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  1. Article ; Online: Tuberculosis osteomyelitis in an old fused hip; activated by prednisolone, salazosulfapyridine, and low-dose methotrexate therapy in a patient with rheumatoid arthritis.

    Okada, Fumi / Fukushi, Jun-Ichi / Matsubara, Hirokazu / Ishitani, Ei-Ichi / Sonoda, Yasuo / Katsuki, Ichiro

    Modern rheumatology case reports

    2020  Volume 4, Issue 2, Page(s) 171–175

    Abstract: Osteoarticular tuberculosis can occur in patients with rheumatoid arthritis (RA) receiving immunosuppressive therapy. Here, we describe a case of tubercular osteomyelitis in an old fused hip of a patient with RA who received prednisolone, ... ...

    Abstract Osteoarticular tuberculosis can occur in patients with rheumatoid arthritis (RA) receiving immunosuppressive therapy. Here, we describe a case of tubercular osteomyelitis in an old fused hip of a patient with RA who received prednisolone, salazosulfapyridine (SASP), and low-dose methotrexate (MTX). A 77-year-old man with a 4-year history of RA was admitted with a complaint of general fatigue. His symptoms of RA had been well controlled with a combination of prednisolone, SASP, and low-dose MTX. Because the laboratory data showed an increase in serum C-reactive protein levels, we suspected pneumonia. There was expansion of a pre-existing consolidation in the right lower lobe of his lung on chest computed tomography, and the sputum culture was positive for
    MeSH term(s) Aged ; Antirheumatic Agents/administration & dosage ; Antirheumatic Agents/adverse effects ; Antirheumatic Agents/therapeutic use ; Antitubercular Agents/therapeutic use ; Arthritis, Rheumatoid/complications ; Arthritis, Rheumatoid/drug therapy ; Drug Therapy, Combination ; Humans ; Immunosuppressive Agents/administration & dosage ; Immunosuppressive Agents/adverse effects ; Immunosuppressive Agents/therapeutic use ; Male ; Methotrexate/administration & dosage ; Osteomyelitis/diagnosis ; Osteomyelitis/drug therapy ; Osteomyelitis/etiology ; Prednisolone/administration & dosage ; Sulfasalazine/administration & dosage ; Treatment Outcome ; Tuberculosis, Osteoarticular/diagnosis ; Tuberculosis, Osteoarticular/drug therapy ; Tuberculosis, Osteoarticular/etiology
    Chemical Substances Antirheumatic Agents ; Antitubercular Agents ; Immunosuppressive Agents ; Sulfasalazine (3XC8GUZ6CB) ; Prednisolone (9PHQ9Y1OLM) ; Methotrexate (YL5FZ2Y5U1)
    Language English
    Publishing date 2020-03-13
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 2472-5625
    ISSN (online) 2472-5625
    DOI 10.1080/24725625.2020.1739194
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Tendon stump type on magnetic resonance imaging is a predictive factor for retear after arthroscopic rotator cuff repair.

    Ishitani, Eiichi / Harada, Nobuya / Sonoda, Yasuo / Okada, Fumi / Yara, Takahiro / Katsuki, Ichiro

    Journal of shoulder and elbow surgery

    2019  Volume 28, Issue 9, Page(s) 1647–1653

    Abstract: Background: Fatty infiltration of the rotator cuff musculature increases in larger tears and is a factor in retearing. However, tearing may recur even in patients with small original tears and little fatty infiltration of the rotator cuff musculature. ... ...

    Abstract Background: Fatty infiltration of the rotator cuff musculature increases in larger tears and is a factor in retearing. However, tearing may recur even in patients with small original tears and little fatty infiltration of the rotator cuff musculature. We devised a system to classify the rotator cuff tendon stump by magnetic resonance imaging (MRI) signal intensity and investigated prognosis-related factors associated with retear based on other MRI findings.
    Methods: We analyzed and compared the signal intensity of the rotator cuff tendon stump and deltoid on preoperative T2-weighted fat-suppressed MRI in 305 patients who underwent primary arthroscopic rotator cuff repair. We also investigated the tear size, Goutallier stage, and global fatty degeneration index.
    Results: In a type 1 stump, the tendon stump had a lower (darker) signal intensity than the deltoid. In type 2, the signal intensities of the tendon stump and deltoid were equivalent. In type 3, the signal intensity of the tendon stump was higher (whiter) than that of the deltoid. Multiple regression analysis of the association between retear and other parameters identified stump type (odds ratio [OR], 4.28), global fatty degeneration index (OR, 2.99), and anteroposterior tear size (OR, 1.06) as significant factors. The retear rates were 3.4% for type 1 stumps, 4.9% for type 2, and 17.7% for type 3.
    Conclusions: Type 3 stumps had a significantly higher retear rate, suggesting that stump signal intensity may be an important indicator for assessing the stump's condition. Our stump classification may be useful in choosing suture techniques and postoperative therapies.
    MeSH term(s) Aged ; Arthroscopy ; Deltoid Muscle/diagnostic imaging ; Female ; Humans ; Magnetic Resonance Imaging/methods ; Male ; Middle Aged ; Predictive Value of Tests ; Preoperative Period ; Recurrence ; Risk Factors ; Rotator Cuff/diagnostic imaging ; Rotator Cuff/surgery ; Rotator Cuff Injuries/diagnostic imaging ; Rotator Cuff Injuries/surgery ; Treatment Outcome
    Language English
    Publishing date 2019-07-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1170782-3
    ISSN 1532-6500 ; 1058-2746
    ISSN (online) 1532-6500
    ISSN 1058-2746
    DOI 10.1016/j.jse.2019.05.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3973: Show issues Location:
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  3. Article ; Online: Dopamine induces IL-6-dependent IL-17 production via D1-like receptor on CD4 naive T cells and D1-like receptor antagonist SCH-23390 inhibits cartilage destruction in a human rheumatoid arthritis/SCID mouse chimera model.

    Nakano, Kazuhisa / Yamaoka, Kunihiro / Hanami, Kentaro / Saito, Kazuyoshi / Sasaguri, Yasuyuki / Yanagihara, Nobuyuki / Tanaka, Shinya / Katsuki, Ichiro / Matsushita, Sho / Tanaka, Yoshiya

    Journal of immunology (Baltimore, Md. : 1950)

    2011  Volume 186, Issue 6, Page(s) 3745–3752

    Abstract: A major neurotransmitter dopamine transmits signals via five different seven-transmembrane G protein-coupled receptors termed D1-D5. Several studies have shown that dopamine not only mediates interactions into the nervous system, but can contribute to ... ...

    Abstract A major neurotransmitter dopamine transmits signals via five different seven-transmembrane G protein-coupled receptors termed D1-D5. Several studies have shown that dopamine not only mediates interactions into the nervous system, but can contribute to the modulation of immunity via receptors expressed on immune cells. We have previously shown an autocrine/paracrine release of dopamine by dendritic cells (DCs) during Ag presentation to naive CD4(+) T cells and found efficacious results of a D1-like receptor antagonist SCH-23390 in the experimental autoimmune encephalomyelitis mouse model of multiple sclerosis and in the NOD mouse model of type I diabetes, with inhibition of Th17 response. This study aimed to assess the role of dopaminergic signaling in Th17-mediated immune responses and in the pathogenesis of rheumatoid arthritis (RA). In human naive CD4(+) T cells, dopamine increased IL-6-dependent IL-17 production via D1-like receptors, in response to anti-CD3 plus anti-CD28 mAb. Furthermore, dopamine was localized with DCs in the synovial tissue of RA patients and significantly increased in RA synovial fluid. In the RA synovial/SCID mouse chimera model, although a selective D2-like receptor antagonist haloperidol significantly induced accumulation of IL-6(+) and IL-17(+) T cells with exacerbated cartilage destruction, SCH-23390 strongly suppressed these responses. Taken together, these findings indicate that dopamine released by DCs induces IL-6-Th17 axis and causes aggravation of synovial inflammation of RA, which is the first time, to our knowledge, that actual evidence has shown the pathological relevance of dopaminergic signaling with RA.
    MeSH term(s) Animals ; Arthritis, Rheumatoid/immunology ; Arthritis, Rheumatoid/pathology ; Arthritis, Rheumatoid/therapy ; Benzazepines/administration & dosage ; Benzazepines/pharmacology ; CD4-Positive T-Lymphocytes/immunology ; CD4-Positive T-Lymphocytes/metabolism ; CD4-Positive T-Lymphocytes/pathology ; Cartilage, Articular/drug effects ; Cartilage, Articular/immunology ; Cartilage, Articular/pathology ; Cell Differentiation/immunology ; Cells, Cultured ; Disease Models, Animal ; Dopamine/pharmacology ; Humans ; Interleukin-17/biosynthesis ; Interleukin-17/secretion ; Interleukin-6/physiology ; Male ; Mice ; Mice, SCID ; Random Allocation ; Receptors, Dopamine D1/antagonists & inhibitors ; Receptors, Dopamine D1/physiology ; Resting Phase, Cell Cycle/immunology ; Synovial Membrane/immunology ; Synovial Membrane/pathology ; Synovial Membrane/transplantation ; Synovitis/immunology ; Synovitis/pathology ; Synovitis/therapy ; Th17 Cells/immunology ; Th17 Cells/metabolism ; Th17 Cells/pathology ; Transplantation Chimera
    Chemical Substances Benzazepines ; Interleukin-17 ; Interleukin-6 ; Receptors, Dopamine D1 ; SCH 23390 ; Dopamine (VTD58H1Z2X)
    Language English
    Publishing date 2011-03-15
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3056-9
    ISSN 1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
    ISSN (online) 1550-6606
    ISSN 0022-1767 ; 1048-3233 ; 1047-7381
    DOI 10.4049/jimmunol.1002475
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ud II Zs.37: Show issues Location:
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