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Article ; Online: Stacking classifier to improve the classification of shoulder motion in transhumeral amputees.

Kaur, Amanpreet

Biomedizinische Technik. Biomedical engineering

2022 Volume 67, Issue 2, Page(s) 105–117

Abstract: In recent years surface electromyography signals-based machine learning models are rapidly establishing. The efficacy of prosthetic arm growth for transhumeral amputees is aided by efficient classifiers. The paper aims to propose a stacking classifier- ... ...

Abstract	In recent years surface electromyography signals-based machine learning models are rapidly establishing. The efficacy of prosthetic arm growth for transhumeral amputees is aided by efficient classifiers. The paper aims to propose a stacking classifier-based classification system for sEMG shoulder movements. It presents the possibility of various shoulder motions classification of transhumeral amputees. To improve the system performance, adaptive threshold method and wavelet transformation have been applied for features extraction. Six different classifiers Support Vector Machines (SVM), Tree, Random Forest (RF), K-Nearest Neighbour (KNN), AdaBoost and Naïve Bayes (NB) are designed to extract the sEMG data classification accuracy. With cross-validation, the accuracy of RF, Tree and Ada Boost is 97%, 92% and 92% respectively. Stacking classifiers provides an accuracy as 99.4% after combining the best predicted multiple classifiers.
MeSH term(s)	Algorithms ; Amputees ; Arm ; Artificial Limbs ; Bayes Theorem ; Electromyography/methods ; Humans ; Shoulder ; Support Vector Machine
Language	English
Publishing date	2022-04-01
Publishing country	Germany
Document type	Journal Article
ZDB-ID	120817-2
ISSN	1862-278X ; 0013-5585
ISSN (online)	1862-278X
ISSN	0013-5585
DOI	10.1515/bmt-2020-0343
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Article ; Online: Genetically modified crops in India

Kaur Amanpreet

Open Agriculture, Vol 5, Iss 1, Pp 386-

Experiments with Bt Cotton to explore the road ahead

2020 Volume 394

Abstract: The success of genetically modified crops (GMCs), claimed to hold solution to impending environmental problems, depends on land holdings, agroclimatic and geoclimatic conditions, food preferences and sociocultural factors. The direct and indirect impacts ...

Abstract	The success of genetically modified crops (GMCs), claimed to hold solution to impending environmental problems, depends on land holdings, agroclimatic and geoclimatic conditions, food preferences and sociocultural factors. The direct and indirect impacts of these crops on human health, ecology and environment have not been evaluated on long-term basis. In India, with rich background of farming, GMCs remain a minor change. Introduction of first GMC, Bt Cotton (BC), showed varied response throughout the country. New GMCs like Bt Brinjal and GM Mustard approved for open-field trials in the country were marred under contentious debate and were never approved for commercial cultivation. The current research article aims to study the ecological implications of only GMC available for experimentation in India, BC. A three-phase study carried out as field survey, glass dome experiments and open-field trials compared the BC and conventional cotton (CC) plants with extensive experimentation of ecological parameters including vegetation diversity, insect diversity, plant morphology and infestation intensity. Results highlighted the better morphological characteristics of BC over CC, while infestation studies showed 40% survival rate of insect pest on BC for which it is genetically modified. High electrical conductivity and low organic matter content in the BC soil samples as compared to CC soil samples were indicative of impact of Bt toxins in soil but need further in-depth soil studies to reach scientifically valid results. The current research article substantiates the environmental concerns raised against GMCs especially BC in the country. Its objective is to trigger more research in this direction, so that the technology of GMCs is utilized for the benefit of humankind.
Keywords	agriculture ; genetically modified crops ; bt cotton ; india ; conventional cotton ; S ; Agriculture (General) ; S1-972
Language	English
Publishing date	2020-08-01T00:00:00Z
Publisher	De Gruyter
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Wheelchair control for disabled patients using EMG/EOG based human machine interface: a review.

Kaur, Amanpreet

Journal of medical engineering & technology

2020 Volume 45, Issue 1, Page(s) 61–74

Abstract: The human-machine interface (HMI) and bio-signals have been used to control rehabilitation equipment and improve the lives of people with severe disabilities. This research depicts a review of electromyogram (EMG) or electrooculogram (EOG) signal-based ... ...

Abstract	The human-machine interface (HMI) and bio-signals have been used to control rehabilitation equipment and improve the lives of people with severe disabilities. This research depicts a review of electromyogram (EMG) or electrooculogram (EOG) signal-based control system for driving the wheelchair for disabled. For a paralysed person, EOG is one of the most useful signals that help to successfully communicate with the environment by using eye movements. In the case of amputation, the selection of muscles according to the distribution of power and frequency highly contributes to the specific motion of a wheelchair. Taking into account the day-to-day activities of persons with disabilities, both technologies are being used to design EMG or EOG based wheelchairs. This review paper examines a total of 70 EMG studies and 25 EOG studies published from 2000 to 2019. In addition, this paper covers current technologies used in wheelchair systems for signal capture, filtering, characterisation, and classification, including control commands such as left and right turns, forward and reverse motion, acceleration, deceleration, and wheelchair stop.
MeSH term(s)	Disabled Persons ; Electromyography ; Electrooculography ; Humans ; Man-Machine Systems ; Signal Processing, Computer-Assisted ; User-Computer Interface ; Wheelchairs
Language	English
Publishing date	2020-12-11
Publishing country	England
Document type	Journal Article ; Systematic Review
ZDB-ID	243092-7
ISSN	1464-522X ; 0309-1902
ISSN (online)	1464-522X
ISSN	0309-1902
DOI	10.1080/03091902.2020.1853838
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Article ; Online: Metamaterial based AMC backed archimedean spiral antenna for in-vitro microwave hyperthermia of skin cancer.

Kaur, Komalpreet / Kaur, Amanpreet

Electromagnetic biology and medicine

2023 Volume 42, Issue 4, Page(s) 163–181

Abstract: This research article presents a study that uses microwave frequencies (ISM band) for treatment of skin cancer by heating the malignant cells on skin with a Microwave Hyperthermia (MWHT) applicator. The proposed MWHT applicator has been designed as an ... ...

Abstract	This research article presents a study that uses microwave frequencies (ISM band) for treatment of skin cancer by heating the malignant cells on skin with a Microwave Hyperthermia (MWHT) applicator. The proposed MWHT applicator has been designed as an Archimedean Spiral Microstrip Patch Antenna (AMSPA) of dimensions 38 × 38 × 1.64 mm3 backed with a Meshed-shaped AMC (48 × 48 × 3.27mm3) reflector, placed at an optimized distance of 12 mm from AMSPA. The proposed AMSPA is designed as a single spiral resonator and fabricated on FR-4 substrate, excited using a feed network. The proposed AMSPA shows a resonance at 2.5 GHz with an impedance BW of 260 MHz (2.37-2.63 GHz) and peak gain of 3.20 dB with a bidirectional radiation pattern. An AMC is placed at its backside that can be exploited as a phase-compensation surface to attain an in-phase profile for directive emission and improve the BW upto 470 MHz, peak gain to 6.8 dB and also enhance the front-to-back ratio of the radiating antenna with radiation efficiency of 80%. The simulated environment for hyperthermia analysis is set up using penne's Bio-Heat equations to deliver microwave energy to the bio-mimic, that leads to a rise in temperature over the designed bio-mimic in CST MWS in the range of 41-45°C. The validation of MWHT radiation properties and temperature rise inside the malignancy of phantom is carried out by fabricating the bio-mimic using gelatine, vegetable oils and glycerol. This set up enhances the penetration-depth of EM waves inside the tri-layered phantom up-to 29.5 mm with Effective Field Surface of 36 × 36 mm
MeSH term(s)	Humans ; Hyperthermia, Induced/methods ; Microwaves ; Skin Neoplasms/therapy ; Temperature ; Hot Temperature
Language	English
Publishing date	2023-12-29
Publishing country	England
Document type	Journal Article
ZDB-ID	2588120-6
ISSN	1536-8386 ; 1536-8378
ISSN (online)	1536-8386
ISSN	1536-8378
DOI	10.1080/15368378.2023.2297954
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Article ; Online: Computational identification and exploration of novel FGFR tyrosine kinase inhibitors for the treatment of cholangiocarcinoma.

Kaur, Amanpreet / Mandal, Debasish

Journal of biomolecular structure & dynamics

2023 , Page(s) 1–12

Abstract: Tyrosine kinase inhibitors are a specific drug class revolutionizing cancer treatment. FGFR (Fibroblast Growth Factor Receptor) is a member of the receptor tyrosine kinase family that has been involved in various alterations which have been increasingly ... ...

Abstract	Tyrosine kinase inhibitors are a specific drug class revolutionizing cancer treatment. FGFR (Fibroblast Growth Factor Receptor) is a member of the receptor tyrosine kinase family that has been involved in various alterations which have been increasingly recognized as critical molecular drivers in cholangiocarcinoma, a malignant tumor originating from bile duct epithelial cells. The paper focuses on stepwise computational investigations for the discovery of novel inhibitors of FGFR using pharmacophore modeling, virtual screening, docking, ADMET analysis, molecular dynamics, and knowledge-based structure-activity relationship. To begin with, we have considered a library of 120314868 compounds from the ZINC 15 database through pharmacophore modeling, which was narrowed down to 110 having binding affinity >-8.0 kcal mol
Language	English
Publishing date	2023-10-28
Publishing country	England
Document type	Journal Article
ZDB-ID	49157-3
ISSN	1538-0254 ; 0739-1102
ISSN (online)	1538-0254
ISSN	0739-1102
DOI	10.1080/07391102.2023.2274975
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Article ; Online: An Insight into the Repurposing of Phytoconstituents obtained from Delhi's Aravalli Biodiversity Park as Antifungal Agents.

Kaur, Amanpreet / Sharma, Kalicharan / Sharma, Neetika / Aggarwal, Geeta

Infectious disorders drug targets

2024

Abstract: The global prevalence of fungal infections is alarming in both the pre- and postCOVID period. Due to a limited number of antifungal drugs, there are hurdles in treatment strategies for fungal infections due to toxic potential, drug interactions, and the ... ...

Abstract	The global prevalence of fungal infections is alarming in both the pre- and postCOVID period. Due to a limited number of antifungal drugs, there are hurdles in treatment strategies for fungal infections due to toxic potential, drug interactions, and the development of fungal resistance. All the antifungal targets (existing and newer) and pipeline molecules showing promise against these targets are reviewed. The objective was to predict or repurpose phyto-based antifungal compounds based on a dual target inhibition approach (Sterol-14-αdemethylase and HSP-90) using a case study. In pursuit of repurposing the phytochemicals as antifungal agents, a team of researchers visited Aravalli Biodiversity Park (ABP), Delhi, India, to collect information on available medicinal plants. From 45 plants, a total of 1149 ligands were collected, and virtual screening was performed using Schrodinger Suite 2016 software to get 83 hits against both the target proteins: Sterol-14-α-demethylase and HSP-90. After analysis of docking results, ligands were selected based on their interaction against both the target proteins and comparison with respective standard ligands (fluconazole and ganetespib). We have selected Isocarthamidin, Quercetin and Boeravinone B based on their docking score and binding interaction against the HSP-90 (Docking Score -9.65, -9.22 and -9.21, respectively) and 14-α-demethylase (Docking Score -9.19, -10.76 and -9.74 respectively). The docking protocol was validated and MM/GBSA studies depicted better stability of selected three ligands (Isocarthamidin, Quercetin, Boeravinone B) complex as compared to standard complex. Further, MD simulation studies were performed using the Desmond (67) software package version 2018-4. All the findings are presented as a case study for the prediction of dual targets for the repurposing of certain phytochemicals as antifungal agents.
Language	English
Publishing date	2024-02-02
Publishing country	United Arab Emirates
Document type	Journal Article
ZDB-ID	2234298-9
ISSN	2212-3989 ; 1871-5265
ISSN (online)	2212-3989
ISSN	1871-5265
DOI	10.2174/0118715265282411240119061441
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Article ; Online: Mindfulness Integrated Cognitive Behavioural Intervention: Effects on Palliative Cancer Care Professionals.

Kaur, Amanpreet / Sharma, Mahendra P / Chaturvedi, Santosh K

BMJ supportive & palliative care

2024 Volume 13, Issue e3, Page(s) e1048–e1055

Abstract: Objective: Being a palliative cancer care professional is challenging and stressful. In recent decades, there has been more interest in mindfulness to improve overall well-being of healthcare professionals. Mindfulness integrated cognitive behavioural ... ...

Abstract	Objective: Being a palliative cancer care professional is challenging and stressful. In recent decades, there has been more interest in mindfulness to improve overall well-being of healthcare professionals. Mindfulness integrated cognitive behavioural interventions (MICBI) are more practical, flexible and understandable than traditional psychological therapies alone. There is a dearth of studies in India with no psychological intervention in palliative cancer care professionals to date. The aim was to examine the effects of MICBI for professional care workers at palliative cancer care centres in Bengaluru city of Southern India. Methods: A single group study design was adopted with pre, post and 3-month follow-up assessment with a sample of 25 participants working full-time at a hospice. The MICBI programme was for six sessions, once a week for 2-2.5 hours. Outcome variables were professional quality of life measures (burnout, secondary traumatic stress and compassion satisfaction), psychological well-being score and mindfulness skills score (assessed using Professional Quality of Life Scale-V.5, Psychological Well-Being Scale and Five Facet Mindfulness Questionnaire). Wilcoxon signed rank test and Friedman test analysed differences between pre, post and follow-up data. Results: The MICBI could significantly reduce burnout and secondary traumatic stress; it improved compassion satisfaction, psychological well-being and mindfulness skills; treatment gains were maintained at 3 months follow-up. Conclusions: MICBI was feasible and effective for palliative cancer care professionals with implications for training, practice and future research. Prospero registration number: The study was registered under the Clinical Trials Registry- India (CTRI) (number: CTRI/2018/03/019170).
MeSH term(s)	Humans ; Mindfulness/education ; Compassion Fatigue ; Quality of Life ; Cognitive Behavioral Therapy ; Burnout, Professional ; Cognition ; Empathy ; Neoplasms/therapy
Language	English
Publishing date	2024-01-08
Publishing country	England
Document type	Journal Article
ISSN	2045-4368
ISSN (online)	2045-4368
DOI	10.1136/bmjspcare-2021-003318
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Article: Palatal rugoscopy as an adjunct for sex determination in forensic odontology (Sri Ganganagar population): A cross-sectional study of 100 subjects.

Gupta, Vineet / Kaur, Amanpreet

Journal of oral and maxillofacial pathology : JOMFP

2022 Volume 25, Issue 3, Page(s) 556

Abstract: Introduction: Palatorugoscopy is the term used to study the rugae patterns. The word rugae came from the Greek word seam. Moreover, it relates the crisscrossing or joining or stitching of the parts of two biological structures during fetal ... ...

Abstract	Introduction: Palatorugoscopy is the term used to study the rugae patterns. The word rugae came from the Greek word seam. Moreover, it relates the crisscrossing or joining or stitching of the parts of two biological structures during fetal differentiation. The aim of this study is to determine the gender difference in rugae pattern with regard to length, number, shape, unification and direction in the population of Sri Ganganagar, Rajasthan. Objective: The objective is to determine the gender difference in rugae pattern with regard to length, number, shape, unification and direction; to investigate the difference in division of rugae in males and females and to compare rugae pattern in males and females of different age group. Materials and methods: This study included 100 subjects, in which 50 were males (Group A) and other 50 were females (Group B). After the formation of primary cast, all quantitative as well as qualitative characteristics of palatal rugae patterns were recorded. Mainly, two classifications were used in this study, Thomas Statistical analysis: Student Results: A statistically significant value was found in left-sided palatal rugae patterns depending upon the size, where we found that primary rugae were more in males. On comparing the angulation of palatal rugae patterns of left-sided rugae, a statistically significant value was found among the negative angulation which was higher in male subjects. Next, while comparing the angulation of palatal rugae of right side, we found a statistically significant value among zero (perpendicular rugae), which was more in male population. On comparing the unification of right-sided rugae patterns, we found that divergent rugae were more in male subjects. Conclusion: Palatal rugae patterns act as individualistic, and are unique patterns, and are helpful in determining the human gender. Further, more studies are required on palatal rugae patterns used in forensics on large population scale.
Language	English
Publishing date	2022-01-11
Publishing country	India
Document type	Journal Article
ZDB-ID	2390999-7
ISSN	1998-393X ; 0973-029X
ISSN (online)	1998-393X
ISSN	0973-029X
DOI	10.4103/jomfp.jomfp_155_21
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Article ; Online: Optimization of Particle Properties of Nanocrystalline Solid Dispersion Based Dry Powder for Inhalation of Voriconazole.

Kaur, Amanpreet / Bansal, Arvind K

Journal of pharmaceutical sciences

2022 Volume 111, Issue 9, Page(s) 2592–2605

Abstract: A one-step spray drying based process was employed to generate ready-to-use nanocrystalline solid dispersion (NCSD) dry powder for inhalation (DPI) of voriconazole (VRC). The solid dispersion was prepared by spray drying VRC, MAN (mannitol) and soya ... ...

Abstract	A one-step spray drying based process was employed to generate ready-to-use nanocrystalline solid dispersion (NCSD) dry powder for inhalation (DPI) of voriconazole (VRC). The solid dispersion was prepared by spray drying VRC, MAN (mannitol) and soya lecithin (LEC) from mixture of methanol-water. Various formulation and process related parameters were screened, including LEC, inlet temperature, total solid content and feed flow rate to generate particles of geometric size ≤5 µm. Aerosil® 200 was explored as the quaternary excipient either during spray drying or by physically mixing with the optimized ternary NCSD. The powders were extensively characterized for solid form, primary particle size, assay, embedded nanocrystal size, morphology, porosity, density and moisture content. Aerodynamic properties were studied using next generation impactor (NGI), while surface elemental composition and topography were investigated using SEM-EDS (scanning electron microscopy- energy dispersive spectroscopy) and AFM (atomic force microscopy), respectively. At selected inlet temperature of 120 ˚C, total solid content and feed flow rate significantly impacted the size of primary NCSD particles. Size of primary particles increased with increase in total solid content and feed flow rate of the solution. VRC nanocrystals were obtained in polymorphic Form B whereas the matrix of MAN consisted of mixture of polymorphic Forms α, β and δ. SEM-EDS analysis confirmed deposition of Aerosil® 200 on surface of spray dried particles. In addition to increased porosity and reduced density, increase in surface roughness of particles (evident from AFM topographic analysis) contributed to enhanced powder deposition at stages 3 and 4 in NGI. In comparison, physical blending of NCSD with Aerosil® 200 showed improvement in aerosolization due to flow enhancement property.
MeSH term(s)	Administration, Inhalation ; Aerosols/chemistry ; Dry Powder Inhalers/methods ; Humans ; Particle Size ; Powders/chemistry ; Silicon Dioxide ; Voriconazole
Chemical Substances	Aerosols ; Powders ; Silicon Dioxide (7631-86-9) ; Voriconazole (JFU09I87TR)
Language	English
Publishing date	2022-06-11
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3151-3
ISSN	1520-6017 ; 0022-3549
ISSN (online)	1520-6017
ISSN	0022-3549
DOI	10.1016/j.xphs.2022.06.007
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Article: Genetically modified crops in India: Experiments with Bt Cotton to explore the road ahead

Kaur, Amanpreet

Open Agriculture. 2020 Aug. 03, v. 5, no. 1

2020

Abstract	The success of genetically modified crops (GMCs), claimed to hold solution to impending environmental problems, depends on land holdings, agroclimatic and geoclimatic conditions, food preferences and sociocultural factors. The direct and indirect impacts of these crops on human health, ecology and environment have not been evaluated on long-term basis. In India, with rich background of farming, GMCs remain a minor change. Introduction of first GMC, Bt Cotton (BC), showed varied response throughout the country. New GMCs like Bt Brinjal and GM Mustard approved for open-field trials in the country were marred under contentious debate and were never approved for commercial cultivation. The current research article aims to study the ecological implications of only GMC available for experimentation in India, BC. A three-phase study carried out as field survey, glass dome experiments and open-field trials compared the BC and conventional cotton (CC) plants with extensive experimentation of ecological parameters including vegetation diversity, insect diversity, plant morphology and infestation intensity. Results highlighted the better morphological characteristics of BC over CC, while infestation studies showed 40% survival rate of insect pest on BC for which it is genetically modified. High electrical conductivity and low organic matter content in the BC soil samples as compared to CC soil samples were indicative of impact of Bt toxins in soil but need further in-depth soil studies to reach scientifically valid results. The current research article substantiates the environmental concerns raised against GMCs especially BC in the country. Its objective is to trigger more research in this direction, so that the technology of GMCs is utilized for the benefit of humankind.
Keywords	agriculture ; cotton ; eggplants ; electrical conductivity ; glass ; human health ; insect pests ; organic matter ; plant morphology ; soil ; surveys ; survival rate ; vegetation ; India
Language	English
Dates of publication	2020-0803
Size	p. 386-394.
Publishing place	De Gruyter
Document type	Article
ISSN	2391-9531
DOI	10.1515/opag-2020-0044
Database	NAL-Catalogue (AGRICOLA)

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