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  1. Article ; Online: Evaluation of the late life disability instrument in the lifestyle interventions and independence for elders pilot (LIFE-P) study

    Blair Steven N / Studenski Stephanie A / Jette Alan M / Fielding Roger / Katula Jeff A / Ip Edward H / Rejeski W Jack / Hsu Fang-Chi / Miller Michael E

    Health and Quality of Life Outcomes, Vol 8, Iss 1, p

    2010  Volume 115

    Abstract: Abstract Background The late life disability instrument (LLDI) was developed to assess limitations in instrumental and management roles using a small and restricted sample. In this paper we examine the measurement properties of the LLDI using data from ... ...

    Abstract Abstract Background The late life disability instrument (LLDI) was developed to assess limitations in instrumental and management roles using a small and restricted sample. In this paper we examine the measurement properties of the LLDI using data from the Lifestyle Interventions and Independence for Elders Pilot (LIFE-P) study. Methods LIFE-P participants, aged 70-89 years, were at elevated risk of disability. The 424 participants were enrolled at the Cooper Institute, Stanford University, University of Pittsburgh, and Wake Forest University. Physical activity and successful aging health education interventions were compared after 12-months of follow-up. Using factor analysis, we determined whether the LLDI's factor structure was comparable with that reported previously. We further examined how each item related to measured disability using item response theory (IRT). Results The factor structure for the limitation domain within the LLDI in the LIFE-P study did not corroborate previous findings. However, the factor structure using the abbreviated version was supported. Social and personal role factors were identified. IRT analysis revealed that each item in the social role factor provided a similar level of information, whereas the items in the personal role factor tended to provide different levels of information. Conclusions Within the context of community-based clinical intervention research in aged populations, an abbreviated version of the LLDI performed better than the full 16-item version. In addition, the personal subscale would benefit from additional research using IRT. Trial registration The protocol of LIFE-P is consistent with the principles of the Declaration of Helsinki and is registered at http://www.ClinicalTrials.gov (registration # NCT00116194).
    Keywords Computer applications to medicine. Medical informatics ; R858-859.7
    Subject code 306
    Language English
    Publishing date 2010-10-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Telephone interview for cognitive status (TICS) screening for clinical trials of physical activity and cognitive training: the seniors health and activity research program pilot (SHARP-P) study.

    Espeland, Mark A / Rapp, Stephen R / Katula, Jeff A / Andrews, Lee Ann / Felton, Deborah / Gaussoin, Sarah A / Dagenbach, Dale / Legault, Claudine / Jennings, Janine M / Sink, Kaycee M

    International journal of geriatric psychiatry

    2011  Volume 26, Issue 2, Page(s) 135–143

    Abstract: Objective: To examine the performance of the Telephone Interview for Cognitive Status (TICS) for identifying participants appropriate for trials of physical activity and cognitive training interventions.: Methods: Volunteers (N=343), ages 70-85 years, ...

    Abstract Objective: To examine the performance of the Telephone Interview for Cognitive Status (TICS) for identifying participants appropriate for trials of physical activity and cognitive training interventions.
    Methods: Volunteers (N=343), ages 70-85 years, who were being recruited for a pilot clinical trial on approaches to prevent cognitive decline, were administered TICS and required to score ≥ 31 prior to an invitation to attend clinic-based assessments. The frequencies of contraindications for physical activity and cognitive training interventions were tallied for individuals grouped by TICS scores. Relationships between TICS scores and other measures of cognitive function were described by scatterplots and correlation coefficients.
    Results: Eligibility criteria to identify candidates who were appropriate candidates for the trial interventions excluded 51.7% of the volunteers with TICS<31. TICS scores above this range were not strongly related to cognition or attendance at screening visits, however overall enrollment yields were approximately half for participants with TICS=31 versus TICS=41, and increased in a graded fashion throughout the range of scores.
    Conclusions: Use of TICS to define eligibility criteria in trials of physical activity and cognitive training interventions may not be worthwhile in that many individuals with low scores would already be eliminated by intervention-specific criteria and the relationship of TICS with clinic-based tests of cognitive function among appropriate candidates for these interventions may be weak. TICS may be most useful in these trials to identify candidates for oversampling in order to obtain a balanced cohort of participants at risk for cognitive decline.
    MeSH term(s) Aged ; Aged, 80 and over ; Cognition/physiology ; Cognition Disorders/diagnosis ; Cognition Disorders/prevention & control ; Cognitive Behavioral Therapy ; Exercise/psychology ; Female ; Geriatric Assessment/methods ; Humans ; Logistic Models ; Male ; Mass Screening/methods ; Physical Exertion ; Pilot Projects ; Remote Consultation/methods ; Telephone
    Language English
    Publishing date 2011-05-24
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 806736-3
    ISSN 1099-1166 ; 0885-6230
    ISSN (online) 1099-1166
    ISSN 0885-6230
    DOI 10.1002/gps.2503
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Evaluation of the late life disability instrument in the Lifestyle Interventions and Independence for Elders Pilot (LIFE-P) study.

    Hsu, Fang-Chi / Rejeski, W Jack / Ip, Edward H / Katula, Jeff A / Fielding, Roger / Jette, Alan M / Studenski, Stephanie A / Blair, Steven N / Miller, Michael E

    Health and quality of life outcomes

    2010  Volume 8, Page(s) 115

    Abstract: Background: The late life disability instrument (LLDI) was developed to assess limitations in instrumental and management roles using a small and restricted sample. In this paper we examine the measurement properties of the LLDI using data from the ... ...

    Abstract Background: The late life disability instrument (LLDI) was developed to assess limitations in instrumental and management roles using a small and restricted sample. In this paper we examine the measurement properties of the LLDI using data from the Lifestyle Interventions and Independence for Elders Pilot (LIFE-P) study.
    Methods: LIFE-P participants, aged 70-89 years, were at elevated risk of disability. The 424 participants were enrolled at the Cooper Institute, Stanford University, University of Pittsburgh, and Wake Forest University. Physical activity and successful aging health education interventions were compared after 12-months of follow-up. Using factor analysis, we determined whether the LLDI's factor structure was comparable with that reported previously. We further examined how each item related to measured disability using item response theory (IRT).
    Results: The factor structure for the limitation domain within the LLDI in the LIFE-P study did not corroborate previous findings. However, the factor structure using the abbreviated version was supported. Social and personal role factors were identified. IRT analysis revealed that each item in the social role factor provided a similar level of information, whereas the items in the personal role factor tended to provide different levels of information.
    Conclusions: Within the context of community-based clinical intervention research in aged populations, an abbreviated version of the LLDI performed better than the full 16-item version. In addition, the personal subscale would benefit from additional research using IRT.
    Trial registration: The protocol of LIFE-P is consistent with the principles of the Declaration of Helsinki and is registered at http://www.ClinicalTrials.gov (registration # NCT00116194).
    MeSH term(s) Aged ; Aged, 80 and over ; Disability Evaluation ; Factor Analysis, Statistical ; Female ; Follow-Up Studies ; Geriatric Assessment ; Humans ; Life Style ; Male ; Middle Aged ; Pennsylvania ; Pilot Projects ; Quality of Life ; Surveys and Questionnaires
    Language English
    Publishing date 2010-10-06
    Publishing country England
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ISSN 1477-7525
    ISSN (online) 1477-7525
    DOI 10.1186/1477-7525-8-115
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Effects of exercise on mobility in obese and nonobese older adults.

    Manini, Todd M / Newman, Anne B / Fielding, Roger / Blair, Steven N / Perri, Michael G / Anton, Stephen D / Goodpaster, Bret C / Katula, Jeff A / Rejeski, Walter J / Kritchevsky, Stephen B / Hsu, Fang-Chi / Pahor, Marco / King, Abby C

    Obesity (Silver Spring, Md.)

    2009  Volume 18, Issue 6, Page(s) 1168–1175

    Abstract: Coupled with an aging society, the rising obesity prevalence is likely to increase the future burden of physical disability. We set out to determine whether obesity modified the effects of a physical activity (PA) intervention designed to prevent ... ...

    Abstract Coupled with an aging society, the rising obesity prevalence is likely to increase the future burden of physical disability. We set out to determine whether obesity modified the effects of a physical activity (PA) intervention designed to prevent mobility disability in older adults. Older adults at risk for disability (N = 424, age range: 70-88 years) were randomized to a 12 month PA intervention involving moderate intensity aerobic, strength, balance, and flexibility exercise (150 min per week) or a successful aging (SA) intervention involving weekly educational workshops. Individuals were stratified by obesity using a BMI >or=30 (n = 179). Mobility function was assessed as usual walking speed over 400 m and scores on a short physical performance battery (SPPB), which includes short distance walking, balance tests, and chair rises. Over 12 months of supervised training, the attendance and total amount of walking time was similar between obese and nonobese subjects and no weight change was observed. Nonobese participants in the PA group had significant increases in 400-m walking speed (+1.5%), whereas their counterparts in the SA group declined (-4.3%). In contrast, obese individuals declined regardless of their assigned intervention group (PA: -3.1%; SA: -4.9%). SPPB scores, however, increased following PA in both obese (PA: +13.5%; SA: +2.5%) and nonobese older adults (PA: +18.6%; SA: +6.1%). A moderate intensity PA intervention improves physical function in older adults, but the positive benefits are attenuated with obesity.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Body Mass Index ; Clinical Trials, Phase III as Topic ; Exercise/physiology ; Female ; Humans ; Ideal Body Weight/physiology ; Life Style ; Male ; Mobility Limitation ; Obesity/complications ; Obesity/physiopathology ; Obesity/therapy ; Patient Compliance/statistics & numerical data ; Pilot Projects ; Walking/physiology
    Language English
    Publishing date 2009-10-15
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2230457-5
    ISSN 1930-739X ; 1071-7323 ; 1930-7381
    ISSN (online) 1930-739X
    ISSN 1071-7323 ; 1930-7381
    DOI 10.1038/oby.2009.317
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Effects of Exercise on Mobility in Obese and Nonobese Older Adults

    Manini, Todd M. / Newman, Anne B. / Fielding, Roger / Blair, Steven N. / Perri, Michael G. / Anton, Stephen D. / Goodpaster, Bret C. / Katula, Jeff A. / Rejeski, Walter J. / Kritchevsky, Stephen B. / Hsu, Fang-Chi / Pahor, Marco

    Obesity

    Volume v. 18,, Issue no. 6

    Abstract: Coupled with an aging society, the rising obesity prevalence is likely to increase the future burden of physical disability. We set out to determine whether obesity modified the effects of a physical activity (PA) intervention designed to prevent ... ...

    Abstract Coupled with an aging society, the rising obesity prevalence is likely to increase the future burden of physical disability. We set out to determine whether obesity modified the effects of a physical activity (PA) intervention designed to prevent mobility disability in older adults. Older adults at risk for disability (N = 424, age range: 70–88 years) were randomized to a 12 month PA intervention involving moderate intensity aerobic, strength, balance, and flexibility exercise (150 min per week) or a successful aging (SA) intervention involving weekly educational workshops. Individuals were stratified by obesity using a BMI ≥30 (n = 179). Mobility function was assessed as usual walking speed over 400 m and scores on a short physical performance battery (SPPB), which includes short distance walking, balance tests, and chair rises. Over 12 months of supervised training, the attendance and total amount of walking time was similar between obese and nonobese subjects and no weight change was observed. Nonobese participants in the PA group had significant increases in 400-m walking speed (+1.5%), whereas their counterparts in the SA group declined (−4.3%). In contrast, obese individuals declined regardless of their assigned intervention group (PA: −3.1%; SA: −4.9%). SPPB scores, however, increased following PA in both obese (PA: +13.5%; SA: +2.5%) and nonobese older adults (PA: +18.6%; SA: +6.1%). A moderate intensity PA intervention improves physical function in older adults, but the positive benefits are attenuated with obesity.
    Keywords risk ; walking ; society ; obesity ; exercise ; body mass index ; elderly ; exercise test
    Language English
    Document type Article
    ISSN 1930-7381
    Database AGRIS - International Information System for the Agricultural Sciences and Technology

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