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  1. Article ; Online: Involvement of folate and vitamin B12 deficiency in patients with normocytic anemia.

    Bando, Tatsuya / Tokuda, Masutaka / Katsuda, Itsuro / Emi, Nobuhiko / Tomita, Akihiro

    Fujita medical journal

    2022  Volume 9, Issue 2, Page(s) 134–141

    Abstract: Objectives: Deficiencies in folate (FA) and vitamin B12 (VB12) are causes of macrocytic anemia. However, in clinical practice, FA and/or VB12 deficiency can occur in patients with normocytic anemia. This study aimed to determine the prevalence of FA/ ... ...

    Abstract Objectives: Deficiencies in folate (FA) and vitamin B12 (VB12) are causes of macrocytic anemia. However, in clinical practice, FA and/or VB12 deficiency can occur in patients with normocytic anemia. This study aimed to determine the prevalence of FA/VB12 deficiency in patients with normocytic anemia and the importance of vitamin replacement therapy in these patients.
    Methods: We retrospectively reviewed electronic medical record information of patients whose hemoglobin and serum FA/VB12 concentrations were measured at the Department of Hematology (N=1,388) and other departments (N=1,421) of Fujita Health University Hospital.
    Results: In the Hematology Department, 530 (38%) patients showed normocytic anemia. Of these, 49 (9.2%) had FA/VB12 deficiency. Twenty of 49 (41%) patients had some hematological malignancies and 27 (55%) had benign hematological disorders. Of the nine patients who received vitamin replacement therapy, one showed a partial improvement in the hemoglobin concentration of ≥1 g/dL.
    Conclusions: In the clinical setting, the measurement of FA/VB12 concentrations in patients with normocytic anemia may be useful. Replacement therapy may be a treatment option to consider in patients with low FA/VB12 concentrations. However, physicians need to pay attention to the presence of background diseases, and the mechanisms of this situation require further investigation.
    Language English
    Publishing date 2022-10-28
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 3011241-2
    ISSN 2189-7255 ; 2189-7247
    ISSN (online) 2189-7255
    ISSN 2189-7247
    DOI 10.20407/fmj.2022-016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book: Rinshō byōtaigaku

    Katsuda, Itsurō

    igaku gairon, rinshō igaku nyūmon, rinshō byōrigaku sōron, rinshō zenka shikkan kakuron

    2011  

    Author's details kanshū Satō Yoshinobu ; henshū Katsuda Itsurō, Matsumoto Sadayuki
    MeSH term(s) Pathology
    Language Japanese
    Size xii, 408 pages :, illustrations
    Edition Kaitei dai 4-han.
    Document type Book
    ISBN 9784524262274 ; 452426227X
    Database Catalogue of the US National Library of Medicine (NLM)

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  3. Article: Congenital Hypofibrinogenemia in a Neonate with a Novel Mutation in the

    Shinozuka, Jun / Okumura, Nobuo / Nagasawa, Mayumi / Nishikado, Motokazu / Kadowaki, Sayaka / Katsuda, Itsuro / Imashuku, Shinsaku

    Pediatric reports

    2021  Volume 13, Issue 1, Page(s) 113–117

    Abstract: Detection of severe hypofibrinogenemia (<50 mg/dL) in a neonate soon after birth is alarming because of the risk of hemorrhage. A female neonate was noted to be hypofibrinogenemic (<50 mg/dL) on day 0 of birth; she showed no thrombocytopenia/coagulopathy ...

    Abstract Detection of severe hypofibrinogenemia (<50 mg/dL) in a neonate soon after birth is alarming because of the risk of hemorrhage. A female neonate was noted to be hypofibrinogenemic (<50 mg/dL) on day 0 of birth; she showed no thrombocytopenia/coagulopathy or hemorrhagic symptoms. Considering the possibility of afibrinogenemia, which may cause bleeding, fresh frozen plasma (FFP) was initiated twice a week to maintain her plasma fibrinogen level at 50-100 mg/dL. Thereafter, we found hypofibrinogenemia in her father and elder sister and plasma fibrinogen levels, determined by clot formation and immunological methods, showed similarly reduced values in both the neonate (proband) and her father. Based on a presumed diagnosis of congenital hypofibrinogenemia, sequencing of the fibrinogen genes was performed, revealing a novel heterozygous mutation of
    Language English
    Publishing date 2021-03-01
    Publishing country Switzerland
    Document type Case Reports
    ISSN 2036-749X
    ISSN 2036-749X
    DOI 10.3390/pediatric13010016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book: Bijuaru rinshō ketsueki keitaigaku

    Katsuda, Itsurō

    Visual textbook of blood cells hematology

    2004  

    Title variant Visual textbook of blood cells hematology
    Author's details kanshū Hirano Masami ; kyōcho Katsuda Itsurō ... [et al.]
    MeSH term(s) Hematologic Diseases/pathology ; Blood Cells/pathology ; Hematology/methods
    Language Japanese
    Size xiii, 386 p. :, ill.
    Edition Kaitei dai 2-han.
    Publisher Nankōdō
    Publishing place Tōkyō
    Document type Book
    Note Text in Japanese.
    ISBN 9784524236848 ; 4524236848
    Database Catalogue of the US National Library of Medicine (NLM)

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  5. Book: Bijuaru rinshō ketsueki keitaigaku

    Katsuda, Itsurō

    1999  

    Title variant Visual textbook of blood cells hematology
    Author's details kanshū Hirano Masami ; kyōcho Katsuda Itsurō ... [et al.]
    MeSH term(s) Hematologic Diseases/pathology ; Hematology/methods
    Language Japanese
    Size xii, 323 p. :, ill.
    Publisher Nankōdō
    Publishing place Tōkyō
    Document type Book
    ISBN 9784524217915 ; 4524217916
    Database Catalogue of the US National Library of Medicine (NLM)

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  6. Article ; Online: Andrographolide, isolated from

    Doi, Hiroki / Matsui, Taei / Dijkstra, Johannes M / Ogasawara, Atsushi / Higashimoto, Yuki / Imamura, Seiji / Ohye, Tamae / Takematsu, Hiromu / Katsuda, Itsuro / Akiyama, Hidehiko

    F1000Research

    2021  Volume 10, Page(s) 542

    Abstract: ... ...

    Abstract Background
    MeSH term(s) Andrographis paniculata ; Apoptosis ; Cell Line, Tumor ; Cytarabine/pharmacology ; Diterpenes/pharmacology ; Hematologic Neoplasms ; Humans ; Leukemia ; Multiple Myeloma/drug therapy ; Reactive Oxygen Species/metabolism
    Chemical Substances Diterpenes ; Reactive Oxygen Species ; Cytarabine (04079A1RDZ) ; andrographolide (410105JHGR)
    Language English
    Publishing date 2021-07-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 2699932-8
    ISSN 2046-1402 ; 2046-1402
    ISSN (online) 2046-1402
    ISSN 2046-1402
    DOI 10.12688/f1000research.53595.3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: A new type of plasma prekallikrein deficiency associated with homozygosity for Gly104Arg and Asn124Ser in apple domain 2 of the heavy-chain region.

    Katsuda, Itsuro / Maruyama, Fumio / Ezaki, Kohji / Sawamura, Toru / Ichihara, Yoshikazu

    European journal of haematology

    2007  Volume 79, Issue 1, Page(s) 59–68

    Abstract: Three Japanese patients demonstrated plasma prekallikrein (PK) deficiency (PKD) after an examination of the proband family line named 'PKD Seki'. A molecular genetic analysis of these PK genes showed homozygous amino acid substitutions Gly104Arg and ... ...

    Abstract Three Japanese patients demonstrated plasma prekallikrein (PK) deficiency (PKD) after an examination of the proband family line named 'PKD Seki'. A molecular genetic analysis of these PK genes showed homozygous amino acid substitutions Gly104Arg and Asn124Ser in exon 5, which encodes part of the apple domain 2 (A2) of the heavy chain. This is the first case involving substitutions in the heavy chain of the PK gene which affected blood coagulation. Because the apple domains of PK bind to the C-terminal domain (D6(H)) of high-molecular weight kininogen (HMWK), the two substitutions in A2 may therefore be the main cause of PKD Seki. We subsequently investigated the effects of amino acid substitutions in A2 to elucidate the binding activity of PK to HMWK using mutant A2 proteins produced in Escherichia coli. We clearly demonstrated that the Gly104Arg-substitution with the Asn124Ser-substitution in A2 reduce the binding activity of A2 to HMWK. PKD Seki is the first significant case to show the amino acid substitutions in the A2 affecting the binding capacity of PK with HMWK. Our findings therefore suggest that the binding of PK to HMWK may play a crucial role in the first step of blood coagulation.
    MeSH term(s) Amino Acid Substitution ; Arginine/genetics ; Asparagine/genetics ; Base Sequence ; Blotting, Western ; DNA Primers ; Female ; Glycine/genetics ; Homozygote ; Humans ; Male ; Pedigree ; Polymerase Chain Reaction ; Prekallikrein/chemistry ; Prekallikrein/genetics ; Prekallikrein/metabolism ; Serine/genetics
    Chemical Substances DNA Primers ; Serine (452VLY9402) ; Asparagine (7006-34-0) ; Prekallikrein (9055-02-1) ; Arginine (94ZLA3W45F) ; Glycine (TE7660XO1C)
    Language English
    Publishing date 2007-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 392482-8
    ISSN 1600-0609 ; 0902-4441
    ISSN (online) 1600-0609
    ISSN 0902-4441
    DOI 10.1111/j.1600-0609.2007.00871.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 323: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  8. Article ; Online: Factor VII deficiency: a double heterozygote of an Arg402Stop with a deletion of the C-terminal five amino acids and a Thr359Met.

    Okamoto, Masataka / Katsuda, Itsuro / Ohshika, Yasuna / Maruyama, Fumio / Ezaki, Kohji / Emi, Nobuhiko / Ichihara, Yoshikazu

    European journal of haematology

    2009  Volume 82, Issue 5, Page(s) 405–407

    MeSH term(s) Adult ; Codon, Nonsense ; Factor VII Deficiency/genetics ; Female ; Heterozygote ; Humans ; Mutation ; Mutation, Missense ; Sequence Deletion
    Chemical Substances Codon, Nonsense
    Language English
    Publishing date 2009-05
    Publishing country England
    Document type Case Reports ; Letter
    ZDB-ID 392482-8
    ISSN 1600-0609 ; 0902-4441
    ISSN (online) 1600-0609
    ISSN 0902-4441
    DOI 10.1111/j.1600-0609.2009.01219.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 323: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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