Artikel ; Online: The 103,200-arm acceleration dataset in the UK Biobank revealed a landscape of human sleep phenotypes.
Proceedings of the National Academy of Sciences of the United States of America
2022 Band 119, Heft 12, Seite(n) e2116729119
Abstract: SignificanceHuman sleep phenotypes are diversified by genetic and environmental factors, and a quantitative classification of sleep phenotypes would lead to the advancement of biomedical mechanisms underlying human sleep diversity. To achieve that, a ... ...
Abstract | SignificanceHuman sleep phenotypes are diversified by genetic and environmental factors, and a quantitative classification of sleep phenotypes would lead to the advancement of biomedical mechanisms underlying human sleep diversity. To achieve that, a pipeline of data analysis, including a state-of-the-art sleep/wake classification algorithm, the uniform manifold approximation and projection (UMAP) dimension reduction method, and the density-based spatial clustering of applications with noise (DBSCAN) clustering method, was applied to the 100,000-arm acceleration dataset. This revealed 16 clusters, including seven different insomnia-like phenotypes. This kind of quantitative pipeline of sleep analysis is expected to promote data-based diagnosis of sleep disorders and psychiatric disorders that tend to be complicated by sleep disorders. |
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Mesh-Begriff(e) | Acceleration ; Biological Specimen Banks ; Humans ; Phenotype ; Sleep ; Sleep Wake Disorders ; United Kingdom |
Sprache | Englisch |
Erscheinungsdatum | 2022-03-18 |
Erscheinungsland | United States |
Dokumenttyp | Journal Article |
ZDB-ID | 209104-5 |
ISSN | 1091-6490 ; 0027-8424 |
ISSN (online) | 1091-6490 |
ISSN | 0027-8424 |
DOI | 10.1073/pnas.2116729119 |
Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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