LIVIVO - Search results -

Search results

Result 1 - 10 of total 35

Search options

Article ; Online: Antiosteoarthritis activities of 70% ethanol extract of eleutherine bulbosa (mill.) urb. bulb on rats monosodium iodoacetate-induced osteoarthritis

Riza Ambar Sari / Fina Luthfiana / Irawati Sholihah / Katsuyoshi Matsunami / Sukardiman Sukardiman / Retno Widyowati

Journal of Public Health in Africa, Vol 14, Iss s

2023 Volume 1

Abstract: Background: Osteoarthritis (OA) is a common degenerative joint situation that induces pain and disability in the elderly. Traditionally, Eleutherine bulbosa bulb from Pasuruan, East Java, is used to treat many diseases, also as an anti-inflammatory. ... ...

Abstract	Background: Osteoarthritis (OA) is a common degenerative joint situation that induces pain and disability in the elderly. Traditionally, Eleutherine bulbosa bulb from Pasuruan, East Java, is used to treat many diseases, also as an anti-inflammatory. Objective: In this research, we employed an in vivo model to examine the effects of 70% ethanol extracts of E. bulbosa (EBE) on the progression and development of OA. Methods: A singular intraarticular injection of Monosodium Iodoacetate (MIA) was used to create the OA model in rats. The progression of OA was observed for three weeks. Furthermore, treatment of EBE at a dose of 6, 12, and 24 mg/200g BW orally for four weeks was conducted to assess the effects on decreasing IL- 1ß level, joint swelling, and hyperalgesia. Results: Induction was successful, indicated by a significant difference (P<0.05) in decreasing latency time, increasing joint swelling, and IL-1ß level. EBE 24 mg/200 g BW treatment has significantly (P<0.05) reduced IL-1ß levels, joint swelling, and response to hyperalgesia. Conclusion: The 70% ethanol extract of E. bulbosa bulb has therapeutic effects on inflammation through reducing IL-1ß in experimental MIA-induced osteoarthritis in a rat model. According to this study, EBE may have an effective potential new agent for OA therapy.
Keywords	Osteoarthritis ; Antiinflammatory ; Eleutherine bulbosa ; MIA ; IL-1β ; Public aspects of medicine ; RA1-1270
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	PAGEPress Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: In silico study of phytochemicals contained in brucea javanica in inhibiting the InhA enzyme as antituberculosis

Melanny Ika Sulistyowaty / Galih Satrio Putra / Juni Ekowati / Tri Widiandani / Katsuyoshi Matsunami

Journal of Public Health in Africa, Vol 14, Iss s

2023 Volume 1

Abstract: Background: Currently Mycobacterium tuberculosis is found to be resistant to the treatment of tuberculosis with rifampin and isoniazid (INH) and often stated as multi-drug resistance (MDR). Knowledge and determination of biological properties of plant ... ...

Abstract	Background: Currently Mycobacterium tuberculosis is found to be resistant to the treatment of tuberculosis with rifampin and isoniazid (INH) and often stated as multi-drug resistance (MDR). Knowledge and determination of biological properties of plant extracts is a source of drug candidates in various health fields. Therefore, natural products are important in the discovery of new drugs, especially in disease therapy, particularly for tropical dis- eases, tuberculosis. Brucea javanica, known as Buah Makasar, is found in many Asian countries including Indonesia. This plant fruit has a very bitter taste so it cannot be directly consumed and is often used as a traditional medicine to prevent some diseases, especially malaria. There has been no research on the effectiveness of Buah Makasar in tuberculosis. Objective: This study aims to identify compounds contained in Brucea javanica, namely bruceines, bruceosides and yadanzio-sides in inhibiting the InhA enzyme found in the wall of Mycobacterium tuberculosis. Methods: This in-silico study is using Molegro Virtual Docker (MVD) Ver. 5.5. We compared it to the native ligand, namely N-(4- Methylbenzoyl)-4-Benzylpiperidine (code: 4PI) and the reference drug standard, INH. Results: In-silico results show that yadanziosides found in Brucea javanica have the potential to inhibit the InhA enzyme. Bruceoside F (-190.76 Kcal/mol) has the lowest MolDock score among the 27 other compounds. It is also having lower MolDock score than the native ligand 4PI (-120.61 Kcal/mol) and INH (- 54.44 Kcal/mol). Conclusions: Brucea javanica can be considered as source of drug development for againts tuberculosis.
Keywords	Derivatives of brucein ; bruceocide and yadanzioside ; Molecular docking ; Tuberculosis ; Brucea javanica ; Prediction ; Public aspects of medicine ; RA1-1270
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	PAGEPress Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Effects of eleutherine bulbosa (mill.) urb. bulb extract on mice glucocorticoid-induced osteoporosis models

Fina Luthfiana / Riza Ambar Sari / Irawati Sholikhah / Katsuyoshi Matsunami / Sukardiman Sukardiman / Retno Widyowati

Journal of Public Health in Africa, Vol 14, Iss s

2023 Volume 1

Abstract: Background: Low bone mass accompanied by microarchitectural alterations in the bone that cause fragility fractures is known as secondary osteoporosis and occurs when there is an underlying condition or medication present. Eleutherine bulbosa bulb extract ...

Abstract	Background: Low bone mass accompanied by microarchitectural alterations in the bone that cause fragility fractures is known as secondary osteoporosis and occurs when there is an underlying condition or medication present. Eleutherine bulbosa bulb extract has been shown to affect bone because of its content, which can help osteoblast differentiation and inhibit osteoclast differentiation. Objective: This study aimed to assess the effects of 70% ethanol extract of E. bulbosa Bulbs (EBE) from Pasuruan-East Java on blood calcium levels, osteoblast cell count, and bone density of trabecular femur in osteoporosis rats. Methods: Six groups of 30 female Wistar rats were created. There were no test materials offered to the healthy group; the negative group received 0.5% CMC; the positive group received alendronate 0.9 mg/kg BW; and the dose group received 30, 60, and 120 mg/kg BW. Glucocorticoid (Dexamethasone) 0.1015 mg/kg BW/day induction was given to all groups except the healthy group to create osteoporosis rats for approximately four weeks. Then they were given oral therapy for approximately 28 days. Followed by the determination of blood calcium levels, the number of osteoblast cells, and bone density of the rat femur trabecular. Results: The result showed that E. bulbosa bulbs extract could raise blood calcium levels and bone density percentage at doses of 60 and 120 mg/kg BW, as well as raise osteoblast cell levels at doses of 120 mg/kg BW. Conclusions: The findings indicate that E.bulbosa bulb extract is a potential complementary medicine for osteoporosis.
Keywords	Eleutherine bulbosa ; Calcium ; Osteoblast cell ; Bone density ; Osteoporosis ; Public aspects of medicine ; RA1-1270
Subject code	630
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	PAGEPress Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Formulation and evaluation of encapsulated Graptophyllum pictum (L.) Griff. ethanolic extract in lipid vesicles for hemorrhoid treatment

Idha Kusumawati / Subhan Rullyansyah / Mega Ferdina Warsito / Yusuf Alif Pratama / Eka Pramrytha Hestianah / Katsuyoshi Matsunami

Journal of Pharmacy & Pharmacognosy Research, Vol 12, Iss 1, Pp 27-

2024 Volume 38

Abstract: Context: Graptophyllum pictum (L.) Griff. leaves (GPL) are traditionally used in Indonesia to treat hemorrhoids, and the anti-hemorrhoid activity of the ethanolic extract of G. pictum leaves (GPLE) has been proven scientifically. However, since it ... ...

Abstract	Context: Graptophyllum pictum (L.) Griff. leaves (GPL) are traditionally used in Indonesia to treat hemorrhoids, and the anti-hemorrhoid activity of the ethanolic extract of G. pictum leaves (GPLE) has been proven scientifically. However, since it contains a variety of compounds, both hydrophilic and lipophilic, which has diverse solubility, absorption, and penetration characteristic, there is a need to be formulated to improve its effectiveness. Lipid nanocarrier formulations, such as liposome and ethosome, can be developed as the delivery system for GPLE to enhance its effectiveness. Aims: To evaluate the anti-hemorrhoid activity of the liposomal and ethosomal formulation of GPLE. Methods: The hydration method was used to prepare GPLE liposomal (GL) and ethosomal (GE) formulations. An in vivo study was conducted to evaluate the penetration and effectiveness of both formulations. The in vivo test was evaluated based on the recto-anal tissue histological observation after treatment of the formulation to croton oil-induced hemorrhoid mice. The number of inflammatory cells, goblet cells, hemorrhage area, and mucosal thickness were compared between both formulations and the extract. Results: GE had a smaller particle size, 145.7 ± 5.75 nm, with a polydispersity index (PDI) value of 0.376 ± 0.031. Meanwhile, GL showed a particle size of 407.80 ± 11.32 nm, with a PDI value of 0.389 ± 0.019. The zeta potential (ZP) of GL was -2.0200 ± 0.0513 mV and -0.0109 ± 0.0257 mV for GE. GE exhibited a better penetration and activity profile than GL, which was assumed to be correlated to its smaller particle size and component of the formulation. GE was able to penetrate up to the submucosa layer; meanwhile, GL only reached the muscularis mucosa. GE revealed better anti-hemorrhoid activity as it showed a lesser number of inflammatory cells, goblet cells, and necrosis cells. Additionally, it exhibited a smaller hemorrhage area and muscular mucose cell thickness compared to GL. However, there was no significant difference ...
Keywords	encapsulation ; hemorrhoid ; herbal ; lipid carrier ; medicine ; Therapeutics. Pharmacology ; RM1-950 ; Pharmacy and materia medica ; RS1-441
Subject code	630
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	GarVal Editorial Ltda.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Synthesis, In Silico Study, Antibacterial and Antifungal Activities of N -phenylbenzamides

Melanny Ika Sulistyowaty / Galih Satrio Putra / Tutuk Budiati / Anastasia Wheni Indrianingsih / Farida Anwari / Dini Kesuma / Katsuyoshi Matsunami / Takayasu Yamauchi

International Journal of Molecular Sciences, Vol 24, Iss 2745, p

2023 Volume 2745

Abstract: Antibiotic and antifungal resistance problems have been prevalent in recent decades. One of the efforts to solve the problems is to develop new medicines with more potent antibacterial and antifungal activity. N -phenylbenzamides have the potential to be ...

Abstract	Antibiotic and antifungal resistance problems have been prevalent in recent decades. One of the efforts to solve the problems is to develop new medicines with more potent antibacterial and antifungal activity. N -phenylbenzamides have the potential to be developed as antibacterial and antifungal medicine. This study aimed to synthesize N -phenylbenzamides and evaluate their in silico and in vitro antibacterial and antifungal activities. The in silico studies conducted absorption, distribution, metabolism, excretion and toxicity (ADMET) predictions along with molecular docking studies. ADMET predictions used pkCSM software online, while the docking studies used MVD software (Molegro ® Virtual Docker version 5.5) on Aminoglycosid-2 ″-phosphotransferase-IIa (APH2 ″-IIa) enzyme with protein data bank (PDB) ID code 3HAV as antibacterial and aspartic proteinases enzyme (Saps) with PDB ID code 2QZX as an antifungal. In vitro, antibacterial and antifungal tests were carried out using the zone of inhibition (ZOI) method. The five N -phenylbenzamides ( 3a – e ) were successfully synthesized with a high yield. Based on in silico and in vitro studies, compounds 3a – e have antibacterial and antifungal activities, where they can inhibit the growth of Gram-positive bacteria ( Staphylococcus aureus ), Gram-negative ( Escherichia coli ), and Candida albicans . Therefore, compounds 3a – e can be developed as a topical antibacterial and antifungal agent.
Keywords	synthesis ; in silico ; antibacterial ; antifungal ; N -phenylbenzamides derivatives ; 3HAV ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	540
Language	English
Publishing date	2023-02-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: New ψ -Santonin Derivatives from Crossostephium chinense and Their Anti-Proliferative Activities against Leishmania major and Human Cancer Cells A549

Zhichao Wang / Yoshi Yamano / Susumu Kawakami / Gadah Abdulaziz Al-Hamoud / Sachiko Sugimoto / Hideaki Otsuka / Katsuyoshi Matsunami

Molecules, Vol 28, Iss 24, p

2023 Volume 8108

Abstract: Previously, we reported two cytotoxic ψ -santonin–amino acid conjugates isolated from the EtOAc layer of Crossostephium chinense . However, a further phytochemical investigation seems to be required because of the few reports of similar derivatives. In ... ...

Abstract	Previously, we reported two cytotoxic ψ -santonin–amino acid conjugates isolated from the EtOAc layer of Crossostephium chinense . However, a further phytochemical investigation seems to be required because of the few reports of similar derivatives. In this study, we targeted the 1-BuOH layer, which resulted in the isolation of seven new ψ -santonin derivatives ( 1 – 7 ) together with ten known compounds ( 8 – 17 ). The structures of 1 – 7 were elucidated based on spectroscopic methods, including 1D and 2D NMR experiments ( 1 H, 13 C, DEPT, COSY, HSQC, and HMBC), IR spectrum, and high-resolution electrospray ionization–mass spectrometry (HR-ESI–MS). The stereochemistry of new compounds was confirmed by NOESY and ECD calculations. All isolated compounds were evaluated by in vitro experiments for their anti-proliferative activities against Leishmania major , human lung cancer cell line A549, and Vero cells. As a result, most of the ψ -santonin derivatives, especially 1 – 5 , showed significant cytotoxicity against L. major with a lower IC 50 than the positive control we used (miltefosine).
Keywords	Crossostephium chinense ; sesquiterpene ; ψ -santonin ; Leishmania major ; A549 ; Organic chemistry ; QD241-441
Subject code	540
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Two New Cytotoxic Sesquiterpene-Amino Acid Conjugates and a Coumarin-Glucoside from Crossostephium chinense

Zhichao Wang / Ben-Yeddy Abel Chitama / Keisuke Suganuma / Yoshi Yamano / Sachiko Sugimoto / Susumu Kawakami / Osamu Kaneko / Hideaki Otsuka / Katsuyoshi Matsunami

Molecules, Vol 28, Iss 4696, p

2023 Volume 4696

Abstract: The Asteraceae family is a promising source of bioactive compounds, such as the famous Asteraceae plants Tanacetum cinerariifolium (pyrethrin) and Artemisia annua (artemisinin). As a result of our series of phytochemical studies of the subtropical plants, ...

Abstract	The Asteraceae family is a promising source of bioactive compounds, such as the famous Asteraceae plants Tanacetum cinerariifolium (pyrethrin) and Artemisia annua (artemisinin). As a result of our series of phytochemical studies of the subtropical plants, two novel sesquiterpenes, named crossoseamines A and B in this study ( 1 and 2 , respectively), one undescribed coumarin-glucoside ( 3 ), and eighteen known compounds ( 4 – 21 ) were isolated from the aerial part of Crossostephium chinense (Asteraceae). The structures of isolated compounds were elucidated by spectroscopic methods, including 1D and 2D NMR experiments ( 1 H, 13 C, DEPT, COSY, HSQC, HMBC, and NOESY), IR spectrum, circular dichroism spectrum (CD), and high-resolution electrospray ionization–mass spectrometry (HR-ESI–MS). All isolated compounds were evaluated for their cytotoxic activities against Leishmania major , Plasmodium falciparum , Trypanosoma brucei ( gambiense and rhodesiense ), and human lung cancer cell line A549 because of the high demand for the discovery of new drug leads to overcome the present side effects and emerging drug-resistant strains. As a result, the new compounds ( 1 and 2 ) showed significant activities against A549 (IC 50 , 1 : 3.3 ± 0.3; 2 : 12.3 ± 1.0 μg/mL), L. major (IC 50 , 1 : 6.9 ± 0.6; 2 : 24.9 ± 2.2 μg/mL), and P. falciparum (IC 50 , 1 : 12.1 ± 1.1; 2 : 15.6 ± 1.2 μg/mL).
Keywords	Crossostephium chinense ; sesquiterpene ; A549 ; Leishmania major ; Plasmodium falciparum ; Trypanosoma brucei ; Organic chemistry ; QD241-441
Subject code	500
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Immunomodulatory effect from ethanol extract and ethyl acetate fraction of Curcuma heyneana Valeton and Zijp

Fifteen Aprila Fajrin / Melanny Ika Sulistyowaty / Mohammad Labib Ghiffary / Swara Adla Zuhra / Wulan Rosa Panggalih / Dwi Koko Pratoko / Fransiska Maria Christianty / Katsuyoshi Matsunami / Anastasia Wheni Indrianingsih

Heliyon, Vol 9, Iss 5, Pp e15582- (2023)

Transient receptor vanilloid protein approach

2023

Abstract: This study aims to discover the immunomodulatory potential of the ethanol extract (EE) and the ethyl acetate fraction (EAF) of Curcuma heyneana Valeton and Zijp (Indonesian name: temu giring) rhizome using mice models. The affinity of the curcuminoid ( ... ...

Abstract	This study aims to discover the immunomodulatory potential of the ethanol extract (EE) and the ethyl acetate fraction (EAF) of Curcuma heyneana Valeton and Zijp (Indonesian name: temu giring) rhizome using mice models. The affinity of the curcuminoid (curcumin, dimethoxy-, and bisdemethoxy-) through the Transient Receptor Potential Vanilloid 1 (TRPV1) was determined using Mollegro molecular docking in silico. The curcuminoid concentration of the EE and EAF of C. heyneana rhizome were determined using thin-layer chromatography densitometry. In vivo studies in mice models were conducted using the carbon clearance method to determine the phagocytosis index, and the number of leukocytes in the blood and spleen. Forty mice were divided into eight groups, including negative control (given 1% CMC-Na), positive control (given Stimuno Forte® suspension at a dose of 6.5 mg/kg BW), three groups given the EAF of C. heyneana rhizome extract at a dose of 125 mg/kg BW, 250 mg/kg BW, and 500 mg/kg BW, respectively, and three groups were given EE of temu giring rhizome extract with doses of 125 mg/kg BW, 250 mg/kg BW, and 500 mg/kg BW, respectively. E.E. and E.A.F. of C. heyneana (temu giring) rhizome extract contained dimethoxy curcumin (0.176 ± 0.01 and 4.53 ± 0.02 %b/b) greater than another curcuminoid, bisdemetoxy curcumin and curcumin. EE at 125 mg/kg BW and EAF dose at 500 mg/kg B W. of temu giring rhizome have immunostimulant activity with a phagocytosis index value of >1 compared to the negative control (p < 0.05). Additionally, both increase the number of lymphocytes, monocytes, and neutrophil cells in peripheral blood and spleen compared to the negative control (p < 0.05). Their activity was seen as similar to the positive control. Therefore, the EE of C. heyneana rhizome has immunostimulant activity, and the EAF of C. heyneana rhizome has immunosuppressant activity at 125 mg/kg BW and immunostimulant at a higher dose. The activity of temu giring as an immunomodulator was associataed with its affinity to TRPV1.
Keywords	Immunomodulator ; Carbon clearance ; Curcuma heyneana ; Phagocytic index ; Leukocyte cell count ; Mice ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
Subject code	630
Language	English
Publishing date	2023-05-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Ameliorative Effect of Ocimum forskolei Benth on Diabetic, Apoptotic, and Adipogenic Biomarkers of Diabetic Rats and 3T3-L1 Fibroblasts Assisted by In Silico Approach

Hany Ezzat Khalil / Miada F. Abdelwahab / Promise Madu Emeka / Lorina I. Badger-Emeka / Krishnaraj Thirugnanasambantham / Hairul-Islam Mohamed Ibrahim / Sara Mohamed Naguib / Katsuyoshi Matsunami / Nada M. Abdel-Wahab

Molecules, Vol 27, Iss 2800, p

2022 Volume 2800

Abstract: Diabetes mellitus (DM) is a complicated condition that is accompanied by a plethora of metabolic symptoms, including disturbed serum glucose and lipid profiles. Several herbs are reputed as traditional medicine to improve DM. The current study was ... ...

Abstract	Diabetes mellitus (DM) is a complicated condition that is accompanied by a plethora of metabolic symptoms, including disturbed serum glucose and lipid profiles. Several herbs are reputed as traditional medicine to improve DM. The current study was designed to explore the chemical composition and possible ameliorative effects of Ocimum forskolei on blood glucose and lipid profile in high-fat diet/streptozotocin-induced diabetic rats and in 3T3-L1 cell lines as a first report of its bioactivity. Histopathological study of pancreatic and adipose tissues was performed in control and treatment groups, along with quantification of glucose and lipid profiles and the assessment of NF-κB, cleaved caspase-3, BAX, and BCL2 markers in rat pancreatic tissue. Glucose uptake, adipogenic markers, DGAT1, CEBP/α, and PPARγ levels were evaluated in the 3T3-L1 cell line. Hesperidin was isolated from total methanol extract (TME). TME and hesperidin significantly controlled the glucose and lipid profile in DM rats. Glibenclamide was used as a positive control. Histopathological assessment showed that TME and hesperidin averted necrosis and infiltration in pancreatic tissues, and led to a substantial improvement in the cellular structure of adipose tissue. TME and hesperidin distinctly diminished the mRNA and protein expression of NF-κB, cleaved caspase-3, and BAX, and increased BCL2 expression (reflecting its protective and antiapoptotic actions). Interestingly, TME and hesperidin reduced glucose uptake and oxidative lipid accumulation in the 3T3-L1 cell line. TME and hesperidin reduced DGAT1, CEBP/α, and PPARγ mRNA and protein expression in 3T3-L1 cells. Moreover, docking studies supported the results via deep interaction of hesperidin with the tested biomarkers. Taken together, the current study demonstrates Ocimum forskolei and hesperidin as possible candidates for treating diabetes mellitus.
Keywords	Ocimum forskolei ; hesperidin ; streptozotocin ; diabetes ; 3T3-L1 ; NF-κB ; Organic chemistry ; QD241-441
Subject code	571
Language	English
Publishing date	2022-04-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: New Methyl Threonolactones and Pyroglutamates of Spilanthes acmella (L.) L. and Their Bone Formation Activities

Retno Widyowati / Melanny Ika Sulistyowaty / Nguyen Hoang Uyen / Sachiko Sugimoto / Yoshi Yamano / Hideaki Otsuka / Katsuyoshi Matsunami

Molecules, Vol 25, Iss 2500, p

2020 Volume 2500

Abstract: In our continuing research for bioactive constituents from natural resources, a new methyl threonolactone glucopyranoside ( 1 ), a new methyl threonolactone fructofuranoside ( 2 ), 2 new pyroglutamates ( 3 and 4 ), and 10 known compounds ( 5 – 14 ) were ... ...

Abstract	In our continuing research for bioactive constituents from natural resources, a new methyl threonolactone glucopyranoside ( 1 ), a new methyl threonolactone fructofuranoside ( 2 ), 2 new pyroglutamates ( 3 and 4 ), and 10 known compounds ( 5 – 14 ) were isolated from the whole plant of Spilanthes acmella (L.) L. The structures of these compounds were determined based on various spectroscopic and chemical analyses. All of the isolated compounds were evaluated on bone formation parameters, such as ALP (alkaline phosphatase) and mineralization stimulatory activities of MC3T3-E1 cell lines. The results showed that the new compound, 1,3-butanediol 3-pyroglutamate ( 4 ), 2-deoxy-D-ribono-1,4-lactone ( 6 ), methyl pyroglutamate ( 7 ), ampelopsisionoside ( 10 ), icariside B 1 ( 11 ), and benzyl α-L-arabinopyranosyl-(1→6)-β-D-glucopyranoside ( 12 ) stimulated both ALP and mineralization activities.
Keywords	Spilanthes acmella ; alkaline phosphatase ; mineralization ; methyl threonolactone ; pyroglutamate ; Organic chemistry ; QD241-441
Subject code	540
Language	English
Publishing date	2020-05-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED