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  1. Article: Silver-catalyzed decarboxylative cyclization for the synthesis of substituted pyrazoles from 1,2-diaza-1,3-dienes and α-keto acids

    Katiyar, Sarita / Kumar, Abhishek / Sashidhara, Koneni V.

    Chemical communications. 2022 June 28, v. 58, no. 52

    2022  

    Abstract: A silver-catalyzed decarboxylative cyclization process has been developed for the synthesis of substituted pyrazoles from the readily available 1,2-diaza-1,3-dienes and α-keto acids. Under the optimized conditions, a series of multisubstituted pyrazoles ... ...

    Abstract A silver-catalyzed decarboxylative cyclization process has been developed for the synthesis of substituted pyrazoles from the readily available 1,2-diaza-1,3-dienes and α-keto acids. Under the optimized conditions, a series of multisubstituted pyrazoles were well prepared in moderate to good yields. In addition, the synthetic utility of this protocol has been demonstrated by synthesizing analogs of FDA approved drugs such as anti-inflammatory drug, lonazolac and antiobesity drug, rimonabant.
    Keywords acids ; chemical communication ; pyrazoles
    Language English
    Dates of publication 2022-0628
    Size p. 7297-7300.
    Publishing place The Royal Society of Chemistry
    Document type Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d2cc01793h
    Database NAL-Catalogue (AGRICOLA)

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  2. Article ; Online: Silver-catalyzed decarboxylative cyclization for the synthesis of substituted pyrazoles from 1,2-diaza-1,3-dienes and α-keto acids.

    Katiyar, Sarita / Kumar, Abhishek / Sashidhara, Koneni V

    Chemical communications (Cambridge, England)

    2022  Volume 58, Issue 52, Page(s) 7297–7300

    Abstract: A silver-catalyzed decarboxylative cyclization process has been developed for the synthesis of substituted pyrazoles from the readily available 1,2-diaza-1,3-dienes and α-keto acids. Under the optimized conditions, a series of multisubstituted pyrazoles ... ...

    Abstract A silver-catalyzed decarboxylative cyclization process has been developed for the synthesis of substituted pyrazoles from the readily available 1,2-diaza-1,3-dienes and α-keto acids. Under the optimized conditions, a series of multisubstituted pyrazoles were well prepared in moderate to good yields. In addition, the synthetic utility of this protocol has been demonstrated by synthesizing analogs of FDA approved drugs such as anti-inflammatory drug, lonazolac and antiobesity drug, rimonabant.
    MeSH term(s) Catalysis ; Cyclization ; Keto Acids ; Molecular Structure ; Polyenes ; Pyrazoles ; Silver
    Chemical Substances Keto Acids ; Polyenes ; Pyrazoles ; Silver (3M4G523W1G)
    Language English
    Publishing date 2022-06-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d2cc01793h
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: PIDA-mediated oxidative aromatic C[sbnd]N bond cleavage: Efficient methodology for the synthesis of 1,2-diaza-1,3-dienes under ambient conditions

    Kumar, Abhishek / Katiyar, Sarita / Kumar Jaiswal, Arvind / Kant, Ruchir / Sashidhara, Koneni V.

    Tetrahedron letters 2021 Aug. 3, v. 77, p. 153252

    2021  , Page(s) 153252

    Abstract: A series of functionalized 1,2-diaza-1,3-diene derivatives were synthesized from 5–aminopyrazoles via oxidative cleavage of the aromatic CN bond under transition metal-free conditions. A control experiment revealed that the presence of a free NH₂ group ... ...

    Abstract A series of functionalized 1,2-diaza-1,3-diene derivatives were synthesized from 5–aminopyrazoles via oxidative cleavage of the aromatic CN bond under transition metal-free conditions. A control experiment revealed that the presence of a free NH₂ group on the 5–aminopyrazole is important for the reaction. The utility of this valuable synthon for building diverse heterocyclic structures is also presented, which otherwise would be difficult to access using conventional methods.
    Keywords Metal-free ; Hypervalent iodine ; Selective CN bond cleavage ; Ambient temperature
    Language English
    Dates of publication 2021-0803
    Size p. 153252
    Publishing place Pergamon Press.
    Document type Article ; Online
    ZDB-ID 204287-3
    ISSN 1873-3581 ; 0040-4039
    ISSN (online) 1873-3581
    ISSN 0040-4039
    DOI 10.1016/j.tetlet.2021.153252
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2837: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  4. Article ; Online: Design, synthesis, and biological evaluation of quinoline-piperazine/pyrrolidine derivatives as possible antileishmanial agents.

    Katiyar, Sarita / Ramalingam, Karthik / Kumar, Abhishek / Ansari, Alisha / Bisen, Amol Chhatrapati / Mishra, Garvita / Sanap, Sachin Nashik / Bhatta, Rabi Sankar / Purkait, Bidyut / Goyal, Neena / Sashidhara, Koneni V

    European journal of medicinal chemistry

    2023  Volume 261, Page(s) 115863

    Abstract: In pursuance of our efforts to expand the scope of novel antileishmanial entities, a series of thirty-five quinoline-piperazine/pyrrolidine, and other heterocyclic amine derivatives were synthesized via a molecular hybridization approach and examined ... ...

    Abstract In pursuance of our efforts to expand the scope of novel antileishmanial entities, a series of thirty-five quinoline-piperazine/pyrrolidine, and other heterocyclic amine derivatives were synthesized via a molecular hybridization approach and examined against intracellular amastigotes of luciferase-expressing Leishmania donovani. The preliminary in vitro screening suggests that twelve compounds in the series exhibited better inhibition against amastigote form with good IC
    MeSH term(s) Antiprotozoal Agents ; Leishmania donovani ; Piperazine ; Quinolines/pharmacology
    Chemical Substances Antiprotozoal Agents ; Piperazine (1RTM4PAL0V) ; Quinolines ; pyrrolidine (LJU5627FYV)
    Language English
    Publishing date 2023-10-07
    Publishing country France
    Document type Journal Article
    ZDB-ID 188597-2
    ISSN 1768-3254 ; 0009-4374 ; 0223-5234
    ISSN (online) 1768-3254
    ISSN 0009-4374 ; 0223-5234
    DOI 10.1016/j.ejmech.2023.115863
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 784: Show issues Location:
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  5. Article ; Online: Discovery, SAR and mechanistic studies of quinazolinone-based acetamide derivatives in experimental visceral leishmaniasis.

    Ansari, Alisha / Seth, Anuradha / Dutta, Mukul / Qamar, Tooba / Katiyar, Sarita / Jaiswal, Arvind K / Rani, Ankita / Majhi, Swetapadma / Kumar, Mukesh / Bhatta, Rabi S / Guha, Rajdeep / Mitra, Kalyan / Sashidhara, Koneni V / Kar, Susanta

    European journal of medicinal chemistry

    2023  Volume 257, Page(s) 115524

    Abstract: Towards identification of novel therapeutic candidates, a series of quinazolinone-based acetamide derivatives were synthesized and assessed for their anti-leishmanial efficacy. Amongst synthesized derivatives, compounds F12, F27 and F30 demonstrated ... ...

    Abstract Towards identification of novel therapeutic candidates, a series of quinazolinone-based acetamide derivatives were synthesized and assessed for their anti-leishmanial efficacy. Amongst synthesized derivatives, compounds F12, F27 and F30 demonstrated remarkable activity towards intracellular L. donovani amastigotes in vitro, with IC
    MeSH term(s) Cricetinae ; Animals ; Mice ; Leishmaniasis, Visceral/drug therapy ; Leishmaniasis, Visceral/metabolism ; Leishmania donovani ; Quinazolinones/pharmacology ; Quinazolinones/therapeutic use ; Quinazolinones/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Antiprotozoal Agents/pharmacology ; Antiprotozoal Agents/therapeutic use ; Acetamides/pharmacology ; Acetamides/therapeutic use ; Acetamides/metabolism ; Mice, Inbred BALB C
    Chemical Substances Quinazolinones ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Antiprotozoal Agents ; Acetamides
    Language English
    Publishing date 2023-06-01
    Publishing country France
    Document type Journal Article
    ZDB-ID 188597-2
    ISSN 1768-3254 ; 0009-4374 ; 0223-5234
    ISSN (online) 1768-3254
    ISSN 0009-4374 ; 0223-5234
    DOI 10.1016/j.ejmech.2023.115524
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 784: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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