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  1. Article ; Online: Novel management of internal root resorption with vertical root fracture using mineral trioxide aggregate - A case report.

    Karumaran, Chellaswamy Savarimalai / Ramachandran, Anil Kumar / Chandrasekaran, Nirmala / Manuel, Corrine Esther / Kattula, Deepthi

    Indian journal of dental research : official publication of Indian Society for Dental Research

    2022  Volume 33, Issue 2, Page(s) 223–226

    Abstract: Introduction: This case report presents the diagnosis and management of extensive internal root resorption (IRR) in a 17-year-old male patient, with a 9-year-old history of trauma.: Method: The affected tooth 21 was associated with vertical root ... ...

    Abstract Introduction: This case report presents the diagnosis and management of extensive internal root resorption (IRR) in a 17-year-old male patient, with a 9-year-old history of trauma.
    Method: The affected tooth 21 was associated with vertical root fracture (VRF) and incomplete apex closure with a substantial loss of tooth structure, including dentin and cementum. Encouraged by a healthy periodontal condition, the choice was made to use mineral trioxide aggregate (MTA) to reconstruct and reinforce the resorptive defect and the fractured segment. A composite veneer was placed to enhance the aesthetics.
    Result: A follow-up of the patient after 2 years revealed healing with a resolution of the lesion.
    Conclusion: This case report highlights the use of MTA as a lone-standing filling material for the treatment of IRR with VRF in a non-vital immature tooth.
    MeSH term(s) Adolescent ; Aluminum Compounds/therapeutic use ; Calcium Compounds/therapeutic use ; Child ; Drug Combinations ; Humans ; Male ; Oxides/therapeutic use ; Pemetrexed ; Root Canal Filling Materials/therapeutic use ; Root Resorption/diagnostic imaging ; Root Resorption/therapy ; Silicates/therapeutic use
    Chemical Substances Aluminum Compounds ; Calcium Compounds ; Drug Combinations ; Oxides ; Root Canal Filling Materials ; Silicates ; mineral trioxide aggregate ; Pemetrexed (04Q9AIZ7NO)
    Language English
    Publishing date 2022-09-19
    Publishing country India
    Document type Case Reports
    ZDB-ID 1354886-4
    ISSN 1998-3603 ; 0970-9290
    ISSN (online) 1998-3603
    ISSN 0970-9290
    DOI 10.4103/ijdr.ijdr_350_21
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  2. Article ; Online: Expression of CD44 in Head and Neck Squamous Cell Carcinoma-An

    Kavitha, Loganathan / Vijayashree Priyadharsini, Jayaseelan / Kattula, Deepthi / Rao, Umadevi Krishna Mohan / Balaji Srikanth, Rajabather / Kuzhalmozhi, Manogaran / Ranganathan, Kannan

    Global medical genetics

    2023  Volume 10, Issue 3, Page(s) 221–228

    Abstract: ... ...

    Abstract Introduction
    Language English
    Publishing date 2023-08-16
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 3009997-3
    ISSN 2699-9404 ; 2699-9404
    ISSN (online) 2699-9404
    ISSN 2699-9404
    DOI 10.1055/s-0043-1772459
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  3. Article: Expression of CD44 in Head and Neck Squamous Cell Carcinoma—An In-Silico Study

    Kavitha, Loganathan / Vijayashree Priyadharsini, Jayaseelan / Kattula, Deepthi / Rao, Umadevi Krishna Mohan / Balaji Srikanth, Rajabather / Kuzhalmozhi, Manogaran / Ranganathan, Kannan

    Global Medical Genetics

    2023  Volume 10, Issue 03, Page(s) 221–228

    Abstract: Introduction: CD44, a multistructural and multifunctional transmembrane glycoprotein, is a promising cancer stem cell (CSC) marker that regulates the properties of CSCs, including self-renewal, tumor initiation, and metastasis, and confers resistance to ...

    Abstract Introduction: CD44, a multistructural and multifunctional transmembrane glycoprotein, is a promising cancer stem cell (CSC) marker that regulates the properties of CSCs, including self-renewal, tumor initiation, and metastasis, and confers resistance to chemotherapy and radiotherapy. The aim of the present study was to evaluate the gene and protein expression of CD44 and explore its prognostic value in head and neck squamous cell carcinoma (HNSCC).
    Methodology: The present observational study employs computational tools for analysis. The Cancer Genome Atlas Head-Neck Squamous Cell Carcinoma dataset (520 primary HNSCC and 44 normal tissues) from the University of Alabama at Birmingham Cancer platform was used to study the association of CD44 mRNA transcript levels with various clinicopathological characteristics of HNSCC including age, gender, tumor grade, tumor stage, human papillomavirus (HPV) status, p53 mutation status, and overall survival. The CD44 protein expression in HNSCC and normal tissues was ascertained using the National Cancer Institute's Clinical Proteomic Tumor Analysis Consortium Head-and-Neck cancer dataset (108 primary HNSCC and 71 normal tissues).
    Results: CD44 mRNA transcript and protein expression levels were significantly higher in HNSCC tissues than in normal tissues, and high CD44 expression was correlated with poor survival. CD44 was upregulated in Stage 1 and Grade 2 HNSCC compared with other stages and grades. Overexpression of CD44 was observed in HPV-negative and TP53-positive mutant status in HNSCC.
    Conclusion: The pleiotropic roles of CD44 in tumorigenesis urge the need to explore its differential expression in HNSCC. The study concludes that CD44 can be a potential diagnostic and prognostic biomarker for HNSCC and offer new molecular targets for CD44-targeted therapy for cancer management.
    Keywords CD44 ; in-silico ; cancer stem cell ; HNSCC ; UALCAN ; TCGA
    Language English
    Publishing date 2023-08-16
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 3009997-3
    ISSN 2699-9404 ; 2699-9404
    ISSN (online) 2699-9404
    ISSN 2699-9404
    DOI 10.1055/s-0043-1772459
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  4. Article ; Online: Perceived Stress and Psychological (Dis)Stress among Indian Endodontists During COVID19 Pandemic Lock down

    Nair, Anil Kumar Ramachandran / Chellaswamy, Karumaran Savarimalai / Kattula, Deepthi / Thavarajah, Rooban / Mohandoss, Anusa Arunachalam

    medRxiv

    Abstract: Background: The novel 2019 coronavirus(COVID-19) spreads by respiratory and aerosols. COVID19 driven pandemic causes panic, fear and stress among all strata of society. Like all other medical professions, dentists, particularly endodontists, who are ... ...

    Abstract Background: The novel 2019 coronavirus(COVID-19) spreads by respiratory and aerosols. COVID19 driven pandemic causes panic, fear and stress among all strata of society. Like all other medical professions, dentists, particularly endodontists, who are highly exposed to aerosols would be exposed to stress. The aim of this study was to assess the (dis)stress among Indian endodontists and the factors that could influence the (dis)stress. Methods: From 8th April to 16th April 2020, we conducted an online survey in closed endodontic social media using snowball sampling technique, collecting basic demographic data, practice setting and relevant data. Psychological stress and perceived distress were collected through COVID-19 Peri-traumatic Distress Index (CPDI) and Perceived stress scale (PSS). Multinomial regression analysis was performed to estimate relative risk rate and P≤0.05 was considered significant. Results: This study had 586 Indian endodontists completing this survey across India. Of these, 311(53.07%) were males, 325(55%) in the age group of 25-35 years, 64%in urban areas, 13.14% in solo-practice and a fourth of them were residents. Female endodontists had high perceived stress (RRR=2.46,P=0.01) as compared to males, as measured by PSS. Younger endodontists<25 years(RRR=9.75;P=0.002) and 25-35years (RRR=4.60;P=0.004) as compared with >45 years age-group had more distress. Exclusive consultants had RRR= 2.90, P=0.02, for mild-to-moderate distress as compared to normal. Factors driving this phenomenon are considered. Conclusions: During the lock down due to COVID-19, 1-in-2 Indian endodontists had distress, as measured by CPDI and 4-in-5 of them had perceived stress, as indicated by PSS. Our model identified certain factors driving the (dis)stress, which would help policy framers to initiate appropriate response.
    Keywords covid19
    Language English
    Publishing date 2020-05-10
    Publisher Cold Spring Harbor Laboratory Press
    Document type Article ; Online
    DOI 10.1101/2020.05.06.20092601
    Database COVID19

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  5. Article: Profile and outcome of sudden cardiac arrests in the emergency department of a tertiary care hospital in South India.

    Pandian, Gautham Raja / Thampi, Suma Mary / Chakraborty, Nilanchal / Kattula, Deepthi / Kundavaram, Paul Prabhakar Abhilash

    Journal of emergencies, trauma, and shock

    2016  Volume 9, Issue 4, Page(s) 139–145

    Abstract: Background: Sudden cardiac arrest (SCA) requiring cardiopulmonary resuscitation (CPR) is one of the common emergencies encountered in the emergency department (ED) of any hospital. Although several studies have reported the predictors of CPR outcome in ... ...

    Abstract Background: Sudden cardiac arrest (SCA) requiring cardiopulmonary resuscitation (CPR) is one of the common emergencies encountered in the emergency department (ED) of any hospital. Although several studies have reported the predictors of CPR outcome in general, there are limited data from the EDs in India.
    Materials and methods: This retrospective study included all patients above 18 years with SCA who were resuscitated in the ED of a tertiary care hospital with an annual census of 60,000 patients between August 2014 and July 2015. A modified Utstein template was used for data collection. Factors relating to a sustained return of spontaneous circulation and mortality were analyzed using descriptive analytic statistics and logistic regressions.
    Results: The study cohort contained 254 patients, with a male predominance (64.6%). Median age was 55 (interquartile range: 42-64) years. Majority were in-hospital cardiac arrests (73.6%). Only 7.4% (5/67) of the out-of-hospital cardiac arrests received bystander resuscitation before ED arrival. The initial documented rhythm was pulseless electrical activity (PEA)/asystole in the majority (76%) of cases while shockable rhythms pulseless ventricular tachycardia/ventricular fibrillation were noted in only 8% (21/254) of cases. Overall ED-SCA survival to hospital admission was 29.5% and survival to discharge was 9.9%. Multivariate logistic regression analysis showed age ≥65 years (odds ratio [OR]: 12.33; 95% confidence interval [CI]: 1.38-109.59;
    Conclusion: SCA in the ED is being increasingly seen in younger age groups. Despite advances in resuscitation medicine, survival rates of both in-hospital and out-of-hospital SCA remain poor. There exists a great need for improving prehospital care as well as control of risk factors to decrease the incidence and improve the outcome of SCA.
    Language English
    Publishing date 2016-11-30
    Publishing country India
    Document type Journal Article
    ZDB-ID 2461111-6
    ISSN 0974-519X ; 0974-2700
    ISSN (online) 0974-519X
    ISSN 0974-2700
    DOI 10.4103/0974-2700.193348
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  6. Article ; Online: Health utilization for childhood gastroenteritis in southern India.

    Jennifer, M Steffi / Kattula, Deepthi / Sowmyanarayanan, Thuppal V / Sarkar, Rajiv / Kang, Gagandeep

    Indian journal of pediatrics

    2014  Volume 81, Issue 11, Page(s) 1240–1241

    MeSH term(s) Child, Preschool ; Female ; Gastroenteritis/epidemiology ; Gastroenteritis/therapy ; Health Services/statistics & numerical data ; Health Surveys ; Humans ; India/epidemiology ; Infant ; Infant, Newborn ; Male
    Language English
    Publishing date 2014-02-21
    Publishing country India
    Document type Letter ; Research Support, N.I.H., Extramural
    ZDB-ID 218231-2
    ISSN 0973-7693 ; 0019-5456
    ISSN (online) 0973-7693
    ISSN 0019-5456
    DOI 10.1007/s12098-014-1337-3
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    Zs.A 826: Show issues Location:
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  7. Article ; Online: Molecular Identification of Hookworm Isolates in Humans, Dogs and Soil in a Tribal Area in Tamil Nadu, India.

    George, Santosh / Levecke, Bruno / Kattula, Deepthi / Velusamy, Vasanthakumar / Roy, Sheela / Geldhof, Peter / Sarkar, Rajiv / Kang, Gagandeep

    PLoS neglected tropical diseases

    2016  Volume 10, Issue 8, Page(s) e0004891

    Abstract: Background: Hookworms (Necator americanus and Ancylostoma duodenale) remain a major public health problem worldwide. Infections with hookworms (e.g., A. caninum, A. ceylanicum and A. braziliense) are also prevalent in dogs, but the role of dogs as a ... ...

    Abstract Background: Hookworms (Necator americanus and Ancylostoma duodenale) remain a major public health problem worldwide. Infections with hookworms (e.g., A. caninum, A. ceylanicum and A. braziliense) are also prevalent in dogs, but the role of dogs as a reservoir for zoonotic hookworm infections in humans needs to be further explored.
    Methodology/principal findings: As part of an open-label community based cluster-randomized trial in a tribal area in Tamil Nadu (India; 2013-2015), a total of 143 isolates of hookworm eggs from human stool were speciated based on a previously described PCR-RFLP methodology. The presence of hookworm DNA was confirmed in 119 of 143 human samples. N. americanus (100%) was the most prevalent species, followed by A. caninum (16.8%) and A. duodenale (8.4%). Because of the high prevalence of A. caninum in humans, dog samples were also collected to assess the prevalence of A. caninum in dogs. In 68 out of 77 canine stool samples the presence of hookworms was confirmed using PCR-RFLP. In dogs, both A. caninum (76.4%) and A. ceylanicum (27.9%) were identified. Additionally, to determine the contamination of soil with zoonotic hookworm larvae, topsoil was collected from defecating areas. Hookworm DNA was detected in 72 out of 78 soil samples that revealed presence of hookworm-like nematode larvae. In soil, different hookworm species were identified, with animal hookworms being more prevalent (A. ceylanicum: 60.2%, A. caninum: 29.4%, A. duodenale: 16.6%, N. americanus: 1.4%, A. braziliense: 1.4%).
    Conclusions/significance: In our study we regularly detected the presence of A. caninum DNA in the stool of humans. Whether this is the result of infection is currently unknown but it does warrant a closer look at dogs as a potential reservoir.
    MeSH term(s) Ancylostomatoidea/classification ; Animals ; DNA, Helminth/isolation & purification ; Dogs/parasitology ; Feces/parasitology ; Hookworm Infections/epidemiology ; Hookworm Infections/veterinary ; Humans ; India/epidemiology ; Phylogeny ; Polymerase Chain Reaction/veterinary ; Polymorphism, Restriction Fragment Length ; Soil/parasitology ; Species Specificity ; Zoonoses/epidemiology ; Zoonoses/parasitology
    Chemical Substances DNA, Helminth ; Soil
    Language English
    Publishing date 2016-08-03
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2429704-5
    ISSN 1935-2735 ; 1935-2735
    ISSN (online) 1935-2735
    ISSN 1935-2735
    DOI 10.1371/journal.pntd.0004891
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  8. Article ; Online: Occupational safety measures and morbidity among welders in Vellore, Southern India.

    Alexander, Vijay / Sindhu, Kulandaipalayam Natarajan C / Zechariah, Pradeep / Resu, Abigail Veravolu / Nair, Suryanarayan Rajendran / Kattula, Deepthi / Mohan, Venkata Raghava / Alex T, Reginald George

    International journal of occupational and environmental health

    2016  Volume 22, Issue 4, Page(s) 300–306

    Abstract: Background: Welders in the unorganized occupational sector in the economically developing world are exposed to respiratory, skin, eye, ear, and neurological problems exacerbated by non-usage of personal protective equipment (PPE).: Objective: To ... ...

    Abstract Background: Welders in the unorganized occupational sector in the economically developing world are exposed to respiratory, skin, eye, ear, and neurological problems exacerbated by non-usage of personal protective equipment (PPE).
    Objective: To study the frequency of health problems and the usage of PPE among welders in unorganized welding units in Vellore, India.
    Methods: A cross-sectional survey was conducted among 150 welders to determine the frequency of skin, ear, eye, and respiratory morbidity and the usage of PPE. A group of 150 non-welders were chosen for comparison.
    Results: Significant differences in the frequency of skin burns, redness, hyper pigmentation, itching, eye injuries, and sensorineural deafness were observed among the welders and non-welders (P < 0.001). Hypertension was noted in 12.6% of the welders as compared to 0.7% among the non-welders. None of the welders used appropriate PPE. For welders, low educational attainment was associated with an increased risk of eye injury (P < 0.05, OR = 0.29). There was also a significant difference between sensorineural deafness and a welder having less than 10 years of welding work experience (P < 0.001, OR = 18.18) which could probably be accounted for by the healthy worker effect.
    Conclusion: Welders in this sample experienced a significant skin, eye, and ear morbidity accentuated by the non-usage of PPE. All worked without formal training and were unaware of the safe working guidelines that exist, but are not implemented for the welders in India.
    MeSH term(s) Adult ; Burns/epidemiology ; Deafness/epidemiology ; Eye Injuries/epidemiology ; Humans ; India ; Male ; Middle Aged ; Occupational Exposure ; Occupational Health ; Personal Protective Equipment ; Surveys and Questionnaires ; Welding ; Young Adult
    Language English
    Publishing date 2016
    Publishing country England
    Document type Journal Article
    ZDB-ID 1262326-x
    ISSN 2049-3967 ; 1077-3525
    ISSN (online) 2049-3967
    ISSN 1077-3525
    DOI 10.1080/10773525.2016.1228287
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    Zs.A 4454: Show issues Location:
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  9. Article ; Online: Comparison of fieldworker interview and a pictorial diary method for recording morbidity of infants in semi-urban slums.

    Thomas, Rahul Jacob / Ramanujam, Karthikeyan / Velusamy, Vasanthakumar / Puthupalayam Kaliappan, Saravanakumar / Kattula, Deepthi / Muliyil, Jayaprakash / Kang, Gagandeep

    BMC public health

    2015  Volume 15, Page(s) 43

    Abstract: Background: Cohort studies conducted in low-income countries generally use trained fieldworkers for collecting data on home visits. In industrialised countries, researchers use less resource intensive methods, such as self-administered structured ... ...

    Abstract Background: Cohort studies conducted in low-income countries generally use trained fieldworkers for collecting data on home visits. In industrialised countries, researchers use less resource intensive methods, such as self-administered structured questionnaires or symptom diaries. This study compared and assessed the reliability of the data on diarrhoea, fever and cough/cold in children as obtained by a pictorial diary maintained by the mother and collected separately by a fieldworker.
    Methods: A sample of 205 children was randomly selected from an ongoing birth cohort study. Pictorial diaries were distributed weekly to mothers of study children who were asked to maintain a record of morbidity for four weeks. We compared the reliability and completeness of the data on diarrhoea, fever and cough/cold obtained by the two methods.
    Results: Of 205 participants, 186 (91%) ever made a record in the diary and 62 (30%) mothers maintained the diary for all 28 days. The prevalence-adjusted bias-adjusted kappa statistics for diarrhoea, fever, cough/cold and for a healthy child were 92%, 79%, 35% and 35% respectively.
    Conclusion: Diary recording was incomplete in the majority of households. When recorded, the morbidity data by the pictorial diary method for acute illnesses were reliable. Strategies are needed to address behavioural factors affecting maternal recording such that field studies can obtain accurate morbidity measurements with limited resources.
    MeSH term(s) Adult ; Child Mortality ; Child, Preschool ; Cohort Studies ; Data Collection/instrumentation ; Data Collection/methods ; Female ; Fever ; Health Personnel ; Humans ; India ; Infant ; Infant Mortality ; Interviews as Topic/methods ; Male ; Mothers ; Poverty Areas ; Prevalence ; Reproducibility of Results ; Surveys and Questionnaires ; Urban Population ; Young Adult
    Language English
    Publishing date 2015-01-31
    Publishing country England
    Document type Comparative Study ; Journal Article ; Research Support, N.I.H., Extramural
    ISSN 1471-2458
    ISSN (online) 1471-2458
    DOI 10.1186/s12889-015-1372-7
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  10. Article ; Online: Identification of Ancylostoma ceylanicum in children from a tribal community in Tamil Nadu, India using a semi-nested PCR-RFLP tool.

    George, Santosh / Kaliappan, Saravanakumar Puthupalayam / Kattula, Deepthi / Roy, Sheela / Geldhof, Peter / Kang, Gagandeep / Vercruysse, Jozef / Levecke, Bruno

    Transactions of the Royal Society of Tropical Medicine and Hygiene

    2015  Volume 109, Issue 4, Page(s) 283–285

    Abstract: Background: It is generally assumed that hookworm infections in humans are caused by Necator americanus and Ancylostoma duodenale. However, previous studies have also reported the presence of the animal hookworm A. ceylanicum in human stools.: Methods! ...

    Abstract Background: It is generally assumed that hookworm infections in humans are caused by Necator americanus and Ancylostoma duodenale. However, previous studies have also reported the presence of the animal hookworm A. ceylanicum in human stools.
    Methods: We determined hookworm infections in children in a tribal community in Tamil Nadu, India, using a semi-nested PCR-RFLP approach.
    Results: The results indicate that human species account for a majority of the hookworm infections (N. americanus 39/41 [95%]; A. duodenale 6/41 [15%]), whereas the animal hookworm A. ceylanicum only accounts for a minority of the infections (5%; 2/41).
    Conclusions: The results emphasize the need to consider zoonotic ancylostomiasis while developing strategies to control hookworm infections.
    MeSH term(s) Ancylostoma/genetics ; Ancylostoma/isolation & purification ; Ancylostoma/pathogenicity ; Ancylostomiasis/diagnosis ; Ancylostomiasis/epidemiology ; Ancylostomiasis/prevention & control ; Animals ; Child ; Child, Preschool ; Disease Reservoirs ; Dogs ; Feces/parasitology ; Humans ; India/epidemiology ; Molecular Sequence Data ; Polymerase Chain Reaction ; Polymorphism, Restriction Fragment Length ; Species Specificity ; Zoonoses/epidemiology ; Zoonoses/parasitology
    Language English
    Publishing date 2015-04
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 441375-1
    ISSN 1878-3503 ; 0035-9203
    ISSN (online) 1878-3503
    ISSN 0035-9203
    DOI 10.1093/trstmh/trv001
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