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  1. Article ; Online: Anti-cancer peptides: their current trends in the development of peptide-based therapy and anti-tumor drugs

    Lath, Amit / Santal, Anita Rani / Kaur, Nameet / Kumari, Poonam / Singh, Nater Pal

    Biotechnology and Genetic Engineering Reviews. 2023 Jan. 02, v. 39, no. 1 p.45-84

    2023  

    Abstract: Human cancer remains a cause of high mortality throughout the world. The conventional methods and therapies currently employed for treatment are followed by moderate-to-severe side effects. They have not generated curative results due to the ... ...

    Abstract Human cancer remains a cause of high mortality throughout the world. The conventional methods and therapies currently employed for treatment are followed by moderate-to-severe side effects. They have not generated curative results due to the ineffectiveness of treatments. Besides, the associated high costs, technical requirements, and cytotoxicity further characterize their limitations. Due to relatively higher presidencies, bioactive peptides with anti-cancer attributes have recently become treatment choices within the therapeutic arsenal. The peptides act as potential anti-cancer agents explicitly targeting tumor cells while being less toxic to normal cells. The anti-cancer peptides are isolated from various natural sources, exhibit high selectivity and high penetration efficiency, and could be quickly restructured. The therapeutic benefits of compatible anti-cancer peptides have contributed to the significant expansion of cancer treatment; albeit, the mechanisms by which bioactive peptides inhibit the proliferation of tumor cells remain unclear. This review will provide a framework for assessing anti-cancer peptides’ structural and functional aspects. It shall provide appropriate information on their mode of action to support and strengthen efforts to improve cancer prevention. The article will mention the therapeutic health benefits of anti-cancer peptides. Their importance in clinical studies is elaborated for reducing cancer incidences and developing sustainable treatment models.
    Keywords biotechnology ; cancer therapy ; cytotoxicity ; humans ; mechanism of action ; mortality ; neoplasms ; peptides ; Anti-cancer peptides ; therapeutic benefits ; anti-tumor ; bioactive peptides
    Language English
    Dates of publication 2023-0102
    Size p. 45-84.
    Publishing place Taylor & Francis
    Document type Article ; Online
    ZDB-ID 2500039-1
    ISSN 2046-5556 ; 0264-8725
    ISSN (online) 2046-5556
    ISSN 0264-8725
    DOI 10.1080/02648725.2022.2082157
    Database NAL-Catalogue (AGRICOLA)

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  2. Article ; Online: Anti-cancer peptides: their current trends in the development of peptide-based therapy and anti-tumor drugs.

    Lath, Amit / Santal, Anita Rani / Kaur, Nameet / Kumari, Poonam / Singh, Nater Pal

    Biotechnology & genetic engineering reviews

    2022  Volume 39, Issue 1, Page(s) 45–84

    Abstract: Human cancer remains a cause of high mortality throughout the world. The conventional methods and therapies currently employed for treatment are followed by moderate-to-severe side effects. They have not generated curative results due to the ... ...

    Abstract Human cancer remains a cause of high mortality throughout the world. The conventional methods and therapies currently employed for treatment are followed by moderate-to-severe side effects. They have not generated curative results due to the ineffectiveness of treatments. Besides, the associated high costs, technical requirements, and cytotoxicity further characterize their limitations. Due to relatively higher presidencies, bioactive peptides with anti-cancer attributes have recently become treatment choices within the therapeutic arsenal. The peptides act as potential anti-cancer agents explicitly targeting tumor cells while being less toxic to normal cells. The anti-cancer peptides are isolated from various natural sources, exhibit high selectivity and high penetration efficiency, and could be quickly restructured. The therapeutic benefits of compatible anti-cancer peptides have contributed to the significant expansion of cancer treatment; albeit, the mechanisms by which bioactive peptides inhibit the proliferation of tumor cells remain unclear. This review will provide a framework for assessing anti-cancer peptides' structural and functional aspects. It shall provide appropriate information on their mode of action to support and strengthen efforts to improve cancer prevention. The article will mention the therapeutic health benefits of anti-cancer peptides. Their importance in clinical studies is elaborated for reducing cancer incidences and developing sustainable treatment models.
    MeSH term(s) Humans ; Neoplasms/drug therapy ; Antineoplastic Agents ; Peptides/therapeutic use
    Chemical Substances Antineoplastic Agents ; Peptides
    Language English
    Publishing date 2022-06-14
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 49457-4
    ISSN 2046-5556 ; 0264-8725
    ISSN (online) 2046-5556
    ISSN 0264-8725
    DOI 10.1080/02648725.2022.2082157
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Se 1012: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Appraisal of Pancreatic Lipase Inhibitory Potential of

    Vulichi, Srinivasa R / Runthala, Ashish / Rachamreddy, Siva K / Yaramanedi, Radhika S P / Sahoo, Partha Sarathi / Burra, Prasad V L S / Kaur, Nameet / Akkiraju, Sudheer / Kanala, Somasekhar Reddy / Chippada, Appa Rao / Murthy, Sistla Durga Srinivasa

    ACS omega

    2023  Volume 8, Issue 19, Page(s) 16630–16646

    Abstract: Pancreatic lipase is one of the crucial lipolytic enzymes of the gut that actively facilitates the digestion and absorption of the dietary triglycerides and cholesteryl esters. Although it has been deemed as one of the most reliable targets for the ... ...

    Abstract Pancreatic lipase is one of the crucial lipolytic enzymes of the gut that actively facilitates the digestion and absorption of the dietary triglycerides and cholesteryl esters. Although it has been deemed as one of the most reliable targets for the treatment of obesity and/or dyslipidemia, to date, orlistat is the only known FDA-approved, effective, oral pancreatic lipase inhibitor available for clinical use apart from the centrally acting antiobesity agents. However, it is known to be associated with adverse gastrointestinal and renal complications. In this study, we attempted to assess the antioxidant and porcine pancreatic lipase inhibitory potentials of
    Language English
    Publishing date 2023-05-05
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.2c07361
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Therapeutic Implications of Superoxide Dismutase And Its Importance in Kinase Drug Discovery.

    Kaur, Nameet / Sharma, Arun K / Shakeel, Adeeba / Kumar, Vipin / Singh, Aarti / Gupta, Apoorv / Suhag, Deepa / Rajput, Satyendra K / Mukherjee, Monalisa

    Current topics in medicinal chemistry

    2017  Volume 17, Issue 22, Page(s) 2495–2508

    Abstract: In recent years, several scientific investigations have reported the therapeutic implications of superoxide dismutase (SOD) against oxidative stress and -induced pathology in clinical and preclinical trials. Indeed, various kinase, molecular signaling ... ...

    Abstract In recent years, several scientific investigations have reported the therapeutic implications of superoxide dismutase (SOD) against oxidative stress and -induced pathology in clinical and preclinical trials. Indeed, various kinase, molecular signaling and physiological process has altered by reactive oxygen species. In spite of the abundant available literature reports, patents, clinical trials and commercialized products, the therapeutic application of SOD as a potential drug still remains unclear. Owing to the technical challenges associated with the utilization of SOD as a drug, we revisited the structural arrangement and cellular signaling, significant association with kinase, exploring the new target sites and introducing new formulation strategies such as gene modulation, nano-formulations and click chemistry is a prerequisite. In-addition to gene modulation strategies, encapsulated formulation within a nano-carrier for producing promising SOD therapeutic effects, application of click chemistry including bioconjugation and cyclo-addition are the most prominent methods to produce highly efficient SOD formulations. Thus, the present review enlightens the foremost technique which may have better interaction with kinase and other cellular signaling for regulating the physiological process.
    MeSH term(s) Animals ; Drug Discovery ; Humans ; Oxidative Stress/drug effects ; Protein Kinase Inhibitors/chemical synthesis ; Protein Kinase Inhibitors/chemistry ; Protein Kinase Inhibitors/pharmacology ; Protein Kinases/metabolism ; Signal Transduction/drug effects ; Superoxide Dismutase/antagonists & inhibitors ; Superoxide Dismutase/metabolism
    Chemical Substances Protein Kinase Inhibitors ; Superoxide Dismutase (EC 1.15.1.1) ; Protein Kinases (EC 2.7.-)
    Language English
    Publishing date 2017
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2064823-6
    ISSN 1873-4294 ; 1568-0266
    ISSN (online) 1873-4294
    ISSN 1568-0266
    DOI 10.2174/1568026617666170307112837
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5572: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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