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Conference proceedings ; Online: TH2.3

Kato, Edward

Strengthening climate resilience of women farmers through innovative extension approaches: Evidence from video-based extension in Kenya

2022

Abstract: There is growing evidence that lack of equal access to information on climate resilience strategies has contributed to sub-optimal adoption of climate-resilient agricultural practices, institutions and technologies. This study rolled out innovative ... ...

Abstract	There is growing evidence that lack of equal access to information on climate resilience strategies has contributed to sub-optimal adoption of climate-resilient agricultural practices, institutions and technologies. This study rolled out innovative videos of women-identified practices to women farmers through grassroots women's groups (India and Kenya) and through the national extension service (Uganda) to more than 35,000 farmers in Gujarat, India, Kenya and Uganda. Practices identified by women farmers through qualitative fieldwork included climate smart pig and poultry management, integrated pest management, water harvesting, zai pits and conservation agriculture. The presentation will report on changes in awareness, knowledge, adoption as well as in women's empowerment in response to the intervention in Kenya and Uganda were the endline surveys were completed in early 2022. The findings are relevant to next users of video-based extension approaches, such as NGOs, the government and the private sector that are interested in reaching, benefiting and empowerment women farmers.
Keywords	gender ; agriculture
Language	English
Publishing date	2022-11-23T06:52:05Z
Publisher	International Food Policy Research Institute
Publishing country	fr
Document type	Conference proceedings ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Bioactive compounds in plant materials for the prevention of diabetesand obesity.

Kato, Eisuke

Bioscience, biotechnology, and biochemistry

2019 Volume 83, Issue 6, Page(s) 975–985

Abstract: Plant materials have been widely studied for their preventive and therapeutic effects for type 2 diabetes mellitus (T2DM) and obesity. The effect of a plant material arises from its constituents, and the study of these bioactive compounds is important to ...

Abstract	Plant materials have been widely studied for their preventive and therapeutic effects for type 2 diabetes mellitus (T2DM) and obesity. The effect of a plant material arises from its constituents, and the study of these bioactive compounds is important to achieve a deeper understanding of its effect at the molecular level. In particular, the study of the effects of such bioactive compounds on various biological processes, from digestion to cellular responses, is required to fully understand the overall effects of plant materials in these health contexts. In this review, I summarize the bioactive compounds we have recently studied in our research group that target digestive enzymes, dipeptidyl peptidase-4, myocyte glucose uptake, and lipid accumulation in adipocytes. Abbreviations: AC: adenylyl cyclase; AMPK: AMP-activated protein kinase; βAR: β-adrenergic receptor; CA: catecholamine; cAMP: cyclic adenosine monophosphate; cGMP: cyclic guanosine monophosphate; DPP-4: dipeptidyl peptidase-4; ERK: extracellular signal-regulated kinase; GC: guanylyl cyclase; GH: growth hormone; GLP-1: glucagon-like peptide-1; GLUT: glucose transporter; HSL: hormone-sensitive lipase; IR: insulin receptor; IRS: insulin receptor substrate; MAPK: mitogen-activated protein kinase; MEK: MAPK/ERK kinase; MG: maltase-glucoamylase; NP: natriuretic peptide; NPR: natriuretic peptide receptor; mTORC2: mechanistic target of rapamycin complex-2; PC: proanthocyanidin; PI3K: phosphoinositide 3-kinase; PKA: cAMP-dependent protein kinase; PKB (AKT): protein kinase B; PKG: cGMP-dependent protein kinase; PPARγ: peroxisome proliferator-activated receptor-γ; SGLT1: sodium-dependent glucose transporter 1; SI: sucrase-isomaltase; T2DM: type 2 diabetes mellitus; TNFα: tumor necrosis factor-α.
MeSH term(s)	Adipocytes/drug effects ; Biological Products/isolation & purification ; Biological Products/pharmacology ; Biological Products/therapeutic use ; Cell Size/drug effects ; Diabetes Mellitus, Type 2/prevention & control ; Enzyme Inhibitors/therapeutic use ; Humans ; Lipolysis/drug effects ; Muscle Cells/metabolism ; Obesity/prevention & control ; Peptides/therapeutic use ; Plants/chemistry
Chemical Substances	Biological Products ; Enzyme Inhibitors ; Peptides ; glucose utilization inhibitor
Language	English
Publishing date	2019-02-17
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1106450-x
ISSN	1347-6947 ; 0916-8451
ISSN (online)	1347-6947
ISSN	0916-8451
DOI	10.1080/09168451.2019.1580560
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Article ; Online: Rethinking agro-food sector to combat land degradation and desertification

Nkonya, E. M. / Kato, E.

2021

Abstract: The problems related to the process of industrialisation such as biodiversity depletion, climate change and a worsening of health and living conditions, especially but not only in developing countries, intensify. Therefore, there is an increasing need to ...

Abstract	The problems related to the process of industrialisation such as biodiversity depletion, climate change and a worsening of health and living conditions, especially but not only in developing countries, intensify. Therefore, there is an increasing need to search for integrated solutions to make development more sustainable. The United Nations has acknowledged the problem and approved the “2030 Agenda for Sustainable Development”. On 1st January 2016, the 17 Sustainable Development Goals (SDGs) of the Agenda officially came into force. These goals cover the three dimensions of sustainable development: economic growth, social inclusion and environmental protection.
Keywords	desertification
Language	English
Publishing date	2021-01-04T05:40:15Z
Publisher	Springer
Publishing country	fr
Document type	Article ; Online
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Article ; Online: Sampling bag-based emission chamber for measuring volatile organic compounds from household materials using solid-phase extraction-type collection device.

Ueta, Ikuo / Kato, Eriko / Saito, Yoshihiro

Analytical sciences : the international journal of the Japan Society for Analytical Chemistry

2023 Volume 39, Issue 10, Page(s) 1615–1621

Abstract: A simple screening analytical method for determining the emission of volatile organic compounds (VOCs) from household materials was developed using a solid-phase extraction (SPE)-type collection device and a gas sampling bag. The VOCs emitted from the ... ...

Abstract	A simple screening analytical method for determining the emission of volatile organic compounds (VOCs) from household materials was developed using a solid-phase extraction (SPE)-type collection device and a gas sampling bag. The VOCs emitted from the sample material placed in the gas sampling bag with a volume of 20 L were extracted on the SPE-type collection device. In this study, complete sampling mode was developed in addition to a conventional flow sampling mode. The extracted VOCs were then eluted with 8 mL of acetone and measured using gas chromatography-mass spectrometry. The proposed method does not require a stainless-steel chamber and a thermal desorption system; therefore, VOC emission from household materials could be easily evaluated with an affordable cost, suggesting that the method is suitable for the screening technique for evaluating VOC emission from solid materials.
Language	English
Publishing date	2023-05-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1483376-1
ISSN	1348-2246 ; 1348-2246
ISSN (online)	1348-2246
ISSN	1348-2246
DOI	10.1007/s44211-023-00375-9
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Article ; Online: Cerebellar injury in preterm infants less than 28 weeks gestational age.

Sasaki, Yoshihito / Nemoto, Kazuhisa / Goto, Shunji / Kato, Eiji

Pediatrics international : official journal of the Japan Pediatric Society

2023 Volume 66, Issue 1, Page(s) e15734

Abstract: Background: Cerebellar injury is one of the perinatal complications in preterm infants. Recent studies have highlighted the effect of perinatal complications on neurological morbidity. We investigated the perinatal risk factors and morbidity for ... ...

Abstract	Background: Cerebellar injury is one of the perinatal complications in preterm infants. Recent studies have highlighted the effect of perinatal complications on neurological morbidity. We investigated the perinatal risk factors and morbidity for cerebellar injury in extremely premature infants. Methods: This retrospective cohort study included 285 infants born between April 2009 and December 2020 at gestational age <28 weeks at our institution. The infants were divided into two groups based on magnetic resonance imaging findings: those with and without cerebellar injury. We performed a statistical analysis of the perinatal background and short-term morbidity of the two groups. Results: Significant differences (p < 0.05) were observed between the groups with respect to the perinatal background, especially gestational weeks, birthweight, and hemoglobin values at birth. In the short-term morbidity, significant differences (p < 0.05) were observed in the incidence of respiratory distress syndrome, chronic lung disease, hydrocephalus, severe intraventricular hemorrhage (IVH), and cerebellar hemorrhage. Extensive cerebellar lesions, such as cerebellar agenesis or global cerebellar hypoplasia, accounted for 11 of the 22 cases of cerebellar injury; seven of the 11 cases had severe IVH in addition to cerebellar hemorrhage. Conclusions: Gestational age was significantly lower in the cerebellar injury group. The combination of severe IVH and cerebellar hemorrhage may promote cerebellar injury.
MeSH term(s)	Infant ; Pregnancy ; Female ; Infant, Newborn ; Humans ; Gestational Age ; Retrospective Studies ; Infant, Premature, Diseases/diagnosis ; Infant, Premature, Diseases/epidemiology ; Infant, Premature, Diseases/etiology ; Infant, Extremely Premature ; Hemorrhage ; Cerebral Hemorrhage/complications ; Cerebral Hemorrhage/epidemiology
Language	English
Publishing date	2023-12-26
Publishing country	Australia
Document type	Journal Article
ZDB-ID	1470376-2
ISSN	1442-200X ; 1328-8067
ISSN (online)	1442-200X
ISSN	1328-8067
DOI	10.1111/ped.15734
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Article: Bioactive compounds in plant materials for the prevention of diabetesand obesity

Kato, Eisuke

Bioscience, biotechnology, and biochemistry. 2019 June 3, v. 83, no. 6

2019

Abstract	Plant materials have been widely studied for their preventive and therapeutic effects for type 2 diabetes mellitus (T2DM) and obesity. The effect of a plant material arises from its constituents, and the study of these bioactive compounds is important to achieve a deeper understanding of its effect at the molecular level. In particular, the study of the effects of such bioactive compounds on various biological processes, from digestion to cellular responses, is required to fully understand the overall effects of plant materials in these health contexts. In this review, I summarize the bioactive compounds we have recently studied in our research group that target digestive enzymes, dipeptidyl peptidase-4, myocyte glucose uptake, and lipid accumulation in adipocytes. Abbreviations: AC: adenylyl cyclase; AMPK: AMP-activated protein kinase; βAR: β-adrenergic receptor; CA: catecholamine; cAMP: cyclic adenosine monophosphate; cGMP: cyclic guanosine monophosphate; DPP-4: dipeptidyl peptidase-4; ERK: extracellular signal-regulated kinase; GC: guanylyl cyclase; GH: growth hormone; GLP-1: glucagon-like peptide-1; GLUT: glucose transporter; HSL: hormone-sensitive lipase; IR: insulin receptor; IRS: insulin receptor substrate; MAPK: mitogen-activated protein kinase; MEK: MAPK/ERK kinase; MG: maltase-glucoamylase; NP: natriuretic peptide; NPR: natriuretic peptide receptor; mTORC2: mechanistic target of rapamycin complex-2; PC: proanthocyanidin; PI3K: phosphoinositide 3-kinase; PKA: cAMP-dependent protein kinase; PKB (AKT): protein kinase B; PKG: cGMP-dependent protein kinase; PPARγ: peroxisome proliferator-activated receptor-γ; SGLT1: sodium-dependent glucose transporter 1; SI: sucrase-isomaltase; T2DM: type 2 diabetes mellitus; TNFα: tumor necrosis factor-α.
Keywords	AMP-activated protein kinase ; adenylate cyclase ; adipocytes ; biotechnology ; cAMP-dependent protein kinase ; cGMP-dependent protein kinase ; carboxylic ester hydrolases ; catecholamines ; cyclic AMP ; cyclic GMP ; digestion ; glucagon-like peptide 1 ; glucose ; glucose transporters ; guanylate cyclase ; insulin receptor substrate proteins ; insulin receptors ; lipids ; mitogen-activated protein kinase ; natriuretic peptide receptors ; natriuretic peptides ; necrosis ; neoplasms ; non-specific serine/threonine protein kinase ; noninsulin-dependent diabetes mellitus ; obesity ; phosphatidylinositol 3-kinase ; proanthocyanidins ; rapamycin ; somatotropin ; sucrose alpha-glucosidase ; therapeutics
Language	English
Dates of publication	2019-0603
Size	p. 975-985.
Publishing place	Taylor & Francis
Document type	Article
Note	NAL-light
ZDB-ID	1106450-x
ISSN	1347-6947 ; 0916-8451
ISSN (online)	1347-6947
ISSN	0916-8451
DOI	10.1080/09168451.2019.1580560
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: "

Nourjah, Parivash / Kato, Elizabeth

Substance abuse

2021 Volume 42, Issue 2, Page(s) 136–139

Abstract: ... ...

Abstract	Purpose
MeSH term(s)	Health Services Accessibility ; Humans ; Opioid-Related Disorders/drug therapy ; Primary Health Care ; Rural Population
Language	English
Publishing date	2021-03-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	1458030-5
ISSN	1547-0164 ; 0889-7077
ISSN (online)	1547-0164
ISSN	0889-7077
DOI	10.1080/08897077.2021.1891600
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Article ; Online: The TIMI Study Group's Contributions to the Advancement of Cardiology -With Focus on Atherosclerotic Cardiovascular Disease.

Toda Kato, Eri / Goto, Shinya

Journal of atherosclerosis and thrombosis

2021 Volume 28, Issue 6, Page(s) 563–572

Abstract: Atherosclerotic cardiovascular disease (ASCVD) is the leading cause of morbidity and mortality across the world, warranting continuous research in this field. The elucidation of the atherogenesis mechanism is considered one of the most relevant ... ...

Abstract	Atherosclerotic cardiovascular disease (ASCVD) is the leading cause of morbidity and mortality across the world, warranting continuous research in this field. The elucidation of the atherogenesis mechanism is considered one of the most relevant scientific accomplishments of the last century. This has led to the clinical development of various novel therapeutic interventions for patients with or at risk of ASCVD, in which randomized clinical trials played a crucial role.The Thrombolysis in Myocardial Infarction (TIMI) Study Group was initially established to conduct a clinical trial studying thrombolysis for treatment of myocardial infarction. However, over the years, the TIMI Study Group has expanded their research interests to include antithrombotic therapy, lipid lowering, anti-diabetes, anti-obesity, and even heart failure. By leading large-scale, international, randomized, controlled trials of novel therapeutics, the TIMI Study Group has helped shape the very practice of cardiovascular medicine for over a quarter of a century, and decades of research continue to provide future promise for further advancement. Through a mutual goal to improve the care of ASCVD patients, the Japanese scientific community has become one of the important contributors to the TIMI Study Group's clinical research.In this review article, the authors aim to summarize major research lead by the TIMI Study Group in the ASCVD field.
MeSH term(s)	Cardiology/trends ; Coronary Artery Disease/epidemiology ; Coronary Artery Disease/prevention & control ; Coronary Artery Disease/therapy ; Heart Disease Risk Factors ; Humans ; Myocardial Infarction/therapy ; Patient Care Management/methods ; Patient Care Management/standards ; Patient Care Management/trends ; Quality Improvement ; Randomized Controlled Trials as Topic ; Therapies, Investigational/methods
Language	English
Publishing date	2021-04-13
Publishing country	Japan
Document type	Journal Article ; Review
ZDB-ID	2011474-6
ISSN	1880-3873 ; 1340-3478
ISSN (online)	1880-3873
ISSN	1340-3478
DOI	10.5551/jat.RV17049
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Article ; Online: Flavan-3-ols, flavonoids, anthocyanidins and triterpenoids induces TIE2 phosphorylation -a candidate target for the vascular protective effects.

Igarashi, Saki / Hioki, Sayaka / Sakamaru, Naoto / Suzuki, Asahi / Kurokawa, Mihoko / Kato, Eisuke

Natural product research

2024 , Page(s) 1–5

Abstract: Vascular system is essential for the body to maintain health. Dysregulated vascular system leads to cardiovascular diseases and are observed in ischaemic stroke, Alzheimer's disease, amyotrophic lateral sclerosis, and diabetes. TIE2 is a tyrosine kinase ... ...

Abstract	Vascular system is essential for the body to maintain health. Dysregulated vascular system leads to cardiovascular diseases and are observed in ischaemic stroke, Alzheimer's disease, amyotrophic lateral sclerosis, and diabetes. TIE2 is a tyrosine kinase receptor expressed on vascular endothelial cells and contributes to the maintenance of a vascular system. In this paper, we screened for natural products with an activity to induce phosphorylation of TIE2, which will be beneficial for protection of a vascular system. Employing HeLa cells expressing TIE2, flavan-3-ols, flavonoids, anthocyanidins and triterpenoids were identified as active compounds that induce TIE2 phosphorylation. Several of the identified compounds are previously reported to protect endothelial cells from inflammation. Thus, the result provided TIE2 as the candidate receptor protein of those compounds for the protective effect of endothelial cells and the identified compounds will be a good candidate for maintenance of a vascular system.
Language	English
Publishing date	2024-04-12
Publishing country	England
Document type	Journal Article
ZDB-ID	2185747-7
ISSN	1478-6427 ; 1478-6419
ISSN (online)	1478-6427
ISSN	1478-6419
DOI	10.1080/14786419.2024.2340049
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Article ; Online: α-Tocotrienol in rice bran enhances steroidogenesis in mouse Leydig cell via increased gene expression of steroidogenic acute regulatory protein and induction of its mitochondrial translocation.

Terada, Naofumi / Nagase, Tomoaki / Kayooka, Hiromi / Adachi, Yusuke / Kato, Eisuke

Bioscience, biotechnology, and biochemistry

2023 Volume 88, Issue 2, Page(s) 189–195

Abstract: Rice is a staple food in the Asian region and one of the world's major energy sources. Testosterone is a steroid hormone that maintains physical, sexual, and cognitive ability, and its decline causes health problems like late-onset hypogonadism. ... ...

Abstract	Rice is a staple food in the Asian region and one of the world's major energy sources. Testosterone is a steroid hormone that maintains physical, sexual, and cognitive ability, and its decline causes health problems like late-onset hypogonadism. Evaluation of various grain extracts showed rice bran to stimulate testosterone secretion from Leydig model cells. α-Tocotrienol was found as a bioactive compound in rice bran, and mechanistic analysis showed the stimulation of steroid hormone synthesis through enhanced gene expression of steroidogenic acute regulatory protein as well as inducing mitochondrial localization of the protein. Preliminary study showed an increasing trend in serum testosterone levels in mice by oral intake of α-tocotrienol. These results suggest that α-tocotrienol intake may be effective in preventing symptoms caused by low testosterone levels.
MeSH term(s)	Male ; Mice ; Animals ; Leydig Cells/metabolism ; Oryza/genetics ; Oryza/metabolism ; Testosterone ; Phosphoproteins/genetics ; Phosphoproteins/metabolism ; Steroids/metabolism ; Gene Expression ; Tocotrienols
Chemical Substances	steroidogenic acute regulatory protein ; tocotrienol, alpha (B6LXL1832Y) ; Testosterone (3XMK78S47O) ; Phosphoproteins ; Steroids ; Tocotrienols
Language	English
Publishing date	2023-10-25
Publishing country	England
Document type	Journal Article
ZDB-ID	1106450-x
ISSN	1347-6947 ; 0916-8451
ISSN (online)	1347-6947
ISSN	0916-8451
DOI	10.1093/bbb/zbad153
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