LIVIVO - Search results -

Search results

Result 1 - 10 of total 27

Search options

Article: The asymmetries of the biopsychosocial model of depression in lay discourses - Topic modelling online depression forums.

Németh, Renáta / Sik, Domonkos / Katona, Eszter

SSM - population health

2021 Volume 14, Page(s) 100785

Abstract: Background: One of the most comprehensive approaches to depression is the biopsychosocial model. From this wider perspective, social sciences have criticized the reductionist biomedical discourse, which has been dominating expert discourses for a long ... ...

Abstract	Background: One of the most comprehensive approaches to depression is the biopsychosocial model. From this wider perspective, social sciences have criticized the reductionist biomedical discourse, which has been dominating expert discourses for a long time. As these discourses determine the horizon of attributions and interventions, their lay interpretation plays a central role in the coping with depression. Methods: In order to map these patterns, online depression forums are analyzed with natural language processing methods, where computational tools are complemented with a qualitative approach. Latent Dirichlet Allocation topic model of depression-related posts from the most popular English-speaking online health discussion forums (N = ~70 000) reveals the monolog (attributions and self-disclosures) and interactive (consultations and quasi-therapeutic interactions) patterns. Results: Following the evaluation of various models 18 topics were differentiated: Conclusions: Biomedical discourse is underrepresented in lay discussions, while psychological discourse plays an overall dominant role. Even if actors are initially aware of the social mechanisms contributing to depression, they neglect these factors when it comes to considering the countermeasures.
Language	English
Publishing date	2021-03-29
Publishing country	England
Document type	Journal Article
ISSN	2352-8273
ISSN	2352-8273
DOI	10.1016/j.ssmph.2021.100785
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Topic modelling online depression forums: beyond narratives of self-objectification and self-blaming.

Sik, Domonkos / Németh, Renáta / Katona, Eszter

Journal of mental health (Abingdon, England)

2021 Volume 32, Issue 2, Page(s) 386–395

Abstract: Background: Depression raises a double challenge: besides the negative mood and the intrusive thoughts, the relation to the self also becomes difficult. Online forums are analysed as communicative platforms enabling the interactive reconstruction of the ...

Abstract	Background: Depression raises a double challenge: besides the negative mood and the intrusive thoughts, the relation to the self also becomes difficult. Online forums are analysed as communicative platforms enabling the interactive reconstruction of the self. Aims: The discourses of online depression forums are explored. Firstly, narrative patterns are identified according to their thematic focus (e.g. dysfunctional body, challenges of intimacy) and discursive logic (e.g. information exchange, support). Secondly, narratives are analysed in order to describe various ways of grounding a depressed self. Methods: ∼70.000 depression-related posts from the biggest English-speaking online forums (e.g. www.reddit.com/r/depression, www.healthunlocked.com) were analysed. Quantitative (LDA topic modelling) and qualitative (deep reading) approaches were used simultaneously to determine the optimal number of topics and their interpretation. Results: 13 topics were identified and interpreted according to their content and communicative function. Based on the inter-topic distances four clusters were identified (medicalized, intimacy-oriented, critical and uninhabitable self-narratives). Conclusions: The clusters of the 13 topics highlight various ways of narrating depression and the depressed self. Based on a comparison with a systematic review of mental illness recovery narratives, depression forums cover most narrative genres and emotional tones, thus create a unique opportunity for integrating the depressing experiences in the self.
MeSH term(s)	Humans ; Depression ; Narration ; Communication ; Mental Disorders
Language	English
Publishing date	2021-09-28
Publishing country	England
Document type	Systematic Review ; Journal Article
ZDB-ID	1145439-8
ISSN	1360-0567 ; 0963-8237
ISSN (online)	1360-0567
ISSN	0963-8237
DOI	10.1080/09638237.2021.1979493
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 3695: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Using MemBlob to Analyze Transmembrane Regions Based on Cryo-EM Maps.

Csizmadia, Georgina / Farkas, Bianka / Katona, Eszter / Tusnády, Gábor E / Hegedűs, Tamás

Methods in molecular biology (Clifton, N.J.)

2020 Volume 2112, Page(s) 123–130

Abstract: Transmembrane proteins include membrane channels, pores, and receptors and, as such, comprise an important part of the proteome, yet our knowledge about them is much less complete than about soluble, globular proteins. An important aspect of ... ...

Abstract	Transmembrane proteins include membrane channels, pores, and receptors and, as such, comprise an important part of the proteome, yet our knowledge about them is much less complete than about soluble, globular proteins. An important aspect of transmembrane protein structure is their exact position within the lipid bilayer, a feature hard to investigate experimentally at the atomic level. Here we describe MemBlob, a novel approach utilizing difference electron density maps obtained by cryo-EM studies of transmembrane proteins. The idea behind is that the nonprotein part of such maps carries information on the exact localization of the membrane mimetics used in the experiment and can be used to extract the positional information of the protein within the membrane. MemBlob uses a structural model of the protein and an experimental electron density map to provide an estimation of the surface residues interacting with the membrane.
MeSH term(s)	Cryoelectron Microscopy/methods ; Lipid Bilayers/chemistry ; Membrane Proteins/chemistry ; Protein Conformation ; Protein Domains
Chemical Substances	Lipid Bilayers ; Membrane Proteins
Language	English
Publishing date	2020-01-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-0716-0270-6_9
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- Full text online
- Order with fees

Article: Impact of Sex and Exercise on Femoral Artery Function: More Favorable Adaptation in Male Rats.

Vezér, Márton / Jósvai, Attila / Bányai, Bálint / Ács, Nándor / Keszthelyi, Márton / Soltész-Katona, Eszter / Szekeres, Mária / Oláh, Attila / Radovits, Tamás / Merkely, Béla / Horváth, Eszter M / Nádasy, György L / Török, Marianna / Várbíró, Szabolcs

Life (Basel, Switzerland)

2023 Volume 13, Issue 3

Abstract: Blood flow increases in arteries of the skeletal muscles involved in active work. Our aim was to investigate the gender differences as a result of adaptation to sport in the femoral arteries. Vascular reactivity and histology of animals were compared ... ...

Abstract	Blood flow increases in arteries of the skeletal muscles involved in active work. Our aim was to investigate the gender differences as a result of adaptation to sport in the femoral arteries. Vascular reactivity and histology of animals were compared following a 12-week swimming training. Animals were divided into sedentary male (MS), trained male (MTr), sedentary female (FS), and trained female (FTr) groups. Isolated femoral artery rings were examined by wire myography. Contraction induced by phenylephrine (Phe) did not differ between the four groups. The contractile ability in the presence of indomethacin (INDO) was decreased in both sedentary groups. However, we found a specific cyclooxygenase-2 (COX-2) role only in FS rats. After exercise training, we observed increased vasoconstriction in both sexes, when nitro-L-arginine methyl ester (L-NAME) was present. The COX-dependent vasoconstriction effect disappeared in MTr animals, and the COX-2-dependent vasoconstriction effect disappeared in FTr ones. Relaxation was reduced significantly, when L-NAME was present in MTr animals compared to in FTr rats. The training was associated with greater endothelial nitric oxide synthase (eNOS) protein expression in males, but not in females. The present study proves that there are gender differences regarding adaptation mechanisms of musculocutaneous arteries to sports training. In males, relaxation reserve capacity was markedly elevated compared to in females.
Language	English
Publishing date	2023-03-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662250-6
ISSN	2075-1729
ISSN	2075-1729
DOI	10.3390/life13030778
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Optimization of the Heterologous Expression of the Cannabinoid Type-1 (CB

Horváth, Viktória B / Soltész-Katona, Eszter / Wisniewski, Éva / Rajki, Anikó / Halász, Eszter / Enyedi, Balázs / Hunyady, László / Tóth, András Dávid / Szanda, Gergő

Frontiers in endocrinology

2021 Volume 12, Page(s) 740913

Abstract: The G protein-coupled type 1 cannabinoid receptor ( ... ...

Abstract	The G protein-coupled type 1 cannabinoid receptor (CB
MeSH term(s)	Cell Line ; Endoplasmic Reticulum Stress ; Humans ; MAP Kinase Signaling System ; Mitogen-Activated Protein Kinase 3 ; Promoter Regions, Genetic ; Proteasome Endopeptidase Complex ; RNA, Small Interfering/pharmacology ; Receptor, Cannabinoid, CB1/biosynthesis ; Receptor, Cannabinoid, CB1/genetics ; Receptors, G-Protein-Coupled/metabolism ; p38 Mitogen-Activated Protein Kinases/metabolism
Chemical Substances	RNA, Small Interfering ; Receptor, Cannabinoid, CB1 ; Receptors, G-Protein-Coupled ; MAPK3 protein, human (EC 2.7.11.24) ; Mitogen-Activated Protein Kinase 3 (EC 2.7.11.24) ; p38 Mitogen-Activated Protein Kinases (EC 2.7.11.24) ; Proteasome Endopeptidase Complex (EC 3.4.25.1)
Language	English
Publishing date	2021-10-20
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2021.740913
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Biased Coupling to β-Arrestin of Two Common Variants of the CB

Turu, Gábor / Soltész-Katona, Eszter / Tóth, András Dávid / Juhász, Cintia / Cserző, Miklós / Misák, Ádám / Balla, András / Caron, Marc G / Hunyady, László

Frontiers in endocrinology

2021 Volume 12, Page(s) 714561

Abstract: β-arrestins are partners of the G protein-coupled receptors (GPCRs), regulating their intracellular trafficking and signaling. Development of biased GPCR agonists, selectively targeting either G protein or β-arrestin pathways, are in the focus of ... ...

Abstract	β-arrestins are partners of the G protein-coupled receptors (GPCRs), regulating their intracellular trafficking and signaling. Development of biased GPCR agonists, selectively targeting either G protein or β-arrestin pathways, are in the focus of interest due to their therapeutic potential in different pathological conditions. The CB
MeSH term(s)	HEK293 Cells ; Humans ; Mutation, Missense ; Protein Binding ; Protein Transport ; Receptor, Cannabinoid, CB2/chemistry ; Receptor, Cannabinoid, CB2/genetics ; Receptor, Cannabinoid, CB2/metabolism ; beta-Arrestins/genetics ; beta-Arrestins/metabolism
Chemical Substances	Receptor, Cannabinoid, CB2 ; beta-Arrestins
Language	English
Publishing date	2021-08-16
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2021.714561
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Impact of Medium-Sized Extracellular Vesicles on the Transduction Efficiency of Adeno-Associated Viruses in Neuronal and Primary Astrocyte Cell Cultures.

Kovács, Orsolya Tünde / Soltész-Katona, Eszter / Marton, Nikolett / Baricza, Eszter / Hunyady, László / Turu, Gábor / Nagy, György

International journal of molecular sciences

2021 Volume 22, Issue 8

Abstract: 1) Adeno-associated viruses (AAV) are safe and efficient gene therapy vectors with promising results in the treatment of several diseases. Extracellular vesicles (EV) are phospholipid bilayer-surrounded structures carrying several types of lipids, ... ...

Abstract	(1) Adeno-associated viruses (AAV) are safe and efficient gene therapy vectors with promising results in the treatment of several diseases. Extracellular vesicles (EV) are phospholipid bilayer-surrounded structures carrying several types of lipids, proteins, and nucleic acids with the ability to cross biological barriers. EV-associated AAVs might serve as new and efficient gene therapy vectors considering that they carry the benefits of both AAVs and EVs. (2) We tested vesicle-associated AAVs and vesicles mixed with AAVs on two major cell types of the central nervous system: a neural cell line (N2A) and primary astrocyte cells. (3) In contrast to previously published in vivo observations, the extracellular vesicle packaging did not improve but, in the case of primary astrocyte cells, even inhibited the infection capacity of the AAV particles. The observed effect was not due to the inhibitory effects of the vesicles themselves, since mixing the AAVs with extracellular vesicles did not change the effectiveness. (4) Our results suggest that improvement of the in vivo efficacy of the EV-associated AAV particles is not due to the enhanced interaction between the AAV and the target cells, but most likely to the improved delivery of the AAVs through tissue barriers and to the shielding of AAVs from neutralizing antibodies.
MeSH term(s)	Animals ; Astrocytes/metabolism ; Cell Line ; Cells, Cultured ; Dependovirus/metabolism ; Extracellular Vesicles/metabolism ; Genetic Vectors/genetics ; Humans ; Transduction, Genetic/methods
Language	English
Publishing date	2021-04-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms22084221
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: A general method for quantifying ligand binding to unmodified receptors using Gaussia luciferase.

Tóth, András Dávid / Garger, Dániel / Prokop, Susanne / Soltész-Katona, Eszter / Várnai, Péter / Balla, András / Turu, Gábor / Hunyady, László

The Journal of biological chemistry

2021 Volume 296, Page(s) 100366

Abstract: Reliable measurement of ligand binding to cell surface receptors is of outstanding biological and pharmacological importance. Resonance energy transfer-based assays are powerful approaches to achieve this goal, but the currently available methods are ... ...

Abstract	Reliable measurement of ligand binding to cell surface receptors is of outstanding biological and pharmacological importance. Resonance energy transfer-based assays are powerful approaches to achieve this goal, but the currently available methods are hindered by the necessity of receptor tagging, which can potentially alter ligand binding properties. Therefore, we developed a tag-free system to measure ligand‒receptor interactions in live cells using the Gaussia luciferase (GLuc) as a bioluminescence resonance energy transfer donor. GLuc is as small as the commonly applied Nanoluciferase but has enhanced brightness, and its proper substrate is the frequently used coelenterazine. In our assay, bystander bioluminescence resonance energy transfer is detected between a GLuc-based extracellular surface biosensor and fluorescent ligands bound to their unmodified receptors. The broad spectrum of applications includes equilibrium and kinetic ligand binding measurements for both labeled and competitive unlabeled ligands, and the assay can be utilized for different classes of plasma membrane receptors. Furthermore, the assay is suitable for high-throughput screening, as evidenced by the identification of novel α
MeSH term(s)	Biological Assay ; Bioluminescence Resonance Energy Transfer Techniques/methods ; Cell Membrane/metabolism ; Energy Transfer ; HEK293 Cells ; Humans ; Kinetics ; Ligands ; Luciferases/chemistry ; Luciferases/metabolism ; Protein Binding ; Protein Transport ; Receptors, G-Protein-Coupled/metabolism ; Signal Transduction
Chemical Substances	Ligands ; Receptors, G-Protein-Coupled ; Luciferases (EC 1.13.12.-)
Language	English
Publishing date	2021-02-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2997-x
ISSN	1083-351X ; 0021-9258
ISSN (online)	1083-351X
ISSN	0021-9258
DOI	10.1016/j.jbc.2021.100366
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Uc I Zs.108: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: MemBlob database and server for identifying transmembrane regions using cryo-EM maps.

Farkas, Bianka / Csizmadia, Georgina / Katona, Eszter / Tusnády, Gábor E / Hegedűs, Tamás

Bioinformatics (Oxford, England)

2019 Volume 36, Issue 8, Page(s) 2595–2598

Abstract: Summary: The identification of transmembrane helices in transmembrane proteins is crucial, not only to understand their mechanism of action but also to develop new therapies. While experimental data on the boundaries of membrane-embedded regions are ... ...

Abstract	Summary: The identification of transmembrane helices in transmembrane proteins is crucial, not only to understand their mechanism of action but also to develop new therapies. While experimental data on the boundaries of membrane-embedded regions are sparse, this information is present in cryo-electron microscopy (cryo-EM) density maps and it has not been utilized yet for determining membrane regions. We developed a computational pipeline, where the inputs of a cryo-EM map, the corresponding atomistic structure, and the potential bilayer orientation determined by TMDET algorithm of a given protein result in an output defining the residues assigned to the bulk water phase, lipid interface and the lipid hydrophobic core. Based on this method, we built a database involving published cryo-EM protein structures and a server to be able to compute this data for newly obtained structures. Availability and implementation: http://memblob.hegelab.org. Supplementary information: Supplementary data are available at Bioinformatics online.
MeSH term(s)	Algorithms ; Cryoelectron Microscopy ; Membrane Proteins ; Models, Molecular ; Protein Structure, Secondary
Chemical Substances	Membrane Proteins
Language	English
Publishing date	2019-03-01
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1422668-6
ISSN	1367-4811 ; 1367-4803
ISSN (online)	1367-4811
ISSN	1367-4803
DOI	10.1093/bioinformatics/btz539
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 2374: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Cannabinoid receptor type 1 (CB

Szanda, Gergő / Jourdan, Tony / Wisniewski, Éva / Cinar, Resat / Godlewski, Grzegorz / Rajki, Anikó / Liu, Jie / Chedester, Lee / Szalai, Bence / Tóth, András Dávid / Soltész-Katona, Eszter / Hunyady, László / Inoue, Asuka / Horváth, Viktória Bea / Spät, András / Tam, Joseph / Kunos, George

iScience

2023 Volume 26, Issue 7, Page(s) 107207

Abstract: Molecular interactions between anorexigenic leptin and orexigenic endocannabinoids, although of great metabolic significance, are not well understood. We report here that hypothalamic STAT3 signaling in mice, initiated by physiological elevations of ... ...

Abstract	Molecular interactions between anorexigenic leptin and orexigenic endocannabinoids, although of great metabolic significance, are not well understood. We report here that hypothalamic STAT3 signaling in mice, initiated by physiological elevations of leptin, is diminished by agonists of the cannabinoid receptor 1 (CB
Language	English
Publishing date	2023-06-25
Publishing country	United States
Document type	Journal Article
ISSN	2589-0042
ISSN (online)	2589-0042
DOI	10.1016/j.isci.2023.107207
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED