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Article ; Online: New insights into IFN-γ in rheumatoid arthritis: role in the era of JAK inhibitors.

Kato, Masaru

Immunological medicine

2020 Volume 43, Issue 2, Page(s) 72–78

Abstract: The treatment of rheumatoid arthritis (RA) is now entering a new era, the era of Janus kinase (JAK) inhibitors. JAK inhibitors target multiple cytokines including IL-6 and exhibit a beneficial treatment effect in patients with RA and inadequate response ... ...

Abstract	The treatment of rheumatoid arthritis (RA) is now entering a new era, the era of Janus kinase (JAK) inhibitors. JAK inhibitors target multiple cytokines including IL-6 and exhibit a beneficial treatment effect in patients with RA and inadequate response to conventional synthetic or biologic disease-modifying anti-rheumatic drugs. Since the treatment effect of JAK inhibitors is promising even for patients refractory to anti-IL-6 therapy, it needs to be considered how multiple cytokines play roles in the pathogenesis of RA. It is also worth noting that an increased risk of herpes zoster is specifically related to the use of JAK inhibitors. Among cytokines targeted by JAK inhibitors, the current review focuses on IFN-γ, particularly on its role in synovial biology, autoimmunity, bone metabolism, pain, and varicella zoster virus infection. Recent studies provided new insights into IFN-γ in the pathogenesis of RA, which may account for the efficacy of JAK inhibitors.
MeSH term(s)	Arthritis, Rheumatoid/drug therapy ; Arthritis, Rheumatoid/etiology ; Arthritis, Rheumatoid/immunology ; Autoimmunity ; Bone and Bones/metabolism ; Herpes Zoster ; Humans ; Interferon-gamma/metabolism ; Interleukin-6 ; Janus Kinase Inhibitors/therapeutic use ; Receptors, Interferon/metabolism ; Risk ; Signal Transduction ; Synovial Membrane ; Interferon gamma Receptor
Chemical Substances	Interleukin-6 ; Janus Kinase Inhibitors ; Receptors, Interferon ; Interferon-gamma (82115-62-6)
Language	English
Publishing date	2020-04-25
Publishing country	England
Document type	Journal Article ; Review
ISSN	2578-5826
ISSN (online)	2578-5826
DOI	10.1080/25785826.2020.1751908
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Article ; Online: Vertebral involvement detected by tomosynthesis in SAPHO syndrome.

Kato, Masaru / Kiuchi, Yoshitsugu / Atsumi, Tatsuya / Furukawa, Shin

Rheumatology (Oxford, England)

2024

Language	English
Publishing date	2024-01-12
Publishing country	England
Document type	Journal Article
ZDB-ID	1464822-2
ISSN	1462-0332 ; 1462-0324
ISSN (online)	1462-0332
ISSN	1462-0324
DOI	10.1093/rheumatology/keae022
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Zs.B 240: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 497: Show issues

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Article ; Online: Comment on: Beneficial effects of nintedanib on cardiomyopathy in patients with systemic sclerosis: a pilot study: reply.

Kato, Masaru / Ninagawa, Keita / Atsumi, Tatsuya

Rheumatology (Oxford, England)

2023 Volume 62, Issue 9, Page(s) e278–e279

MeSH term(s)	Humans ; Pilot Projects ; Scleroderma, Systemic/complications ; Scleroderma, Systemic/drug therapy ; Lung Diseases, Interstitial ; Cardiomyopathies/drug therapy ; Cardiomyopathies/etiology
Chemical Substances	nintedanib (G6HRD2P839)
Language	English
Publishing date	2023-01-26
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	1464822-2
ISSN	1462-0332 ; 1462-0324
ISSN (online)	1462-0332
ISSN	1462-0324
DOI	10.1093/rheumatology/kead037
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Zs.MO 497: Show issues

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Article ; Online: Development of analytical methods for functional analysis of intracellular protein using signal-responsive silica or organic nanoparticles.

Kato, Masaru

Journal of pharmaceutical and biomedical analysis

2016 Volume 118, Page(s) 292–306

Abstract: Because proteins control cellular function, intracellular protein analysis is needed to gain a better understanding of life and disease. However, in situ protein analysis still faces many difficulties because proteins are heterogeneously located within ... ...

Abstract	Because proteins control cellular function, intracellular protein analysis is needed to gain a better understanding of life and disease. However, in situ protein analysis still faces many difficulties because proteins are heterogeneously located within the cell and the types and amount of proteins within the cell are ever changing. Recently, nanotechnology has received increasing attention and multiple protein-containing nanoparticles have been developed. Nanoparticles offer a promising tool for intracellular protein analysis because (1) they can permeate the cellular membrane after modification or changing composition, (2) the stability of various proteins is improved by encapsulation within nanoparticles, and (3) protein release and activity can be controlled. In this review, we discuss the development of analytical methods for intracellular functional protein analysis using signal-responsive silica and organic nanoparticles.
MeSH term(s)	Animals ; Humans ; Intracellular Signaling Peptides and Proteins/analysis ; Intracellular Signaling Peptides and Proteins/chemistry ; Nanoparticles/chemistry ; Nanotechnology/methods ; Nanotechnology/trends ; Protein Structure, Secondary ; Silicon Dioxide/chemistry
Chemical Substances	Intracellular Signaling Peptides and Proteins ; Silicon Dioxide (7631-86-9)
Language	English
Publishing date	2016-01-25
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	604917-5
ISSN	1873-264X ; 0731-7085
ISSN (online)	1873-264X
ISSN	0731-7085
DOI	10.1016/j.jpba.2015.10.021
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Article ; Online: Predicting factors for omitting beta-blockers in patients with tachycardia-induced cardiomyopathy after successful catheter ablation for atrial fibrillation.

Takami, Aiko / Kato, Masaru / Kotake, Yasuhito / Okamura, Akihiro / Tomomori, Takuya / Kawatani, Shunsuke / Yamamoto, Kazuhiro

Heart and vessels

2024

Abstract: Tachycardia induces a reduction in the left ventricular ejection fraction (LVEF), which is defined as tachycardia-induced cardiomyopathy (TIC). Conversion to and maintenance of sinus rhythm by catheter ablation can improve LVEF in patients with TIC due ... ...

Abstract	Tachycardia induces a reduction in the left ventricular ejection fraction (LVEF), which is defined as tachycardia-induced cardiomyopathy (TIC). Conversion to and maintenance of sinus rhythm by catheter ablation can improve LVEF in patients with TIC due to atrial fibrillation (AF). Beta-blockers are mandatory for the treatment of heart failure with reduced LVEF(HFrEF), but the necessity of beta-blockers in TIC patients even after catheter ablation remains unclear. We examined the effect of beta-blockers on cardiac function in TIC patients after catheter ablation. We retrospectively analyzed 124 patients with a history of heart failure and an LVEF of ≤ 50% who underwent catheter ablation for AF. TIC was defined as a ≥ 10% improvement in the baseline LVEF and an improvement to an LVEF of ≥ 50% at 6 months after ablation. Patients with other cardiomyopathy diagnosed before the ablation were excluded. LVEF was significantly increased with the reductions of the left ventricular and left atrial volumes at the 6-month follow-up in all 80 patients with TIC. No beta-blockers were prescribed during the post-ablation follow-up in 21 patients with TIC. The absolute values of and changes in the echocardiographic parameters between before and after ablation were not significantly different between patients with and without beta-blockers after the ablation. A simple score using the history of hospitalization for heart failure and use of beta-blockers or diuretics prior to ablation was useful in identifying TIC patients who did not need prescription of beta-blockers after catheter ablation. LVEF similarly improved in both patients with and without prescription of beta-blockers after the ablation. Beta-blockers may not need to be prescribed after successful catheter ablation for AF in LVEF of ≤ 50% patients without other cause of cardiomyopathy diagnosed before the ablation, a history of hospitalization for heart failure and prescription of beta-blockers and diuretics before the ablation.
Language	English
Publishing date	2024-03-06
Publishing country	Japan
Document type	Journal Article
ZDB-ID	89678-0
ISSN	1615-2573 ; 0910-8327 ; 0935-736X
ISSN (online)	1615-2573
ISSN	0910-8327 ; 0935-736X
DOI	10.1007/s00380-024-02385-7
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Article ; Online: Preliminary Investigation of a Rapid and Feasible Therapeutic Drug Monitoring Method for the Real-Time Estimation of Blood Pazopanib Concentrations.

Kato, Masaru / Maruyama, Shinichi / Watanabe, Noriko / Yamada, Risa / Suzaki, Yuki / Ishida, Masaru / Kanno, Hiroshi

The AAPS journal

2024 Volume 26, Issue 3, Page(s) 48

Abstract: Pazopanib is a multi-kinase inhibitor used to treat advanced/metastatic renal cell carcinoma and advanced soft tissue tumors; however, side effects such as diarrhea and hypertension have been reported, and dosage adjustment based on drug concentration in ...

Abstract	Pazopanib is a multi-kinase inhibitor used to treat advanced/metastatic renal cell carcinoma and advanced soft tissue tumors; however, side effects such as diarrhea and hypertension have been reported, and dosage adjustment based on drug concentration in the blood is necessary. However, measuring pazopanib concentrations in blood using the existing methods is time-consuming; and current dosage adjustments are made using the results of blood samples taken at the patient's previous hospital visit (approximately a month prior). If the concentration of pazopanib could be measured during the waiting period for a doctor's examination at the hospital (in approximately 30 min), the dosage could be adjusted according to the patient's condition on that day. Therefore, we aimed to develop a method for rapidly measuring blood pazopanib concentrations (in approximately 25 min) using common analytical devices (a tabletop centrifuge and a spectrometer). This method allowed for pazopanib quantification in the therapeutic concentration range (25-50 μg/mL). Additionally, eight popular concomitant medications taken simultaneously with pazopanib did not interfere with the measurements. We used the developed method to measure blood concentration in two patients and obtained similar results to those measured using the previously reported HPLC method. By integrating it with the point of care and sample collection by finger pick, this method can be used for measurements in pharmacies and patients' homes. This method can maximize the therapeutic effects of pazopanib by dose adjustment to control adverse events.
MeSH term(s)	Humans ; Carcinoma, Renal Cell/drug therapy ; Carcinoma, Renal Cell/pathology ; Carcinoma, Renal Cell/secondary ; Kidney Neoplasms/chemically induced ; Kidney Neoplasms/drug therapy ; Kidney Neoplasms/pathology ; Drug Monitoring ; Pyrimidines ; Indazoles ; Sulfonamides
Chemical Substances	pazopanib (7RN5DR86CK) ; Pyrimidines ; Indazoles ; Sulfonamides
Language	English
Publishing date	2024-04-15
Publishing country	United States
Document type	Journal Article
ISSN	1550-7416
ISSN (online)	1550-7416
DOI	10.1208/s12248-024-00918-6
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Article ; Online: Quantitative determination of plasma cabozantinib concentration using HPLC-UV and its application to patients with renal cell carcinoma.

Maruyama, Shinichi / Kato, Masaru / Hiraga, Tatsuru / Ishida, Masaru / Kanno, Hiroshi

Biomedical chromatography : BMC

2023 Volume 37, Issue 5, Page(s) e5599

Abstract: Cabozantinib is an oral small-molecule tyrosine kinase inhibitor that has become a standard of care for advanced renal cell carcinoma (RCC). However, cabozantinib is associated with a high rate of adverse events. Therefore, individualised cabozantinib ... ...

Abstract	Cabozantinib is an oral small-molecule tyrosine kinase inhibitor that has become a standard of care for advanced renal cell carcinoma (RCC). However, cabozantinib is associated with a high rate of adverse events. Therefore, individualised cabozantinib administration and monitoring could help maximise its therapeutic efficacy and avoid serious adverse events. This study developed and validated a method to determine cabozantinib concentration in plasma using HPLC-UV. Sorafenib, an internal standard, was added to the plasma sample containing cabozantinib. A calibration curve for cabozantinib showed good linearity (R
MeSH term(s)	Humans ; Carcinoma, Renal Cell/drug therapy ; Kidney Neoplasms/drug therapy ; Antineoplastic Agents/therapeutic use ; Chromatography, High Pressure Liquid ; Anilides/therapeutic use
Chemical Substances	cabozantinib (1C39JW444G) ; Antineoplastic Agents ; Anilides
Language	English
Publishing date	2023-02-21
Publishing country	England
Document type	Journal Article
ZDB-ID	632848-9
ISSN	1099-0801 ; 0269-3879
ISSN (online)	1099-0801
ISSN	0269-3879
DOI	10.1002/bmc.5599
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Zs.A 2166: Show issues

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Article: Axial Spondyloarthritis in Diffuse Idiopathic Skeletal Hyperostosis.

Aso, Kuniyuki / Kato, Masaru / Atsumi, Tatsuya

The Journal of rheumatology

2022 Volume 49, Issue 8, Page(s) 956–957

MeSH term(s)	Axial Spondyloarthritis ; Humans ; Hyperostosis, Diffuse Idiopathic Skeletal/complications ; Hyperostosis, Diffuse Idiopathic Skeletal/diagnostic imaging
Language	English
Publishing date	2022-03-15
Publishing country	Canada
Document type	Journal Article
ZDB-ID	194928-7
ISSN	1499-2752 ; 0315-162X
ISSN (online)	1499-2752
ISSN	0315-162X
DOI	10.3899/jrheum.220082
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Zs.A 1168: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 135: Show issues

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Article ; Online: Hydrogel-Coated Gate Field-Effect Transistor for Real-Time and Label-Free Monitoring of β-Amyloid Aggregation and Its Inhibition.

Sakata, Toshiya / Shiratori, Reiko / Kato, Masaru

Analytical chemistry

2022 Volume 94, Issue 6, Page(s) 2820–2826

Abstract: In this paper, we propose a hydrogel-coated gate field-effect transistor (FET) for the real-time and label-free monitoring of β-amyloid (Aβ) aggregation and its inhibition. The hydrogel used in this study is composed of poly tetramethoxysilane (TMOS), in ...

Abstract	In this paper, we propose a hydrogel-coated gate field-effect transistor (FET) for the real-time and label-free monitoring of β-amyloid (Aβ) aggregation and its inhibition. The hydrogel used in this study is composed of poly tetramethoxysilane (TMOS), in which Aβ monomers are entrapped and then aggregate, and coated on the gate insulator; that is, Aβ aggregation is induced in the vicinity of the sensing surface. With the Aβ hydrogel-coated gate FET, the steplike decrease in the surface potential of the Aβ hydrogel-coated gate electrode is electrically monitored in real time, according to the stepwise aggregation of Aβ monomers to form into fibrils through oligomers and so forth in stages. This is because the capacitance of the Aβ-hydrogel membrane decreases depending on the stage of aggregation; that is, the hydrophobicity of the Aβ-hydrogel membrane increases stepwise depending on the amount of Aβ aggregates. The formation of Aβ fibrils is also confirmed in the measurement solution using a fluorescent dye, thioflavin T, which selectively binds to the Aβ fibrils. Moreover, the addition of daunomycin, an inhibitor of Aβ aggregation, to the measurement solution suppresses the stepwise electrical response of the Aβ hydrogel-coated gate FET. Thus, a platform based on the Aβ hydrogel-coated gate FET is suitable for a simple screening system for inhibitors of Aβ aggregation, which may lead the identification of potential therapeutic agents for Alzheimer's disease.
MeSH term(s)	Alzheimer Disease/metabolism ; Amyloid beta-Peptides/metabolism ; Fluorescent Dyes/therapeutic use ; Humans ; Hydrogels ; Hydrophobic and Hydrophilic Interactions ; Peptide Fragments/metabolism
Chemical Substances	Amyloid beta-Peptides ; Fluorescent Dyes ; Hydrogels ; Peptide Fragments
Language	English
Publishing date	2022-02-04
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1508-8
ISSN	1520-6882 ; 0003-2700
ISSN (online)	1520-6882
ISSN	0003-2700
DOI	10.1021/acs.analchem.1c04339
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Zs.A 4033: Show issues

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Article ; Online: Methylnigakinone content determination and geographical origin discrimination for P. quassioides via fluorescence fingerprint and principal component analyses.

Hamazaki, Yasunori / Kato, Masaru / Karasawa, Koji

Journal of pharmaceutical and biomedical analysis

2022 Volume 219, Page(s) 114932

Abstract: Picrasma quassioides is used as a bittersweet stomach medicine. Because it is a natural product obtained from various geographical regions, the production area is important when P. quassioides is used as a crude drug. Herein, we developed a method to ... ...

Abstract	Picrasma quassioides is used as a bittersweet stomach medicine. Because it is a natural product obtained from various geographical regions, the production area is important when P. quassioides is used as a crude drug. Herein, we developed a method to determine the content of methylnigakinone, one of the major active ingredients in P. quassioides, and a protocol for discriminating the geographical origin of this natural product using a fluorescence fingerprint analysis and principal component analysis (PCA). Because methylnigakinone is fluorescent (excitation wavelength: 352 nm, emission wavelength: 458 nm), the content of this molecule can be determined in the concentration range of 0.1-1 μg/mL. The quantification results of methylnigakinone obtained using the developed method were similar to those obtained from an HPLC analysis. Furthermore, the PCA of the fluorescence fingerprint of P. quassioides produced a score plot with the three different geographical origins (Kyushu island (Japan), Shikoku island (Japan), and China) plotted in the regions. Thus, it was possible to discriminate the geographical origin of the P. quassioides samples. The developed method is simple, quick, and has a minimal environmental impact. Therefore, the developed method will be useful for confirming the origin of P. quassioides.
MeSH term(s)	Biological Products ; Chromatography, High Pressure Liquid/methods ; Geography ; Picrasma ; Principal Component Analysis
Chemical Substances	Biological Products
Language	English
Publishing date	2022-07-07
Publishing country	England
Document type	Journal Article
ZDB-ID	604917-5
ISSN	1873-264X ; 0731-7085
ISSN (online)	1873-264X
ISSN	0731-7085
DOI	10.1016/j.jpba.2022.114932
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