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  1. Article ; Online: Aromatic oil from lavender as an atopic dermatitis suppressant.

    Sato, Haruna / Kato, Kosuke / Koreishi, Mayuko / Nakamura, Yoshimasa / Tsujino, Yoshio / Satoh, Ayano

    PloS one

    2024  Volume 19, Issue 1, Page(s) e0296408

    Abstract: In atopic dermatitis (AD), nerves are abnormally stretched near the surface of the skin, making it sensitive to itching. Expression of neurotrophic factor Artemin (ARTN) involved in such nerve stretching is induced by the xenobiotic response (XRE) to air ...

    Abstract In atopic dermatitis (AD), nerves are abnormally stretched near the surface of the skin, making it sensitive to itching. Expression of neurotrophic factor Artemin (ARTN) involved in such nerve stretching is induced by the xenobiotic response (XRE) to air pollutants and UV radiation products. Therefore, AD can be monitored by the XRE response. Previously, we established a human keratinocyte cell line stably expressing a NanoLuc reporter gene downstream of XRE. We found that 6-formylindolo[3,2-b]carbazole (FICZ), a tryptophan metabolite and known inducer of the XRE, increased reporter and Artemin mRNA expression, indicating that FICZ-treated cells could be a model for AD. Lavender essential oil has been used in folk medicine to treat AD, but the scientific basis for its use is unclear. In the present study, we investigated the efficacy of lavender essential oil and its major components, linalyl acetate and linalool, to suppress AD and sensitize skin using the established AD model cell line, and keratinocyte and dendritic cell activation assays. Our results indicated that lavender essential oil from L. angustifolia and linalyl acetate exerted a strong AD inhibitory effect and almost no skin sensitization. Our model is useful in that it can circumvent the practice of using animal studies to evaluate AD medicines.
    MeSH term(s) Animals ; Humans ; Dermatitis, Atopic/drug therapy ; Lavandula ; Skin ; Monoterpenes
    Chemical Substances linalyl acetate (5K47SSQ51G) ; Monoterpenes
    Language English
    Publishing date 2024-01-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0296408
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Transdermal drug delivery using a porous microneedle device driven by a hydrogel electroosmotic pump.

    Wang, Gaobo / Kato, Kosuke / Aoki, Izuru / Ichinose, Sae / Inoue, Daisuke / Tottori, Soichiro / Nishizawa, Matsuhiko

    Journal of materials chemistry. B

    2024  Volume 12, Issue 6, Page(s) 1490–1494

    Abstract: Integrating a hydrogel electroosmotic pump with a parylene C-coated porous microneedle (PMN) is developed for transdermal drug delivery applications. The hydrogel pump is fabricated by combining an anionic and a cationic hydrogel to generate enhanced ... ...

    Abstract Integrating a hydrogel electroosmotic pump with a parylene C-coated porous microneedle (PMN) is developed for transdermal drug delivery applications. The hydrogel pump is fabricated by combining an anionic and a cationic hydrogel to generate enhanced electroosmosis flow (EOF) to drive the transportation of molecules
    MeSH term(s) Electroosmosis ; Hydrogels ; Porosity ; Administration, Cutaneous ; Cations
    Chemical Substances Hydrogels ; Cations
    Language English
    Publishing date 2024-02-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 2702241-9
    ISSN 2050-7518 ; 2050-750X
    ISSN (online) 2050-7518
    ISSN 2050-750X
    DOI 10.1039/d3tb02208k
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Total Synthesis of 2-Isocyanoallopupukeanane: Construction of Caged Skeleton by Intramolecular Alkylation of Bromonitriles

    Kato, Kosuke / Ikeuchi, Kazutada / Suzuki, Takahiro / Tanino, Keiji

    Organic letters. 2022 Aug. 26, v. 24, no. 35

    2022  

    Abstract: A new method for constructing the bicyclo[3.2.1]octane skeleton was developed by the intramolecular alkylation of a nitrile-side-chain-containing cyclohexanone derivative. The cyclization precursors were prepared via the stereoselective bromination of ... ...

    Abstract A new method for constructing the bicyclo[3.2.1]octane skeleton was developed by the intramolecular alkylation of a nitrile-side-chain-containing cyclohexanone derivative. The cyclization precursors were prepared via the stereoselective bromination of the triisopropylsilyl enol ethers of 4-substituted cyclohexanones. Upon treatment with LiNEt₂, the bromonitriles underwent a stereoselective intramolecular SN2 reaction to afford bicyclo[3.2.1]octane derivatives with a cyano group on the convex face. The total synthesis of 2-isocyanoallopupukeanane (6.5% yield) from methyl vinyl ketone was accomplished via a 17-step transformation.
    Keywords alkylation ; bromination ; cyclohexanones ; enols ; stereoselectivity
    Language English
    Dates of publication 2022-0826
    Size p. 6407-6411.
    Publishing place American Chemical Society
    Document type Article
    ISSN 1523-7052
    DOI 10.1021/acs.orglett.2c02434
    Database NAL-Catalogue (AGRICOLA)

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  4. Article ; Online: Total Synthesis of 2-Isocyanoallopupukeanane: Construction of Caged Skeleton by Intramolecular Alkylation of Bromonitriles.

    Kato, Kosuke / Ikeuchi, Kazutada / Suzuki, Takahiro / Tanino, Keiji

    Organic letters

    2022  Volume 24, Issue 35, Page(s) 6407–6411

    Abstract: A new method for constructing the bicyclo[3.2.1]octane skeleton was developed by the intramolecular alkylation of a nitrile-side-chain-containing cyclohexanone derivative. The cyclization precursors were prepared via the stereoselective bromination of ... ...

    Abstract A new method for constructing the bicyclo[3.2.1]octane skeleton was developed by the intramolecular alkylation of a nitrile-side-chain-containing cyclohexanone derivative. The cyclization precursors were prepared via the stereoselective bromination of the triisopropylsilyl enol ethers of 4-substituted cyclohexanones. Upon treatment with LiNEt
    MeSH term(s) Alkylation ; Cyclization ; Molecular Structure ; Octanes ; Skeleton ; Stereoisomerism
    Chemical Substances Octanes
    Language English
    Publishing date 2022-08-26
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1523-7052
    ISSN (online) 1523-7052
    DOI 10.1021/acs.orglett.2c02434
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Necessity of performing a routine chest radiograph following the insertion of tunnelled Hickman catheter under imaging guidance: A single centre experience.

    Kato, Kosuke / Gan, Calvin / Rhodes, Alexander

    Journal of medical imaging and radiation oncology

    2022  Volume 67, Issue 5, Page(s) 482–486

    Abstract: Introduction: A chest radiograph has traditionally been performed following the insertion of a tunnelled Hickman catheter to immediately exclude rare but potentially serious complications such as pneumothorax and haemothorax and confirm appropriate ... ...

    Abstract Introduction: A chest radiograph has traditionally been performed following the insertion of a tunnelled Hickman catheter to immediately exclude rare but potentially serious complications such as pneumothorax and haemothorax and confirm appropriate positioning of the catheter tip. The value of completing the routine chest radiograph has been questioned when fluoroscopic image may be easily obtained in the angiography suite for the same purpose, and the rate of iatrogenic pneumothorax remains extremely low in the Medical literature. We describe our experience of performing Hickman catheter insertion under ultrasound and fluoroscopic guidance and whether routinely performing the chest radiograph is justifiable.
    Methods: A single centre retrospective review was performed of patients who received a tunnelled Hickman catheter and underwent postprocedural chest radiograph in the Interventional Radiology Department during a fifteen-year period from August 2007 to April 2021. Patient demographics and complications were documented.
    Results: Delayed iatrogenic pneumothorax was diagnosed in one asymptomatic patient (0.06%) on a chest radiograph out of 1735 patients, and they required chest tube insertion. Other complications included two cases of right common carotid artery puncture, one case of right internal jugular vein dissection and one case of left internal jugular perforation. Two patients required a repeat procedure within 24 h due to superior migration of the Hickman catheter on chest radiograph.
    Conclusion: Given the extremely low rate of iatrogenic pneumothorax, chest radiograph following the insertion of a tunnelled Hickman catheter under ultrasound and fluoroscopic guidance may be an unnecessary investigation unless the patient is symptomatic, or there is sufficient clinical concern.
    MeSH term(s) Humans ; Catheterization, Central Venous/adverse effects ; Catheterization, Central Venous/methods ; Pneumothorax/diagnostic imaging ; Pneumothorax/etiology ; Ultrasonography ; Retrospective Studies ; Catheters/adverse effects
    Language English
    Publishing date 2022-09-26
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2389687-5
    ISSN 1754-9485 ; 1440-1673 ; 1754-9477 ; 0004-8461
    ISSN (online) 1754-9485 ; 1440-1673
    ISSN 1754-9477 ; 0004-8461
    DOI 10.1111/1754-9485.13479
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 66: Show issues Location:
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  6. Article ; Online: NADPH oxidases: Pathophysiology and therapeutic potential in age-associated pulmonary fibrosis.

    Kato, Kosuke / Hecker, Louise

    Redox biology

    2020  Volume 33, Page(s) 101541

    Abstract: Oxidative stress has been associated with a number of human fibrotic diseases, including idiopathic pulmonary fibrosis (IPF). Although oxidative stress is associated with both fibrosis and aging, the precise cellular sources(s) of reactive oxygen species ...

    Abstract Oxidative stress has been associated with a number of human fibrotic diseases, including idiopathic pulmonary fibrosis (IPF). Although oxidative stress is associated with both fibrosis and aging, the precise cellular sources(s) of reactive oxygen species (ROS) that contribute to the disease pathogenesis remain poorly understood. NADPH oxidase (Nox) enzymes are an evolutionarily conserved family, where their only known function is the production of ROS. A growing body of evidence supports a link between excessive Nox-derived ROS and numerous chronic diseases (including fibrotic disease), which is most prevalent among the elderly population. In this review, we examine the evidence for Nox isoforms in the pathogenesis of IPF, and the potential to target this enzyme family for the treatment of IPF and related fibrotic disorders. A better understanding of the Nox-mediated redox imbalance in aging may be critical to the development of more effective therapeutic strategies for age-associated fibrotic disorders. Strategies aimed at specifically blocking the source(s) of ROS through Nox inhibition may prove to be more effective as anti-fibrotic therapies, as compared to antioxidant approaches. This review also discusses the potential of Nox-targeting therapeutics currently in development.
    MeSH term(s) Aged ; Humans ; Idiopathic Pulmonary Fibrosis/drug therapy ; NADPH Oxidases/genetics ; NADPH Oxidases/metabolism ; Oxidation-Reduction ; Oxidative Stress ; Reactive Oxygen Species
    Chemical Substances Reactive Oxygen Species ; NADPH Oxidases (EC 1.6.3.-)
    Language English
    Publishing date 2020-04-17
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
    ZDB-ID 2701011-9
    ISSN 2213-2317 ; 2213-2317
    ISSN (online) 2213-2317
    ISSN 2213-2317
    DOI 10.1016/j.redox.2020.101541
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  7. Article: Splenic necrosis requiring ultrasound-guided drainage following meningococcal septicaemia.

    Kato, Kosuke / Gleeson, Thomas A

    Oxford medical case reports

    2019  Volume 2019, Issue 3, Page(s) omz020

    Abstract: Splenic necrosis is an extremely rare complication in the context of meningococcal septicaemia and disseminated intravascular coagulopathy. We present the case of a previously healthy 22-year-old male who was diagnosed and treated for meningococcal ... ...

    Abstract Splenic necrosis is an extremely rare complication in the context of meningococcal septicaemia and disseminated intravascular coagulopathy. We present the case of a previously healthy 22-year-old male who was diagnosed and treated for meningococcal septicaemia. He represented 4 days following discharge with significant splenic necrosis and associated abscess formation despite previously unremarkable imaging on his first admission. The splenic collection was successfully treated with ultrasound-guided percutaneous drainage. We discuss the leading causes of atraumatic splenic infarction and the recent shift towards treating splenic necrosis with minimally invasive procedure.
    Language English
    Publishing date 2019-03-29
    Publishing country England
    Document type Case Reports
    ZDB-ID 2766251-2
    ISSN 2053-8855
    ISSN 2053-8855
    DOI 10.1093/omcr/omz020
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  8. Article ; Online: Small bowel perforation secondary to CMV-positive terminal ileitis postrenal transplant.

    Kato, Kosuke / Cooper, Michelle

    BMJ case reports

    2019  Volume 12, Issue 11

    Abstract: Cytomegalovirus (CMV) infection of the gastrointestinal tract is common in immunosuppressed patients; however, small bowel perforation from tissue-invasive CMV disease after many years of immunosuppressive therapy is a rare complication requiring timely ... ...

    Abstract Cytomegalovirus (CMV) infection of the gastrointestinal tract is common in immunosuppressed patients; however, small bowel perforation from tissue-invasive CMV disease after many years of immunosuppressive therapy is a rare complication requiring timely medical and surgical intervention. We report a case of a postrenal transplant patient who presented to the emergency department with severe lower abdominal pain with CT of the abdomen/pelvis revealing a small bowel perforation. He underwent an emergent laparoscopic right hemicolectomy, and his histopathology of the terminal ileum was positive for CMV disease. He was successfully treated with intravenous ganciclovir postoperatively. We discuss the pathophysiology, histopathological features and treatment of CMV infection.
    MeSH term(s) Abdominal Pain/diagnosis ; Abdominal Pain/etiology ; Administration, Intravenous ; Aged ; Antiviral Agents/administration & dosage ; Antiviral Agents/therapeutic use ; Colectomy/methods ; Cytomegalovirus/metabolism ; Cytomegalovirus Infections/complications ; Cytomegalovirus Infections/metabolism ; Cytomegalovirus Infections/virology ; Diagnosis, Differential ; Ganciclovir/administration & dosage ; Ganciclovir/therapeutic use ; Humans ; Ileum/pathology ; Ileum/virology ; Immunocompromised Host ; Intestinal Perforation/diagnostic imaging ; Intestinal Perforation/drug therapy ; Intestinal Perforation/etiology ; Intestinal Perforation/surgery ; Kidney Transplantation/adverse effects ; Laparoscopy/methods ; Male ; Transplants/drug effects ; Transplants/virology ; Treatment Outcome
    Chemical Substances Antiviral Agents ; Ganciclovir (P9G3CKZ4P5)
    Language English
    Publishing date 2019-11-25
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2019-231662
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Dural venous sinus tumour thrombus from metastatic thymoma.

    Kato, Kosuke / Brusic, Ana / Gaillard, Frank

    Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia

    2021  Volume 86, Page(s) 267–270

    Abstract: Thymomas are the most common primary tumours of the anterior mediastinum. While intrathoracic disease progression through local invasion is well described in the literature, extrathoracic extension of disease is uncommon and intracranial metastases have ... ...

    Abstract Thymomas are the most common primary tumours of the anterior mediastinum. While intrathoracic disease progression through local invasion is well described in the literature, extrathoracic extension of disease is uncommon and intracranial metastases have seldom been reported. We present a case of extensive dural venous sinus tumour thrombus in a patient with metastatic invasive thymoma.
    MeSH term(s) Aged ; Brain Neoplasms/diagnostic imaging ; Brain Neoplasms/secondary ; Cranial Sinuses/diagnostic imaging ; Fatal Outcome ; Female ; Humans ; Sinus Thrombosis, Intracranial/diagnostic imaging ; Sinus Thrombosis, Intracranial/etiology ; Thymoma/diagnostic imaging ; Thymus Neoplasms/diagnostic imaging
    Language English
    Publishing date 2021-02-18
    Publishing country Scotland
    Document type Case Reports
    ZDB-ID 1193674-5
    ISSN 1532-2653 ; 0967-5868
    ISSN (online) 1532-2653
    ISSN 0967-5868
    DOI 10.1016/j.jocn.2021.02.003
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3999: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  10. Article ; Online: The probiotic

    Cook, Chad M / Makino, Hiroshi / Kato, Kosuke / Blonquist, Traci / Derrig, Linda / Shibata, Hideyuki

    International journal of food sciences and nutrition

    2023  Volume 74, Issue 5, Page(s) 645–653

    Abstract: The probiotic ... ...

    Abstract The probiotic strain
    MeSH term(s) Adult ; Humans ; Animals ; Milk ; Lacticaseibacillus ; Lacticaseibacillus paracasei ; Gastrointestinal Tract ; Probiotics
    Language English
    Publishing date 2023-08-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 1121877-0
    ISSN 1465-3478 ; 0963-7486
    ISSN (online) 1465-3478
    ISSN 0963-7486
    DOI 10.1080/09637486.2023.2246693
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    Zs.A 3864: Show issues Location:
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