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  1. Article: Barriers to and requirements for a successful transition in inflammatory bowel disease from pediatric to adult care in Greece.

    Giouleme, Olga / Koutsoumourakis, Anastasios / Katsoula, Anastasia / Katsaros, Marios / Soufleris, Konstantinos / Vasilaki, Konstantina / Xinias, Ioannis

    Annals of gastroenterology

    2023  Volume 36, Issue 5, Page(s) 541–548

    Abstract: Background: The incidence of pediatric-onset inflammatory bowel disease (IBD) is rising, while the relapsing and often severe nature of IBD, and its impact on emotional and pubertal development and social maturation underline the need for a successful ... ...

    Abstract Background: The incidence of pediatric-onset inflammatory bowel disease (IBD) is rising, while the relapsing and often severe nature of IBD, and its impact on emotional and pubertal development and social maturation underline the need for a successful transition from pediatric to adult care.
    Methods: A web-based survey was distributed via the Hellenic Group for the Study of IBD, the Hellenic Society of Gastroenterology Department of North Greece, and the Hellenic Society of Pediatric Gastroenterology, Hepatology, and Nutrition.
    Results: The questionnaire was answered by 98 individuals (78 adult and 20 pediatric gastroenterologists, out of 357 and 30, respectively). The response rate was 25.3%. A higher response rate was found among pediatric (66.6%) vs. adult gastroenterologists 21.8% (P<0.001). Pediatric gastroenterologists believed that the appropriate age for transition was either 16-17 or 17-18 years, whereas 59% of the adult gastroenterologists chose the age group of 16-17 years. Both adult and pediatric gastroenterologists stated that the most significant initiators for a successful transition process were cognitive maturity and patients' ability to manage their disease independently. The lack of communication and collaboration between pediatric and adult gastroenterologists was the main barrier to the transition process, as identified by adult gastroenterologists (27.7%). In contrast, 43.5% of pediatric gastroenterologists suggested that differences in the follow up of patients with IBD between pediatric and adult clinics were the main restrictions.
    Conclusion: These results highlight the need for a transitional education program for pediatric IBD patients, and the importance of improving collaboration among adult and pediatric gastroenterologists.
    Language English
    Publishing date 2023-07-03
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 2032850-3
    ISSN 1108-7471
    ISSN 1108-7471
    DOI 10.20524/aog.2023.0817
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2455: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Red cell distribution width as a marker of activity in inflammatory bowel disease: a narrative review.

    Katsaros, Marios / Paschos, Paschalis / Giouleme, Olga

    Annals of gastroenterology

    2020  Volume 33, Issue 4, Page(s) 348–354

    Abstract: Red blood cell distribution width is a parameter measured automatically in every complete blood count that actually reflects the degree of anisocytosis of the red blood cell population. It is a cost-effective tool used in everyday clinical practice along ...

    Abstract Red blood cell distribution width is a parameter measured automatically in every complete blood count that actually reflects the degree of anisocytosis of the red blood cell population. It is a cost-effective tool used in everyday clinical practice along with other parameters to define and narrow the cause of anemia. In a series of pathologic entities, such as cardiovascular diseases, autoimmune diseases, malignancy, chronic renal diseases and chronic respiratory diseases, where inflammation and oxidative stress comprise the major pathophysiologic insults, red cell distribution width behaves as a significant and competent marker able to predict and assess disease activity and severity. A number of clinical studies based on these observations have aimed to evaluate its potential utility as an index of activity in inflammatory bowel disease. In this narrative review we present data from the international literature regarding its ability to express disease activity and we look into its relation with clinical, laboratory and endoscopic indices used to identify active disease. According to the results of published clinical trials, red cell distribution width is considerably correlated with disease activity and might serve as an index to differentiate Crohn's disease from ulcerative colitis.
    Language English
    Publishing date 2020-05-10
    Publishing country Greece
    Document type Journal Article ; Review
    ZDB-ID 2032850-3
    ISSN 1108-7471
    ISSN 1108-7471
    DOI 10.20524/aog.2020.0486
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2455: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Is diabetes a causal agent for colorectal cancer? Pathophysiological and molecular mechanisms.

    Giouleme, Olga / Diamantidis, Michael D / Katsaros, Marios G

    World journal of gastroenterology

    2010  Volume 17, Issue 4, Page(s) 444–448

    Abstract: The possible relationship between diabetes mellitus (DM) and colorectal cancer (CRC), concerning pathophysiological and molecular mechanisms is highlighted in this review. The most recent and complete articles and developments in this particular field ... ...

    Abstract The possible relationship between diabetes mellitus (DM) and colorectal cancer (CRC), concerning pathophysiological and molecular mechanisms is highlighted in this review. The most recent and complete articles and developments in this particular field were thoroughly reviewed. Common risk factors, such as obesity, sedentary lifestyle, and Western diet between DM and CRC, led to the theory that DM might be a causal agent for CRC development. Various studies have connected type 2 DM and CRC, either proximal or distal, in both sexes. Additionally, chronic insulin treatment has been linked with increased colorectal tumor risk among type 2 diabetic patients. Interestingly, elevated hemoglobin A1c has been proven to be an independent predictor of aggressive clinical behavior in CRC patients. These mechanisms include the insulin-like growth factor-hyperinsulinemia theory and the participation of oncogenic intracellular signaling pathways. Furthermore, it has been proposed that Cox-2 inhibitors might have a role in decreasing the incidence of CRC. Finally, the use of statins to reduce the risk for colon cancer in patients with diabetes has remained controversial. Diabetic patients over 50 should receive counseling regarding their elevated risk for CRC, and screening colonoscopy should be recommended before initiating insulin therapy. However, there are no current guidelines, and this strategy is not yet applicable to some countries, as the corresponding risk would not allow screening colonoscopy to be adopted. There is strong evidence to indicate that DM is a causal agent for CRC development. This conclusion provides new impetus for re-evaluating CRC screening worldwide.
    MeSH term(s) Clinical Trials as Topic ; Colorectal Neoplasms/etiology ; Colorectal Neoplasms/pathology ; Colorectal Neoplasms/physiopathology ; Colorectal Neoplasms/prevention & control ; Diabetes Complications/pathology ; Diabetes Complications/physiopathology ; Diabetes Mellitus, Type 2/pathology ; Diabetes Mellitus, Type 2/physiopathology ; Humans ; Insulin/metabolism ; Mass Screening ; Risk Factors ; Somatomedins/metabolism
    Chemical Substances Insulin ; Somatomedins
    Language English
    Publishing date 2010-05-09
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2185929-2
    ISSN 2219-2840 ; 1007-9327
    ISSN (online) 2219-2840
    ISSN 1007-9327
    DOI 10.3748/wjg.v17.i4.444
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6039: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Effect of golimumab on health-related quality of life, other patient-reported outcomes and healthcare resource utilization in patients with moderate-to-severe ulcerative colitis: a real-world multicenter, noninterventional, observational study in Greece.

    Gatopoulou, Anthia / Christodoulou, Dimitrios K / Katsanos, Konstantinos H / Bakos, Dimitrios / Mouzas, Ioannis / Tzouvala, Maria / Theodoropoulou, Angeliki / Paspatis, Gregorios / Theocharis, George / Thomopoulos, Konstantinos / Giouleme, Olga / Kourikou, Anastasia / Manolakopoulos, Spilios / Zampeli, Evanthia / Michopoulos, Spyros / Karatzas, Pantelis / Katsaros, Marios / Moschovis, Dimitris / Orfanoudaki, Eleni /
    Livieratos, Achilleas / Petrikkou, Evangelia / Mantzaris, Gerassimos J

    European journal of gastroenterology & hepatology

    2021  Volume 33, Issue 1S Suppl 1, Page(s) e615–e624

    Abstract: Background and aims: This real-world study assessed the impact of golimumab on health-related quality of life (HRQoL) and other patient-reported outcomes (PROs) in patients with ulcerative colitis over 12 months in Greece.: Methods: GO-LIFE was a ... ...

    Abstract Background and aims: This real-world study assessed the impact of golimumab on health-related quality of life (HRQoL) and other patient-reported outcomes (PROs) in patients with ulcerative colitis over 12 months in Greece.
    Methods: GO-LIFE was a noninterventional, prospective, multicenter, 12-month study. Patients who had moderately-to-severely active ulcerative colitis were naïve to antitumor necrosis factor (anti-TNFα) therapy and had failed previous conventional therapy. Patients received golimumab as per label. The primary endpoint was patients achieving inflammatory bowel disease questionnaire 32-item (IBDQ-32) remission at 12 months. Secondary endpoints, at 6 and 12 months, included patients achieving IBDQ-32 response; the mean change in the treatment satisfaction questionnaire for medication (TSQM) and the work productivity and activity impairment in ulcerative colitis (WPAI:UC) questionnaires; changes in healthcare utilization; patients achieving clinical response and remission; adherence rates and the percentage of patients who discontinued golimumab.
    Results: IBDQ-32 remission was achieved by 76.9% of patients at 12 months. Mean changes in all TSQM and WPAI:UC domain scores at 12 months were statistically significant. Clinical remission was achieved by 49.4 and 50.6% of patients at 6 and 12 months, and clinical response by 59.3 and 56.8%, respectively. All patients but one (80/81) had high adherence (≥80%) to golimumab treatment over 12 months. Ulcerative colitis-related health care resource utilization was reduced during the follow-up period.
    Conclusions: In real-world settings, treatment with golimumab resulted in meaningful improvements in HRQoL and other PROs, and in disease activity at 6 and 12 months in patients with moderately-to-severely active ulcerative colitis who were naïve to anti-TNFa therapy.
    MeSH term(s) Antibodies, Monoclonal ; Colitis, Ulcerative/complications ; Colitis, Ulcerative/diagnosis ; Colitis, Ulcerative/drug therapy ; Greece ; Humans ; Patient Acceptance of Health Care ; Patient Reported Outcome Measures ; Prospective Studies ; Quality of Life ; Severity of Illness Index
    Chemical Substances Antibodies, Monoclonal ; golimumab (91X1KLU43E)
    Language English
    Publishing date 2021-05-23
    Publishing country England
    Document type Journal Article ; Multicenter Study ; Observational Study
    ZDB-ID 1034239-4
    ISSN 1473-5687 ; 0954-691X
    ISSN (online) 1473-5687
    ISSN 0954-691X
    DOI 10.1097/MEG.0000000000002182
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2932: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: 4,4'-Methylenedianiline-induced hepatitis in an industrial worker: case report and review of the literature.

    Giouleme, Olga / Karabatsou, Sofia / Hytiroglou, Prodromos / Xanthis, Andreas / Tsiaousi, Eleni / Katsaros, Marios / Koliouskas, Dimitrios

    Human & experimental toxicology

    2011  Volume 30, Issue 7, Page(s) 762–767

    Abstract: 4,4'-Methylenedianiline (MDA) is a chemical used in manufacturing and insulation processes and is a well-known hepatotoxin. We report the case of a 42-year-old construction-site worker who was accidentally exposed to large amounts of MDA and developed ... ...

    Abstract 4,4'-Methylenedianiline (MDA) is a chemical used in manufacturing and insulation processes and is a well-known hepatotoxin. We report the case of a 42-year-old construction-site worker who was accidentally exposed to large amounts of MDA and developed acute liver damage. The clinical course is described, with particular emphasis on the timely identification of the underlying cause and prompt management that led to an uneventful recovery. We review the relevant literature and discuss the safety measures necessary to minimize similar occupational hazards in industrial workers.
    MeSH term(s) Acute Disease ; Adult ; Allergens/toxicity ; Aniline Compounds/toxicity ; Chemical and Drug Induced Liver Injury/drug therapy ; Chemical and Drug Induced Liver Injury/etiology ; Chemical and Drug Induced Liver Injury/pathology ; Humans ; Liver/drug effects ; Liver/pathology ; Liver Function Tests ; Male ; Methylprednisolone/therapeutic use ; Occupational Diseases/drug therapy ; Occupational Diseases/etiology ; Occupational Diseases/pathology ; Treatment Outcome
    Chemical Substances Allergens ; Aniline Compounds ; 4,4'-diaminodiphenylmethane (GG5LL7OBZC) ; Methylprednisolone (X4W7ZR7023)
    Language English
    Publishing date 2011-07
    Publishing country England
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 1027454-6
    ISSN 1477-0903 ; 0144-5952 ; 0960-3271
    ISSN (online) 1477-0903
    ISSN 0144-5952 ; 0960-3271
    DOI 10.1177/0960327110376549
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1697: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Intestinal tuberculosis: a diagnostic challenge--case report and review of the literature.

    Giouleme, Olga / Paschos, Paschalis / Katsaros, Marios / Papalexi, Fani / Karabatsou, Sofia / Masmanidou, Maria / Koliouskas, Dimitrios

    European journal of gastroenterology & hepatology

    2011  Volume 23, Issue 11, Page(s) 1074–1077

    Abstract: Even though tuberculosis is considered rare in developed countries, its rising incidence, especially in high-risk populations, places intestinal tuberculosis in the differential diagnosis of patients with atypical abdominal symptoms or signs. We, herein, ...

    Abstract Even though tuberculosis is considered rare in developed countries, its rising incidence, especially in high-risk populations, places intestinal tuberculosis in the differential diagnosis of patients with atypical abdominal symptoms or signs. We, herein, report the case of an immunocompetent woman, from a nonendemic area, who developed intestinal tuberculosis, emphasizing the diagnostic challenges caused due to nonspecific symptoms, inconclusive clinical, laboratory, and imaging findings, which could not rule in or rule out tuberculosis. Antituberculosis treatment was administered based on endoscopic findings and histological features of mucosal biopsies, which were indicative of intestinal tuberculosis, and the patient showed a marked clinical and laboratory improvement. We also review the evidence with regard to the diagnostic accuracy of the different available tests for intestinal tuberculosis.
    MeSH term(s) Adult ; Antitubercular Agents/therapeutic use ; Biopsy ; Colon/pathology ; Colonoscopy ; Diagnosis, Differential ; Female ; Follow-Up Studies ; Gastric Mucosa/pathology ; Humans ; Immunocompetence ; Intestinal Mucosa/pathology ; Tuberculosis, Gastrointestinal/diagnosis ; Tuberculosis, Gastrointestinal/drug therapy ; Tuberculosis, Gastrointestinal/immunology ; Tuberculosis, Gastrointestinal/pathology
    Chemical Substances Antitubercular Agents
    Language English
    Publishing date 2011-11
    Publishing country England
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 1034239-4
    ISSN 1473-5687 ; 0954-691X
    ISSN (online) 1473-5687
    ISSN 0954-691X
    DOI 10.1097/MEG.0b013e32834a9470
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2932: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

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