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Article ; Online: Combination of serum 5-S-cysteinyldopa, melanoma inhibitory activity and IL-8 improves the diagnostic accuracy of malignant melanoma compared with individual markers.

Katoh, Yuki / Hara, Hiroyuki / Harada, Tomonori / Hirai, Shuichi

2022 Volume 101, Issue 35, Page(s) e30471

Abstract: Early diagnosis of malignant melanoma is critical for effective treatment and reduced patient mortality. However, current clinical and histological variables show limited accuracy in diagnosis. Serum or urine level of 5-S-cysteinyldopa (5-S-CD) is a ... ...

Abstract	Early diagnosis of malignant melanoma is critical for effective treatment and reduced patient mortality. However, current clinical and histological variables show limited accuracy in diagnosis. Serum or urine level of 5-S-cysteinyldopa (5-S-CD) is a commonly used melanoma biomarker in Japan owing to its increased sensitivity compared with other melanoma markers. However, its use as a diagnostic marker has shown some limitations. Therefore, here we examined the combination of 5-S-CD with melanoma inhibitory activity, which showed sensitivity in detecting melanoma comparable with that of 5-S-CD, and interleukin-8, a cytokine linked with melanoma progression, in a cohort of Japanese patients with melanoma. Our results revealed that the triple combination of 5-S-CD, melanoma inhibitory activity, and interleukin-8 showed high diagnostic accuracy in detecting melanoma compared with each of the individual factors. Importantly, the triple marker showed specificity and utility in detecting early-stage melanoma. Our results suggest the utility of the triple marker as a diagnostic biomarker for melanoma patients.
MeSH term(s)	Biomarkers, Tumor ; Cysteinyldopa ; Cytokines ; Humans ; Interleukin-8 ; Melanoma/pathology ; Skin Neoplasms ; Melanoma, Cutaneous Malignant
Chemical Substances	Biomarkers, Tumor ; Cytokines ; Interleukin-8 ; Cysteinyldopa (19641-92-0)
Language	English
Publishing date	2022-09-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000030471
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Article: [Ⅰ. Immunotherapy in Cervical Cancer-Current Approaches and Future Horizons].

Iwata, Takashi / Matsui, Tomoya / Matsuda, Risa / Katoh, Yuki / Sugawara, Masaki / Nogami, Yuya / Nishio, Hiroshi / Yamagami, Wataru

Gan to kagaku ryoho. Cancer & chemotherapy

2024 Volume 51, Issue 2, Page(s) 134–137

MeSH term(s)	Female ; Humans ; Uterine Cervical Neoplasms/therapy ; Immunotherapy
Language	Japanese
Publishing date	2024-03-07
Publishing country	Japan
Document type	Journal Article
ZDB-ID	604842-0
ISSN	0385-0684
ISSN	0385-0684
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Article ; Online: Evaluation of CD4

Chen, Guanliang / Iwata, Takashi / Sugawara, Masaki / Nishio, Hiroshi / Katoh, Yuki / Kukimoto, Iwao / Aoki, Daisuke

Journal of gynecologic oncology

2022 Volume 34, Issue 1, Page(s) e2

Abstract: Objective: To identify candidate predictors for the prognosis of cervical intraepithelial neoplasia 2 (CIN2) lesions and evaluate the prognostic value of the local immune response.: Methods: One hundred fifteen CIN2 patients were enrolled. The ... ...

Abstract	Objective: To identify candidate predictors for the prognosis of cervical intraepithelial neoplasia 2 (CIN2) lesions and evaluate the prognostic value of the local immune response. Methods: One hundred fifteen CIN2 patients were enrolled. The percentage of p16-, minichromosome maintenance complex component 2- or apolipoprotein B mRNA editing enzyme catalytic subunit 3G (APOBEC3G)-positive cells was determined immunohistochemically. Tumor-infiltrating lymphocytes (TILs) in intertumoral lesions were scored using an automated system. CIN3 disease progression and regression rates were estimated by the Kaplan-Meier method. A case-control study was conducted to screen CIN2 prognostic factors in 10 regression and 10 progression patients. Selected factors were examined in a cohort study to determine their prognostic value for CIN2. Results: Among all participants, the cumulative progression and regression rates at 60 months were 0.477 and 0.510, respectively. In the case-control study, p16- and APOBEC3G-positive cells were higher in the progression group (p=0.043, p=0.023). Additionally, CD4 Conclusion: CD4
MeSH term(s)	Female ; Humans ; Uterine Cervical Neoplasms/pathology ; Prognosis ; Cohort Studies ; Case-Control Studies ; Uterine Cervical Dysplasia ; Papillomavirus Infections
Language	English
Publishing date	2022-10-04
Publishing country	Korea (South)
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2478405-9
ISSN	2005-0399 ; 2005-0380
ISSN (online)	2005-0399
ISSN	2005-0380
DOI	10.3802/jgo.2023.34.e2
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Article ; Online: SCD1 inhibition enhances the effector functions of CD8

Sugi, Toshihiro / Katoh, Yuki / Ikeda, Toshikatsu / Seta, Daichi / Iwata, Takashi / Nishio, Hiroshi / Sugawara, Masaki / Kato, Daiki / Katoh, Kanoko / Kawana, Kei / Yaguchi, Tomonori / Kawakami, Yutaka / Hirai, Shuichi

Cancer science

2023 Volume 115, Issue 1, Page(s) 48–58

Abstract: We previously reported that the inhibition of stearoyl-CoA desaturase 1 (SCD1) enhances the antitumor function of ... ...

Abstract	We previously reported that the inhibition of stearoyl-CoA desaturase 1 (SCD1) enhances the antitumor function of CD8
MeSH term(s)	Mice ; Animals ; Oleic Acid/pharmacology ; CD8-Positive T-Lymphocytes ; Acetyltransferases ; Cholesterol ; Neoplasms ; Stearoyl-CoA Desaturase
Chemical Substances	Oleic Acid (2UMI9U37CP) ; Acetyltransferases (EC 2.3.1.-) ; Cholesterol (97C5T2UQ7J) ; Stearoyl-CoA Desaturase (EC 1.14.19.1)
Language	English
Publishing date	2023-10-25
Publishing country	England
Document type	Journal Article
ZDB-ID	2115647-5
ISSN	1349-7006 ; 1349-7006
ISSN (online)	1349-7006
ISSN	1349-7006
DOI	10.1111/cas.15999
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Article ; Online: Serum Free Fatty Acid Changes Caused by High Expression of Stearoyl-CoA Desaturase 1 in Tumor Tissues Are Early Diagnostic Markers for Ovarian Cancer.

Katoh, Kanoko / Katoh, Yuki / Kubo, Akiko / Iida, Miho / Ikeda, Yuji / Iwata, Takashi / Nishio, Hiroshi / Sugawara, Masaki / Kato, Daiki / Suematsu, Makoto / Hirai, Shuichi / Kawana, Kei

Cancer research communications

2023 Volume 3, Issue 9, Page(s) 1840–1852

Abstract: Ovarian cancer has a poor prognosis and is difficult to detect in early stages. Therefore, developing new diagnostic markers for early-stage ovarian cancer is critical. Here, we developed a diagnostic marker for early-stage ovarian cancer on the basis of ...

Abstract	Ovarian cancer has a poor prognosis and is difficult to detect in early stages. Therefore, developing new diagnostic markers for early-stage ovarian cancer is critical. Here, we developed a diagnostic marker for early-stage ovarian cancer on the basis of fatty acid metabolism characteristics of cancer cells. The expression of various fatty acid metabolizing enzymes such as stearoyl-CoA desaturase 1 (SCD1) was altered in early-stage ovarian cancer tissue compared with that in normal ovarian tissue. Changes in the expression of fatty acid metabolizing enzymes, particularly SCD1, in cancer tissues were found to alter concentrations of multiple free fatty acids (FFA) in serum. We were the first to show that fatty acid metabolic characteristics in tissues are related to the FFA composition of serum. Surprisingly, patients with stage I/II ovarian cancer also showed significant changes in serum levels of eight FFAs, which can be early diagnostic markers. Finally, using statistical analysis, an optimal early diagnostic model combining oleic and arachidic acid levels, fatty acids associated with SCD1, was established and confirmed to have higher diagnostic power than CA125, regardless of histology. Thus, our newly developed diagnostic model using serum FFAs may be a powerful tool for the noninvasive early detection of ovarian cancer. Significance: Measurement of serum FFA levels by changes in the expression of fatty acid metabolizing enzymes in tumor tissue would allow early detection of ovarian cancer. In particular, the SCD1-associated FFAs, oleic and arachidic acid, would be powerful new screening tools for early-stage ovarian cancer.
MeSH term(s)	Female ; Humans ; Fatty Acids, Nonesterified ; Stearoyl-CoA Desaturase ; Ovarian Neoplasms/diagnosis ; Fatty Acids
Chemical Substances	Fatty Acids, Nonesterified ; Stearoyl-CoA Desaturase (EC 1.14.19.1) ; Fatty Acids
Language	English
Publishing date	2023-09-15
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2767-9764
ISSN (online)	2767-9764
DOI	10.1158/2767-9764.CRC-23-0138
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Article ; Online: Decrease in the cytosolic NADP

Katoh, Yuki / Tamba, Michiko / Matsuda, Manabu / Kikuchi, Kazuhiro / Okamura, Naomichi

Biochemical and biophysical research communications

2018 Volume 497, Issue 1, Page(s) 374–380

Abstract: In order to understand the molecular mechanisms involved in the sperm capacitation, we have identified the proteins tyrosine-phosphorylated during the capacitation especially in conjunction with the regulation of the levels of reactive oxygen species ( ... ...

Abstract	In order to understand the molecular mechanisms involved in the sperm capacitation, we have identified the proteins tyrosine-phosphorylated during the capacitation especially in conjunction with the regulation of the levels of reactive oxygen species (ROS) in sperm. In the present study, the effects of the tyrosine phosphorylation of cytosolic NADP
MeSH term(s)	Animals ; Catalysis ; Cells, Cultured ; Down-Regulation/physiology ; Enzyme Activation ; Gene Expression Regulation, Enzymologic/physiology ; Isocitrate Dehydrogenase/metabolism ; Male ; NADP/metabolism ; Reactive Oxygen Species/metabolism ; Sperm Capacitation/physiology ; Sperm Motility/physiology ; Spermatozoa/physiology ; Swine
Chemical Substances	Reactive Oxygen Species ; NADP (53-59-8) ; Isocitrate Dehydrogenase (EC 1.1.1.41)
Language	English
Publishing date	2018--26
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	205723-2
ISSN	1090-2104 ; 0006-291X ; 0006-291X
ISSN (online)	1090-2104 ; 0006-291X
ISSN	0006-291X
DOI	10.1016/j.bbrc.2018.02.087
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Article: Decrease in the cytosolic NADP+-dependent isocitrate dehydrogenase activity through porcine sperm capacitation

Katoh, Yuki / Michiko Tamba / Manabu Matsuda / Kazuhiro Kikuchi / Naomichi Okamura

Biochemical and biophysical research communications. 2018 Feb. 26, v. 497, no. 1

2018

Abstract	In order to understand the molecular mechanisms involved in the sperm capacitation, we have identified the proteins tyrosine-phosphorylated during the capacitation especially in conjunction with the regulation of the levels of reactive oxygen species (ROS) in sperm. In the present study, the effects of the tyrosine phosphorylation of cytosolic NADP+-dependent isocitrate dehydrogenase (IDPc) on its catalytic activity and on the levels of ROS in sperm have been studied. The tyrosine phosphorylated IDPc showed a significantly lowered enzymatic activity. The immunocytochemical analyses using the highly specific antisera against IDPc revealed that IDPc was mainly localized to the principal piece of the porcine sperm flagellum. As IDPc is one of the major NADPH regenerating enzymes in porcine sperm, it is strongly suggested that the decrease in IDPc activity is involved in the increased levels of ROS, which results in the induction of hyperactivated flagellar movement and capacitation.
Keywords	NADP (coenzyme) ; antiserum ; catalytic activity ; enzyme activity ; flagellum ; isocitrate dehydrogenase ; phosphorylation ; proteins ; sperm capacitation ; spermatozoa ; swine ; tyrosine
Language	English
Dates of publication	2018-0226
Size	p. 374-380.
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	205723-2
ISSN	0006-291X ; 0006-291X
ISSN (online)	0006-291X
ISSN	0006-291X
DOI	10.1016/j.bbrc.2018.02.087
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Article ; Online: Inhibition of stearoyl-CoA desaturase 1 (SCD1) enhances the antitumor T cell response through regulating β-catenin signaling in cancer cells and ER stress in T cells and synergizes with anti-PD-1 antibody.

Katoh, Yuki / Yaguchi, Tomonori / Kubo, Akiko / Iwata, Takashi / Morii, Kenji / Kato, Daiki / Ohta, Shigeki / Satomi, Ryosuke / Yamamoto, Yasuhiro / Oyamada, Yoshitaka / Ouchi, Kota / Takahashi, Shin / Ishioka, Chikashi / Matoba, Ryo / Suematsu, Makoto / Kawakami, Yutaka

Journal for immunotherapy of cancer

2022 Volume 10, Issue 7

Abstract: Background: Understanding the mechanisms of non-T cell inflamed tumor microenvironment (TME) and their modulation are important to improve cancer immunotherapies such as immune checkpoint inhibitors. The involvement of various immunometabolisms has ... ...

Abstract	Background: Understanding the mechanisms of non-T cell inflamed tumor microenvironment (TME) and their modulation are important to improve cancer immunotherapies such as immune checkpoint inhibitors. The involvement of various immunometabolisms has recently been indicated in the formation of immunosuppressive TME. In this study, we investigated the immunological roles of stearoyl-CoA desaturase 1 (SCD1), which is essential for fatty acid metabolism, in the cancer immune response. Methods: We investigated the roles of SCD1 by inhibition with the chemical inhibitor or genetic manipulation in antitumor T cell responses and the therapeutic effect of anti-programmed cell death protein 1 (anti-PD-1) antibody using various mouse tumor models, and their cellular and molecular mechanisms. The roles of SCD1 in human cancers were also investigated by gene expression analyses of colon cancer tissues and by evaluating the related free fatty acids in sera obtained from patients with non-small cell lung cancer who were treated with anti-PD-1 antibody. Results: Systemic administration of a SCD1 inhibitor in mouse tumor models enhanced production of CCL4 by cancer cells through reduction of Wnt/β-catenin signaling and by CD8 Conclusions: SCD1 expressed in cancer cells and immune cells causes immunoresistant conditions, and its inhibition augments antitumor T cells and therapeutic effects of anti-PD-1 antibody. Therefore, SCD1 is an attractive target for the development of new diagnostic and therapeutic strategies to improve current cancer immunotherapies including immune checkpoint inhibitors.
MeSH term(s)	Animals ; CD8-Positive T-Lymphocytes/immunology ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/immunology ; Colonic Neoplasms/drug therapy ; Colonic Neoplasms/immunology ; Immune Checkpoint Inhibitors/pharmacology ; Lung Neoplasms/drug therapy ; Lung Neoplasms/immunology ; Mice ; Mice, Knockout ; Stearoyl-CoA Desaturase/antagonists & inhibitors ; Stearoyl-CoA Desaturase/immunology ; Tumor Microenvironment ; Wnt Signaling Pathway/immunology ; beta Catenin/immunology
Chemical Substances	CTNNB1 protein, mouse ; Immune Checkpoint Inhibitors ; beta Catenin ; Scd1 protein, mouse (EC 1.14.19.1) ; Stearoyl-CoA Desaturase (EC 1.14.19.1)
Language	English
Publishing date	2022-07-03
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2719863-7
ISSN	2051-1426 ; 2051-1426
ISSN (online)	2051-1426
ISSN	2051-1426
DOI	10.1136/jitc-2022-004616
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Article ; Online: Total Synthesis of Crotophorbolone.

Asaba, Taro / Katoh, Yuki / Urabe, Daisuke / Inoue, Masayuki

Angewandte Chemie (International ed. in English)

2015 Volume 54, Issue 48, Page(s) 14457–14461

Abstract: The complex ABC-tricyclic structure of crotophorbolone, a derivative of the tigliane diterpenoids, was assembled by coupling of simple fragments. The six-membered C-ring fragment, having five contiguous stereocenters, was stereoselectively constructed ... ...

Abstract	The complex ABC-tricyclic structure of crotophorbolone, a derivative of the tigliane diterpenoids, was assembled by coupling of simple fragments. The six-membered C-ring fragment, having five contiguous stereocenters, was stereoselectively constructed from (R)-carvone. After attachment of the five-membered A-ring through the π-allyl Stille coupling reaction, the α-alkoxy bridgehead radical reaction effected the endo-cyclization of the seven-membered B-ring by forming the sterically congested bond at C9 and C10 stereospecifically and stereoselectively, respectively. Finally, the functional groups on the 5/7/6-membered ring system were manipulated by rhodium-catalyzed C2 olefin isomerization, C13 decarboxylative oxidation, and C4 hydroxylation, thus completing the first total synthesis of crotophorbolone.
Language	English
Publishing date	2015-11-23
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2011836-3
ISSN	1521-3773 ; 1433-7851
ISSN (online)	1521-3773
ISSN	1433-7851
DOI	10.1002/anie.201509160
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Article: Transcription Factor Homeobox D9 Drives the Malignant Phenotype of HPV18-Positive Cervical Cancer Cells via Binding to the Viral Early Promoter.

Hayashi, Shigenori / Iwata, Takashi / Imagawa, Ryotaro / Sugawara, Masaki / Chen, Guanliang / Tanimoto, Satoko / Sugawara, Yo / Tanaka, Ikumo / Matsui, Tomoya / Nishio, Hiroshi / Nakamura, Masaru / Katoh, Yuki / Mori, Seiichiro / Kukimoto, Iwao / Aoki, Daisuke

Cancers

2021 Volume 13, Issue 18

Abstract: Persistent infections with two types of human papillomaviruses (HPV), HPV16 and HPV18, are the most common cause of cervical cancer (CC). Two viral early genes, ...

Abstract	Persistent infections with two types of human papillomaviruses (HPV), HPV16 and HPV18, are the most common cause of cervical cancer (CC). Two viral early genes,
Language	English
Publishing date	2021-09-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers13184613
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