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Article ; Online: Plasticity of Epithelial Cells during Skin Wound Healing.

Sun, Xiaoyan / Joost, Simon / Kasper, Maria

Cold Spring Harbor perspectives in biology

2023 Volume 15, Issue 5

Abstract: Epithelial tissues line the outer surfaces of the mammalian body and protect from external harm. In skin, the epithelium is maintained by distinct stem cell populations residing in the interfollicular epidermis and various niches of the hair follicle. ... ...

Abstract	Epithelial tissues line the outer surfaces of the mammalian body and protect from external harm. In skin, the epithelium is maintained by distinct stem cell populations residing in the interfollicular epidermis and various niches of the hair follicle. These stem cells give rise to the stratified epidermal layers and the protective hair coat, while being confined to their respective niches. Upon injury, however, all stem cell progenies can leave their niche and collectively contribute to a central wound healing process, called reepithelialization, for restoring the skin's barrier function. This review explores how epithelial cells from distinct niches respond and adapt during acute wound repair. We discuss when and where cells sense and react to damage, how cellular identity is regulated at the molecular and behavioral level, and how cells memorize past experiences and their origin. This collective knowledge highlights cellular plasticity as a brilliant feature of epithelial tissues to heal.
MeSH term(s)	Animals ; Epithelial Cells ; Epithelium ; Skin ; Epidermis ; Hair Follicle ; Wound Healing ; Mammals
Language	English
Publishing date	2023-05-02
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ISSN	1943-0264
ISSN (online)	1943-0264
DOI	10.1101/cshperspect.a041232
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Article ; Online: TREMendous Macrophages Inhibit Hair Growth.

Dalessandri, Tim / Kasper, Maria

Cell stem cell

2019 Volume 24, Issue 4, Page(s) 501–502

Abstract: Tissue-resident immune cells with potent sensing and effector functions are well-placed to fundamentally aid tissue homeostasis via crosstalk with stem cells. In this issue of Cell Stem Cell, Wang et al. (2019) identify a dermis-resident TREM2+ ... ...

Abstract	Tissue-resident immune cells with potent sensing and effector functions are well-placed to fundamentally aid tissue homeostasis via crosstalk with stem cells. In this issue of Cell Stem Cell, Wang et al. (2019) identify a dermis-resident TREM2+ macrophage subpopulation that promotes hair follicle stem cell quiescence via cytokine-mediated JAK-STAT signaling.
MeSH term(s)	Dermis ; Hair Follicle ; Macrophages ; Oncostatin M ; Stem Cells
Chemical Substances	Oncostatin M (106956-32-5)
Language	English
Publishing date	2019-04-05
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	2375354-7
ISSN	1875-9777 ; 1934-5909
ISSN (online)	1875-9777
ISSN	1934-5909
DOI	10.1016/j.stem.2019.03.014
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Zs.A 6589: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MG 75: Show issues

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Article ; Online: Metabolic rewiring controlled by c-Fos governs cartilage integrity in osteoarthritis.

Matsuoka, Kazuhiko / Bakiri, Latifa / Bilban, Martin / Toegel, Stefan / Haschemi, Arvand / Yuan, Hao / Kasper, Maria / Windhager, Reinhard / Wagner, Erwin F

Annals of the rheumatic diseases

2023 Volume 82, Issue 9, Page(s) 1227–1239

Abstract: Objectives: The activator protein-1 (AP-1) transcription factor component c-Fos regulates chondrocyte proliferation and differentiation, but its involvement in osteoarthritis (OA) has not been functionally assessed.: Methods: c-Fos expression was ... ...

Abstract	Objectives: The activator protein-1 (AP-1) transcription factor component c-Fos regulates chondrocyte proliferation and differentiation, but its involvement in osteoarthritis (OA) has not been functionally assessed. Methods: c-Fos expression was evaluated by immunohistochemistry on articular cartilage sections from patients with OA and mice subjected to the destabilisation of the medial meniscus (DMM) model of OA. Cartilage-specific c-Fos knockout (c-Fos Results: FOS-positive chondrocytes were increased in human and murine OA cartilage during disease progression. Compared with c-Fos Conclusions: c-Fos modulates cellular bioenergetics in chondrocytes by balancing pyruvate flux between anaerobic glycolysis and the tricarboxylic acid cycle in response to OA signals. We identify a novel metabolic adaptation of chondrocytes controlled by c-Fos-containing AP-1 dimers that could be therapeutically relevant.
MeSH term(s)	Animals ; Humans ; Mice ; Cartilage, Articular/metabolism ; Chondrocytes/metabolism ; Collagen/metabolism ; Disease Models, Animal ; Osteoarthritis/pathology ; Transcription Factor AP-1/metabolism ; Proto-Oncogene Proteins c-fos/genetics
Chemical Substances	Collagen (9007-34-5) ; Transcription Factor AP-1 ; FOS protein, human ; Fos protein, mouse ; Proto-Oncogene Proteins c-fos
Language	English
Publishing date	2023-06-21
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	7090-7
ISSN	1468-2060 ; 0003-4967
ISSN (online)	1468-2060
ISSN	0003-4967
DOI	10.1136/ard-2023-224002
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Uh III Zs.114: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 167: Show issues

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Article ; Online: Tenascin-C expressing touch dome keratinocytes exhibit characteristics of all epidermal lineages.

Nguyen, Minh Binh / Flora, Pooja / Branch, Meagan C / Weber, Madison / Zheng, Xiang Yu / Sivan, Unnikrishnan / Joost, Simon / Annusver, Karl / Zheng, Deyou / Kasper, Maria / Ezhkova, Elena

Science advances

2024 Volume 10, Issue 3, Page(s) eadi5791

Abstract: The touch dome (TD) keratinocytes are specialized epidermal cells that intimately associate with the light touch sensing Merkel cells (MCs). The TD keratinocytes function as a niche for the MCs and can induce de novo hair follicles upon stimulation; ... ...

Abstract	The touch dome (TD) keratinocytes are specialized epidermal cells that intimately associate with the light touch sensing Merkel cells (MCs). The TD keratinocytes function as a niche for the MCs and can induce de novo hair follicles upon stimulation; however, how the TD keratinocytes are maintained during homeostasis remains unclear. scRNA-seq identified a specific TD keratinocyte marker,
MeSH term(s)	Tenascin/genetics ; Keratinocytes ; Epidermis ; Skin ; Merkel Cells/physiology ; Hair Follicle
Chemical Substances	Tenascin
Language	English
Publishing date	2024-01-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	2810933-8
ISSN	2375-2548 ; 2375-2548
ISSN (online)	2375-2548
ISSN	2375-2548
DOI	10.1126/sciadv.adi5791
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Article ; Online: Stimulation of skeletal stem cells in the growth plate promotes linear bone growth.

Trompet, Dana / Kurenkova, Anastasiia D / Zhou, Baoyi / Li, Lei / Dregval, Ostap / Usanova, Anna P / Chu, Tsz Long / Are, Alexandra / Nedorubov, Andrei A / Kasper, Maria / Chagin, Andrei S

JCI insight

2024 Volume 9, Issue 6

Abstract: Recently, skeletal stem cells were shown to be present in the epiphyseal growth plate (epiphyseal skeletal stem cells, epSSCs), but their function in connection with linear bone growth remains unknown. Here, we explore the possibility that modulating the ...

Abstract	Recently, skeletal stem cells were shown to be present in the epiphyseal growth plate (epiphyseal skeletal stem cells, epSSCs), but their function in connection with linear bone growth remains unknown. Here, we explore the possibility that modulating the number of epSSCs can correct differences in leg length. First, we examined regulation of the number and activity of epSSCs by Hedgehog (Hh) signaling. Both systemic activation of Hh pathway with Smoothened agonist (SAG) and genetic activation of Hh pathway by Patched1 (Ptch1) ablation in Pthrp-creER Ptch1fl/fl tdTomato mice promoted proliferation of epSSCs and clonal enlargement. Transient intra-articular administration of SAG also elevated the number of epSSCs. When SAG-containing beads were implanted into the femoral secondary ossification center of 1 leg of rats, this leg was significantly longer 1 month later than the contralateral leg implanted with vehicle-containing beads, an effect that was even more pronounced 2 and 6 months after implantation. We conclude that Hh signaling activates growth plate epSSCs, which effectively leads to increased longitudinal growth of bones. This opens therapeutic possibilities for the treatment of differences in leg length.
MeSH term(s)	Mice ; Rats ; Animals ; Growth Plate ; Hedgehog Proteins/metabolism ; Bone Development ; Stem Cells/metabolism ; Red Fluorescent Protein
Chemical Substances	tdTomato ; Hedgehog Proteins ; Red Fluorescent Protein
Language	English
Publishing date	2024-02-13
Publishing country	United States
Document type	Journal Article
ISSN	2379-3708
ISSN (online)	2379-3708
DOI	10.1172/jci.insight.165226
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Article ; Online: Gradual differentiation uncoupled from cell cycle exit generates heterogeneity in the epidermal stem cell layer.

Cockburn, Katie / Annusver, Karl / Gonzalez, David G / Ganesan, Smirthy / May, Dennis P / Mesa, Kailin R / Kawaguchi, Kyogo / Kasper, Maria / Greco, Valentina

Nature cell biology

2022 Volume 24, Issue 12, Page(s) 1692–1700

Abstract: Highly regenerative tissues continuously produce terminally differentiated cells to replace those that are lost. How they orchestrate the complex transition from undifferentiated stem cells towards post-mitotic, molecularly distinct and often spatially ... ...

Abstract	Highly regenerative tissues continuously produce terminally differentiated cells to replace those that are lost. How they orchestrate the complex transition from undifferentiated stem cells towards post-mitotic, molecularly distinct and often spatially segregated differentiated populations is not well understood. In the adult skin epidermis, the stem cell compartment contains molecularly heterogeneous subpopulations
MeSH term(s)	Cell Division ; Cell Cycle/genetics ; Stem Cells ; Cell Differentiation
Language	English
Publishing date	2022-11-10
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1474722-4
ISSN	1476-4679 ; 1465-7392
ISSN (online)	1476-4679
ISSN	1465-7392
DOI	10.1038/s41556-022-01021-8
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Zs.A 5169: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 12: Show issues

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Article ; Online: Correction: Cell cycle controls long-range calcium signaling in the regenerating epidermis.

Moore, Jessica L / Bhaskar, Dhananjay / Gao, Feng / Matte-Martone, Catherine / Du, Shuangshuang / Lathrop, Elizabeth / Ganesan, Smirthy / Shao, Lin / Norris, Rachael / Sanz, Nil Campamà / Annusver, Karl / Kasper, Maria / Cox, Andy / Hendry, Caroline / Rieck, Bastian / Krishnaswamy, Smita / Greco, Valentina

The Journal of cell biology

2024 Volume 223, Issue 4

Language	English
Publishing date	2024-03-13
Publishing country	United States
Document type	Published Erratum
ZDB-ID	218154-x
ISSN	1540-8140 ; 0021-9525
ISSN (online)	1540-8140
ISSN	0021-9525
DOI	10.1083/jcb.20230209503052024c
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Article ; Online: Molecular and spatial landmarks of early mouse skin development.

Jacob, Tina / Annusver, Karl / Czarnewski, Paulo / Dalessandri, Tim / Kalk, Christina / Levra Levron, Chiara / Campamà Sanz, Nil / Kastriti, Maria Eleni / Mikkola, Marja L / Rendl, Michael / Lichtenberger, Beate M / Donati, Giacomo / Björklund, Åsa K / Kasper, Maria

Developmental cell

2023 Volume 58, Issue 20, Page(s) 2140–2162.e5

Abstract: A wealth of specialized cell populations within the skin facilitates its hair-producing, protective, sensory, and thermoregulatory functions. How the vast cell-type diversity and tissue architecture develops is largely unexplored. Here, with single-cell ... ...

Abstract	A wealth of specialized cell populations within the skin facilitates its hair-producing, protective, sensory, and thermoregulatory functions. How the vast cell-type diversity and tissue architecture develops is largely unexplored. Here, with single-cell transcriptomics, spatial cell-type assignment, and cell-lineage tracing, we deconstruct early embryonic mouse skin during the key transitions from seemingly uniform developmental precursor states to a multilayered, multilineage epithelium, and complex dermal identity. We identify the spatiotemporal emergence of hair-follicle-inducing, muscle-supportive, and fascia-forming fibroblasts. We also demonstrate the formation of the panniculus carnosus muscle (PCM), sprouting blood vessels without pericyte coverage, and the earliest residence of mast and dendritic immune cells in skin. Finally, we identify an unexpected epithelial heterogeneity within the early single-layered epidermis and a signaling-rich periderm layer. Overall, this cellular and molecular blueprint of early skin development-which can be explored at https://kasperlab.org/tools-establishes histological landmarks and highlights unprecedented dynamic interactions among skin cells.
MeSH term(s)	Mice ; Animals ; Skin ; Epidermis ; Hair Follicle/pathology ; Hair ; Epithelium
Language	English
Publishing date	2023-08-16
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	2054967-2
ISSN	1878-1551 ; 1534-5807
ISSN (online)	1878-1551
ISSN	1534-5807
DOI	10.1016/j.devcel.2023.07.015
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Zs.A 5742: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 76: Show issues

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Article ; Online: Autophagy critically controls skin inflammation and apoptosis-induced stem cell activation.

Van Hove, Lisette / Toniolo, Annagiada / Ghiasloo, Mohammad / Lecomte, Kim / Boone, Fleur / Ciers, Maarten / Raaijmakers, Kris / Vandamme, Niels / Roels, Jana / Maschalidi, Sophia / Ravichandran, Kodi S / Kasper, Maria / van Loo, Geert / Hoste, Esther

Autophagy

2023 Volume 19, Issue 11, Page(s) 2958–2971

Abstract: Macroautophagy/autophagy is a cellular recycling program regulating cell survival and controlling inflammatory responses in a context-dependent manner. Here, we demonstrate that keratinocyte-selective ablation ... ...

Abstract	Macroautophagy/autophagy is a cellular recycling program regulating cell survival and controlling inflammatory responses in a context-dependent manner. Here, we demonstrate that keratinocyte-selective ablation of
Language	English
Publishing date	2023-09-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2454135-7
ISSN	1554-8635 ; 1554-8627
ISSN (online)	1554-8635
ISSN	1554-8627
DOI	10.1080/15548627.2023.2247742
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Article ; Online: Skin mesenchymal niches maintain and protect AML-initiating stem cells.

Sandhow, Lakshmi / Cai, Huan / Leonard, Elory / Xiao, Pingnan / Tomaipitinca, Luana / Månsson, Alma / Kondo, Makoto / Sun, Xiaoyan / Johansson, Anne-Sofie / Tryggvason, Karl / Kasper, Maria / Järås, Marcus / Qian, Hong

The Journal of experimental medicine

2023 Volume 220, Issue 10

Abstract: Leukemia cutis or leukemic cell infiltration in skin is one of the common extramedullary manifestations of acute myeloid leukemia (AML) and signifies a poorer prognosis. However, its pathogenesis and maintenance remain understudied. Here, we report ... ...

Abstract	Leukemia cutis or leukemic cell infiltration in skin is one of the common extramedullary manifestations of acute myeloid leukemia (AML) and signifies a poorer prognosis. However, its pathogenesis and maintenance remain understudied. Here, we report massive AML cell infiltration in the skin in a transplantation-induced MLL-AF9 AML mouse model. These AML cells could regenerate AML after transplantation. Prospective niche characterization revealed that skin harbored mesenchymal progenitor cells (MPCs) with a similar phenotype as BM mesenchymal stem cells. These skin MPCs protected AML-initiating stem cells (LSCs) from chemotherapy in vitro partially via mitochondrial transfer. Furthermore, Lama4 deletion in skin MPCs promoted AML LSC proliferation and chemoresistance. Importantly, more chemoresistant AML LSCs appeared to be retained in Lama4-/- mouse skin after cytarabine treatment. Our study reveals the characteristics and previously unrecognized roles of skin mesenchymal niches in maintaining and protecting AML LSCs during chemotherapy, meriting future exploration of their impact on AML relapse.
MeSH term(s)	Animals ; Mice ; Prospective Studies ; Stem Cells ; Skin ; Leukemia, Myeloid, Acute ; Mesenchymal Stem Cells
Language	English
Publishing date	2023-07-26
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	218343-2
ISSN	1540-9538 ; 0022-1007
ISSN (online)	1540-9538
ISSN	0022-1007
DOI	10.1084/jem.20220953
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Ua VI Zs.107: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MG 45: Show issues

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