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  1. Article: Association of clinical symptoms and metabolic syndrome-related factors in patients undergoing high tibial osteotomy.

    Azuma, Toshiki / Ueno, Katsuya / Goto, Shinsuke / Sugiki, Syunsuke / Izumoji, Tomo / Kamiji, Mototaka / Kuroda, Kazunari / Takahashi, Masaki / Asa, Ryousuke / Katsuki, Tatsuo / Haba, Toshihiro

    Journal of physical therapy science

    2023  Volume 35, Issue 5, Page(s) 373–378

    Abstract: Purpose] This study aimed to investigate the relationship between clinical outcomes after high tibial osteotomy and metabolic syndrome-related factors, such as hypertension, dyslipidemia, diabetes mellitus, and obesity. [Participants and Methods] A ... ...

    Abstract [Purpose] This study aimed to investigate the relationship between clinical outcomes after high tibial osteotomy and metabolic syndrome-related factors, such as hypertension, dyslipidemia, diabetes mellitus, and obesity. [Participants and Methods] A total of 73 patients (73 knees) who underwent high tibial osteotomy for knee osteoarthritis between 2018 and 2020 were included. We investigated the correlation between metabolic syndrome-related factors and clinical symptom assessment (Japanese Orthopedic Association Score) and examined knee function and lower alignment. [Results] At three months postoperatively, the Japanese Orthopedic Association score showed no main and synergistic effects on metabolic syndrome-related factors, and the preoperative Japanese Orthopedic Association score only showed a main effect on metabolic syndrome-related factors. At 12 months postoperatively, the Japanese Orthopedic Association score showed main and synergistic effects on diabetes mellitus, obesity, hypertension and dislipidemia. [Conclusion] Metabolic syndrome-related factors are associated with poorer clinical outcomes after high tibial osteotomy.
    Language English
    Publishing date 2023-05-01
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2038898-6
    ISSN 0915-5287
    ISSN 0915-5287
    DOI 10.1589/jpts.35.373
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Association between the severity of symptomatic knee osteoarthritis and cumulative metabolic factors.

    Yasuda, Emi / Nakamura, Ryuichi / Matsugi, Ryo / Goto, Shinsuke / Ikenaga, Yasunori / Kuroda, Kazunari / Nakamura, Syunsuke / Katsuki, Yasuo / Katsuki, Tatsuo

    Aging clinical and experimental research

    2017  Volume 30, Issue 5, Page(s) 481–488

    Abstract: Background: The association between cumulative metabolic syndrome (MS) factors and knee osteoarthritis (KOA) has been highlighted over the past two decades.: Aims: To clarify the relationship between cumulative MS factors and symptomatic KOA.: ... ...

    Abstract Background: The association between cumulative metabolic syndrome (MS) factors and knee osteoarthritis (KOA) has been highlighted over the past two decades.
    Aims: To clarify the relationship between cumulative MS factors and symptomatic KOA.
    Methods: A cross-sectional survey involving 119 women aged 45-88 years who were scheduled to undergo knee surgery was conducted. They were stratified into tertiles of symptoms as assessed by the Japanese Orthopedic Association score for KOA. Multinomial logistic regressions were performed using the severity of symptomatic KOA as the dependent variable and each MS factor or the cumulative MS factors as the independent variables.
    Results: Logistic regression analyses were performed with the upper tertile of stratified symptoms of subjects used as the reference group. After adjustment for confounders, KOA patients who had two (p = 0.004) or three or more (p < 0.0001) MS factors were significantly more likely to have severe symptoms compared to those who had no MS factors. MS factors excluding obesity were similarly analyzed. Even after additional adjustment for body mass index (BMI), KOA patients who had two or more (p = 0.005) MS factors were significantly more likely to have severe symptoms.
    Conclusion: Among KOA female patients diagnosed using radiographic definition, the severity of symptomatic KOA was significantly associated with hypertension, dyslipidemia, and the number of MS factors after adjustment for age, BMI, strength of the knee extensor, and Kellgren-Lawrence grade. The severity of radiographic KOA was not associated with any MS factor or cumulative MS factors.
    MeSH term(s) Aged ; Aged, 80 and over ; Blood Glucose/analysis ; Body Mass Index ; Cross-Sectional Studies ; Dyslipidemias/classification ; Female ; Humans ; Hypertension/classification ; Hypertension/etiology ; Knee Joint/diagnostic imaging ; Logistic Models ; Metabolic Syndrome/classification ; Metabolic Syndrome/etiology ; Metabolic Syndrome/physiopathology ; Middle Aged ; Obesity/classification ; Obesity/epidemiology ; Osteoarthritis, Knee/classification ; Osteoarthritis, Knee/complications ; Osteoarthritis, Knee/diagnostic imaging ; Radiography ; Retrospective Studies ; Severity of Illness Index
    Chemical Substances Blood Glucose
    Language English
    Publishing date 2017-07-31
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2104785-6
    ISSN 1720-8319 ; 1594-0667
    ISSN (online) 1720-8319
    ISSN 1594-0667
    DOI 10.1007/s40520-017-0808-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Hokuriku-plus familial hypercholesterolaemia registry study: rationale and study design.

    Tada, Hayato / Okada, Hirofumi / Yoshida, Shohei / Shimojima, Masaya / Nomura, Akihiro / Tsuda, Toyonobu / Mori, Mika / Takashima, Shin-Ichiro / Kato, Takeshi / Usui, Soichiro / Sakata, Kenji / Hayashi, Kenshi / Fujino, Noboru / Inazu, Akihiro / Takahara, Shizuko / Imai, Yasuhito / Matsubara, Takao / Nohara, Atsushi / Miwa, Kenji /
    Namura, Masanobu / Terai, Hidenobu / Yoshida, Taiji / Araki, Tsutomu / Minamoto, Masahiro / Aburao, Toru / Ito, Yuji / Nakanishi, Chiaki / Kawasaki, Suguru / Todo, Yasuhiro / Koizumi, Junji / Kita, Yoshihito / Matsumoto, Hiroshi / Shintaku, Hiroaki / Hodatsu, Akihiko / Ino, Hidekazu / Higashikata, Toshinori / Takata, Mutsuko / Misawa, Katsushi / Yamaguchi, Masato / Noji, Yoshihiro / Osato, Kazuo / Mabuchi, Tomohito / Ichise, Taro / Kaku, Bunji / Katsuda, Shoji / Fujimoto, Manabu / Uchiyama, Katsuharu / Fujioka, Kensuke / Nakahashi, Takuya / Nozue, Tsuyoshi / Michishita, Ichiro / Usuda, Kazuo / Otowa, Kanichi / Okeie, Kazuyasu / Hirota, Satoshi / Aburadani, Isao / Kurokawa, Keisuke / Takatori, Osamu / Hondo, Shunichiro / Oda, Hiroyuki / Takata, Shigeo / Murai, Hisayoshi / Kinoshita, Masaki / Nagai, Hideo / Sekiguchi, Yoshiteru / Sakagami, Satoru / Omi, Wataru / Fujita, Chikara / Katsuki, Tatsuo / Ootsuji, Hiroshi / Igarashi, Atsushi / Nakano, Manabu / Okura, Seiichiro / Maeno, Koji / Mitamura, Yasuhito / Sugimoto, Naoki / Yamamoto, Masakazu / Akao, Hironobu / Kajinami, Kouji / Takamura, Masayuki / Kawashiri, Masa-Aki

    BMJ open

    2020  Volume 10, Issue 9, Page(s) e038623

    Abstract: Introduction: Familial hypercholesterolaemia (FH) is an autosomal-dominant inherited genetic disease. It carries an extremely high cardiovascular risk associated with significantly elevated low-density lipoprotein (LDL) cholesterol. The diagnostic rate ... ...

    Abstract Introduction: Familial hypercholesterolaemia (FH) is an autosomal-dominant inherited genetic disease. It carries an extremely high cardiovascular risk associated with significantly elevated low-density lipoprotein (LDL) cholesterol. The diagnostic rate of this disease in some European nations is quite high, due to the presence of multiple prospective registries. On the other hand, few data-and in particular multicentre data-exist regarding this issue among Japanese subjects. Therefore, this study intends to assemble a multicentre registry that aims to comprehensively assess cardiovascular risk among Japanese FH patients while taking into account their genetic backgrounds.
    Methods and analysis: The Hokuriku-plus FH registry is a prospective, observational, multicentre cohort study, enrolling consecutive FH patients who fulfil the clinical criteria of FH in Japan from 37 participating hospitals mostly in Hokuriku region of Japan from April 2020 to March 2024. A total of 1000 patients will be enrolled into the study, and we plan to follow-up participants over 5 years. We will collect clinical parameters, including lipids, physical findings, genetic backgrounds and clinical events covering atherosclerotic and other important events, such as malignancies. The primary endpoint of this study is new atherosclerotic cardiovascular disease (ASCVD) events. The secondary endpoints are as follows: LDL cholesterol, secondary ASCVD events and the occurrence of other diseases including hypertension, diabetes and malignancies.
    Ethics and dissemination: This study is being conducted in compliance with the Declaration of Helsinki, the Ethical Guidelines for Medical and Health Research Involving Human Subjects, and all other applicable laws and guidelines in Japan. This study protocol has been approved by the Institutional Review Board at Kanazawa University. We will disseminate the final results at international conferences and in a peer-reviewed journal.
    Trial registration number: UMIN000038210.
    MeSH term(s) Cohort Studies ; Humans ; Hyperlipoproteinemia Type II/epidemiology ; Hyperlipoproteinemia Type II/genetics ; Japan/epidemiology ; Prospective Studies ; Registries
    Language English
    Publishing date 2020-09-10
    Publishing country England
    Document type Journal Article ; Multicenter Study ; Observational Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2020-038623
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: PPARgamma gene polymorphism is associated with exercise-mediated changes of insulin resistance in healthy men.

    Kahara, Toshio / Takamura, Toshinari / Hayakawa, Tetsuo / Nagai, Yukihiro / Yamaguchi, Hiromi / Katsuki, Tatsuo / Katsuki, Ken-Ichi / Katsuki, Michio / Kobayashi, Ken-Ichi

    Metabolism: clinical and experimental

    2003  Volume 52, Issue 2, Page(s) 209–212

    Abstract: Exercise training improves insulin sensitivity, but individual responses vary greatly. Peroxisome proliferator-activated receptor-gamma (PPARgamma) is a regulator of adipose cell differentiation and plays an important role in systemic insulin action. We ... ...

    Abstract Exercise training improves insulin sensitivity, but individual responses vary greatly. Peroxisome proliferator-activated receptor-gamma (PPARgamma) is a regulator of adipose cell differentiation and plays an important role in systemic insulin action. We investigated whether PPARgamma gene polymorphism affects insulin resistance in response to exercise in Japanese healthy men. The exercise program at an individual intensity of 50% of the maximal heart rate was performed for 20 to 60 min/d, and 2 to 3 days per week to attain a level of physical activity of 700 kcal/wk. The program was conducted for 3 months without any dietary intervention, and the clinical and metabolic characteristics were examined before and after the exercise program. Body mass index (BMI) did not change significantly after the exercise program, whereas percentage of body fat (% body fat), fasting plasma glucose (FPG), and serum leptin levels decreased significantly. Pro12Ala polymorphism in PPARgamma gene was performed on genomic DNA isolated from human leukocytes and examined with polymerase chain reaction (PCR) and subsequent restriction enzyme analysis using BstU-I. In this study, the Ala allele did not correlate with fasting immunoreactive insulin (IRI) and homeostasis model assessment-insulin resistance index (HOMA-R) at baseline, but did so with the changes in IRI and HOMA-R after exercise (DeltaIRI, Pro/Pro 0.55 +/- 3.49 microU/mL v Pro/Ala -2.83 +/- 1.47 microU/mL, P <.05; DeltaHOMA-R, Pro/Pro 0.09 +/- 0.86 v Pro/Ala -0.61 +/- 0.32, P <.05). This result suggests that the Ala allele is associated with improvement in insulin resistance after exercise. We conclude that PPARgamma gene polymorphism may be a reliable indicator of whether exercise will have a beneficial effect as part of the treatment of insulin resistance syndrome.
    MeSH term(s) Adult ; Aged ; Blood Glucose/analysis ; Exercise/physiology ; Fasting/blood ; Humans ; Insulin Resistance/physiology ; Leptin/blood ; Male ; Middle Aged ; Polymorphism, Genetic/physiology ; Prospective Studies ; Receptors, Cytoplasmic and Nuclear/genetics ; Reference Values ; Transcription Factors/genetics
    Chemical Substances Blood Glucose ; Leptin ; Receptors, Cytoplasmic and Nuclear ; Transcription Factors
    Language English
    Publishing date 2003-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80230-x
    ISSN 1532-8600 ; 0026-0495
    ISSN (online) 1532-8600
    ISSN 0026-0495
    DOI 10.1053/meta.2003.50038
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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.316: Show issues Location:
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  5. Article: Prediction of exercise-mediated changes in metabolic markers by gene polymorphism.

    Kahara, Toshio / Takamura, Toshinari / Hayakawa, Tetsuo / Nagai, Yukihiro / Yamaguchi, Hiromi / Katsuki, Tatsuo / Katsuki, Ken-ichi / Katsuki, Michio / Kobayashi, Ken-ichi

    Diabetes research and clinical practice

    2002  Volume 57, Issue 2, Page(s) 105–110

    Abstract: The effects of regular physical exercise on obesity-associated metabolic abnormalities vary for each individual. In this study, we investigated whether genotypes of genes associated with obesity can predict the effects of exercise on changes in metabolic ...

    Abstract The effects of regular physical exercise on obesity-associated metabolic abnormalities vary for each individual. In this study, we investigated whether genotypes of genes associated with obesity can predict the effects of exercise on changes in metabolic markers in healthy men. Healthy Japanese men (n=106) performed the exercise program at 50% of their maximal heart rate for 20-60 min a day, 2-3 days each week for 3 months. The levels of fasting plasma glucose (FPG) and serum leptin significantly decreased after the exercise program. Polymorphisms of the beta3-adrenergic receptor (beta3AR) and uncoupling protein-1 (UCP-1) genes were analyzed with RFLP methods. In the Trp/Trp genotype of the beta3AR gene, the levels of serum leptin, FPG and fructosamine (FrAm) decreased significantly after the exercise program, but not in the Arg/Arg genotype. In the AG heterozygote and the GG homozygote of the UCP-1 gene, FPG and FrAm levels were significantly reduced, respectively. In conclusion, gene polymorphism of the beta3AR and UCP-1 was found to be associated with the exercise-mediated improvement in glucose tolerance and leptin resistance in healthy Japanese men.
    MeSH term(s) Adult ; Aged ; Asian Continental Ancestry Group ; Biomarkers/blood ; Blood Glucose/metabolism ; Blood Pressure ; Body Mass Index ; Carrier Proteins/genetics ; Exercise/physiology ; Humans ; Ion Channels ; Japan ; Leptin/blood ; Membrane Proteins/genetics ; Middle Aged ; Mitochondria/genetics ; Mitochondrial Proteins ; Obesity/genetics ; Obesity/physiopathology ; Polymorphism, Genetic ; Polymorphism, Restriction Fragment Length ; Receptors, Adrenergic, beta-3/genetics ; Reference Values ; Uncoupling Protein 1
    Chemical Substances Biomarkers ; Blood Glucose ; Carrier Proteins ; Ion Channels ; Leptin ; Membrane Proteins ; Mitochondrial Proteins ; Receptors, Adrenergic, beta-3 ; UCP1 protein, human ; Uncoupling Protein 1
    Language English
    Publishing date 2002-08
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 632523-3
    ISSN 1872-8227 ; 0168-8227
    ISSN (online) 1872-8227
    ISSN 0168-8227
    DOI 10.1016/s0168-8227(02)00023-2
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2047: Show issues Location:
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