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  1. Article ; Online: Introducing individual sentience profiles in nonhuman primate neuroscience research.

    Kaufmann, Angelica

    Current research in neurobiology

    2023  Volume 5, Page(s) 100104

    Abstract: The Animal Research Declaration is committed to establishing cohesive and rigorous ethical standards to safeguard the welfare of nonhuman primates (NHPs) engaged in neuroscience research (Petkov et al., 2022 this issue). As part of this mission, there is ...

    Abstract The Animal Research Declaration is committed to establishing cohesive and rigorous ethical standards to safeguard the welfare of nonhuman primates (NHPs) engaged in neuroscience research (Petkov et al., 2022 this issue). As part of this mission, there is an expanding dialogue amongst neuroscientists, philosophers, and policymakers, that is centred on diverse aspects of animal welfare and scientific practice. This paper emphasises the necessity of integrating the assessment of animal sentience into the declaration. Animal sentience, in this context, refers to the recognized capacity that animals have for various kinds of subjective experience, with an associated positive or negative valence (Browning and Birch, 2022). Accordingly, NHP neuroscience researchers should work toward instituting a standardised approach for evaluating what can be termed "individual sentience profiles," representing the unique manner in which an individual NHP experiences specific events or environments. The adoption of this novel parameter would serve a triad of indispensable purposes: enhancing NHP welfare throughout research involvement, elevating the quality of life for NHPs in captivity, and refining the calibre of research outcomes.
    Language English
    Publishing date 2023-07-29
    Publishing country Netherlands
    Document type Journal Article ; Review
    ISSN 2665-945X
    ISSN (online) 2665-945X
    DOI 10.1016/j.crneur.2023.100104
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Experience-Specific Dimensions of Consciousness (Observable in Flexible and Spontaneous Action Planning Among Animals).

    Kaufmann, Angelica

    Frontiers in systems neuroscience

    2021  Volume 15, Page(s) 741579

    Abstract: The multidimensional framework to the study of consciousness, which comes as an alternative to a single sliding scale model, offers a set of experimental paradigms for investigating dimensions of animal consciousness, acknowledging the compelling urge ... ...

    Abstract The multidimensional framework to the study of consciousness, which comes as an alternative to a single sliding scale model, offers a set of experimental paradigms for investigating dimensions of animal consciousness, acknowledging the compelling urge for a novel approach. One of these dimensions investigates whether non-human animals can flexibly and spontaneously plan for a future event, and for future desires, without relying on reinforcement learning. This is a critical question since different intentional structures for action in non-human animals are described as served by different neural mechanisms underpinning the capacity to represent temporal properties. And a lack of appreciation of this variety of intentional structures and neural correlates has led many experts to doubt that animals have access to temporal reasoning and to not recognize temporality as a mark of consciousness, and as a psychological resource for their life. With respect to this, there is a significant body of ethological evidence for planning abilities in non-human animals, too often overlooked, and that instead should be taken into serious account. This could contribute to assigning consciousness profiles, across and within species, that should be tailored according to an implemented and expansive use of the multidimensional framework. This cannot be fully operational in the absence of an additional tag to its dimensions of variations: the
    Language English
    Publishing date 2021-09-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2453005-0
    ISSN 1662-5137
    ISSN 1662-5137
    DOI 10.3389/fnsys.2021.741579
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Therapieoptionen der weiblichen Belastungsharninkontinenz.

    Kaufmann, Albert

    Aktuelle Urologie

    2021  Volume 52, Issue 3, Page(s) 245–254

    Abstract: Stress urinary incontinence in female patients is characterised by loss of urine without the need to urinate. Causes are manifold and require a good knowledge of the pelvic floor structures and the functionality of the bladder's occlusion system. Before ... ...

    Title translation Therapeutic options in female stress urinary incontinence.
    Abstract Stress urinary incontinence in female patients is characterised by loss of urine without the need to urinate. Causes are manifold and require a good knowledge of the pelvic floor structures and the functionality of the bladder's occlusion system. Before any treatment can be initiated, differentiated diagnostic investigation must uncover the causes in order to be able to show incontinent women the ideal therapeutic options. In addition to conservative treatment strategies, there are several surgical alternatives available that can be used depending on the functional and/or anatomical deficit. Surgical correction produces good results, although a minor rate of possible complications must be accepted.
    MeSH term(s) Exercise Therapy ; Female ; Humans ; Pelvic Floor ; Urinary Incontinence, Stress/diagnosis ; Urinary Incontinence, Stress/surgery
    Language German
    Publishing date 2021-04-19
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 124847-9
    ISSN 1438-8820 ; 0001-7868
    ISSN (online) 1438-8820
    ISSN 0001-7868
    DOI 10.1055/a-1439-9628
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Neurogene, nicht-obstruktive Harnretention: Diagnose und Therapie.

    Kaufmann, Albert / Leitner, Lorenz

    Aktuelle Urologie

    2024  

    Abstract: Neurogenic, non-obstructive urinary retention has a varied aetiology. The condition can be caused by central-nervous diseases as well as by disorders of the peripheral nervous system. The formation of residual urine may lead to considerable problems that ...

    Title translation Neurogenic, non-obstructive urinary retention: diagnosis and treatment.
    Abstract Neurogenic, non-obstructive urinary retention has a varied aetiology. The condition can be caused by central-nervous diseases as well as by disorders of the peripheral nervous system. The formation of residual urine may lead to considerable problems that can have a significant impact on a patient's everyday life. A treatment appropriate for the lower urinary tract dysfunction and suited to the patient's situation in life is only possible if a differentiated diagnostic evaluation has been performed. Both conservative and surgical therapeutic strategies are available, while drug treatment approaches are less relevant. Neuromodulative procedures are particularly suitable for causal treatment of the dysfunction. For patients requiring artificial bladder voiding, intermittent self-catheterization is generally preferable to using an indwelling catheter.
    Language German
    Publishing date 2024-04-24
    Publishing country Germany
    Document type English Abstract ; Journal Article
    ZDB-ID 124847-9
    ISSN 1438-8820 ; 0001-7868
    ISSN (online) 1438-8820
    ISSN 0001-7868
    DOI 10.1055/a-2266-4721
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Urodynamik vor operativer Inkontinenztherapie : Was ist sinnvoll?

    Kaufmann, A

    Der Urologe. Ausg. A

    2017  Volume 56, Issue 12, Page(s) 1539–1547

    Abstract: Surgery is often necessary after failure of conservative therapy for urinary incontinence. Guidelines recommend urodynamic studies before surgery. A distinction is made between non-invasive (uroflowmetry) and invasive methods (cystometry and pressure- ... ...

    Title translation Urodynamic studies prior to urinary incontinence surgery : What is useful?
    Abstract Surgery is often necessary after failure of conservative therapy for urinary incontinence. Guidelines recommend urodynamic studies before surgery. A distinction is made between non-invasive (uroflowmetry) and invasive methods (cystometry and pressure-flow study, if necessary as combined videourodynamics, as well as urethral pressure profile). All examinations serve to objectify and quantify the symptoms, to correctly assign symptoms to the pathophysiology and anatomy as well as to identify risk factors, which often have a significant influence on the success of surgical therapy. Given appropriate experience, complications and often significant sequelae of bladder dysfunction affecting the patient's quality of life and life expectancy can be recognized. Urodynamic studies are performed to help narrow down potential diagnoses, to develop therapeutic strategies, and to obtain prognostic parameters. The following article is intended to provide some support.
    MeSH term(s) Aged ; Benzilates/therapeutic use ; Combined Modality Therapy ; Diagnosis, Differential ; Female ; Guideline Adherence ; Humans ; Male ; Nortropanes/therapeutic use ; Postoperative Complications/etiology ; Postoperative Complications/physiopathology ; Postoperative Complications/surgery ; Prostatectomy ; Risk Factors ; Suburethral Slings ; Urinary Bladder/drug effects ; Urinary Bladder/physiopathology ; Urinary Bladder, Overactive/etiology ; Urinary Bladder, Overactive/physiopathology ; Urinary Bladder, Overactive/surgery ; Urinary Incontinence/etiology ; Urinary Incontinence/physiopathology ; Urinary Incontinence/surgery ; Urinary Incontinence, Stress/etiology ; Urinary Incontinence, Stress/physiopathology ; Urinary Incontinence, Stress/surgery ; Urodynamics/physiology ; Video Recording
    Chemical Substances Benzilates ; Nortropanes ; trospium chloride (1E6682427E)
    Language German
    Publishing date 2017-10-27
    Publishing country Germany
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 204041-4
    ISSN 1433-0563 ; 0340-2592 ; 0375-4685
    ISSN (online) 1433-0563
    ISSN 0340-2592 ; 0375-4685
    DOI 10.1007/s00120-017-0530-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: [Neurogenic detrusor overactivity and onabotulinumtoxin A (Botox

    Kaufmann, A

    Der Urologe. Ausg. A

    2017  Volume 56, Issue 2, Page(s) 241–242

    Title translation Neurogene Detrusorhyperaktivität und Onabotulinumtoxin A (Botox
    MeSH term(s) Botulinum Toxins, Type A ; Humans ; Neuromuscular Agents ; Urinary Bladder, Neurogenic ; Urinary Bladder, Overactive ; Urodynamics
    Chemical Substances Neuromuscular Agents ; onabotulinumtoxinA (E211KPY694) ; Botulinum Toxins, Type A (EC 3.4.24.69)
    Language German
    Publishing date 2017-02
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 204041-4
    ISSN 1433-0563 ; 0340-2592 ; 0375-4685
    ISSN (online) 1433-0563
    ISSN 0340-2592 ; 0375-4685
    DOI 10.1007/s00120-016-0304-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Auf den Bio-Messen 2022: das Demeter-Regional-Regal. Demeter-Produkte in Szene setzen

    Kaufmann, Angelika

    Lebendige Erde

    2022  Volume 73, Issue 4, Page(s) 15

    Language German
    Document type Article
    ZDB-ID 537115-6
    ISSN 0023-9917
    Database Current Contents Nutrition, Environment, Agriculture

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  8. Article ; Online: Is that all there is? Or is chimpanzees group hunt "fair" enough?

    Kaufmann, Angelica

    The Behavioral and brain sciences

    2020  Volume 43, Page(s) e74

    Abstract: Tomasello claims that we lack convincing evidence that nonhuman animals manifest a sense of moral obligation (i.e., the concept of fairness) in their group activities. The philosophical analysis of distinctive evidence from ethology, namely group hunting ...

    Abstract Tomasello claims that we lack convincing evidence that nonhuman animals manifest a sense of moral obligation (i.e., the concept of fairness) in their group activities. The philosophical analysis of distinctive evidence from ethology, namely group hunting practices among chimpanzees, can help the author appreciate the distinctive character of this behaviour as a display of fairness put into practice.
    MeSH term(s) Animals ; Morals ; Pan troglodytes
    Language English
    Publishing date 2020-04-30
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 423721-3
    ISSN 1469-1825 ; 0140-525X
    ISSN (online) 1469-1825
    ISSN 0140-525X
    DOI 10.1017/S0140525X19002309
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: High-resolution mass spectrometry for bioanalytical applications: Is this the new gold standard?

    Kaufmann, Anton

    Journal of mass spectrometry : JMS

    2020  Volume 55, Issue 9, Page(s) e4533

    Abstract: Liquid chromatography coupled to quadrupole-based tandem mass spectrometry (QqQ) is termed the "gold standard" for bioanalytical applications because of its unpreceded selectivity, sensitivity, and the ruggedness of the technology. More recently, however, ...

    Abstract Liquid chromatography coupled to quadrupole-based tandem mass spectrometry (QqQ) is termed the "gold standard" for bioanalytical applications because of its unpreceded selectivity, sensitivity, and the ruggedness of the technology. More recently, however, high-resolution mass spectrometry (HRMS) has become increasingly popular for bioanalytical applications. Nonetheless, this technique is still viewed, either as a screening technology or as a research tool. Although HRMS is actively discussed during scientific conferences, it is yet to be widely utilised in routine laboratory settings and there remains a reluctance to use HRMS for quantitative measurements in regulated environments. This paper does not aim to comprehensively describe the potential of the latest HRMS technology, but rather, it focuses on what results can be obtained and outlines the author's experiences over a period of many years of the routine application of various forms of HRMS instrumentation. Fifteen years ago, some nine different QqQ methods were used in the author's laboratory to analyse a variety of different veterinary drug resides. Today, many more analytes are quantified by seven HRMS methods and just three QqQ methods remain in use for the analysis of a small set of compounds yet to be upgraded to HRMS analysis. This continual upgrading and migration of analytical methods were accompanied by regularly participating in laboratory proficiency tests (PTs). The PT reports (covering a range of analytes and analytical methods) were used to compare the accuracy of HRMS- versus QqQ-based measurements. In the second part of this paper, the particular strengths and limitations of HRMS for both method development and routine measurements are critically discussed. This also includes some anecdotal experiences encountered when replacing QqQ assays with HRMS methods.
    MeSH term(s) Animals ; Chromatography, Liquid/methods ; Food Additives/analysis ; Food Analysis/methods ; Mass Spectrometry/methods ; Mass Spectrometry/standards ; Mass Spectrometry/trends ; Pesticide Residues/analysis ; Quality Control ; Reference Standards ; Reproducibility of Results ; Sensitivity and Specificity ; Tandem Mass Spectrometry/methods ; Time Factors
    Chemical Substances Food Additives ; Pesticide Residues
    Language English
    Publishing date 2020-06-16
    Publishing country England
    Document type Comparative Study ; Journal Article
    ZDB-ID 1221763-3
    ISSN 1096-9888 ; 1076-5174
    ISSN (online) 1096-9888
    ISSN 1076-5174
    DOI 10.1002/jms.4533
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: The use of UHPLC, IMS, and HRMS in multiresidue analytical methods: A critical review.

    Kaufmann, Anton

    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

    2020  Volume 1158, Page(s) 122369

    Abstract: Residue chemists who analyse pesticides in vegetables or veterinary drugs in animal-based food are currently facing a situation where there is a requirement to detect more and more compounds at lower and lower concentrations. Conventional tandem ... ...

    Abstract Residue chemists who analyse pesticides in vegetables or veterinary drugs in animal-based food are currently facing a situation where there is a requirement to detect more and more compounds at lower and lower concentrations. Conventional tandem quadrupole instruments provide sufficient sensitivity, but speed and selectivity appear as future limitations. This will become an even larger issue when there is a need to not only detect active compounds but also their degradation products and metabolites. This will likely lead to a situation in which the conventional targeted approach must be expanded or augmented by a certain non-targeted strategy. High-resolution mass spectrometry provides such capabilities, but it frequently requires an additional degree of selectivity for the unequivocal confirmation of analytes present at trace levels in highly complex and variable food matrices. The hyphenation of ultrahigh performance liquid chromatography with ion mobility and high-resolution mass spectrometry provides analytical chemists with a new tool for performing such a demanding multiresidue analysis. The objective of this paper is to investigate the benefits of the added ion mobility dimension as well as to critically discuss the current limitations of this commercially available technology.
    MeSH term(s) Chromatography, High Pressure Liquid ; Drug Residues/analysis ; Food Analysis ; Mass Spectrometry ; Pesticide Residues/analysis ; Veterinary Drugs/analysis
    Chemical Substances Pesticide Residues ; Veterinary Drugs
    Language English
    Publishing date 2020-10-01
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 1180823-8
    ISSN 1873-376X ; 0378-4347 ; 1570-0232 ; 1387-2273
    ISSN (online) 1873-376X
    ISSN 0378-4347 ; 1570-0232 ; 1387-2273
    DOI 10.1016/j.jchromb.2020.122369
    Database MEDical Literature Analysis and Retrieval System OnLINE

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