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Article ; Online: Reduced Monocyte and Neutrophil Infiltration and Activation by P-Selectin/CD62P Inhibition Enhances Thrombus Resolution in Mice.

Kral-Pointner, Julia B / Haider, Patrick / Szabo, Petra L / Salzmann, Manuel / Brekalo, Mira / Schneider, Karl H / Schrottmaier, Waltraud C / Kaun, Christoph / Bleichert, Sonja / Kiss, Attila / Sickha, Romana / Hengstenberg, Christian / Huber, Kurt / Brostjan, Christine / Bergmeister, Helga / Assinger, Alice / Podesser, Bruno K / Wojta, Johann / Hohensinner, Philipp

Arteriosclerosis, thrombosis, and vascular biology

2024 Volume 44, Issue 4, Page(s) 954–968

Abstract: Background: Venous thromboembolism is a major health problem. After thrombus formation, its resolution is essential to re-establish blood flow, which is crucially mediated by infiltrating neutrophils and monocytes in concert with activated platelets and ...

Abstract	Background: Venous thromboembolism is a major health problem. After thrombus formation, its resolution is essential to re-establish blood flow, which is crucially mediated by infiltrating neutrophils and monocytes in concert with activated platelets and endothelial cells. Thus, we aimed to modulate leukocyte function during thrombus resolution post-thrombus formation by blocking P-selectin/CD62P-mediated cell interactions. Methods: Thrombosis was induced by inferior vena cava stenosis through ligation in mice. After 1 day, a P-selectin-blocking antibody or isotype control was administered and thrombus composition and resolution were analyzed. Results: Localizing neutrophils and macrophages in thrombotic lesions of wild-type mice revealed that these cells enter the thrombus and vessel wall from the caudal end. Neutrophils were predominantly present 1 day and monocytes/macrophages 3 days after vessel ligation. Blocking P-selectin reduced circulating platelet-neutrophil and platelet-Ly6C Conclusions: Inhibition of P-selectin-dependent activation of monocytes and neutrophils accelerates venous thrombosis resolution due to reduced infiltration and activation of innate immune cells at the site of thrombus formation, which prevents early thrombus stabilization and facilitates fibrinolysis.
MeSH term(s)	Mice ; Humans ; Animals ; Monocytes/pathology ; P-Selectin ; Endothelial Cells ; Thromboplastin ; Neutrophil Infiltration ; Thrombosis ; Neutrophils
Chemical Substances	P-Selectin ; Thromboplastin (9035-58-9)
Language	English
Publishing date	2024-02-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	1221433-4
ISSN	1524-4636 ; 1079-5642
ISSN (online)	1524-4636
ISSN	1079-5642
DOI	10.1161/ATVBAHA.123.320016
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Article ; Online: The pro-inflammatory marker soluble suppression of tumorigenicity-2 (ST2) is reduced especially in diabetic morbidly obese patients undergoing bariatric surgery.

Demyanets, Svitlana / Kaun, Christoph / Kaider, Alexandra / Speidl, Walter / Prager, Manfred / Oravec, Stanislav / Hohensinner, Philipp / Wojta, Johann / Rega-Kaun, Gersina

Cardiovascular diabetology

2020 Volume 19, Issue 1, Page(s) 26

Abstract: Background: High soluble suppression of tumorigenicity-2 (sST2) is a marker of poor prognosis in chronic inflammatory conditions. ST2 and its ligand interleukin (IL)-33 are elevated in adipose tissue of obese individuals. We aimed to evaluate ... ...

Abstract	Background: High soluble suppression of tumorigenicity-2 (sST2) is a marker of poor prognosis in chronic inflammatory conditions. ST2 and its ligand interleukin (IL)-33 are elevated in adipose tissue of obese individuals. We aimed to evaluate circulating sST2 and IL-33 as possible markers of metabolic benefit in morbidly overweight patients after Roux-en-Y gastric bypass (RYGB) bariatric surgery. Methods: sST2, IL-33, high sensitive IL-6, high sensitive C-reactive protein (hsCRP), leptin, cholesterol metabolism and liver parameters were measured in 80 morbidly obese individuals before and 1 year after bariatric surgery. Results: sST2 was higher (P = 0.03) in diabetics as compared to individuals without diabetes. Baseline sST2 was also higher in males than in females (P= 0.0002). One year after bariatric surgery, sST2 levels were decreased (median 120, IQR 59-176 pg/mL) as compared to sST2 before surgery (median 141, IQR 111-181, P = 0.0024), and the diabetic group showed most pronounced reduction in sST2 (P = 0.0016). An association was found between sST2 and liver function parameters before and after bariatric surgery, and between baseline sST2 and total cholesterol, triglyceride, total low density lipoprotein (LDL), small dense LDL, Apolipoprotein B as well as with small dense high density lipoproteins (HDL). In the subgroup of diabetic patients positive correlation between IL-33 and sST2 (r = 0.44, P = 0.05) was noticed. Conclusions: Circulating sST2 is associated with markers of liver functions and lipid metabolism in severely obese patients and a reduction of sST2 was shown after successful bariatric surgery, most prominently in diabetic patients.
MeSH term(s)	Adult ; Biomarkers/blood ; Case-Control Studies ; Diabetes Mellitus/blood ; Diabetes Mellitus/diagnosis ; Down-Regulation ; Female ; Gastric Bypass ; Humans ; Inflammation Mediators/blood ; Interleukin-1 Receptor-Like 1 Protein/blood ; Interleukin-33/blood ; Male ; Middle Aged ; Obesity, Morbid/blood ; Obesity, Morbid/diagnosis ; Obesity, Morbid/surgery ; Time Factors ; Treatment Outcome
Chemical Substances	Biomarkers ; IL1RL1 protein, human ; IL33 protein, human ; Inflammation Mediators ; Interleukin-1 Receptor-Like 1 Protein ; Interleukin-33
Language	English
Publishing date	2020-02-26
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1475-2840
ISSN (online)	1475-2840
DOI	10.1186/s12933-020-01001-y
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The adipokine vaspin is associated with decreased coronary in-stent restenosis in vivo and inhibits migration of human coronary smooth muscle cells in vitro.

Kastl, Stefan P / Katsaros, Katharina M / Krychtiuk, Konstantin A / Jägersberger, Gerlinde / Kaun, Christoph / Huber, Kurt / Wojta, Johann / Speidl, Walter S

PloS one

2020 Volume 15, Issue 5, Page(s) e0232483

Abstract: Background: Percutaneous coronary intervention represents the most important treatment modality of coronary artery stenosis. In-stent restenosis (ISR) is still a limitation for the long-term outcome despite the introduction of drug eluting stents. It ... ...

Abstract	Background: Percutaneous coronary intervention represents the most important treatment modality of coronary artery stenosis. In-stent restenosis (ISR) is still a limitation for the long-term outcome despite the introduction of drug eluting stents. It has been shown that adipokines directly influence vessel wall homeostasis by influencing the function of endothelial cells and arterial smooth muscle cells. Visceral adipose tissue-derived serpin vaspin was recently identified as a member of serine protease inhibitor family and serveral studies could demonstrate a relation to metabolic diseases. The aim of this study was to investigate a role of vaspin in the development of in-stent restenosis in vivo and on migration of smooth muscle cells and endothelial cells in vitro. Methods: We studied 85 patients with stable coronary artery disease who underwent elective and successful PCI with implatation of drug eluting stents. Blood samples were taken directly before PCI. Vaspin plasma levels were measured by specific ELISA. ISR was evaluated eight months later by coronary angiography. Human coronary artery smooth muscle cells (HCASMC) and human umbilical vein endothelial cells (HUVEC) migration was analyzed by an in-vitro migration assay with different concentrations (0.004ng/mL up to 40ng/mL) of vaspin as well as by an scratch assay. For proliferation an impedance measurement with specialiced E-Plates was performed. Results: During the follow up period, 14 patients developed ISR. Patients with ISR had significantly lower vaspin plasma levels compared to patients without ISR (0.213 ng/ml vs 0.382 ng/ml; p = 0.001). In patients with plasma vaspin levels above 1.35 ng/ml we could not observe any restenosis. There was also a significant correlation of plasma vaspin levels and late lumen loss in the stented coronary segments. Further we could demonstrate that vaspin nearly abolishes serum induced migration of HCASMC (100% vs. 9%; p<0.001) in a biphasic manner but not migration of HUVEC. Proliferation of HCASMC and HUVEC was not modulated by vaspin treatment. Conclusion: We were able to show that the adipokine vaspin selectively inhibits human coronary SMC migration in vitro and has no effect on HUVEC migration. Vaspin had no effect on proliferation of HUVEC which is an important process of the healing of the stented vessel. In addition, the occurrence of ISR after PCI with implantation of drug eluting stents was significantly associated with low vaspin plasma levels before intervention. Determination of vaspin plasma levels before PCI might be helpful in the identification of patients with high risk for development of ISR after stent implantation. In addition, the selective effects of vaspin on smooth muscle cell migration could potentially be used to reduce ISR without inhibition of re-endothelialization of the stented segment.
MeSH term(s)	Adipokines/blood ; Adipokines/pharmacology ; Adipokines/physiology ; Aged ; Cell Movement/drug effects ; Cell Movement/physiology ; Cell Proliferation/drug effects ; Cell Proliferation/physiology ; Cells, Cultured ; Coronary Artery Disease/blood ; Coronary Artery Disease/pathology ; Coronary Artery Disease/surgery ; Coronary Restenosis/etiology ; Coronary Restenosis/pathology ; Coronary Restenosis/physiopathology ; Coronary Vessels/pathology ; Coronary Vessels/physiopathology ; Female ; Human Umbilical Vein Endothelial Cells ; Humans ; In Vitro Techniques ; Male ; Middle Aged ; Myocytes, Smooth Muscle/drug effects ; Myocytes, Smooth Muscle/pathology ; Myocytes, Smooth Muscle/physiology ; Percutaneous Coronary Intervention/adverse effects ; Serpins/blood ; Serpins/pharmacology ; Serpins/physiology
Chemical Substances	Adipokines ; SERPINA12 protein, human ; Serpins
Language	English
Publishing date	2020-05-11
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0232483
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Article: MiRNA Let-7a and Let-7d Are Induced by Globotriaosylceramide via NF-kB Activation in Fabry Disease

Maier, Nadine / Gatterer, Constantin / Haider, Patrick / Salzmann, Manuel / Kaun, Christoph / Speidl, Walter S. / Sunder-Plassmann, Gere / Podesser, Bruno K. / Wojta, Johann / Graf, Senta / Lenz, Max / Hohensinner, Philipp J.

Genes. 2021 July 30, v. 12, no. 8

2021

Abstract: Background: Fabry disease is a hereditary genetic defect resulting in reduced activity of the enzyme α-galactosidase-A and the accumulation of globotriaosylceramide (Gb3) in body fluids and cells. Gb3 accumulation was especially reported for the vascular ...

Abstract	Background: Fabry disease is a hereditary genetic defect resulting in reduced activity of the enzyme α-galactosidase-A and the accumulation of globotriaosylceramide (Gb3) in body fluids and cells. Gb3 accumulation was especially reported for the vascular endothelium in several organs. Methods: Three Fabry disease patients were screened using a micro-RNA screen. An in vitro approach in human endothelial cells was used to determine miRNA regulation by Gb3. Results: In a micro-RNA screen of three Fabry patients undergoing enzyme replacement therapy, we found that miRNAs let-7a and let-7d were significantly increased after therapy. We demonstrate in vitro in endothelial cells that Gb3 induced activation of NF-κB and activated downstream targets. In addition, NF-κB activity directly reduced let-7a and let-7d miRNA expression as inhibiting NF-kB nuclear entry abolished the Gb3 effects. Conclusion: We suggest that let-7a and let-7d are potential markers for enzyme activity and inflammation in Fabry disease patients.
Keywords	Fabry disease ; endothelium ; enzyme activity ; enzyme replacement therapy ; humans ; inflammation ; microRNA ; transcription factor NF-kappa B
Language	English
Dates of publication	2021-0730
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2527218-4
ISSN	2073-4425
ISSN	2073-4425
DOI	10.3390/genes12081184
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Pharmacologic modulation of intracellular Na

Lenz, Max / Salzmann, Manuel / Ciotu, Cosmin I / Kaun, Christoph / Krychtiuk, Konstantin A / Rehberger Likozar, Andreja / Sebestjen, Miran / Goederle, Laura / Rauscher, Sabine / Krivaja, Zoriza / Binder, Christoph J / Huber, Kurt / Hengstenberg, Christian / Podesser, Bruno K / Fischer, Michael J M / Wojta, Johann / Hohensinner, Philipp J / Speidl, Walter S

Proceedings of the National Academy of Sciences of the United States of America

2022 Volume 119, Issue 29, Page(s) e2207020119

Abstract: Changes in ... ...

Abstract	Changes in Ca2
MeSH term(s)	Acute Coronary Syndrome/drug therapy ; Animals ; C-Reactive Protein/analysis ; C-Reactive Protein/metabolism ; Cardiovascular Agents/pharmacology ; Cardiovascular Agents/therapeutic use ; Coronary Artery Disease/drug therapy ; Endothelial Cells/metabolism ; Humans ; Inflammation/chemically induced ; Inflammation/drug therapy ; Mice ; Ranolazine/pharmacology ; Ranolazine/therapeutic use ; Sodium/metabolism ; Sodium Channel Blockers/pharmacology ; Sodium Channel Blockers/therapeutic use
Chemical Substances	Cardiovascular Agents ; Sodium Channel Blockers ; C-Reactive Protein (9007-41-4) ; Sodium (9NEZ333N27) ; Ranolazine (A6IEZ5M406)
Language	English
Publishing date	2022-07-13
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.2207020119
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Article ; Online: MiRNA Let-7a and Let-7d Are Induced by Globotriaosylceramide via NF-kB Activation in Fabry Disease.

Maier, Nadine / Gatterer, Constantin / Haider, Patrick / Salzmann, Manuel / Kaun, Christoph / Speidl, Walter S / Sunder-Plassmann, Gere / Podesser, Bruno K / Wojta, Johann / Graf, Senta / Lenz, Max / Hohensinner, Philipp J

Genes

2021 Volume 12, Issue 8

Abstract	Background: Fabry disease is a hereditary genetic defect resulting in reduced activity of the enzyme α-galactosidase-A and the accumulation of globotriaosylceramide (Gb3) in body fluids and cells. Gb3 accumulation was especially reported for the vascular endothelium in several organs. Methods: Three Fabry disease patients were screened using a micro-RNA screen. An in vitro approach in human endothelial cells was used to determine miRNA regulation by Gb3. Results: In a micro-RNA screen of three Fabry patients undergoing enzyme replacement therapy, we found that miRNAs let-7a and let-7d were significantly increased after therapy. We demonstrate in vitro in endothelial cells that Gb3 induced activation of NF-κB and activated downstream targets. In addition, NF-κB activity directly reduced let-7a and let-7d miRNA expression as inhibiting NF-kB nuclear entry abolished the Gb3 effects. Conclusion: We suggest that let-7a and let-7d are potential markers for enzyme activity and inflammation in Fabry disease patients.
MeSH term(s)	Adult ; Cells, Cultured ; Endothelial Cells/metabolism ; Enzyme Replacement Therapy ; Fabry Disease/genetics ; Fabry Disease/metabolism ; Female ; Gene Expression Regulation ; Humans ; Male ; MicroRNAs/genetics ; Middle Aged ; NF-kappa B/metabolism ; Trihexosylceramides/metabolism
Chemical Substances	MicroRNAs ; NF-kappa B ; Trihexosylceramides ; mirnlet7 microRNA, human ; globotriaosylceramide (71965-57-6)
Language	English
Publishing date	2021-07-30
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2527218-4
ISSN	2073-4425 ; 2073-4425
ISSN (online)	2073-4425
ISSN	2073-4425
DOI	10.3390/genes12081184
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Article: Effects of Nicorandil on Inflammation, Apoptosis and Atherosclerotic Plaque Progression.

Lenz, Max / Kaun, Christoph / Krychtiuk, Konstantin A / Haider, Patrick / Brekalo, Mira / Maier, Nadine / Goederle, Laura / Binder, Christoph J / Huber, Kurt / Hengstenberg, Christian / Wojta, Johann / Hohensinner, Philipp J / Speidl, Walter S

Biomedicines

2021 Volume 9, Issue 2

Abstract: Nicorandil, a balanced vasodilator, is used in the second-line therapy of angina pectoris. In this study, we aimed to illuminate the effects of nicorandil on inflammation, apoptosis, and atherosclerotic plaque progression. Twenty-five LDL-R -/- mice were ...

Abstract	Nicorandil, a balanced vasodilator, is used in the second-line therapy of angina pectoris. In this study, we aimed to illuminate the effects of nicorandil on inflammation, apoptosis, and atherosclerotic plaque progression. Twenty-five LDL-R -/- mice were fed a high-fat diet for 14 weeks. After 6 weeks mice were randomly allocated to treatment with nicorandil (10 mg/kg/day) or tap water. Nicorandil treatment led to a more stable plaque phenotype, displaying an increased thickness of the fibrous cap (
Language	English
Publishing date	2021-01-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines9020120
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Article ; Online: Changes of Circulating Extracellular Vesicles from the Liver after Roux-en-Y Bariatric Surgery.

Rega-Kaun, Gersina / Ritzel, Dorothea / Kaun, Christoph / Ebenbauer, Benjamin / Thaler, Barbara / Prager, Manfred / Demyanets, Svitlana / Wojta, Johann / Hohensinner, Philipp J

International journal of molecular sciences

2019 Volume 20, Issue 9

Abstract: Circulating extracellular vesicles are small particles enclosed by a phospholipid bilayer. Vesicles deriving directly from the cellular membrane by an active budding process retain cell origin specific proteins and RNA. These vesicles carry ... ...

Abstract	Circulating extracellular vesicles are small particles enclosed by a phospholipid bilayer. Vesicles deriving directly from the cellular membrane by an active budding process retain cell origin specific proteins and RNA. These vesicles carry pathophysiological information from their parental cell and hold the potential to allow analysis of organs without the need for a biopsy. We included in our study 27 patients undergoing bariatric surgery. Hepatic extracellular vesicles were determined by flow cytometry. mRNA specific for hepatic cellular origin was determined in the extracellular vesicle fraction using qPCR. Surgery led to a massive reduction of weight and overall hepatic stress as determined by alanine transaminase (ALT), aspartate transaminase (AST) and γ-glutamyltransferase (GGT). Total extracellular vesicle numbers were reduced after bariatric surgery. Liver specific vesicles identified by HepPar1 or asialoglycoprotein receptor (ASGPR) were significantly reduced after bariatric surgery in both AnnexinV
MeSH term(s)	Adult ; Biomarkers/blood ; Cell-Free Nucleic Acids/blood ; Extracellular Vesicles/metabolism ; Female ; Gastric Bypass ; Humans ; Liver/metabolism ; Male ; Middle Aged ; Obesity, Morbid/blood ; Obesity, Morbid/metabolism ; Obesity, Morbid/surgery
Chemical Substances	Biomarkers ; Cell-Free Nucleic Acids
Language	English
Publishing date	2019-04-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms20092153
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Article ; Online: The plasminogen receptor Plg-R

Samad, Fahumiya / Bai, Hongdong / Baik, Nagyung / Haider, Patrick / Zhang, Yuqing / Rega-Kaun, Gersina / Kaun, Christoph / Prager, Manfred / Wojta, Johann / Bui, Quyen / Chakrabarty, Sagarika / Wang, Jing / Parmer, Robert J / Miles, Lindsey A

Journal of thrombosis and haemostasis : JTH

2021 Volume 20, Issue 3, Page(s) 742–754

Abstract: Background: Plg-R: Objectives: We investigated the role of Plg-R: Methods: We used adipose tissue (AT) sections from bariatric surgery patients and from high fat diet (HFD)-induced obese mice together with immunofluorescence and real-time ... ...

Abstract	Background: Plg-R Objectives: We investigated the role of Plg-R Methods: We used adipose tissue (AT) sections from bariatric surgery patients and from high fat diet (HFD)-induced obese mice together with immunofluorescence and real-time polymerase chain reaction to study adipose expression of Plg-R Results: Plg-R Conclusions: Plg-R
MeSH term(s)	Adipose Tissue/metabolism ; Animals ; Diabetes Mellitus, Type 2/metabolism ; Dietary Fats/pharmacology ; Fibrosis ; Glucose Tolerance Test ; Homeostasis ; Humans ; Inflammation/metabolism ; Insulin Resistance ; Mice ; Plasminogen/metabolism ; Receptors, Cell Surface/metabolism
Chemical Substances	Dietary Fats ; PLG-R(KT) protein, mouse ; PLGRKT protein, human ; Receptors, Cell Surface ; Plasminogen (9001-91-6)
Language	English
Publishing date	2021-12-21
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2112661-6
ISSN	1538-7836 ; 1538-7933
ISSN (online)	1538-7836
ISSN	1538-7933
DOI	10.1111/jth.15622
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Zs.A 5805: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Innate Immune Training with Bacterial Extracts Enhances Lung Macrophage Recruitment to Protect from Betacoronavirus Infection.

Salzmann, Manuel / Haider, Patrick / Kaun, Christoph / Brekalo, Mira / Hartmann, Boris / Lengheimer, Theresia / Pichler, Rebecca / Filip, Thomas / Derdak, Sophia / Podesser, Bruno / Hengstenberg, Christian / Speidl, Walter S / Wojta, Johann / Plasenzotti, Roberto / Hohensinner, Philipp J

Journal of innate immunity

2021 Volume 14, Issue 4, Page(s) 293–305

Abstract: Training of the innate immune system with orally ingested bacterial extracts was demonstrated to have beneficial effects on infection clearance and disease outcome. The aim of our study was to identify cellular and molecular processes responsible for ... ...

Abstract	Training of the innate immune system with orally ingested bacterial extracts was demonstrated to have beneficial effects on infection clearance and disease outcome. The aim of our study was to identify cellular and molecular processes responsible for these immunological benefits. We used a murine coronavirus (MCoV) A59 mouse model treated with the immune activating bacterial extract Broncho-Vaxom (BV) OM-85. Tissue samples were analysed with qPCR, RNA sequencing, histology, and flow cytometry. After BV OM-85 treatment, interstitial macrophages accumulated in lung tissue leading to a faster response of type I interferon (IFN) signalling after MCoV infection resulting in overall lung tissue protection. Moreover, RNA sequencing showed that lung tissue from mice receiving BV OM-85 resembled an intermediate stage between healthy and viral infected lung tissue at day 4, indicating a faster return to normal tissue homoeostasis. The pharmacologic effect was mimicked by adoptively transferring naive lung macrophages into lungs from recipient mice before virus infection. The beneficial effect of BV OM-85 was abolished when inhibiting initial type I IFN signalling. Overall, our data suggest that BV OM-85 enhances lung macrophages allowing for a faster IFN response towards a viral challenge as part of the oral-induced innate immune system training.
MeSH term(s)	Adjuvants, Immunologic ; Animals ; Bacteria ; Betacoronavirus ; Immunity, Innate ; Lung ; Macrophages ; Mice
Chemical Substances	Adjuvants, Immunologic
Language	English
Publishing date	2021-11-12
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2454158-8
ISSN	1662-8128 ; 1662-811X
ISSN (online)	1662-8128
ISSN	1662-811X
DOI	10.1159/000519699
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