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Article ; Online: Portal and Mesenteric Vein Thrombosis Associated with Hyperthyroidism.

Kato, Aya / Matsuo, Yuichiro / Miyagaki, Aki / Endo, Keita / Hiraoka, Eiji

2021 Volume 22, Page(s) e929565

Abstract: BACKGROUND Non-malignant and non-cirrhotic portal and mesenteric vein thrombosis is rare. It has been reported that the hyperthyroid state is associated with increased risks of venous thrombosis due to increases in levels of various coagulation and anti- ... ...

Abstract	BACKGROUND Non-malignant and non-cirrhotic portal and mesenteric vein thrombosis is rare. It has been reported that the hyperthyroid state is associated with increased risks of venous thrombosis due to increases in levels of various coagulation and anti-fibrinolytic factors. Particularly, changes in levels of these factors are also reported in cases of portal and mesenteric vein thrombosis. Although hyperthyroidism is not known as a risk factor for portal and mesenteric vein thrombosis, it might be an underlying pathogenesis of hyperthyroidism-associated portal and mesenteric vein thrombosis. CASE REPORT A 59-year-old Japanese man with a history of Grave's disease presented with acute portal and mesenteric vein thrombosis and hyperthyroidism. Anticoagulation therapy was initiated and the dose of antithyroid drug was increased. He underwent various tests to identify causes of portal and mesenteric vein thrombosis. However, all test results were within normal range except for hyperthyroidism. Therefore, we discontinued anticoagulation therapy after normalization of thyroid hormone status. After 3 years, he experienced recurrence of portal vein thrombosis concomitant with hyperthyroidism. CONCLUSIONS Hyperthyroidism might be associated with portal vein thrombosis. Thyroid function tests should be performed in cases of portal and mesenteric vein thrombosis in the absence of other risk factors.
MeSH term(s)	Humans ; Hyperthyroidism/complications ; Male ; Mesenteric Veins/diagnostic imaging ; Middle Aged ; Portal Vein/diagnostic imaging ; Thrombolytic Therapy ; Venous Thrombosis/drug therapy ; Venous Thrombosis/etiology
Language	English
Publishing date	2021-04-05
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	2517183-5
ISSN	1941-5923 ; 1941-5923
ISSN (online)	1941-5923
ISSN	1941-5923
DOI	10.12659/AJCR.929565
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Disseminated tuberculosis following invasive procedures for peripancreatic lymph node tuberculosis with portal vein obstruction: a case report.

Kato, Aya / Mashiba, Takahisa / Tateishi, Yoshinori / Oda, Rentaro / Funakoshi, Hiraku / Iwanami, Keiichi / Motomura, Yasuaki

Clinical journal of gastroenterology

2022 Volume 15, Issue 3, Page(s) 673–679

Abstract: Peripancreatic tuberculous lymphadenopathy can mimic pancreatic cancer on imaging. There have only a few reports on varices from portal vein obstruction due to abdominal tuberculous lymphadenopathy. Iatrogenic disseminated tuberculosis is also rare. ... ...

Abstract	Peripancreatic tuberculous lymphadenopathy can mimic pancreatic cancer on imaging. There have only a few reports on varices from portal vein obstruction due to abdominal tuberculous lymphadenopathy. Iatrogenic disseminated tuberculosis is also rare. Herein, we present a rare case of peripancreatic tuberculous lymphadenopathy with ruptured duodenal varices due to portal vein obstruction. The patient presented to our hospital with hematemesis. Computed tomography revealed a peripancreatic mass. Duodenal varices rupture from portal vein obstruction due to pancreatic cancer were initially suspected. The patient underwent portal vein stenting for portal vein obstruction and endoscopic ultrasound-guided fine-needle aspiration for diagnosis, which revealed granulomas indicative of tuberculosis. The patient was discharged once because fine-needle aspiration did not lead to a definitive diagnosis of tuberculosis. Subsequently, he developed disseminated tuberculosis. Peripancreatic tuberculous lymphadenopathy can cause ectopic varices with portal vein obstruction. Tuberculosis should also be included in the differential diagnosis in the case of portal vein obstruction, to facilitate early treatment and avoid unnecessary surgery. Furthermore, fine-needle aspiration or portal vein stenting for tuberculous lesions can cause disseminated tuberculosis. Since a diagnosis might not be made until after several fine-needle aspirations have been conducted, careful follow-up is necessary after the procedure for such lesions.
MeSH term(s)	Endoscopic Ultrasound-Guided Fine Needle Aspiration/adverse effects ; Granuloma ; Humans ; Liver Diseases ; Lymphadenopathy ; Male ; Pancreatic Neoplasms/diagnosis ; Portal Vein/pathology ; Tuberculosis, Lymph Node/complications ; Tuberculosis, Lymph Node/diagnosis ; Tuberculosis, Miliary ; Varicose Veins ; Pancreatic Neoplasms
Language	English
Publishing date	2022-03-25
Publishing country	Japan
Document type	Case Reports ; Journal Article
ZDB-ID	2429411-1
ISSN	1865-7265 ; 1865-7257
ISSN (online)	1865-7265
ISSN	1865-7257
DOI	10.1007/s12328-022-01624-6
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Article ; Online: Validity of computed mean compressed fibroglandular tissue thickness and breast composition for stratification of masking risk in Japanese women.

Oiwa, Mikinao / Suda, Namiko / Morita, Takako / Takahashi, Yuko / Sato, Yasuyuki / Hayashi, Takako / Kato, Aya / Nishimura, Rieko / Ichihara, Shu / Endo, Tokiko

Breast cancer (Tokyo, Japan)

2023 Volume 30, Issue 4, Page(s) 541–551

Abstract: Background: The volumetric measurement system for mammographic breast density is a high-precision objective method for evaluating the percentage of fibroglandular tissue volume (FG%). Nonetheless, FG% does not precisely correlate with subjective visual ... ...

Abstract	Background: The volumetric measurement system for mammographic breast density is a high-precision objective method for evaluating the percentage of fibroglandular tissue volume (FG%). Nonetheless, FG% does not precisely correlate with subjective visual estimation (SVE) and shows poor evaluation performance regarding masking risk in patients with comparatively thin compressed breast thickness (CBT), commonly found in Japanese women. We considered that the mean compressed fibroglandular tissue thickness (mCGT), which incorporates the CBT element into the evaluation of breast density, may better predict masking risk. Methods: Volumetric measurements and SVEs were performed on mammograms of 108 breast cancer patients from our center. mCGT was calculated as the product of CBT and FG%. SVE was classified using the Breast Imaging-Reporting and Data System classification, 5th edition. Subsequently, the performance of mCGT, SVE, and FG% in predicting masking risk was estimated using the AUC. Results: The AUC values of mCGT and SVE were 0.84 (95% confidence interval, 0.71-0.92) and 0.78 (0.66-0.86), respectively (P = 0.16). The AUC of the FG% was 0.65 (0.52-0.77), which was significantly lower than that of mCGT (P < 0.001). The sensitivity and specificity of mCGT in predicting negative detection were 89% and 71%, respectively; of SVE 83% and 61% (versus 72% and 57% with FG%), suggesting that mCGT was superior to FG% in both sensitivity and specificity, and comparable with SVE. Conclusions: Objective mCGT calculated from the volumetric measurement system will highly likely be useful in evaluating breast density and supporting visual assessment for masking risk stratification.
MeSH term(s)	Female ; Humans ; Breast Neoplasms/diagnostic imaging ; East Asian People ; Breast/diagnostic imaging ; Mammography/methods ; Breast Density
Language	English
Publishing date	2023-03-15
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2052429-8
ISSN	1880-4233 ; 1340-6868
ISSN (online)	1880-4233
ISSN	1340-6868
DOI	10.1007/s12282-023-01444-7
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Article: [A Case of Neuroendocrine Carcinoma of the Extrahepatic Bile Duct].

Suzuki, Chihiro / Sawazaki, Sho / Nakazono, Masato / Sueishi, Yui / Murata, Mitsutaka / Tanaka, Shoma / Minowa, Kazuaki / Izukawa, Shota / Kato, Aya / Kawabe, Taiichi / Higuchi, Akio / Matsukawa, Hiroshi / Rino, Yasushi / Saito, Aya / Saeki, Hiroyuki

Gan to kagaku ryoho. Cancer & chemotherapy

2024 Volume 50, Issue 13, Page(s) 1563–1565

Abstract: A 77-year-old man visited a clinic because of nausea and chest discomfort. On blood test, hepatobiliary enzymes were elevated, and he referred to our hospital. Contrast-enhanced CT revealed stenosis of the extrahepatic bile duct and brush cytology of the ...

Abstract	A 77-year-old man visited a clinic because of nausea and chest discomfort. On blood test, hepatobiliary enzymes were elevated, and he referred to our hospital. Contrast-enhanced CT revealed stenosis of the extrahepatic bile duct and brush cytology of the bile duct showed adenocarcinoma. We therefore performed pancreatoduodenectomy for extrahepatic bile duct cancer. Pathological diagnosis was small cell neuroendocrine carcinoma, pT3N2M0, Stage ⅢA. The patient did not receive adjuvant chemotherapy and 3 months later contrast-enhanced CT and MRI showed multiple liver metastases. The patient was treated with cisplatin plus irinotecan in the first-line, cisplatin plus etoposide in the second-line, and amrubicin in the third-line and accordingly he died 1 year and 3 months after the surgery. Chemotherapy for neuroendocrine carcinoma of the bile duct is recommended as in small cell lung cancer, but the prognosis is extremely poor. We report this case with a review of some of the literature.
MeSH term(s)	Male ; Humans ; Aged ; Cisplatin/therapeutic use ; Carcinoma, Neuroendocrine/drug therapy ; Carcinoma, Neuroendocrine/surgery ; Bile Ducts, Extrahepatic/surgery ; Adenocarcinoma/diagnosis ; Bile Duct Neoplasms/drug therapy ; Bile Duct Neoplasms/surgery ; Bile Duct Neoplasms/diagnosis
Chemical Substances	Cisplatin (Q20Q21Q62J)
Language	Japanese
Publishing date	2024-02-01
Publishing country	Japan
Document type	Case Reports ; Review ; English Abstract ; Journal Article
ZDB-ID	604842-0
ISSN	0385-0684
ISSN	0385-0684
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Article: [A Case of T-Cell Lymphoma Treated by Emergency Surgery Due to Bleeding of Jejunal Lesion].

Fujii, Yu / Sawazaki, Sho / Higuchi, Akio / Fukuda, Toshiyuki / Minowa, Kazuaki / Nakazono, Masato / Kato, Aya / Kawabe, Taiichi / Kojima, Yui / Aoyama, Toru / Tamakawa, Hiroshi / Yukawa, Norio / Rino, Yasushi / Saito, Aya / Saeki, Hiroyuki

Gan to kagaku ryoho. Cancer & chemotherapy

2024 Volume 50, Issue 13, Page(s) 1641–1643

Abstract: A 78-year-old man was aware of lightheadedness and darkness at a routine outpatient visit, and his blood pressure was declined at 87/51 mmHg. Contrast-enhanced CT scan showed an extravascular leakage image at jejunum. We diagnosed as small intestinal ... ...

Abstract	A 78-year-old man was aware of lightheadedness and darkness at a routine outpatient visit, and his blood pressure was declined at 87/51 mmHg. Contrast-enhanced CT scan showed an extravascular leakage image at jejunum. We diagnosed as small intestinal hemorrhage. Because he was in hemorrhagic shock, emergency surgery was performed. A tumor was found coincident with the bleeding site, and partial resection of the small intestine including enlarged lymph nodes was performed. Based on the pathological findings of T-cell origin and positive for serum anti-HTLV-1 antibody, he was suspected as adult T-cell leukemia/lymphoma(ATLL). Endoscopic examination of the upper and lower gastrointestinal tracts, bone marrow examination, and PET-CT scan were performed, but no other lesions were found. We report a case of the T-cell lymphoma with suspected solitary ATLL of the jejunum.
MeSH term(s)	Aged ; Humans ; Male ; Gastrointestinal Hemorrhage ; Jejunum/surgery ; Leukemia-Lymphoma, Adult T-Cell/complications ; Leukemia-Lymphoma, Adult T-Cell/surgery ; Lymphoma, T-Cell ; Lymphoma, T-Cell, Peripheral ; Positron Emission Tomography Computed Tomography
Language	Japanese
Publishing date	2024-02-02
Publishing country	Japan
Document type	Case Reports ; English Abstract ; Journal Article
ZDB-ID	604842-0
ISSN	0385-0684
ISSN	0385-0684
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Article ; Online: The Prognostic Immune and Nutritional Indices Are Independent Prognostic Factors for Esophageal Cancer Patients Who Receive Curative Treatment.

Aoyama, Toru / Hashimoto, Itaru / Maezawa, Yukio / Hara, Kentaro / Kato, Aya / Kazama, Keisuke / Tamagawa, Ayako / Cho, Haruhiko / Nakazono, Masato / Numata, Masakatsu / Kawahara, Shinnosuke / Oshima, Takashi / Saito, Aya / Yukawa, Norio

Anticancer research

2024 Volume 44, Issue 5, Page(s) 2185–2192

Abstract: Background/aim: Recently, the prognostic immune and nutritional index (PINI) was developed and reported to be a promising nutritional and inflammatory prognostic marker. The aim of the present study was to clarify the clinical impact of the PINI for ... ...

Abstract	Background/aim: Recently, the prognostic immune and nutritional index (PINI) was developed and reported to be a promising nutritional and inflammatory prognostic marker. The aim of the present study was to clarify the clinical impact of the PINI for esophageal cancer patients who received curative treatment. Patients and methods: We conducted a retrospective review of medical records and collected data on consecutive esophageal cancer patients who underwent curative resection at Yokohama City University between 2005 and 2020. The PINI was calculated by dividing the serum ALB concentration (g/dl) by the serum monocyte concentration, both of which were measured before surgery. Results: A total of 180 patients were included in this study. The cutoff value of the PINI was 3.0 in the present study. The 3- and 5-year overall survival rates were 45.2% and 33.5%, respectively, in the PINI-low subgroup, and 69.1% and 61.8%, respectively, in the PINI-high subgroup. A multivariate analysis demonstrated that the PINI was an independent prognostic factor for overall survival (hazard ratio=2.091, 95% confidence interval=1.287-3.399, p=0.003). Similar results were observed for recurrence-free survival. When comparing the sites of recurrence between the two groups, the incidence of hematological recurrence was significantly greater in the PINI-low subgroup compared to the PINI-high subgroup (46.8% vs. 21.1%, p<0.001). Conclusion: The PINI is a promising nutritional and inflammatory marker for esophageal cancer patients. The PINI might be a useful marker for the treatment and management of esophageal cancer patients.
MeSH term(s)	Humans ; Esophageal Neoplasms/immunology ; Esophageal Neoplasms/pathology ; Esophageal Neoplasms/blood ; Esophageal Neoplasms/mortality ; Esophageal Neoplasms/therapy ; Esophageal Neoplasms/surgery ; Male ; Female ; Prognosis ; Aged ; Middle Aged ; Nutrition Assessment ; Retrospective Studies ; Nutritional Status ; Aged, 80 and over ; Neoplasm Recurrence, Local/immunology ; Neoplasm Recurrence, Local/pathology ; Adult
Language	English
Publishing date	2024-04-27
Publishing country	Greece
Document type	Journal Article
ZDB-ID	604549-2
ISSN	1791-7530 ; 0250-7005
ISSN (online)	1791-7530
ISSN	0250-7005
DOI	10.21873/anticanres.17025
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Article ; Online: The Clinical Benefit of the Modified Neutrophil-Platelet Score as a Surrogate Prognostic Marker in Patients With Resectable Gastric Cancer.

Otani, Kazuki / Aoyama, Toru / Maezawa, Yukio / Hashimoto, Itaru / Kamiya, Natsumi / Kato, Aya / Numata, Masakatsu / Kawahara, Shinnosuke / Tamagawa, Ayako / Nakazono, Masato / Tamagawa, Hiroshi / Segami, Kenki / Kazama, Keisuke / Sawazaki, Sho / Yukawa, Norio / Saito, Aya / Rino, Yasushi

In vivo (Athens, Greece)

2024 Volume 38, Issue 2, Page(s) 897–903

Abstract: Background/aim: Gastric cancer is a common cause of cancer death worldwide, especially in East Asia. This study evaluated the impact of preoperative modified Neutrophil-Platelet Score (mNPS) on the survival and recurrence of patients with resectable ... ...

Abstract	Background/aim: Gastric cancer is a common cause of cancer death worldwide, especially in East Asia. This study evaluated the impact of preoperative modified Neutrophil-Platelet Score (mNPS) on the survival and recurrence of patients with resectable gastric cancer. Patients and methods: The study analyzed 168 patients who underwent curative gastrectomy and subsequently received adjuvant treatment for gastric cancer between 2015 and 2021. Univariate and multivariate analyses were performed to identify the risk factors for overall survival (OS) and recurrence-free survival (RFS). Results: Patients were divided into two groups: 76 patients with an mNPS of 0 were classified into the low-mNPS group, whereas 92 patients with an mNPS of ≥1 were classified into the high-mNPS group. The 3- and 5-year OS rates in the low-mNPS group were 65.6% and 56.2%, respectively, and those in the high-mNPS group were 45.3% and 36.9%, respectively. The difference in OS between the two groups was statistically significant (p=0.007). The 3- and 5-year RFS rates in the low-mNPS group were 45.6% and 38.7%, respectively, whereas those in the high-mNPS group were 33.4% and 28.1%, respectively. The difference in RFS between the two groups was statistically significant (p=0.043). A multivariate analysis showed that the mNPS was a significant independent prognostic factor for OS and RFS. Conclusion: mNPS is a potential prognostic marker for patients with gastric cancer who underwent curative gastrectomy. Higher mNPS values were associated with lower 3- and 5-year OS and RFS rates, indicating a potential correlation between elevated mNPS and worse outcomes.
MeSH term(s)	Humans ; Prognosis ; Neutrophils ; Stomach Neoplasms/diagnosis ; Stomach Neoplasms/surgery ; Blood Platelets ; Biomarkers, Tumor ; Retrospective Studies
Chemical Substances	Biomarkers, Tumor
Language	English
Publishing date	2024-02-27
Publishing country	Greece
Document type	Journal Article
ZDB-ID	807031-3
ISSN	1791-7549 ; 0258-851X
ISSN (online)	1791-7549
ISSN	0258-851X
DOI	10.21873/invivo.13516
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Zs.A 2288: Show issues

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Article ; Online: The CRP-albumin-lymphocyte (CALLY) Index Is an Independent Prognostic Factor for Gastric Cancer Patients who Receive Curative Treatment.

Aoyama, Toru / Maezawa, Yukio / Hashimoto, Itaru / Hara, Kentaro / Tamagawa, Ayako / Kazama, Keusike / Kato, Aya / Cho, Haruhiko / Nakazono, Masato / Numata, Masakatsu / Kawahara, Shinnosuke / Tanabe, Mie / Morita, Jyunya / Oshima, Takashi / Saito, Aya / Yukawa, Norio / Rino, Yasushi

Anticancer research

2024 Volume 44, Issue 4, Page(s) 1629–1636

Abstract: Background/aim: The CRP-albumin-lymphocyte (CALLY) index is a promising biomarker. We clarified the clinical impact of the CALLY index in gastric cancer patients who received curative treatment.: Patients and methods: Consecutive patients who ... ...

Abstract	Background/aim: The CRP-albumin-lymphocyte (CALLY) index is a promising biomarker. We clarified the clinical impact of the CALLY index in gastric cancer patients who received curative treatment. Patients and methods: Consecutive patients who underwent curative resection for gastric cancer at Yokohama City University from 2005 to 2020 were selected based on medical records. The CALYY index was calculated as follows: serum ALB level (g/dl) × lymphocyte count (cells/μl)/C-reactive protein (mg/dl) ×10 Conclusion: The CALLY score was an independent prognostic factor for patients with gastric cancer. Our results suggest that the CALLY index is a promising tool for assessing inflammation and nutritional status in patients undergoing gastric cancer treatment and management.
MeSH term(s)	Humans ; Prognosis ; Stomach Neoplasms/surgery ; Lymphocytes/metabolism ; Lymphocyte Count ; C-Reactive Protein/analysis ; Retrospective Studies
Chemical Substances	C-Reactive Protein (9007-41-4)
Language	English
Publishing date	2024-03-25
Publishing country	Greece
Document type	Journal Article
ZDB-ID	604549-2
ISSN	1791-7530 ; 0250-7005
ISSN (online)	1791-7530
ISSN	0250-7005
DOI	10.21873/anticanres.16961
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Zs.A 1642: Show issues

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Article ; Online: The Clinical Impact of the Pretreatment Albumin to Fibrinogen Ratio in Esophageal Cancer Patients Who Receive Curative Treatment.

Aoyama, Toru / Maezawa, Yukio / Hashimoto, Itaru / Hara, Kentaro / Kazama, Keisuke / Komori, Keisuke / Kato, Aya / Otani, Kazuki / Tamagawa, Ayako / Cho, Haruhiko / Morita, Junya / Kawahara, Shinnosuke / Tanabe, Mie / Oshima, Takashi / Saito, Aya / Yukawa, Norio / Rino, Yasushi

In vivo (Athens, Greece)

2024 Volume 38, Issue 3, Page(s) 1253–1259

Abstract: Background/aim: The albumin to fibrinogen ratio (AFR) has been identified as a promising prognostic marker for some malignancies. The aim of the present study was to evaluate the clinical impact of AFR in esophageal cancer patients who received curative ...

Abstract	Background/aim: The albumin to fibrinogen ratio (AFR) has been identified as a promising prognostic marker for some malignancies. The aim of the present study was to evaluate the clinical impact of AFR in esophageal cancer patients who received curative resection. Patients and methods: The present study included 123 patients who underwent curative treatment for esophageal cancer between 2005 and 2020. The prognosis and clinicopathological parameters were compared between patients with high and low AFRs. Results: The overall survival (OS) stratified by each clinical factor was compared using the log-rank test, and a significant difference was observed when using a pretreatment AFR of 1.23. When comparing the patient backgrounds between the high-AFR (AFR ≥12.3) and low-AFR (AFR<12.3) groups, significant differences were noted in the pathological T status. The high-AFR group had significantly higher OS rates at 3 years (70.8%) and 5 years (59.3%) after surgery in comparison to the low-AFR group (46.6% and 37.4%, respectively). Univariate and multivariate analyses for OS showed that the AFR was a significant prognostic factor. In addition, when comparing the site of first recurrence, a marginally significant difference was noted in hematological recurrence. Conclusion: The AFR is a significant risk factor in patients with esophageal cancer, holding promise as a valuable prognostic factor.
MeSH term(s)	Humans ; Esophageal Neoplasms/blood ; Esophageal Neoplasms/surgery ; Esophageal Neoplasms/mortality ; Esophageal Neoplasms/pathology ; Male ; Female ; Fibrinogen/metabolism ; Middle Aged ; Aged ; Prognosis ; Biomarkers, Tumor/blood ; Serum Albumin/analysis ; Neoplasm Staging ; Neoplasm Recurrence, Local/pathology ; Aged, 80 and over ; Adult
Chemical Substances	Fibrinogen (9001-32-5) ; Biomarkers, Tumor ; Serum Albumin
Language	English
Publishing date	2024-04-28
Publishing country	Greece
Document type	Journal Article
ZDB-ID	807031-3
ISSN	1791-7549 ; 0258-851X
ISSN (online)	1791-7549
ISSN	0258-851X
DOI	10.21873/invivo.13562
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Article ; Online: A case report of contrast-enhanced harmonic ultrasonography for the diagnosis of an esophageal duplication cyst.

Adachi, Kazunori / Tashiro, Takashi / Kato, Makiko / Ito, Takanori / Kato, Aya / Takayama, Masaaki / Kato, Shunsuke / Ono, Satoshi / Yoshimine, Hisako / Koshino, Akira / Nagao, Kazuhiro / Kobayashi, Yuji / Ebi, Masahide / Ogasawara, Naotaka / Sasaki, Makoto / Kasugai, Kunio

DEN open

2023 Volume 3, Issue 1, Page(s) e218

Abstract: A 54-year-old man was referred to our hospital because of a suspected esophageal submucosal tumor on upper gastrointestinal radiography. Contrast-enhanced computed tomography showed a 52 mm homogeneous mass attached to the lower thoracic esophagus. ... ...

Abstract	A 54-year-old man was referred to our hospital because of a suspected esophageal submucosal tumor on upper gastrointestinal radiography. Contrast-enhanced computed tomography showed a 52 mm homogeneous mass attached to the lower thoracic esophagus. Esophagogastroduodenoscopy revealed a 50 mm submucosal tumor in the lower esophagus, and endoscopic ultrasonography (EUS) showed a continuous hypoechoic lesion in the esophageal muscularis propria. Contrast-enhanced harmonic EUS revealed a non-echogenic area. T1 and T2 magnetic resonance imaging revealed a high-signal lesion. Based on imaging studies, an esophageal duplication cyst was diagnosed. Although asymptomatic, the patient underwent video-assisted thoracic surgery because of the possibility of rupture and the appearance of symptoms due to a future infection or enlargement, although this was not noted before. In our case, the esophageal duplication cyst appeared as a hypoechoic mass, requiring differentiation from submucosal tumor other than the cyst. Histologically, the cyst was covered by two layers of muscle covered by the chorioepithelial columnar epithelium. EUS fine-needle aspiration is effective in diagnosing submucosal tumor but also carries the risk of infection. Contrast-enhanced ultrasonography was used in this case to observe the interior and reach a preoperative diagnosis. Contrast-enhanced harmonic EUS appears to be effective in examining the interior of submucosal tumor lesions noninvasively.
Language	English
Publishing date	2023-03-17
Publishing country	Australia
Document type	Case Reports
ISSN	2692-4609
ISSN (online)	2692-4609
DOI	10.1002/deo2.218
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