris) / Kashyap, Amita / Jyothsna, G.

    Novel Coronavirus 2019

    Abstract: Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)/Novel Corona Virus Disease-19 (nCOVID-19)/COVID-19 has only been discovered recently, and so our understanding of the disease epidemiology is continuously evolving. WHO has declared it a ... ...

    Abstract Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)/Novel Corona Virus Disease-19 (nCOVID-19)/COVID-19 has only been discovered recently, and so our understanding of the disease epidemiology is continuously evolving. WHO has declared it a worldwide pandemic with high morbidity and significant mortality, hence it has been announced as the global health and wealth emergency. At present there is no any specific therapy available to fight against this virus, hence the drug repositioning is the most challenging to entire scientific community. The aim of this study is to determine the mutation(s) in the sequence of the spike protein, which plays a significant role in transmission from human to human. By using bioinformatics approach first we analyzed spike protein sequence of four nearest coronavirus family that include COVID-19, bat coronavirus RaTG13, pangolian coronavirus and SARS CoV, to determine phylogenetic distance between them. The homology modeling of COVID-19 spike protein has been done by iTASSER. and the protein-protein docking with human receptor ACE2 by Frodock web based docking tool showing the less binding energy of COVID-19 (−12.7 kcal/mol) in comparison with SARS CoV (10.3 kcal/mol). Further, the superimposed structure of COVID-19 and SARS CoV viruses has been performed to find the mutational site in association with human ACE2 protein. The extensive and detailed computational analyses approaches help to identify conserved region of COVID-19 and SARS CoV. Hence, our present data might help to identify potential target site and to develop antiviral drugs/vaccine to combat this pandemic.
    Keywords covid19
    Publisher PMC
    Document type Article ; Online
    DOI 10.1007/978-981-15-7918-9_7
    Database COVID19

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  10. Article ; Online: Rational Drug Design and Docking of the RNA Dependent RNA Polymerase Domain of NCoV

    Kumar, Amit / Saxena, Ajit Kumar / Lee, Gwo Giun (Chris) / Kashyap, Amita / Jyothsna, G.

    Novel Coronavirus 2019

    Abstract: It is an urgent requirement of 2020 to develop a drug which can successfully treat the patients of COVID19 and gift them a healthy life back. ...

    Abstract It is an urgent requirement of 2020 to develop a drug which can successfully treat the patients of COVID19 and gift them a healthy life back.
    Keywords covid19
    Publisher PMC
    Document type Article ; Online
    DOI 10.1007/978-981-15-7918-9_5
    Database COVID19

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