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  1. Book ; Conference proceedings: New horizons in antibody induction therapy

    Kaufman, Dixon B.

    symposium [in March 2003 in Chicago, IL]

    (Transplantation reviews ; 17,4, Suppl. [1])

    2003  

    Author's details guest ed. Dixon B. Kaufman
    Series title Transplantation reviews ; 17,4, Suppl. [1]
    Collection
    Language English
    Size S29 S. : Ill., graph. Darst.
    Publisher Saunders
    Publishing place S.l.
    Publishing country United States
    Document type Book ; Conference proceedings
    HBZ-ID HT013866045
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Se 1072 -17,4,Suppl.- verfügbar in Königswinter Königswinter

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  2. Article ; Online: Master protocol to assess the long-term safety in kidney transplant recipients who previously received Medeor's cellular immunotherapy products: the MDR-105-SAE.

    Kant, Sam / Kaufman, Dixon B / Micsa, Lenuta / Brennan, Daniel C

    Trials

    2023  Volume 24, Issue 1, Page(s) 178

    Abstract: Background: Immunosuppression in transplantation continues to be associated with a multitude of adverse effects. Induction of immune tolerance may be a viable strategy to reduce dependence on immunosuppression. Various trials are currently underway to ... ...

    Abstract Background: Immunosuppression in transplantation continues to be associated with a multitude of adverse effects. Induction of immune tolerance may be a viable strategy to reduce dependence on immunosuppression. Various trials are currently underway to assess the efficacy of this strategy. However, long-term safety data for these immune tolerance regimes has yet to be established.
    Methods/design: At the completion of primary follow-up of various Medeor kidney transplant studies, subjects receiving cellular immunotherapy products will be followed annually as per protocolized schedule for up to an additional 84 months (7 years) to evaluate long-term safety. Long-term safety will be assessed by summarizing incidence of serious adverse events, adverse events leading to study withdrawal and hospitalization rates.
    Discussion: This extension study will be an important step in evaluating safety issues pertaining to immune tolerance regimens, long-term effects of which are largely unknown. These data are essential for furthering an unrealized goal of kidney transplantation- graft longevity without the adverse effects from long-term immunosuppression. The study design utilizes the methodology of a master protocol, wherein multiple therapies can be assessed simultaneously with accompanied gathering of long-term safety data.
    MeSH term(s) Humans ; Kidney Transplantation/adverse effects ; Immunosuppression Therapy/methods ; Immunosuppressive Agents/adverse effects ; Graft Rejection
    Chemical Substances Immunosuppressive Agents
    Language English
    Publishing date 2023-03-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2040523-6
    ISSN 1745-6215 ; 1468-6694 ; 1745-6215
    ISSN (online) 1745-6215
    ISSN 1468-6694 ; 1745-6215
    DOI 10.1186/s13063-023-07204-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Foreword.

    Kaufman, Dixon B

    Chimerism

    2015  Volume 6, Issue 1-2, Page(s) 1

    Language English
    Publishing date 2015-04-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2660084-5
    ISSN 1938-1964 ; 1938-1956
    ISSN (online) 1938-1964
    ISSN 1938-1956
    DOI 10.1080/19381956.2015.1176759
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Early Increases in Posttransplant Pancreatic Enzymes Are Associated With Surgical Complications But Not Graft Failure Among Pancreas Transplant Recipients.

    Parajuli, Sandesh / Leverson, Glen E / Kaufman, Dixon B / Djamali, Arjang / Welch, Bridget M / Sollinger, Hans W / Mandelbrot, Didier A / Odorico, Jon S

    Pancreas

    2023  Volume 51, Issue 10, Page(s) 1381–1387

    Abstract: Objectives: This study aimed to find the association between immediate postoperative increases in pancreatic enzymes and posttransplant complications among pancreas transplant recipients (PTRs).: Methods: We analyzed all PTRs transplanted at the ... ...

    Abstract Objectives: This study aimed to find the association between immediate postoperative increases in pancreatic enzymes and posttransplant complications among pancreas transplant recipients (PTRs).
    Methods: We analyzed all PTRs transplanted at the University of Wisconsin between June 2009 and September 2018. Enzyme levels were presented as a ratio of absolute numbers to the upper limit of normal value, with value >1 considered as abnormal. We specifically evaluated bleeding, fluid collections, and thrombosis complications based on the amylase or lipase ratios on day 1 (Amylase1, Lipase1) and maximum ratios within 5 days of transplant (Amylasemax, Lipasemax). For early complications, we focused on technical complications that occurred within 90 days of transplant. For long-term outcomes, we assessed patient and graft survival, and rejections.
    Results: There were a total of 443 PTRs, 287 were simultaneous pancreas and kidney recipients, and 156 were solitary pancreas recipients. Higher Amylase1, Liplase1, Amylasemax, and Lipasemax were associated with an increase in early complications, mainly need for pancreatectomy, fluid collections, bleeding complications, or graft thrombosis, particularly in the solitary pancreas group.
    Conclusions: Our finding suggests that cases of early perioperative enzyme increase merit consideration for early imaging investigation to mitigate detrimental outcomes.
    MeSH term(s) Humans ; Pancreas Transplantation/adverse effects ; Pancreas Transplantation/methods ; Transplant Recipients ; Kidney Transplantation/adverse effects ; Kidney Transplantation/methods ; Pancreas/surgery ; Thrombosis/etiology ; Graft Survival ; Postoperative Complications/etiology ; Graft Rejection
    Language English
    Publishing date 2023-04-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 632831-3
    ISSN 1536-4828 ; 0885-3177
    ISSN (online) 1536-4828
    ISSN 0885-3177
    DOI 10.1097/MPA.0000000000002187
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2160: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Immunosuppression-Free Kidney Transplantation: Advancing New Treatments by Building on Our Past Foundations.

    Kaufman, Dixon B / Hematti, Peiman / Golden, Robert N

    WMJ : official publication of the State Medical Society of Wisconsin

    2019  Volume 118, Issue 3, Page(s) 146–147

    MeSH term(s) Humans ; Immunosuppression ; Kidney Transplantation/methods ; Schools, Medical ; Wisconsin
    Language English
    Publishing date 2019-10-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 441051-8
    ISSN 2379-3961 ; 0043-6542 ; 1098-1861
    ISSN (online) 2379-3961
    ISSN 0043-6542 ; 1098-1861
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 225: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Early allogeneic immune modulation after establishment of donor hematopoietic cell-induced mixed chimerism in a nonhuman primate kidney transplant model.

    Little, Christopher J / Kim, Steven C / Fechner, John H / Post, Jen / Coonen, Jennifer / Chlebeck, Peter / Winslow, Max / Kobuzi, Dennis / Strober, Samuel / Kaufman, Dixon B

    Frontiers in immunology

    2024  Volume 15, Page(s) 1343616

    Abstract: Background: Mixed lymphohematopoietic chimerism is a proven strategy for achieving operational transplant tolerance, though the underlying immunologic mechanisms are incompletely understood.: Methods: A post-transplant, non-myeloablative, tomotherapy- ...

    Abstract Background: Mixed lymphohematopoietic chimerism is a proven strategy for achieving operational transplant tolerance, though the underlying immunologic mechanisms are incompletely understood.
    Methods: A post-transplant, non-myeloablative, tomotherapy-based total lymphoid (TLI) irradiation protocol combined with anti-thymocyte globulin and T cell co-stimulatory blockade (belatacept) induction was applied to a 3-5 MHC antigen mismatched rhesus macaque kidney and hematopoietic cell transplant model. Mechanistic investigations of early (60 days post-transplant) allogeneic immune modulation induced by mixed chimerism were conducted.
    Results: Chimeric animals demonstrated expansion of circulating and graft-infiltrating CD4+CD25+Foxp3+ regulatory T cells (Tregs), as well as increased differentiation of allo-protective CD8+ T cell phenotypes compared to naïve and non-chimeric animals.
    Conclusions: These studies demonstrated that donor immune cell engraftment was associated with early immunomodulation via mechanisms of homeostatic expansion of Tregs and early PD-1 upregulation among CD8+ T effector memory cells. These responses may contribute to TLI-based mixed chimerism-induced allogenic tolerance.
    MeSH term(s) Animals ; Hematopoietic Stem Cell Transplantation/methods ; Transplantation, Homologous ; Kidney Transplantation ; Chimerism ; Macaca mulatta ; Programmed Cell Death 1 Receptor
    Chemical Substances Programmed Cell Death 1 Receptor
    Language English
    Publishing date 2024-01-22
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2024.1343616
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Digital Image Analysis to Assess Quantity and Morphological Quality of Isolated Pancreatic Islets.

    Wang, Ling-Jia / Kaufman, Dixon B

    Cell transplantation

    2016  Volume 25, Issue 7, Page(s) 1219–1225

    Abstract: Quantity and quality assessment of human pancreatic islets are essential processes to define a safe and potent quality product used for clinical transplantation. The conventional method of manual assessment has been used in the field for longer than two ... ...

    Abstract Quantity and quality assessment of human pancreatic islets are essential processes to define a safe and potent quality product used for clinical transplantation. The conventional method of manual assessment has been used in the field for longer than two decades. The high degree of variability in product quantity and lack of archival imaging records of the product for verification are two major disadvantages of using the manual method for quantity and quality assessment of human pancreatic islets. Investigators have developed promising new methods for technical improvement. In this study, we briefly review the published methods and highlight the advantages of digital imaging analysis (DIA) when compared to the manual method. The application of DIA reduces measurement variability and increases the precision of islet equivalent (IEQ) determination for batch analysis. It produces images that can be archived for retrospective analysis and validation, and the data can be transmitted electronically for off-site analysis. These features are important for quality pancreatic islet assessment and are consistent with FDA requirements of current good manufacturing practice for clinical islet transplantation.
    MeSH term(s) Animals ; Color ; Humans ; Image Processing, Computer-Assisted/methods ; Islets of Langerhans/anatomy & histology
    Language English
    Publishing date 2016
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1135816-6
    ISSN 1555-3892 ; 0963-6897
    ISSN (online) 1555-3892
    ISSN 0963-6897
    DOI 10.3727/096368915X689947
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3556: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Emergence of naturally occurring scaffolds for cell transplantation in type 1 diabetes.

    Kaufman, Dixon B / Rink, Jonathan S

    Pediatric transplantation

    2015  Volume 19, Issue 4, Page(s) 345–347

    MeSH term(s) Animals ; Cell Culture Techniques ; Coculture Techniques ; Diabetes Mellitus, Experimental/blood ; Diabetes Mellitus, Type 1/blood ; Female ; Insulin-Secreting Cells/cytology ; Male
    Language English
    Publishing date 2015-06
    Publishing country Denmark
    Document type Comment ; Editorial
    ZDB-ID 1390284-2
    ISSN 1399-3046 ; 1397-3142
    ISSN (online) 1399-3046
    ISSN 1397-3142
    DOI 10.1111/petr.12451
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    Zs.A 4947: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Pancreas-after-kidney transplantation: to have and not have not.

    Kaufman, Dixon B

    Clinical transplantation

    2009  Volume 23, Issue 4, Page(s) 435–436

    MeSH term(s) Cadaver ; Diabetic Nephropathies/surgery ; Humans ; Kidney Transplantation ; Living Donors ; Pancreas Transplantation ; Survival Analysis ; Tissue and Organ Procurement/standards ; Waiting Lists
    Language English
    Publishing date 2009-08
    Publishing country Denmark
    Document type Comment ; Editorial
    ZDB-ID 639001-8
    ISSN 1399-0012 ; 0902-0063
    ISSN (online) 1399-0012
    ISSN 0902-0063
    DOI 10.1111/j.1399-0012.2009.01032.x
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2204: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Isolated pancreas transplantation: Is rank list position related to outcomes of imported grafts?

    Adler, Joel T / Redfield, Robert R / Kaufman, Dixon B / Odorico, Jon S

    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

    2019  Volume 19, Issue 11, Page(s) 3124–3130

    Abstract: Transplant centers may decline an import pancreas offer based on demographics and laboratory test results, without information on actual gland quality. The relationship between position on the match run, indicative of the number of centers that chose not ...

    Abstract Transplant centers may decline an import pancreas offer based on demographics and laboratory test results, without information on actual gland quality. The relationship between position on the match run, indicative of the number of centers that chose not to use a pancreas, and patient and death-censored graft survival, is not known. We studied all 199 isolated pancreas grafts transplanted at the University of Wisconsin since July 2000 and compared overall patient and death-censored graft survival based on import vs local status. Of the 199 isolated pancreas transplants, 184 (92.5%) were imported from another donor service area with a median match rank of 49 (interquartile range 14-129). Median cold ischemia time was longer for imported pancreata (16.6 vs 13.4 hours, P = .02). In multivariate Cox modeling, there was no association with position on the rank list and patient (P = .44) or death-censored graft survival (P = .99). There was an overall rate of 6.5% of graft failure within 30 days; however, there was no association with position on the rank list and graft failure at 30 days (P = .33). Although the logistics may be challenging, sound judgment to accept offers independent of prior centers' decisions can result in quality utilization of imported pancreata.
    MeSH term(s) Adult ; Female ; Follow-Up Studies ; Graft Rejection/etiology ; Graft Rejection/mortality ; Graft Survival ; Histocompatibility Testing/standards ; Humans ; Male ; Middle Aged ; Pancreas Transplantation/adverse effects ; Pancreas Transplantation/mortality ; Prognosis ; Retrospective Studies ; Risk Factors ; Survival Rate ; Tissue Donors/supply & distribution ; Tissue and Organ Procurement/statistics & numerical data ; Waiting Lists/mortality
    Language English
    Publishing date 2019-05-07
    Publishing country United States
    Document type Clinical Trial ; Journal Article
    ZDB-ID 2060594-8
    ISSN 1600-6143 ; 1600-6135
    ISSN (online) 1600-6143
    ISSN 1600-6135
    DOI 10.1111/ajt.15387
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5542: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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