LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 7 of total 7

Search options

  1. Article ; Online: Action Research and Transformation

    Katherine Gibson

    Documents d'Anàlisi Geogràfica, Vol 70, Iss

    Lessons from Three Decades of Practice

    2024  Volume 1

    Abstract: In this paper I look back over three decades of doing participatory action research and extract some lessons that bear upon the pressing issues of our time—namely, how to act in the face of unsustainable socio-economic growth trajectories and cascading ... ...

    Abstract In this paper I look back over three decades of doing participatory action research and extract some lessons that bear upon the pressing issues of our time—namely, how to act in the face of unsustainable socio-economic growth trajectories and cascading environmental degradation. I start with my circuitous journey into action research and to the importance of human subjectivity to transformation processes. I then trace the thinking that shaped a postmodern feminist social research agenda. Next follows an account of developing a research design for poststructuralist participatory action research (PPAR) that foregrounds understanding ‘ways of living’ in place. Drawing on actual action research projects, the lessons that emerge concern the importance of 1) inventory and bearing witness to difference; 2) new techniques of resubjectivation that encourage transformation; and 3) shifting the action focus from human subjects to socio-technical assemblages in which humans, material infrastructures, habits and experimentation are interwoven. Throughout my three decades of involvement with action research I have learnt about the limits to the durability of subjectivity change and the need to work on support from wider ecosystems of governance, infrastructure, health and social expectation.
    Keywords subjectivity ; inventory ; economic difference ; resubjectivation ; poststructuralist ; socio-technical assemblage ; Geography (General) ; G1-922
    Subject code 300
    Language Catalan
    Publishing date 2024-01-01T00:00:00Z
    Publisher Universitat Autònoma de Barcelona
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  2. Article ; Online: Drastic times need drastic measures: COVID-19 and widening access to medicine.

    Smith, Katherine Gibson / Cleland, Jennifer

    The journal of the Royal College of Physicians of Edinburgh

    2021  Volume 50, Issue 4, Page(s) 431–435

    Abstract: In response to COVID-19, schools, colleges and universities across the world have closed or shifted to online/remote or blended teaching, learning and assessment. These changed ways of working pose challenges to students and will likely exacerbate ... ...

    Abstract In response to COVID-19, schools, colleges and universities across the world have closed or shifted to online/remote or blended teaching, learning and assessment. These changed ways of working pose challenges to students and will likely exacerbate existing educational attainment gaps between different societal groups. Our focus is the potential impact of COVID-19 on widening access to medicine. We provide an account of the process, in the form of comparative cases, of applying for medical school for two applicants from differing backgrounds. Three challenges were identified: family circumstances and support (financial security and parental educational support); staying connected (access to educational material, technology and Wifi); getting the grades and meeting other entry criteria (predicting grades and work experience). We propose that medical schools adopt drastic measures to protect widening access including increasing the use of aptitude tests, contextualised admissions, online multiple mini interviews (MMIs), creative outreach and promotion of alternative means of gaining relevant experience.
    MeSH term(s) COVID-19 ; Digital Divide ; Education, Medical, Undergraduate ; Humans ; Pandemics ; SARS-CoV-2 ; School Admission Criteria ; Schools, Medical ; Social Class ; Social Justice ; Students, Medical ; United Kingdom ; Universities
    Language English
    Publishing date 2021-01-05
    Publishing country Scotland
    Document type Journal Article ; Review
    ZDB-ID 2866363-9
    ISSN 2042-8189 ; 0953-0932
    ISSN (online) 2042-8189
    ISSN 0953-0932
    DOI 10.4997/JRCPE.2020.419
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 3088 -Suppl.-: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Novel Development of Predictive Feature Fingerprints to Identify Chemistry-Based Features for the Effective Drug Design of SARS-CoV‑2 Target Antagonists and Inhibitors Using Machine Learning

    Kelvin Cooper / Christopher Baddeley / Bernie French / Katherine Gibson / James Golden / Thiam Lee / Sadrach Pierre / Brent Weiss / Jason Yang

    ACS Omega, Vol 6, Iss 7, Pp 4857-

    2021  Volume 4877

    Keywords Chemistry ; QD1-999
    Language English
    Publishing date 2021-02-01T00:00:00Z
    Publisher American Chemical Society
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  4. Book ; Online: Novel Development of Predictive Feature Fingerprints to Identify Chemistry-Based Features for Effective Drug Design of SARS-CoV-2 Target Antagonists and Inhibitors Using Machine Learning

    Kelvin Cooper / Christopher Baddeley / Bernie French / Katherine Gibson / James Golden / Thiam Lee / Sadrach Pierre / Brent Weiss / Jason Yang

    2020  

    Abstract: A unique approach to bioactivity and chemical data curation coupled with Random forest analyses has led to a series of target-specific and cross-validated Predictive Feature Fingerprints (PFF) that have high predictability across multiple therapeutic ... ...

    Abstract A unique approach to bioactivity and chemical data curation coupled with Random forest analyses has led to a series of target-specific and cross-validated Predictive Feature Fingerprints (PFF) that have high predictability across multiple therapeutic targets and disease stages involved in the SARS-CoV-2 induced COVID-19 pandemic, which include plasma kallikrein, HIV protease, NSP5, NSP12, JAK family and AT-1. The approach was highly accurate in determining the matched target for the different compound sets and suggests that the models could be used for virtual screening of target specific compound libraries. The curation-modeling process was successfully applied to a SARS-CoV-2 phenotypic screen and could be used for predictive bioactivity estimation and prioritization for clinical trial selection, virtual screening of drug libraries for repurposing of drug molecules, and analysis and direction of proprietary datasets.
    Keywords Drug Discovery and Drug Delivery Systems ; SARS-CoV-2 ; COVID-19 ; Artificial Intelligence ; QSAR modeling approaches ; Random Forest ; Cluster Analysis ; Plasma Kallikrein ; HIV protease ; NSP5 ; NSP12 ; JAK 1 ; JAK 2 ; JAK 3 ; Angiotensin II receptors ; covid19
    Publishing date 2020-10-29T06:02:04Z
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  5. Article ; Online: Human Gut-Derived Commensal Bacteria Suppress CNS Inflammatory and Demyelinating Disease

    Ashutosh Mangalam / Shailesh K. Shahi / David Luckey / Melissa Karau / Eric Marietta / Ningling Luo / Rok Seon Choung / Josephine Ju / Ramakrishna Sompallae / Katherine Gibson-Corley / Robin Patel / Moses Rodriguez / Chella David / Veena Taneja / Joseph Murray

    Cell Reports, Vol 20, Iss 6, Pp 1269-

    2017  Volume 1277

    Abstract: The human gut is colonized by a large number of microorganisms (∼1013 bacteria) that support various physiologic functions. A perturbation in the healthy gut microbiome might lead to the development of inflammatory diseases, such as multiple sclerosis ( ... ...

    Abstract The human gut is colonized by a large number of microorganisms (∼1013 bacteria) that support various physiologic functions. A perturbation in the healthy gut microbiome might lead to the development of inflammatory diseases, such as multiple sclerosis (MS). Therefore, gut commensals might provide promising therapeutic options for treating MS and other diseases. We report the identification of human gut-derived commensal bacteria, Prevotella histicola, which can suppress experimental autoimmune encephalomyelitis (EAE) in a human leukocyte antigen (HLA) class II transgenic mouse model. P. histicola suppresses disease through the modulation of systemic immune responses. P. histicola challenge led to a decrease in pro-inflammatory Th1 and Th17 cells and an increase in the frequencies of CD4+FoxP3+ regulatory T cells, tolerogenic dendritic cells, and suppressive macrophages. Our study provides evidence that the administration of gut commensals may regulate a systemic immune response and may, therefore, have a possible role in treatment strategies for MS.
    Keywords multiple sclerosis ; human commensal ; gut microbiome ; experimental autoimmune encephalomyelitis ; EAE ; Prevotella histicola ; immunomodulation ; inflammation ; demyelination ; regulatory T cells ; Biology (General) ; QH301-705.5
    Subject code 610
    Language English
    Publishing date 2017-08-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  6. Article ; Online: Evaluation of a novel silicate substituted hydroxyapatite bone graft substitute in a rabbit posterolateral fusion model.

    Fredericks, Douglas C / Petersen, Emily B / Sahai, Nikhil / Corley, Katherine Gibson N / DeVries, Nicole / Grosland, Nicole M / Smucker, Joseph D

    The Iowa orthopaedic journal

    2013  Volume 33, Page(s) 25–32

    Abstract: Study design/setting: Randomized, controlled study in a laboratory setting. Blinded observations/assessment of study outcomes.: Objective: The purpose of this study is to determine the performance characteristics of a novel silicate-substituted ... ...

    Abstract Study design/setting: Randomized, controlled study in a laboratory setting. Blinded observations/assessment of study outcomes.
    Objective: The purpose of this study is to determine the performance characteristics of a novel silicate-substituted hydroxyapatite bone graft substitute (BGS), SiCaP EP (Baxter Healthcare/ ApaTech, Elstree, UK), in a stand-alone mode, a stand-alone with bone marrow aspirate (BMA) mode, and an extender mode with iliac crest autograft (ICBG) in a rabbit posterolateral spine fusion model. The investigational BGS is compared to a standard iliac crest autograft (ICBG) control.
    Summary of background data: The rabbit posterolateral fusion model is an established environment for testing of fusion efficacy. It offers the opportunity to obtain radiographic, histological, and biomechanical data on novel bone graft substitutes.
    Methods: One hundred and twenty rabbits were entered into the study with 116 used for analysis. Bilateral posterolateral lumbar intertransverse fusions were performed at L5-L6. The lateral two thirds of the transverse processes were decorti cated and covered with graft material in the following five groups: ICBG, SiCaP EP stand-alone, SiCaP EP with BMA (1:0.5 by volume), and SiCaP EP with ICBG (1:3 by volume). Rabbits were necropsied at 4, 8, and 12-week time points and fusion rate, quantity, and quality was evaluated based on manual palpation, mechanical stiffness testing, pqCT, and histological assessment.
    Results: SiCaP EP, ICBG+SiCaP EP (3:1), and SiCaP EP+BMA (1:0.5) compare favorably to iliac crest autologous bone by multiple metrics in this rabbit posterolateral fusion model. Fusion efficacy via manual palpation and mechanical stiffness testing metrics indicate that all SiCaP EP groups had similar group-to-group performance, and were not significantly different than the ICBG control at each time period evaluated.
    Conclusions: In this commonly used rabbit posterolateral fusion model, SiCaP EP utilized as a stand-alone, as a stand-alone with BMA, and as an autograft (ICBG) extender produces results that are clinically and radiographically similar to ICBG.
    MeSH term(s) Animals ; Bone Substitutes/therapeutic use ; Bone Transplantation/methods ; Durapatite/therapeutic use ; Ilium/transplantation ; Lumbar Vertebrae/surgery ; Materials Testing ; Models, Animal ; Rabbits ; Spinal Fusion/methods ; Treatment Outcome
    Chemical Substances Bone Substitutes ; Durapatite (91D9GV0Z28)
    Language English
    Publishing date 2013-08-20
    Publishing country United States
    Document type Evaluation Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1204065-4
    ISSN 1555-1377 ; 1541-5457
    ISSN (online) 1555-1377
    ISSN 1541-5457
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Se 1381: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Book ; Online: Manifesto for Living in the Anthropocene

    Katherine Gibson (Ed.) / Deborah Bird Rose (Ed.) / Ruth Fincher (Ed.) / J.K. Gibson-Graham / Ethan Miller / Jessica K. Weir / Kurt Iveson / Lesley Instone / Freya Mathews / Kate Rigby / Thom van Dooren / Gerda Roelvink / George Main / Jenny Cameron / Robert Pekin / Kumi Kato / Margaret Somerville / Anna Yeatman

    2015  

    Abstract: The recent 10,000 year history of climatic stability on Earth that enabled the rise of agriculture and domestication, the growth of cities, numerous technological revolutions, and the emergence of modernity is now over. We accept that in the latest phase ...

    Abstract The recent 10,000 year history of climatic stability on Earth that enabled the rise of agriculture and domestication, the growth of cities, numerous technological revolutions, and the emergence of modernity is now over. We accept that in the latest phase of this era, modernity is unmaking the stability that enabled its emergence. Over the 21st century severe and numerous weather disasters, scarcity of key resources, major changes in environments, enormous rates of extinction, and other forces that threaten life are set to increase. But we are deeply worried that current responses to these challenges are focused on market-driven solutions and thus have the potential to further endanger our collective commons. Today public debate is polarized. On one hand we are confronted with the immobilizing effects of knowing “the facts” about climate change. On the other we see a powerful will to ignorance and the effects of a pernicious collaboration between climate change skeptics and industry stakeholders. Clearly, to us, the current crisis calls for new ways of thinking and producing knowledge. Our collective inclination has been to go on in an experimental and exploratory mode, in which we refuse to foreclose on options or jump too quickly to “solutions.”In this spirit we feel the need to acknowledge the tragedy of anthropogenic climate change. It is important to tap into the emotional richness of grief about extinction and loss without getting stuck on the “blame game.” Our research must allow for the expression of grief and mourning for what has been and is daily being lost. But it is important to adopt a reparative rather than a purely critical stance toward knowing. Might it be possible to welcome the pain of “knowing” if it led to different ways of working with non-human others, recognizing a confluence of desire across the human/non-human divide and the vital rhythms that animate the world? Our discussions have focused on new types of ecological economic thinking and ethical practices of living. We are interested in:Resituating humans within ecological systemsResituating non-humans in ethical termsSystems of survival that are resilient in the face of changeDiversity and dynamism in ecologies and economiesEthical responsibility across space and time, between places and in the futureCreating new ecological economic narratives.Starting from the recognition that there is no “one size fits all” response to climate change, we are concerned to develop an ethics of place that appreciates the specificity and richness of loss and potentiality. While connection to earth others might be an overarching goal, it will be to certain ecologies, species, atmospheres and materialities that we actually connect. We could see ourselves as part of country, accepting the responsibility not forgotten by Indigenous people all over the world, of “singing” country into health. This might mean cultivating the capacity for deep listening to each other, to the land, to other species and thereby learning to be affected and transformed by the body-world we are part of; seeing the body as a center of animation but not the ground of a separate self; renouncing the narcissistic defense of omnipotence and an equally narcissistic descent into despair.We think that we can work against singular and global representations of “the problem” in the face of which any small, multiple, place-based action is rendered hopeless. We can choose to read for difference rather than dominance; think connectivity rather than hyper-separation; look for multiplicity — multiple climate changes, multiple ways of living with earth others. We can find ways forward in what is already being done in the here and now; attend to the performative effects of any analysis; tell stories in a hopeful and open way — allowing for the possibility that life is dormant rather than dead. We can use our critical capacities to recover our rich traditions of counter-culture and theorize them outside the mainstream/alternative binary. All these ways of thinking and researching give rise to new strategies for going forward. Think of the chapters of this book as tentative hoverings, as the fluttering of butterfly wings, scattering germs of ideas that can take root and grow.
    Keywords ethics ; critical animal studies ; Anthropocene ; climate change ; economics ; environmental humanities ; ecology ; extinction ; food studies ; biodiversity
    Subject code 170
    Language English
    Publisher punctum books
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top