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  1. Article ; Online: 297 The Acute to Chronic Pain Signatures Program (A2CPS)

    Giovanni Berardi / Carol GT Vance / Dana L Dailey / Dixie Ecklund / Christopher Coffey / Emine Bayman / Kathleen A. Sluka

    Journal of Clinical and Translational Science, Vol 6, Pp 51-

    Conceptual Design and Protocol Implementation of a Multi-site Observational Study Assessing Risk and Resilience Biomarkers

    2022  Volume 51

    Abstract: OBJECTIVES/GOALS: The A2CPS was funded by the National Institutes of Health (NIH) Common Fund to identify biomarkers and their collective biosignatures (combination of several biomarkers) that predict susceptibility or resilience to the development of ... ...

    Abstract OBJECTIVES/GOALS: The A2CPS was funded by the National Institutes of Health (NIH) Common Fund to identify biomarkers and their collective biosignatures (combination of several biomarkers) that predict susceptibility or resilience to the development of chronic pain. METHODS/STUDY POPULATION: The A2CPS includes 2-Multisite Clinical Centers (10 recruitment sites and 6 data collection sites), 1-Clinical Coordinating Center, 1-Data Integration and Resource Center, 3-Omics Data Generation Centers, and representation from the NIH. The A2CPS will recruit a large cohort from 2 different surgical interventions, total knee arthroplasty (n?1800) and thoracotomy (n?1800). This observational study will collect candidate and exploratory biomarkers across the following domains: clinical pain, fatigue, function, sleep, psychosocial, genomics, proteomics, metabolomics, lipidomics, pain sensitivity, and brain imaging. Data will be collected before and up to 3 months after surgery to determine factors that predict chronic pain at 6 months. RESULTS/ANTICIPATED RESULTS: Recruitment started in 2021 following standard operating procedures and is ongoing at both Multisite Clinical Centers. The A2CPS will provide an example of collaborative, multidisciplinary efforts in establishing a data repository consisting of biopsychosocial markers that will be available to the research community to test novel hypotheses. This presentation will describe the conceptual design, study aims, biomarker selection, protocol standardization and study implementation for the A2CPS. An update on study progress and data completeness will be presented. Final results will be reported after study completion which is anticipated by 2024. DISCUSSION/SIGNIFICANCE: Identifying biomarkers and biosignatures that predict high- versus low-risk for the transition to chronic pain will inform future clinical trials, identify novel therapeutic targets, and advance personalized pain treatment strategies; ultimately transforming the prevention and treatment of chronic ...
    Keywords Medicine ; R
    Subject code 310
    Language English
    Publishing date 2022-04-01T00:00:00Z
    Publisher Cambridge University Press
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Effect of Intramuscular Protons, Lactate, and ATP on Muscle Hyperalgesia in Rats.

    Nicholas S Gregory / Phillip E Whitley / Kathleen A Sluka

    PLoS ONE, Vol 10, Iss 9, p e

    2015  Volume 0138576

    Abstract: Chronic muscle pain is a significant health problem leading to disability[1]. Muscle fatigue can exacerbate muscle pain. Metabolites, including ATP, lactate, and protons, are released during fatiguing exercise and produce pain in humans. These substances ...

    Abstract Chronic muscle pain is a significant health problem leading to disability[1]. Muscle fatigue can exacerbate muscle pain. Metabolites, including ATP, lactate, and protons, are released during fatiguing exercise and produce pain in humans. These substances directly activate purinergic (P2X) and acid sensing ion channels (ASICs) on muscle nociceptors, and when combined, produce a greater increase in neuron firing than when given alone. Whether the enhanced effect of combining protons, lactate, and ATP is the sum of individual effects (additive) or more than the sum of individual effects (synergistic) is unknown. Using a rat model of muscle nociceptive behavior, we tested each of these compounds individually over a range of physiologic and supra-physiologic concentrations. Further, we combined all three compounds in a series of dilutions and tested their effect on muscle nociceptive behavior. We also tested a non-hydrolyzable form of ATP (α,β-meATP) alone and in combination with lactate and acidic pH. Surprisingly, we found no dose-dependent effect on muscle nociceptive behavior for protons, lactate, or ATP when given alone. We similarly found no effect after application of each two-metabolite combination. Only pH 4 saline and α,β-meATP produced hyperalgesia when given alone. When all 3 substances were combined, however, ATP (2.4μm), lactate (10mM), and acidic pH (pH 6.0) produced an enhanced effect greater than the sum of the effects of the individual components, i.e. synergism. α,β me ATP (3nmol), on the other hand, showed no enhanced effects when combined with lactate (10mM) or acidic pH (pH 6.0), i.e. additive. These data suggest that combining fatigue metabolites in muscle produces a synergistic effect on muscle nociception.
    Keywords Medicine ; R ; Science ; Q
    Subject code 796
    Language English
    Publishing date 2015-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Development of a national pain management competency profile to guide entry-level physiotherapy education in Canada

    Nathan Augeard / Geoff Bostick / Jordan Miller / David Walton / Yannick Tousignant-Laflamme / Anne Hudon / André Bussières / Lynn Cooper / Nicol McNiven / Aliki Thomas / Lesley Singer / Scott M. Fishman / Marie H. Bement / Julia M. Hush / Kathleen A. Sluka / Judy Watt-Watson / Lisa C. Carlesso / Sinead Dufour / Roland Fletcher /
    Katherine Harman / Judith Hunter / Suzy Ngomo / Neil Pearson / Kadija Perreault / Barbara Shay / Peter Stilwell / Susan Tupper / Timothy H. Wideman

    Canadian Journal of Pain, Vol 6, Iss 1, Pp 1-

    2022  Volume 11

    Abstract: Background National strategies from North America call for substantive improvements in entry-level pain management education to help reduce the burden of chronic pain. Past work has generated a valuable set of interprofessional pain management ... ...

    Abstract Background National strategies from North America call for substantive improvements in entry-level pain management education to help reduce the burden of chronic pain. Past work has generated a valuable set of interprofessional pain management competencies to guide the education of future health professionals. However, there has been very limited work that has explored the development of such competencies for individual professions in different regions. Developing profession-specific competencies tailored to the local context is a necessary first step to integrate them within local regulatory systems. Our group is working toward this goal within the context of entry-level physiotherapy (PT) programs across Canada. Aims This study aimed to create a consensus-based competency profile for pain management, specific to the Canadian PT context. Methods A modified Delphi design was used to achieve consensus across Canadian university-based and clinical pain educators. Results Representatives from 14 entry-level PT programs (93% of Canadian programs) and six clinical educators were recruited. After two rounds, a total of 15 competencies reached the predetermined endorsement threshold (75%). Most participants (85%) reported being “very satisfied” with the process. Conclusions This process achieved consensus on a novel pain management competency profile specific to the Canadian PT context. The resulting profile delineates the necessary abilities required by physiotherapists to manage pain upon entry to practice. Participants were very satisfied with the process. This study also contributes to the emerging literature on integrated research in pain management by profiling research methodology that can be used to inform related work in other health professions and regions.
    Keywords pain management ; competency profile ; participatory research ; knowledge translation ; physiotherapy ; Medicine (General) ; R5-920 ; Therapeutics. Pharmacology ; RM1-950
    Subject code 300
    Language English
    Publishing date 2022-12-01T00:00:00Z
    Publisher Taylor & Francis Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: ASICs Do Not Play a Role in Maintaining Hyperalgesia Induced by Repeated Intramuscular Acid Injections

    Mamta Gautam / Christopher J. Benson / Jon D. Ranier / Alan R. Light / Kathleen A. Sluka

    Pain Research and Treatment, Vol

    2012  Volume 2012

    Abstract: Repeated intramuscular acid injections produce long-lasting mechanical hyperalgesia that depends on activation of ASICs. The present study investigated if pH-activated currents in sensory neurons innervating muscle were altered in response to repeated ... ...

    Abstract Repeated intramuscular acid injections produce long-lasting mechanical hyperalgesia that depends on activation of ASICs. The present study investigated if pH-activated currents in sensory neurons innervating muscle were altered in response to repeated acid injections, and if blockade of ASICs reverses existing hyperalgesia. In muscle sensory neurons, the mean acid-evoked current amplitudes and the biophysical properties of the ASIC-like currents were unchanged following acidic saline injections when compared to neutral pH saline injections or uninjected controls. Moreover, increased mechanical sensitivity of the muscle and paw after the second acid injection was unaffected by local blockade of ASICs (A-317567) in the muscle. As a control, electron microscopic analysis showed that the tibial nerve was undamaged after acid injections. Our previous studies demonstrated that ASICs are important in the development of hyperalgesia to repeated acid injections. However, the current data suggest that ASICs are not involved in maintaining hyperalgesia to repeated intramuscular acid injections.
    Keywords Medicine (General) ; R5-920
    Language English
    Publishing date 2012-01-01T00:00:00Z
    Publisher Hindawi Publishing Corporation
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Multi-Site Observational Study to Assess Biomarkers for Susceptibility or Resilience to Chronic Pain

    Giovanni Berardi / Laura Frey-Law / Kathleen A. Sluka / Emine O. Bayman / Christopher S. Coffey / Dixie Ecklund / Carol G. T. Vance / Dana L. Dailey / John Burns / Asokumar Buvanendran / Robert J. McCarthy / Joshua Jacobs / Xiaohong Joe Zhou / Richard Wixson / Tessa Balach / Chad M. Brummett / Daniel Clauw / Douglas Colquhoun / Steven E. Harte /
    Richard E. Harris / David A. Williams / Andrew C. Chang / Jennifer Waljee / Kathleen M. Fisch / Kristen Jepsen / Louise C. Laurent / Michael Olivier / Carl D. Langefeld / Timothy D. Howard / Oliver Fiehn / Jon M. Jacobs / Panshak Dakup / Wei-Jun Qian / Adam C. Swensen / Anna Lokshin / Martin Lindquist / Brian S. Caffo / Ciprian Crainiceanu / Scott Zeger / Ari Kahn / Tor Wager / Margaret Taub / James Ford

    Frontiers in Medicine, Vol

    The Acute to Chronic Pain Signatures (A2CPS) Study Protocol

    2022  Volume 9

    Abstract: Chronic pain has become a global health problem contributing to years lived with disability and reduced quality of life. Advances in the clinical management of chronic pain have been limited due to incomplete understanding of the multiple risk factors ... ...

    Abstract Chronic pain has become a global health problem contributing to years lived with disability and reduced quality of life. Advances in the clinical management of chronic pain have been limited due to incomplete understanding of the multiple risk factors and molecular mechanisms that contribute to the development of chronic pain. The Acute to Chronic Pain Signatures (A2CPS) Program aims to characterize the predictive nature of biomarkers (brain imaging, high-throughput molecular screening techniques, or “omics,” quantitative sensory testing, patient-reported outcome assessments and functional assessments) to identify individuals who will develop chronic pain following surgical intervention. The A2CPS is a multisite observational study investigating biomarkers and collective biosignatures (a combination of several individual biomarkers) that predict susceptibility or resilience to the development of chronic pain following knee arthroplasty and thoracic surgery. This manuscript provides an overview of data collection methods and procedures designed to standardize data collection across multiple clinical sites and institutions. Pain-related biomarkers are evaluated before surgery and up to 3 months after surgery for use as predictors of patient reported outcomes 6 months after surgery. The dataset from this prospective observational study will be available for researchers internal and external to the A2CPS Consortium to advance understanding of the transition from acute to chronic postsurgical pain.
    Keywords postsurgical pain ; thoracic surgery ; pain ; biomarker ; risk factors ; protocol ; Medicine (General) ; R5-920
    Subject code 616
    Language English
    Publishing date 2022-04-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Estudo da confiabilidade e validade da utilização do hidropletismômetro para medida de edema no tornozelo Study of the reliability and validity of the water plethysmographer for use in measurement of the edema at the ankle/foot

    Ian Lara Lamounier Andrade / André Lacerda Saraiva Costa / Marcos Pinotti Barbosa / Kathleen A Sluka / Luci Fuscaldi Teixeira-Salmela / Marcos Antônio de Resende

    Fisioterapia e Pesquisa, Vol 18, Iss 1, Pp 6-

    2011  Volume 10

    Abstract: Instrumentos confiáveis e válidos são necessários para avaliar a efetividade das técnicas de reabilitação. O objetivo deste estudo foi avaliar a confiabilidade e a validade do Hidropletismômetro. Quatorze sujeitos com idade entre 18 e 59 anos foram ... ...

    Abstract Instrumentos confiáveis e válidos são necessários para avaliar a efetividade das técnicas de reabilitação. O objetivo deste estudo foi avaliar a confiabilidade e a validade do Hidropletismômetro. Quatorze sujeitos com idade entre 18 e 59 anos foram selecionados para participar do estudo. Os tornozelos foram avaliados por dois examinadores treinados com o Hidropletismômetro. Três medidas de cada tornozelo foram obtidas pelos examinadores de forma aleatória para investigar a confiabilidade intra e inter-examinadores. Foram também obtidas vinte e seis medidas com o Hidropletismômetro e comparadas com as medidas obtidas com o Deslocador de Água considerado "padrão ouro", através de provetas de vidro graduadas de 10 ml a 1000 ml. A confiabilidade intra e inter-examinadores foi realizada através do Coeficiente de Correlação Intraclasse (CCI) e a validade através do teste t pareado. O Coeficiente de Correlação de Pearson foi utilizado para estabelecer a associação entre os dois instrumentos. Os dados demonstraram níveis de confiabilidade intra e inter-examinadores com (CCI)3,1 = 0,99 e (CCI)3,2 = 0,99, respectivamente. Nenhuma diferença foi encontrada entre as medidas obtidas com o Hidropletismômetro e as obtidas com as provetas (p=0,404). A Correlação de Coeficiente de Pearson mostrou alta magnitute e nível de significância entre as medidas (r=1,0; p<0,0001). Os resultados evidenciaram que o Hidropletismômetro é um instrumento confiável e válido para medida de volume do tornozelo/pé. Reliable and valid instruments are necessary to evaluate the effectiveness of the rehabilitation techniques.The objective this study was to evaluate the reliability and the validity of the water plethysmography. Fourteen subjects between the ages of 18 and 59 years were selected to participate in the study. Ankles were assessed by two trained examiners with the water plethysmography. Three measures of each ankle were obtained by the two investigators to evaluate intra- and inter-raters reliability. Twenty-six measures were obtained with the water plethysmography and compared with measurements obtained by graduated cylinders from 10 to 1000 ml, water displacement device (gold standart). Intraclass correlation coefficients (ICCs) evaluated intra- and inter-raters reliability, whereas paired Student t-tests and Pearson's correlation coefficients were used to establish validity of the water plethysmography.The results demonstrated excellent intra- and inter-rater reliability levels with levels with CCI3,1=0.99 and CCI3,2=0.99 respectively. No differences were found between the measures obtained with the water plethysmography compared to those of the water displacement device (p=0.40). Pearson's correlation coefficient showed a high magnitude and significance level between the measures (r=1,0; p<0.0001).The findings demonstrated that the water plethysmography is a reliable and valid instrument for measuring ankle/foot volume.
    Keywords Descritores ; volumetria ; edema ; confiabilidade ; validade ; tornozelo ; Volumetry ; reliability ; validity ; ankle ; Therapeutics. Psychotherapy ; RC475-489 ; Psychiatry ; RC435-571 ; Neurology. Diseases of the nervous system ; RC346-429 ; Neurosciences. Biological psychiatry. Neuropsychiatry ; RC321-571 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Therapeutics ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Language Portuguese
    Publishing date 2011-03-01T00:00:00Z
    Publisher Universidade de São Paulo
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article: β-caryophyllene, a dietary cannabinoid, complexed with β-cyclodextrin produced anti-hyperalgesic effect involving the inhibition of Fos expression in superficial dorsal horn

    Quintans-Júnior, Lucindo J / Adriano A.S. Araújo / Flavio M.S. Carvalho / Gabriel F. Silva / Jullyana S.S. Quintans / Kathleen A. Sluka / Mairim R. Serafini / Nicole K. Brogden / Paula P. Menezes / Priscila L. Santos / Renan G. Brito

    Life sciences. 2016 Mar. 15, v. 149

    2016  

    Abstract: Evaluate the anti-hyperalgesic effect of the complex containing β-caryophyllene (βCP) and β-cyclodextrin (βCD) in a non-inflammatory chronic muscle pain mice model and investigated its action on superficial dorsal horn of the lumbar spinal cord.The β ...

    Abstract Evaluate the anti-hyperalgesic effect of the complex containing β-caryophyllene (βCP) and β-cyclodextrin (βCD) in a non-inflammatory chronic muscle pain mice model and investigated its action on superficial dorsal horn of the lumbar spinal cord.The βCP-βCD complex were prepared and characterized through the DSC, TG/DTG, FTIR, XRD and SEM. The model of chronic muscle pain was induced by two injections of pH4.0 saline (20μL) into left gastrocnemius 5days apart. After confirming hyperalgesia, male mice were treated with βCP-βCD (10 or 20mg/kg; p.o.) or vehicle (saline 0.9%, p.o.) daily for 9days. 1h after, the mechanical hyperalgesia, muscle withdrawal thresholds and motor performance were evaluated. To evaluate the βCP-βCD action on spinal cord, animals induced with chronic muscle pain were treated with βCP-βCD (20mg/kg; p.o.) or vehicle (saline 0.9%, p.o.) and 90min. after, were perfused, the lumbar spinal cord collected, crioprotected, cut and submitted in an immunofluorescence protocol for Fos protein.The characterization tests indicated that βCP were efficiently incorporated into βCD. The oral treatment with βCP-βCD, at all doses tested, produced a significant (p<0.05) reduction on mechanical hyperalgesia and a significant (p<0.05) increase in muscle withdrawal thresholds, without produce any alteration in force. In addition, βCP-βCD was able to significantly (p<0.05) decrease Fos expression in the superficial dorsal horn.Thus, βCP-βCD attenuates the non-inflammatory chronic muscle pain in mice and inhibits the Fos expression in the lumbar spinal cord.
    Keywords beta-caryophyllene ; beta-cyclodextrin ; cannabinoids ; fluorescent antibody technique ; Fourier transform infrared spectroscopy ; males ; mice ; models ; muscles ; oral administration ; pain ; scanning electron microscopy ; somatosensory disorders ; spinal cord ; X-ray diffraction
    Language English
    Dates of publication 2016-0315
    Size p. 34-41.
    Publishing place Elsevier Inc.
    Document type Article
    ZDB-ID 3378-9
    ISSN 1879-0631 ; 0024-3205
    ISSN (online) 1879-0631
    ISSN 0024-3205
    DOI 10.1016/j.lfs.2016.02.049
    Database NAL-Catalogue (AGRICOLA)

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