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  1. Article ; Online: "Lockdown-thrombosis"-an unexpected problem of the COVID-19 pandemic?

    Er, Chaozer / Tan, Jing Yuan / Tan, Chuen Wen / Kaur, Hartirathpal / Cheong, May Anne / Lee, Lai Heng / Ng, Heng Joo

    Journal of thrombosis and thrombolysis

    2022  Volume 54, Issue 1, Page(s) 29–32

    Abstract: Seated immobility thromboembolism syndrome (SIT) is the association of prolonged seated immobility with increased risk of venous thromboembolism (VTE). The advent of COVID-19 resulted in implementation of lockdowns to curb its spread. This resulted in ... ...

    Abstract Seated immobility thromboembolism syndrome (SIT) is the association of prolonged seated immobility with increased risk of venous thromboembolism (VTE). The advent of COVID-19 resulted in implementation of lockdowns to curb its spread. This resulted in compulsory work from home and minimization of outdoor activities. Consequently, this would have likely led to increased prolonged sitting and reduced mobility. Few case reports and studies have observed an increase in VTE incidence during the lockdown period. We likewise performed a clinical audit of our weekly thrombosis clinic cases and revealed three cases of VTE associated with prolonged sitting during Singapore's COVID-19 lockdown. Notably, all had other minor VTE risk factors in addition to prolonged sitting. All cases had intermediate-high risk pulmonary embolism and were given extended anticoagulation. With the pandemic still ongoing, periodic lockdown and quarantine measures may continue to be imposed. While the overall VTE risk conferred by prolonged seated immobility associated with lockdown measures is likely to be small, this risk can be easily mitigated and possibly prevented by simply staying mobile.
    MeSH term(s) COVID-19/epidemiology ; Communicable Disease Control ; Humans ; Pandemics ; Pulmonary Embolism/etiology ; Pulmonary Embolism/prevention & control ; Risk Factors ; Thrombosis/complications ; Venous Thromboembolism/complications ; Venous Thromboembolism/prevention & control
    Language English
    Publishing date 2022-06-28
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 1230645-9
    ISSN 1573-742X ; 0929-5305
    ISSN (online) 1573-742X
    ISSN 0929-5305
    DOI 10.1007/s11239-022-02648-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Pralatrexate Induces Long-Term Remission in Relapsed Subcutaneous Panniculitis-Like T-Cell Lymphoma.

    Ong, Shin Yeu / Phipps, Colin / Kaur, Hartirathpal / Tan, Leonard / Lee, Yuh Shan

    Annals of the Academy of Medicine, Singapore

    2019  Volume 48, Issue 9, Page(s) 298–300

    MeSH term(s) Adult ; Aminopterin/analogs & derivatives ; Aminopterin/therapeutic use ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Bone Marrow/pathology ; Cisplatin/administration & dosage ; Cyclophosphamide ; Deoxycytidine/administration & dosage ; Deoxycytidine/analogs & derivatives ; Dexamethasone/administration & dosage ; Doxorubicin ; Folic Acid Antagonists/therapeutic use ; Humans ; Lymphohistiocytosis, Hemophagocytic/etiology ; Lymphohistiocytosis, Hemophagocytic/pathology ; Lymphoma, T-Cell, Peripheral/complications ; Lymphoma, T-Cell, Peripheral/drug therapy ; Lymphoma, T-Cell, Peripheral/pathology ; Male ; Neoplasm Recurrence, Local/drug therapy ; Panniculitis ; Prednisone ; Remission Induction ; Subcutaneous Fat, Abdominal/pathology ; Vincristine
    Chemical Substances 10-propargyl-10-deazaaminopterin ; Folic Acid Antagonists ; Deoxycytidine (0W860991D6) ; Vincristine (5J49Q6B70F) ; Dexamethasone (7S5I7G3JQL) ; Doxorubicin (80168379AG) ; Cyclophosphamide (8N3DW7272P) ; gemcitabine (B76N6SBZ8R) ; Aminopterin (JYB41CTM2Q) ; Cisplatin (Q20Q21Q62J) ; Prednisone (VB0R961HZT)
    Language English
    Publishing date 2019-11-18
    Publishing country Singapore
    Document type Case Reports ; Letter
    ZDB-ID 604527-3
    ISSN 0304-4602
    ISSN 0304-4602
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The Influence of Race on Plasma Thrombin Generation In Healthy Subjects In Singapore.

    Tan, Chuen Wen / Wong, Wan Hui / Tan, Chin Kimg / Chan, Yiong Huak / Kaur, Hartirathpal / Lee, Lai Heng / Ng, Heng Joo

    Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis

    2017  Volume 24, Issue 7, Page(s) 1144–1147

    Abstract: Race is touted as an independent risk factor for venous thromboembolism (VTE), although the basis for this is varied and contentious. Comparison of plasma thrombin generation (TG) using calibrated automated thrombogram (CAT) across races offers a ... ...

    Abstract Race is touted as an independent risk factor for venous thromboembolism (VTE), although the basis for this is varied and contentious. Comparison of plasma thrombin generation (TG) using calibrated automated thrombogram (CAT) across races offers a modality that objectively measures global hemostatic function to evaluate this influence. Direct comparative data across races are currently not available. Aim is to establish the influence of race on plasma TG. Sixty normal participants, matched for age and gender, equally representing 4 races-Caucasian, Chinese, Indian, and Malay-were recruited. Thrombin generation parameters (lag time, time to peak, peak, and endogenous thrombin potential [ETP]) in platelet-poor plasma were measured using CAT. The mean ETP (standard deviation) for the different races were Caucasians: 1338.18 (194.19) nM·min; Chinese, 1318.91 (108.90) nM·min; Indians, 1389.81 (182.61) nM·min; and Malays, 1436.21 (184.24) nM·min. Caucasians had the longest mean lag time of 2.59 ± 0.37 seconds; Indians had the highest mean peak of 284.22 ± 30.74 nM, and Malays had the longest mean time to peak of 5.47 ± 0.59 seconds. Analysis based on race did not demonstrate any significant difference for all TG parameters. The greatest mean difference of ETP between any 2 races (Malays and Chinese) was 117.30 nM·min (95% confidence interval: -45.86 to 280.46 nM·min) which was within the predefined limit of equivalence. In a cohort of healthy participants, TG mediated by plasma factors is not influenced by race and does not explain the reported racial differences in VTE incidence. For the 4 racial groups studied, the use of separate normal ranges for plasma TG might not be essential.
    MeSH term(s) Adult ; Aged ; Continental Population Groups ; Female ; Healthy Volunteers ; Humans ; Male ; Middle Aged ; Singapore ; Thrombin/therapeutic use ; Young Adult
    Chemical Substances Thrombin (EC 3.4.21.5)
    Language English
    Publishing date 2017-12-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1237357-6
    ISSN 1938-2723 ; 1076-0296
    ISSN (online) 1938-2723
    ISSN 1076-0296
    DOI 10.1177/1076029617744319
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Role of platelets in thrombin generation amongst patients with non-transfusion-dependent thalassaemia.

    Tan, Chuen Wen / Wong, Wan Hui / Idros, Roserahayu / Chan, Yiong Huak / Kaur, Hartirathpal / Tng, Alvin Ren Kwang / Lee, Lai Heng / Ng, Heng Joo / Ang, Ai Leen

    Annals of hematology

    2018  Volume 98, Issue 4, Page(s) 861–868

    Abstract: Non-transfusion-dependent thalassaemia (NTDT) is associated with a hypercoagulable state with thrombotic risk highest after splenectomy. Various mechanisms have been proposed. Although an antiplatelet agent is commonly recommended as thromboprophylaxis ... ...

    Abstract Non-transfusion-dependent thalassaemia (NTDT) is associated with a hypercoagulable state with thrombotic risk highest after splenectomy. Various mechanisms have been proposed. Although an antiplatelet agent is commonly recommended as thromboprophylaxis in NTDT, the role of platelets contributing to this hypercoagulable state is not well-defined. This study aims to evaluate the role of platelets contributing to hypercoagulability in NTDT patients using thrombin generation (TG). Platelet-rich (PRP) and platelet-poor plasma (PPP) were collected from NTDT patients (n = 30) and normal controls (n = 20) for TG measurement and compared. Controls had higher endogenous thrombin potential (ETP) in PPP (1204.97 nM.min vs 911.62 nM.min, p < 0.001) and PRP (1424.23 nM.min vs 983.99 nM.min, p < 0.001) than patients. Patients' mean normalized ETP ratio [{PRP ETP (patient)/PPP ETP (patient)}/{mean PPP ETP (controls)/mean PPP ETP (controls)}], demonstrated that the presence of platelet does not alter ETP (mean ratio 0.97, 95% CI 0.93-1.02, equivalence defined as 10%). Types of thalassaemia, splenectomy, and severity of liver iron overload did not significantly influence patients' ETP in PPP and PRP by multivariate analysis. Platelets did not increase the TG potential of NTDT patients. Instead of being hypercoagulable, our NTDT patients were hypocoagulable by ETP measurement, although this could not be conclusively demonstrated to correlate with their iron overloading state giving rise to reduced synthesis of coagulation factors. The guideline recommendations for thromboprophylaxis with antiplatelet agents in similar NTDT patients should be re-examined.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Blood Platelets/metabolism ; Female ; Humans ; Iron Overload/blood ; Iron Overload/surgery ; Male ; Middle Aged ; Plasma/metabolism ; Splenectomy ; Thalassemia/blood ; Thalassemia/surgery ; Thrombin/metabolism ; Thrombophilia/blood ; Thrombophilia/surgery
    Chemical Substances Thrombin (EC 3.4.21.5)
    Language English
    Publishing date 2018-12-13
    Publishing country Germany
    Document type Clinical Trial ; Journal Article
    ZDB-ID 1064950-5
    ISSN 1432-0584 ; 0939-5555 ; 0945-8077
    ISSN (online) 1432-0584
    ISSN 0939-5555 ; 0945-8077
    DOI 10.1007/s00277-018-3579-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Generational performance of three point-of-care testing devices compared with standard laboratory measurement of the international normalised ratio across extended ranges.

    Tay, Hui Ming / Lai, Yi Feng / Kong, Ming Chai / See, Edmund / Yeang, Shu Hui / Koh, Sei Keng / Shim, Yuan Tying / Chan, Fiona Seet Ling / Wong, Wan Hui / Liew, Clifton Xuan You / Kaur, Hartirathpal / Tan, Chuen Wen / Ho, Liam Pock / Ng, Wai Yoong / Yeo, Chin Pin / Ng, Heng Joo

    Journal of clinical pathology

    2019  Volume 72, Issue 4, Page(s) 311–315

    MeSH term(s) Anticoagulants/therapeutic use ; Blood Coagulation/drug effects ; Drug Monitoring/instrumentation ; Drug Monitoring/standards ; Equipment Design ; Humans ; International Normalized Ratio/instrumentation ; International Normalized Ratio/standards ; Point-of-Care Systems/standards ; Point-of-Care Testing/standards ; Predictive Value of Tests ; Prospective Studies ; Reproducibility of Results ; Warfarin/therapeutic use
    Chemical Substances Anticoagulants ; Warfarin (5Q7ZVV76EI)
    Language English
    Publishing date 2019-01-23
    Publishing country England
    Document type Comparative Study ; Journal Article ; Validation Studies
    ZDB-ID 80261-x
    ISSN 1472-4146 ; 0021-9746
    ISSN (online) 1472-4146
    ISSN 0021-9746
    DOI 10.1136/jclinpath-2018-205528
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Reversal of rivaroxaban using Prothromplex Total, a 4-factor prothrombin complex.

    Kaur, Hartirathpal / Yeang, Shu Hui / See, Edmund / Grant, Dixon / Tan, Chuen Wen / Wong, Wan Hui / Tan, Daryl / Ng, Heng Joo / Lee, Lai Heng

    Thrombosis research

    2017  Volume 156, Page(s) 117–118

    Language English
    Publishing date 2017
    Publishing country United States
    Document type Letter
    ZDB-ID 121852-9
    ISSN 1879-2472 ; 0049-3848
    ISSN (online) 1879-2472
    ISSN 0049-3848
    DOI 10.1016/j.thromres.2017.06.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Vox Sanguinis International Forum on paediatric indications for blood component transfusion: Summary.

    Bruun, Mie Topholm / Yazer, Mark H / Spinella, Philip C / Titlestad, Kjell / Lozano, Miquel / Delaney, Meghan / Lejdarová, Hana / Pavlova, Dana E / Trakhtman, Pavel / Starostin, Nikolay / Zhiburt, Eugene / van Kraaij, Marian G J / Huisman, Elise / Kutner, Jose M / Sakashita, Araci M / Yokoyama, Ana P H / Zubicaray, Josune / Sevilla, Julián / Okazaki, Hitoshi /
    Hiwatari, Mitsuteru / Nagura, Yutaka / Manzini, Paola Maria / Facco, Giuseppina / Avdis, Costantino / Singh, Lakhvinder / Hans, Rekha / Sharma, Ratti Ram / Kumar, Praveen / Wikman, Agneta / Deschmann, Emöke / Kaur, Hartirathpal / Mei, Joyce Lam Ching / Ying, Selina Ho Kah / Pei Lin, Koh / New, Helen V / Moss, Rachel / Kinmonth, Anne / Comande, Mary / Savoia, Helen / Crighton, Gemma / Yacobovich, Joanne / Yahalom, Vered / Lau, Wendy

    Vox sanguinis

    2019  Volume 114, Issue 5, Page(s) 523–530

    Language English
    Publishing date 2019-05-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 80313-3
    ISSN 1423-0410 ; 0042-9007
    ISSN (online) 1423-0410
    ISSN 0042-9007
    DOI 10.1111/vox.12763
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Vox Sanguinis International Forum on paediatric indications for blood component transfusion.

    Bruun, Mie Topholm / Yazer, Mark H / Spinella, Philip C / Titlestad, Kjell / Lozano, Miquel / Delaney, Meghan / Lejdarová, Hana / Pavlova, Dana / Trakhtman, Pavel / Starostin, Nikolay / Zhiburt, Eugene / van Kraaij, Marian G J / Huisman, Elise / Kutner, Jose M / Sakashita, Araci M / Yokoyama, Ana P H / Zubicaray, Josune / Sevilla, Julián / Okazaki, Hitoshi /
    Hiwatari, Mitsuteru / Nagura, Yutaka / Manzini, Paola Maria / Facco, Giuseppina / Pecoraro, Clara / Singh, Lakhvinder / Hans, Rekha / Sharma, Ratti Ram / Kumar, Praveen / Wikman, Agneta / Deschmann, Emöke / Kaur, Hartirathpal / Mei Lam, Joyce Ching / Ying Ho, Selina Kah / Koh, Pei Lin / Moss, Rachel / New, Helen V / Kinmonth, Anne / Comande, Mary / Savoia, Helen / Crighton, Gemma / Yacobovich, Joanne / Yahalom, Vered / Lau, Wendy

    Vox sanguinis

    2019  Volume 114, Issue 5, Page(s) e36–e90

    Language English
    Publishing date 2019-05-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 80313-3
    ISSN 1423-0410 ; 0042-9007
    ISSN (online) 1423-0410
    ISSN 0042-9007
    DOI 10.1111/vox.12762
    Database MEDical Literature Analysis and Retrieval System OnLINE

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