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  1. Article ; Online: Hydrophobic solution functions as a multifaceted mosquito repellent by enhancing chemical transfer, altering object tracking, and forming aversive memory.

    Wiedemann, Bianca M / Takeuchi, Kohei / Ohta, Kazumi / Kato-Namba, Aya / Yabuki, Masayuki / Kazama, Hokto / Nakagawa, Takao

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 5422

    Abstract: Developing a safe and potent repellent of mosquitoes applicable to human skins is an effective measure against the spread of mosquito-borne diseases. Recently, we have identified that hydrophobic solutions such as low viscosity polydimethylsiloxane (L- ... ...

    Abstract Developing a safe and potent repellent of mosquitoes applicable to human skins is an effective measure against the spread of mosquito-borne diseases. Recently, we have identified that hydrophobic solutions such as low viscosity polydimethylsiloxane (L-PDMS) spread on a human skin prevent mosquitoes from staying on and biting it. This is likely due to the ability of L-PDMS in wetting mosquito legs and exerting a capillary force from which the mosquitoes attempt to escape. Here we show three additional functions of L-PDMS that can contribute to repel Aedes albopictus, by combining physicochemical analysis and behavioral assays in both an arm cage and a virtual flight arena. First, L-PDMS, when mixed with topical repellents and applied on a human skin, enhances the effect of topical repellents in reducing mosquito bites by efficiently transferring them to mosquito legs upon contact. Second, L-PDMS applied to mosquito tarsi compromises visual object tracking during flight, exerting an influence outlasting the contact. Finally, L-PDMS applied to mosquito tarsi acts as an aversive reinforcer in associative learning, making mosquitoes avoid the conditioned odor. These results uncover a multifaceted potential of L-PDMS in altering a sequence of mosquito behaviors from biting a human skin, visual object tracking following takeoff, to the response to an odor linked with L-PDMS.
    MeSH term(s) Humans ; Animals ; Insect Repellents/pharmacology ; Ankle Joint ; Wettability ; Aedes
    Chemical Substances Insect Repellents
    Language English
    Publishing date 2024-03-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-55975-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Surfactants alter mosquito's flight and physical condition.

    Kato-Namba, Aya / Iida, Toshiaki / Ohta, Kazumi / Suzuki, Masahiro / Saito, Kazuma / Takeuchi, Kohei / Sakamoto, Maki / Kazama, Hokto / Nakagawa, Takao

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 2355

    Abstract: Mosquitoes carry lethal pathogens for humans and hundreds of thousands of people are killed by mosquito-borne diseases every year. Therefore, controlling mosquitoes is essential to protect the lives of people around the world. Insecticides are highly ... ...

    Abstract Mosquitoes carry lethal pathogens for humans and hundreds of thousands of people are killed by mosquito-borne diseases every year. Therefore, controlling mosquitoes is essential to protect the lives of people around the world. Insecticides are highly effective in controlling mosquitoes and have been used extensively worldwide. However, they have potentially harmful effects on biodiversity and environment, and some mosquitoes are resistant to insecticide ingredients and survive upon their application. Therefore, there is a demand for a method to control mosquitoes without using conventional insecticide ingredients. Here, we used Aedes albopictus to test whether solutions with low surface tension, particularly surfactant solutions can alter mosquito behavior by spreading over the hydrophobic cuticle of mosquitoes. We found that solutions with low surface tension indeed attached to mosquitoes flying or resting on the wall, and made them fall. In addition, solutions with yet lower surface tension covered the mosquito surface more quickly and widely, knocking down or killing mosquitoes. These results suggest that surfactants such as sodium dioctyl sulfosuccinate can be used to alter mosquito behavior without relying on conventional insecticides.
    MeSH term(s) Animals ; Humans ; Insecticides/pharmacology ; Surface-Active Agents/pharmacology ; Aedes ; Pulmonary Surfactants ; Mosquito Control/methods ; Insecticide Resistance
    Chemical Substances Insecticides ; Surface-Active Agents ; Pulmonary Surfactants
    Language English
    Publishing date 2023-02-09
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-29455-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Functions of human olfactory mucus and age-dependent changes.

    Shirai, Tomohiro / Takase, Dan / Yokoyama, Junkichi / Nakanishi, Kuniyuki / Uehara, Chisaki / Saito, Naoko / Kato-Namba, Aya / Yoshikawa, Keiichi

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 971

    Abstract: Odorants are detected by olfactory sensory neurons, which are covered by olfactory mucus. Despite the existence of studies on olfactory mucus, its constituents, functions, and interindividual variability remain poorly understood. Here, we describe a ... ...

    Abstract Odorants are detected by olfactory sensory neurons, which are covered by olfactory mucus. Despite the existence of studies on olfactory mucus, its constituents, functions, and interindividual variability remain poorly understood. Here, we describe a human study that combined the collection of olfactory mucus and olfactory psychophysical tests. Our analyses revealed that olfactory mucus contains high concentrations of solutes, such as total proteins, inorganic elements, and molecules for xenobiotic metabolism. The high concentrations result in a capacity to capture or metabolize a specific repertoire of odorants. We provide evidence that odorant metabolism modifies our sense of smell. Finally, the amount of olfactory mucus decreases in an age-dependent manner. A follow-up experiment recapitulated the importance of the amount of mucus in the sensitive detection of odorants by their receptors. These findings provide a comprehensive picture of the molecular processes in olfactory mucus and propose a potential cause of olfactory decline.
    MeSH term(s) Humans ; Smell/physiology ; Receptors, Odorant/metabolism ; Olfactory Receptor Neurons/metabolism ; Odorants/analysis ; Mucus/metabolism
    Chemical Substances Receptors, Odorant
    Language English
    Publishing date 2023-01-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-27937-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Ligand Specificity and Evolution of Mammalian Musk Odor Receptors: Effect of Single Receptor Deletion on Odor Detection.

    Sato-Akuhara, Narumi / Horio, Nao / Kato-Namba, Aya / Yoshikawa, Keiichi / Niimura, Yoshihito / Ihara, Sayoko / Shirasu, Mika / Touhara, Kazushige

    The Journal of neuroscience : the official journal of the Society for Neuroscience

    2016  Volume 36, Issue 16, Page(s) 4482–4491

    Abstract: Musk odors have been used widely for fragrance and medicine for >2000 years because of their fascinating scent and physiological effects. Therefore, fragrance manufacturers have been eager to develop high-quality musk compounds that are safe and easily ... ...

    Abstract Musk odors have been used widely for fragrance and medicine for >2000 years because of their fascinating scent and physiological effects. Therefore, fragrance manufacturers have been eager to develop high-quality musk compounds that are safe and easily synthesized. We recently identified muscone-responsive olfactory receptors (ORs) MOR215-1 and OR5AN1 in mice and humans, respectively (Shirasu et al., 2014). In this study, we identified musk ORs that are evolutionarily closely related to MOR215-1 or OR5AN1 in various primates and investigated structure-activity relationships for various musk odorants and related compounds. We found that each species has one or two functional musk ORs that exhibit specific ligand spectra to musk compounds. Some of them, including the human OR5AN1, responded to nitro musks with chemical properties distinct from muscone. The ligand specificity of OR5AN1 reflects the perception of musk odors in humans. Genetic deletion of MOR215-1 in mice resulted in drastic reduction of sensitivity to muscone, suggesting that MOR215-1 plays a critical role in muscone perception. Therefore, the current study reveals a clear link between the identified OR and muscone perception. Moreover, the strategy established for screening ligands for the muscone OR may facilitate the development of novel and commercially useful musk odors.
    Significance statement: The long-sought musk odor receptor family in mammals was discovered and found to be well conserved and narrowly tuned to musk odors. In mice, deletion of the most sensitive musk receptor resulted in drastic reduction in sensitivity to muscone, demonstrating a strong link between receptor and odor perception. In humans, we found one musk receptor that recognized both macrocyclic and nitro musks that had distinct chemical structures. The structure-activity relationships were in a good agreement with human sensory perception and therefore may be used to develop novel musk aroma in fragrance fields. Finally, identification of a natural ligand(s) for musk receptors in mammals other than musk deer would reveal an evolutionarily pivotal role in each species in the future.
    MeSH term(s) Animals ; Dose-Response Relationship, Drug ; Evolution, Molecular ; Fatty Acids, Monounsaturated/chemistry ; Fatty Acids, Monounsaturated/pharmacology ; Female ; HEK293 Cells ; Humans ; Ligands ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Odorants ; Phylogeny ; Receptors, Odorant/genetics ; Receptors, Odorant/metabolism ; Sequence Deletion/physiology ; Smell/physiology ; Structure-Activity Relationship
    Chemical Substances Fatty Acids, Monounsaturated ; Ligands ; Receptors, Odorant ; musk (095I377U8F)
    Language English
    Publishing date 2016-04-20
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 604637-x
    ISSN 1529-2401 ; 0270-6474
    ISSN (online) 1529-2401
    ISSN 0270-6474
    DOI 10.1523/JNEUROSCI.3259-15.2016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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