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  1. Article: [Increasing resistance against hazardous effects of metals-containing nanoparticles as a prospective approach to health risks management].

    Privalova, L I / Katsnel'son, B A / Sutunkova, M P / Minigalieva, I A / Gurvich, V B / Shur, V Ya / Makeyev, O G / Valamina, I E

    Meditsina truda i promyshlennaia ekologiia

    2018  , Issue 10, Page(s) 29–33

    Abstract: Extremely high toxicity of metal-containing nanoparticles necessitates search of methods to increase body resistance against its harmful effects. The authors' experiments summarized in the article demonstrated that some combinations of certain ... ...

    Abstract Extremely high toxicity of metal-containing nanoparticles necessitates search of methods to increase body resistance against its harmful effects. The authors' experiments summarized in the article demonstrated that some combinations of certain biologically active substances selected according to sound theoretic background and prescribed in harmless doses can significantly decrease integral and specific manifestations of organ and system toxicity and even genotoxicity of such nanoparticles. Further development of this research direction should be recommended for practical implementation.
    MeSH term(s) Animals ; Hazardous Substances/toxicity ; Metal Nanoparticles/toxicity ; Mutagens/toxicity ; Oxides ; Particle Size ; Protective Agents/pharmacology ; Rats ; Risk ; Risk Management/methods
    Chemical Substances Hazardous Substances ; Mutagens ; Oxides ; Protective Agents
    Language Russian
    Publishing date 2018-12-12
    Publishing country Russia (Federation)
    Document type Journal Article ; Review
    ZDB-ID 1169087-2
    ISSN 1026-9428 ; 1727-5903 ; 0016-9919
    ISSN 1026-9428 ; 1727-5903 ; 0016-9919
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: [The concept of acceptable risk is the key debatable issue of the assessment and management of a risk to the population's health].

    Katsnel'son, B A / Kuz'min, S V / Gurvich, V B

    Gigiena i sanitariia

    2007  , Issue 3, Page(s) 76–80

    Abstract: The authors hold that an open discussion on the principles of and approaches to establishing the national standards of acceptable health risks should precede the official introduction of these standards into practice in taking decisions on risk ... ...

    Abstract The authors hold that an open discussion on the principles of and approaches to establishing the national standards of acceptable health risks should precede the official introduction of these standards into practice in taking decisions on risk management. They criticize the sociostatistical and socioeconomic concepts of risk acceptability as both amoral and impracticable and propose an approach based on the use of the Russian standards of permissible exposure levels (maximum permissible concentrations in particular) and on the exposure-response relationships established by epidemiological studies for the computation of responses (i.e. risk levels) corresponding to the permissible exposures. In some cases that such standards of an acceptable risk are too strict in existing technological or economic practice may be introduced in a stepwise fashion, but the risks that exceed the acceptable level should be compensated for.
    MeSH term(s) Health Promotion ; Health Status Indicators ; Humans ; Risk Assessment ; Risk Management ; Russia
    Language Russian
    Publishing date 2007-05
    Publishing country Russia (Federation)
    Document type English Abstract ; Journal Article
    ZDB-ID 410437-7
    ISSN 0016-9900
    ISSN 0016-9900
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  3. Article: [Organization of fractional monitoring of ambient air pollution by suspended matter in Russia].

    Voronin, S A / Katsnel'son, B A / Selezneva, E A

    Gigiena i sanitariia

    2007  , Issue 3, Page(s) 60–63

    Abstract: The authors consider the organization of a system for monitoring of ambient air pollution by suspended matter (by fractions of less than 10 microm and less than 2.5 microm) as one of the most urgent tasks in the harmonization of the Russian and western ... ...

    Abstract The authors consider the organization of a system for monitoring of ambient air pollution by suspended matter (by fractions of less than 10 microm and less than 2.5 microm) as one of the most urgent tasks in the harmonization of the Russian and western methods for assessing the quality of the environment. The frame plan for organization of ambient air suspended matter monitoring in the countries of Eastern Europe, Caucasia, and Central Asia, proposed by the WHO European Regional Office provides basic guidelines for this system and may be adapted to Russian conditions, as evidenced by the author's experience. The paper summarizes the basic results of the studies that have established the association of respiratory disease in junior schoolchildren with exposure to PM10 and PM2.5.
    MeSH term(s) Air Pollutants/adverse effects ; Catchment Area (Health) ; Child ; Dust ; Environmental Exposure/adverse effects ; Environmental Illness/epidemiology ; Environmental Illness/etiology ; Environmental Illness/prevention & control ; Environmental Monitoring/methods ; Epidemiological Monitoring ; Humans ; Russia/epidemiology ; Students
    Chemical Substances Air Pollutants ; Dust
    Language Russian
    Publishing date 2007-05
    Publishing country Russia (Federation)
    Document type English Abstract ; Journal Article
    ZDB-ID 410437-7
    ISSN 0016-9900
    ISSN 0016-9900
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Teoreticheskie aspekty problemy professional'nogo raka.

    Katsnel'son, B A

    Voprosy onkologii

    1991  Volume 37, Issue 11-12, Page(s) 1118–1126

    Title translation The theoretical aspects of the problem of occupational cancer.
    MeSH term(s) Animals ; Carcinogens/toxicity ; Disease Models, Animal ; Disease Susceptibility ; Humans ; Mutagens/toxicity ; Neoplasms/epidemiology ; Neoplasms/etiology ; Neoplasms, Experimental/etiology ; Occupational Diseases/epidemiology ; Occupational Diseases/etiology ; Occupational Exposure/adverse effects ; Prognosis
    Chemical Substances Carcinogens ; Mutagens
    Language Russian
    Publishing date 1991
    Publishing country Russia (Federation)
    Document type Journal Article
    ZDB-ID 955397-6
    ISSN 0507-3758
    ISSN 0507-3758
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  5. Article: [Comparative experimental assessment of the impact of gold and silver nanoparticles on the phagocyting cells of the lower airways].

    Privalova, L I / Sutunkova, M P / Pichugova, S V / Katsnel'son, B A / Tulakina, L G / Beĭkin, Ia B / Shur, V Ia

    Meditsina truda i promyshlennaia ekologiia

    2012  , Issue 11, Page(s) 42–46

    Abstract: Judging by the cytological characteristics of the free cell population of the lower airways obtained with assistance of the bronchoalveolar lavage in 24 hours after the intratracheal instillation of equal doses of equidimensional gold or silver ... ...

    Abstract Judging by the cytological characteristics of the free cell population of the lower airways obtained with assistance of the bronchoalveolar lavage in 24 hours after the intratracheal instillation of equal doses of equidimensional gold or silver nanoparticles, both metals result in active recruitment of phagocytes with domination of neutrophile leukocytes, especially marked after the instillation of the nanosilver. The higher ratio of these cells count to that of alveolar macrophages gives evidence for the significantly higher cytotoxicity of the nanosilver comparing with both nanogold and even the smallest silver particles in the micrometric range. Transmission electron microscopy demonstrates similar pictures of intracellular distribution and ultra-structural damages caused by internalized nanoparticles in both types of phagocytes, while there are significant differences between cells under impact of nanosilver vs. those under impact of nanogold. The highest importance is higher propensity of the nanosilver particles to aggregation and to ingression into mitochondria with damaging these organelles.
    MeSH term(s) Animals ; Bronchoalveolar Lavage Fluid/cytology ; Cell Count/methods ; Cytotoxins/toxicity ; Female ; Gold/administration & dosage ; Gold/toxicity ; Instillation, Drug ; Macrophage Activation/drug effects ; Macrophages, Alveolar/drug effects ; Macrophages, Alveolar/physiology ; Macrophages, Alveolar/ultrastructure ; Metal Nanoparticles/administration & dosage ; Metal Nanoparticles/toxicity ; Microscopy, Electron, Transmission ; Particle Size ; Phagocytosis/drug effects ; Rats ; Silver/administration & dosage ; Silver/toxicity ; Time Factors
    Chemical Substances Cytotoxins ; Silver (3M4G523W1G) ; Gold (7440-57-5)
    Language Russian
    Publishing date 2012
    Publishing country Russia (Federation)
    Document type Comparative Study ; English Abstract ; Journal Article
    ZDB-ID 1169087-2
    ISSN 1026-9428 ; 1727-5903 ; 0016-9919
    ISSN 1026-9428 ; 1727-5903 ; 0016-9919
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  6. Article: [Apropos of V. V. Vorobyev's paper "Effect of food additives on the quality of seafoods"].

    Katsnel'son, B A / Kuz'min, S V / Privalova, L I / Degtiareva, T D

    Gigiena i sanitariia

    2008  , Issue 5, Page(s) 96, 1 p following 96

    MeSH term(s) Food Additives/pharmacology ; Food Industry/standards ; Humans ; Periodicals as Topic ; Russia ; Seafood/standards
    Chemical Substances Food Additives
    Language Russian
    Publishing date 2008-09
    Publishing country Russia (Federation)
    Document type Journal Article ; Review
    ZDB-ID 410437-7
    ISSN 0016-9900
    ISSN 0016-9900
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  7. Article: Gigienicheskaia reglamentatsiia soderzhaniia svarochnykh aérozoleĭ v vozdukhe rabocheĭ zone i pnevmokonioz élektrosvarshchikov (obzor literatury).

    Katsnel'son, B A / Novoselova, T A / Zhovtiak, E P

    Meditsina truda i promyshlennaia ekologiia

    2001  , Issue 4, Page(s) 24–27

    Abstract: The authors represent review of literature on fibrogenic effects of welding aerosols and results of own clinical and epidemiologic studies concerning pneumoconiosis course in electric welders compared to other occupational groups. In conclusion, the ... ...

    Title translation Hygienic regulation of welding aerosols in air of workplace and pneumoconiosis in welders (review of literature).
    Abstract The authors represent review of literature on fibrogenic effects of welding aerosols and results of own clinical and epidemiologic studies concerning pneumoconiosis course in electric welders compared to other occupational groups. In conclusion, the authors necessitate more strict control over total concentration of welding aerosol solid component (WASC) in air of workplace and determination of MAC for WASC.
    MeSH term(s) Aerosols ; Air Pollutants, Occupational/adverse effects ; Facility Regulation and Control ; Humans ; Occupational Health ; Pneumoconiosis/diagnosis ; Pneumoconiosis/etiology ; Welding ; Workplace
    Chemical Substances Aerosols ; Air Pollutants, Occupational
    Language Russian
    Publishing date 2001
    Publishing country Russia (Federation)
    Document type English Abstract ; Journal Article ; Review
    ZDB-ID 1169087-2
    ISSN 1026-9428 ; 1727-5903 ; 0016-9919
    ISSN 1026-9428 ; 1727-5903 ; 0016-9919
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  8. Article: Rol' ékologo-épidemiologicheskikh issledovaniĭ atmosfernykh zagriazneniĭ v otsenke riska "ostroĭ" smertnosti.

    Katsnel'son, B A / Kosheleva, A A / Kuz'min, S V / Privalova, L I

    Vestnik Rossiiskoi akademii meditsinskikh nauk

    2002  , Issue 9, Page(s) 23–28

    Abstract: The paper provides evidence that there is a relationship of daily death rates to variations in the concentrations of total dust and some gaseous ambient pollutants. The great advantage of a procedure to analyze temporary variables is that it makes it ... ...

    Title translation The role of environmental and epidemiological surveys of ambient pollution in the evaluation of a risk for "acute" mortality.
    Abstract The paper provides evidence that there is a relationship of daily death rates to variations in the concentrations of total dust and some gaseous ambient pollutants. The great advantage of a procedure to analyze temporary variables is that it makes it possible to retrospectively use the available materials of routine monitoring of air pollution and to consider these effects (cases of death in particular). Along with the high informative value of environmental and epidemiological surveys (EES) based on the analysis of time series, this advantage allows one to recommend them for widely use within the sociohygienic monitoring system. At the same time the paper shows it necessary to control the quality of available data and to chose monitoring centers comparable in this regard. Inevitable missing data on the concentrations of different pollutants on days off and on some working days are of particular value under the actual conditions of monitoring of air pollution. The approach applied in this study to the choice of the most effective ways of filling of such gaps may be recommended. Nevertheless, incomplete data and the need for their artificial reproduction should be regarded as a source of uncertainty of specific results of EES of this type. Increments in mortality rates for a certain increase in the concentrations of pollutants may be used in the risk assessment projects when a dose-response relationship is analyzed. The larger number of EES based on the analysis of time series will be conducted in the regions of Russia, the more reliable the use of EES-grounded single risks will be at the regional and federal level.
    MeSH term(s) Air Pollutants ; Environmental Monitoring ; Humans ; Mortality ; Surveys and Questionnaires
    Chemical Substances Air Pollutants
    Language Russian
    Publishing date 2002
    Publishing country Russia (Federation)
    Document type English Abstract ; Journal Article
    ZDB-ID 1112761-2
    ISSN 0869-6047 ; 0002-3027
    ISSN 0869-6047 ; 0002-3027
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  9. Article: Dioksiny: fakty i domysly.

    Katsnel'son, B A / Koseleva, A A / Kuz'min, S V / Privalova, L I

    Vestnik Rossiiskoi akademii meditsinskikh nauk

    2002  , Issue 9, Page(s) 29–34

    Abstract: Dioxins and dioxin-like substances are highly toxic and extremely dangerous chemical compounds. Dioxins are formed during the thermal process associated with the use of chlorine. 2,3,7,8-tetrachlorodibenzo-1,4-dioxin is the most toxic, the most typical ... ...

    Title translation Dioxins: facts and conjectures.
    Abstract Dioxins and dioxin-like substances are highly toxic and extremely dangerous chemical compounds. Dioxins are formed during the thermal process associated with the use of chlorine. 2,3,7,8-tetrachlorodibenzo-1,4-dioxin is the most toxic, the most typical and well-studied agent. The most characteristic and constant indicators of intoxication with dioxin-containing substances are altered body weight, chloracne, hepatic damage, thyroid involution, structural changes in the adrenal cortex, spleen, genitals, immunodeficiency. There is evidence for a role of these agents in the development of infertility and neonatal pathology.
    MeSH term(s) Chemical Industry ; Dioxins/adverse effects ; Environmental Pollution ; Hazardous Substances/adverse effects ; Humans ; Reference Values ; Russia
    Chemical Substances Dioxins ; Hazardous Substances
    Language Russian
    Publishing date 2002
    Publishing country Russia (Federation)
    Document type English Abstract ; Journal Article
    ZDB-ID 1112761-2
    ISSN 0869-6047 ; 0002-3027
    ISSN 0869-6047 ; 0002-3027
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  10. Article: Samoocheshchenie legkikh ot malorastvorimykh phleĭ (obzor literatury)

    Katsnel'son, B A

    Gigiena truda i professional'nye zabolevaniia

    1974  , Issue 11, Page(s) 1–6

    Title translation Self-purification of the lungs from weakly soluble dust (review of the literature).
    MeSH term(s) Aerosols/adverse effects ; Animals ; Bronchi/physiology ; Cilia/physiology ; Cricetinae ; Dogs ; Dust ; Humans ; Lung/physiology ; Lung/physiopathology ; Mice ; Particle Size ; Phagocytosis ; Pneumoconiosis/physiopathology ; Pulmonary Alveoli/physiology ; Rabbits ; Rats ; Trachea/physiology
    Chemical Substances Aerosols ; Dust
    Language Russian
    Publishing date 1974
    Publishing country Russia (Federation)
    Document type Journal Article ; Review
    ZDB-ID 390993-1
    ISSN 0016-9919
    ISSN 0016-9919
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