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  1. Article ; Online: Correction

    Cassandra M Burke / Kenneth M K Mark / Judit Kun / Kathryn S Beauchemin / Surachai Supattapone

    PLoS Pathogens, Vol 20, Iss 1, p e

    Emergence of Prions Selectively Resistant to Combination Drug Therapy.

    2024  Volume 1011919

    Abstract: This corrects the article DOI:10.1371/journal.ppat.1008581.]. ...

    Abstract [This corrects the article DOI:10.1371/journal.ppat.1008581.].
    Keywords Immunologic diseases. Allergy ; RC581-607 ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Emergence of prions selectively resistant to combination drug therapy.

    Cassandra M Burke / Kenneth M K Mark / Judit Kun / Kathryn S Beauchemin / Surachai Supattapone

    PLoS Pathogens, Vol 16, Iss 5, p e

    2020  Volume 1008581

    Abstract: Prions are unorthodox infectious agents that replicate by templating misfolded conformations of a host-encoded glycoprotein, collectively termed PrPSc. Prion diseases are invariably fatal and currently incurable, but oral drugs that can prolong ... ...

    Abstract Prions are unorthodox infectious agents that replicate by templating misfolded conformations of a host-encoded glycoprotein, collectively termed PrPSc. Prion diseases are invariably fatal and currently incurable, but oral drugs that can prolong incubation times in prion-infected mice have been developed. Here, we tested the efficacy of combination therapy with two such drugs, IND24 and Anle138b, in scrapie-infected mice. The results indicate that combination therapy was no more effective than either IND24 or Anle138b monotherapy in prolonging scrapie incubation times. Moreover, combination therapy induced the formation of a new prion strain that is specifically resistant to the combination regimen but susceptible to Anle138b. To our knowledge, this is the first report of a pathogen with specific resistance to combination therapy despite being susceptible to monotherapy. Our findings also suggest that combination therapy may be a less effective strategy for treating prions than conventional pathogens.
    Keywords Immunologic diseases. Allergy ; RC581-607 ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2020-05-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

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