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  1. Book ; Online: Connecting the Dots Between Inflammation and the Inner Workings of Programmed Cell Death

    Kaufmann, Thomas / Wei-Lynn Wong, W.

    2020  

    Keywords Science: general issues ; Biology, life sciences ; apoptosis ; necroptosis ; pyroptosis ; mitochondria ; Bcl-2
    Size 1 electronic resource (134 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021231444
    ISBN 9782889636952 ; 288963695X
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book: 75 years of forensic medicine in Mainz - from barrack No. 18 to the high-tech institute

    Becker, Jürgen / Kaufmann, Thomas / Mattern, Rainer / Riepert, Thomas / Rittner, Christian / Schneider, Peter M. / Röhrich, Jörg

    (Rechtsmedizin)

    2023  

    Author's details Christian Rittner, Peter M. Schneider, Jörg Röhrich (eds.)
    Series title Rechtsmedizin
    Keywords Johannes Gutenberg-Universität Mainz ; 1946-2021
    Subject code 614.109434351 ; 610
    Language English
    Size 106 Seiten, Illustrationen, 21 cm
    Publisher Lehmanns Media
    Publishing place Berlin
    Publishing country Germany
    Document type Book
    HBZ-ID HT030629555
    ISBN 978-3-96543-391-5 ; 3-96543-391-1
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Book ; Thesis: Retrospektive Untersuchung von Patienten mit primären Hirntumoren, die im Universitätsklinikum Mannheim von 1991 bis 1999 strahlentherapiert wurden

    Kaufmann, Thomas

    2004  

    Author's details vorgelegt von Thomas Kaufmann
    Language German
    Size 154 S., graph. Darst., 30 cm
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Heidelberg, Univ., Diss., 2004
    HBZ-ID HT016143152
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2010 E 554 order for loan Magazin

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  4. Article ; Online: Pharmacological Induction of Granulocyte Cell Death as Therapeutic Strategy.

    Kaufmann, Thomas / Simon, Hans-Uwe

    Annual review of pharmacology and toxicology

    2022  Volume 63, Page(s) 231–247

    Abstract: Apoptosis is central for the maintenance of health. In the immune system, apoptosis guarantees proper development of immune cells and shutdown of immune reactions by the coordinated elimination of activated immune cells. Limitation of the life span of ... ...

    Abstract Apoptosis is central for the maintenance of health. In the immune system, apoptosis guarantees proper development of immune cells and shutdown of immune reactions by the coordinated elimination of activated immune cells. Limitation of the life span of granulocytes is important, as overactivation of these cells is associated with chronic inflammation and collateral tissue damage. Consequently, targeted induction of granulocyte apoptosis may be beneficial in the course of respective immune disorders. Anti-inflammatory drugs such as glucocorticoids and monoclonal antibodies against IL-5Rα exert their function in part by triggering eosinophil apoptosis. Agonistic antibodies targeting Siglec-8 or death receptors are tested (pre)clinically. Moreover, a new class of inhibitors targeting antiapoptotic BCL-2 proteins shows great promise for anticancer treatments. Because of their specificity and tolerable side effects, these so-called BH3 mimetics may be worthwhile to evaluate in inflammatory disorders. Here, we review past and recent data on pharmacological apoptosis induction of granulocytes and highlight respective therapeutic potential.
    MeSH term(s) Humans ; Cell Death ; Eosinophils ; Apoptosis ; Inflammation/drug therapy
    Language English
    Publishing date 2022-08-26
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 196587-6
    ISSN 1545-4304 ; 0362-1642
    ISSN (online) 1545-4304
    ISSN 0362-1642
    DOI 10.1146/annurev-pharmtox-051921-115130
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Operating under the influence: the effect of alcohol on operative performance using a virtual robotic training platform-an experimental comparative cohort study.

    Muensterer, Oliver / Apelt, Nadja / Schnorpfeil, Corinna / Kaufmann, Thomas / Goedeke, Jan

    Journal of robotic surgery

    2024  Volume 18, Issue 1, Page(s) 139

    Abstract: An elevated percentage of medical personnel reports using alcohol to relieve stress. Levels of alcohol addiction are almost double that of the general population. Robotic surgery is becoming more widespread. The purpose of this study is to evaluate the ... ...

    Abstract An elevated percentage of medical personnel reports using alcohol to relieve stress. Levels of alcohol addiction are almost double that of the general population. Robotic surgery is becoming more widespread. The purpose of this study is to evaluate the effects of alcohol ingestion on performance of a standardized curriculum using a robotic training platform. Surgeons and surgical trainees were recruited. Candidates performed 4 standardized exercises (Vitruvian Operation (VO), Stacking Challenge (SC), Ring Tower (RT), Suture Sponge (SS)) at 0.0 blood alcohol concentration (BAC), followed by testing in the elimination phase at a target BAC of 0.8‰. Learning effects were minimised through prior training. A total of 20 participants were recruited. Scores for RT and SS exercises were significantly worse under the influence of alcohol [instruments out of view (SS (z = 2.012; p = 0.044), RT (z score 1.940, p = 0.049)), drops (SS (z = 3.250; p = 0.001)), instrument collisions (SS (z = 2.460; p = 0.014)), missed targets (SS (z = 2.907; p = 0.004)]. None of the scores improved with alcohol consumption, and there were measurable deleterious effects on the compound indicators risk affinity and tissue handling. Despite the potential mitigating features of robotic surgery including tremor filtration, motion scaling, and improved three-dimensional visualization, alcohol consumption was associated with a significant increase in risk affinity and rough tissue handling, along with a deterioration of performance in select virtual robotic tasks. In the interest of patient safety, alcohol should not be consumed prior to performing robotic surgery and sufficiently long intervals between alcohol ingestion and surgical performance are mandatory.
    MeSH term(s) Humans ; Robotic Surgical Procedures/methods ; Cohort Studies ; Blood Alcohol Content ; Robotics/education ; Curriculum ; Clinical Competence ; Simulation Training/methods ; Computer Simulation
    Chemical Substances Blood Alcohol Content
    Language English
    Publishing date 2024-03-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 2268283-1
    ISSN 1863-2491 ; 1863-2483
    ISSN (online) 1863-2491
    ISSN 1863-2483
    DOI 10.1007/s11701-024-01895-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Sialic Acids and Their Influence on Human NK Cell Function.

    Rosenstock, Philip / Kaufmann, Thomas

    Cells

    2021  Volume 10, Issue 2

    Abstract: Sialic acids are sugars with a nine-carbon backbone, present on the surface of all cells in humans, including immune cells and their target cells, with various functions. Natural Killer (NK) cells are cells of the innate immune system, capable of killing ...

    Abstract Sialic acids are sugars with a nine-carbon backbone, present on the surface of all cells in humans, including immune cells and their target cells, with various functions. Natural Killer (NK) cells are cells of the innate immune system, capable of killing virus-infected and tumor cells. Sialic acids can influence the interaction of NK cells with potential targets in several ways. Different NK cell receptors can bind sialic acids, leading to NK cell inhibition or activation. Moreover, NK cells have sialic acids on their surface, which can regulate receptor abundance and activity. This review is focused on how sialic acids on NK cells and their target cells are involved in NK cell function.
    MeSH term(s) Humans ; Killer Cells, Natural/immunology ; Lymphocyte Activation/immunology ; Receptors, Cell Surface/metabolism ; Sialic Acids/biosynthesis ; Sialic Acids/chemistry ; Sialic Acids/metabolism ; Viral Proteins/metabolism
    Chemical Substances Receptors, Cell Surface ; Sialic Acids ; Viral Proteins
    Language English
    Publishing date 2021-01-29
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells10020263
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Book ; Thesis: Mediatorenkonzept in der Erklärung nicht-optimaler Wiederherstellungsergebnisse bei der Gallenchirurgie

    Kaufmann, Thomas

    eine randomisierte, kontrollierte klinische Studie

    (Wissenschaft in Dissertationen ; 408)

    1998  

    Author's details von Thomas Kaufmann
    Series title Wissenschaft in Dissertationen ; 408
    Collection
    Keywords Cholezystektomie ; Postoperative Phase ; Rehabilitation ; Mediator ; Kontrollierte klinische Studie
    Subject Kontrollierte Therapiestudie ; Mediatorsubstanz ; Rehabilitierung ; Gallenblasenentfernung
    Language German
    Size 106 S. : graph. Darst.
    Publisher Görich & Weiershäuser
    Publishing place Marburg
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Marburg, Univ., Diss., 1998
    HBZ-ID HT010090755
    ISBN 3-89703-231-7 ; 978-3-89703-231-6
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    99 D 900 order for loan Magazin

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  8. Book ; Thesis: Weichmachereinfluß auf die Biodegradation und die Biokompatibilität von Poly-beta-Hydroxybuttersäure

    Kaufmann, Thomas

    1997  

    Author's details vorgelegt von Thomas Kaufmann
    Language German
    Size XII, 141 Bl. : Ill., graph. Darst.
    Edition [Mikrofiche-Ausg.]
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Rostock, Univ., Diss., 1998
    Note Mikrofiche-Ausg.: 2 Mikrofiches : 24x
    HBZ-ID HT009061546
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    1998 MB 2259 order for loan Magazin

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  9. Book ; Online: Reformation als Kommunikationsprozess : Böhmische Kronländer und Sachsen (Volume 51)

    Wąs, Gabriela / Dornheim, Stefan / Kaufmann, Thomas / Winzeler, Marius / Rothkegel, Martin / Zdichynec, Jan / Voit, Petr / Just, Jiří / Wenzel, Kai / Horníčková, Kateřina / Kühne, Hartmut / Schwerhoff, Gerd / Hrachovec, Petr / Jakubec, Ondřej / Holý, Martin / Mikulec, Jiri / Kästner, Alexander / Schilling, Heinz / Flügel, Wolfgang /
    Klingner, Jens / Wernisch, Martin / Soukup, Pavel / Bünz, Enno / Müller, Winfried / Schattkowsky, Martina

    2021  

    Keywords Protestantism & Protestant Churches ; Religion ; Christianity ; Protestant
    Size 1 Online-Ressource
    Document type Book ; Online
    Note German ; Open Access
    HBZ-ID HT021232000
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  10. Article ; Online: Glucose measurements with accu check inform II versus hexokinase plasma method during surgery under general anesthesia, an observational cohort study.

    Kaufmann, Thomas / Slingerland, Robbert J / Edens, Mireille A / Olthof, Cornelis G

    Journal of clinical monitoring and computing

    2023  Volume 38, Issue 2, Page(s) 479–485

    Abstract: Purpose: Limited research exists on translation of in-vitro glucose measurement interfering compounds to the in-vivo situation. We investigated whether Point-of-Care glucose measurements by Accu Chek Inform II (ACI II) were accurate to monitor glucose ... ...

    Abstract Purpose: Limited research exists on translation of in-vitro glucose measurement interfering compounds to the in-vivo situation. We investigated whether Point-of-Care glucose measurements by Accu Chek Inform II (ACI II) were accurate to monitor glucose concentrations during surgery with general anesthesia by comparing with the reference laboratory hexokinase plasma glucose test.
    Method: Patients undergoing surgery with general anesthesia were included. Anesthesia was maintained with either Sevoflurane or Total intravenous anesthesia (TIVA). Prior to and after induction, blood glucose was measured with ACI II and the hexokinase test. Bland-Altman analysis was performed to assess method agreement. Subgroup analyses on glucose measurement differences per type of maintenance anesthesia were performed.
    Results: Thirty-nine patients were included, and 78 measurements were performed. All paired measurements had clinically acceptable agreement with a percentage error of 10.0% (95% CI 8.0 to 11.9). The mean difference (95% limits of agreement) between ACI II and hexokinase for all measurements was 0.0 mmol/L (-0.7 to 0.7 mmol/L). Before induction (n = 39), mean difference was -0.1 mmol/L (-0.6 to 0.4 mmol/L), and after induction (n = 39), mean difference was 0.1 mmol/L (-0.8 to 0.9 mmol/L). Further investigation showed the difference varied per test for patients receiving Sevoflurane compared to patients receiving TIVA (-0.2 ± 0.4 mmol/L vs. 0.4 ± 0.3 mmol/L, p < 0.001). Before and after induction, the difference between ACI II and hexokinase measurements increased for patients receiving Sevoflurane compared to patients receiving TIVA (0.4 ± 0.4 mmol/L vs. -0.4 ± 0.3 mmol/L, p < 0.001).
    Conclusion: The agreement between glucose measurements using ACI II and the reference laboratory hexokinase test was clinically acceptable with a percentage error of 10.0% (95% CI 8.0 to 11.9). The use of TIVA may negatively affect the measurement performance of the ACI II.
    MeSH term(s) Humans ; Sevoflurane ; Hexokinase ; Anesthesia, General ; Blood Glucose/analysis ; Cohort Studies ; Propofol ; Anesthesia, Intravenous ; Anesthetics, Intravenous ; Anesthetics, Inhalation
    Chemical Substances Sevoflurane (38LVP0K73A) ; Hexokinase (EC 2.7.1.1) ; Blood Glucose ; Propofol (YI7VU623SF) ; Anesthetics, Intravenous ; Anesthetics, Inhalation
    Language English
    Publishing date 2023-09-09
    Publishing country Netherlands
    Document type Observational Study ; Journal Article
    ZDB-ID 1418733-4
    ISSN 1573-2614 ; 1387-1307 ; 0748-1977
    ISSN (online) 1573-2614
    ISSN 1387-1307 ; 0748-1977
    DOI 10.1007/s10877-023-01072-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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