Article ; Online: Revolutionizing diabetes care: unveiling tirzepatide's potential in glycemic control and beyond.
Expert review of clinical pharmacology
2024 Volume 17, Issue 3, Page(s) 235–246
Abstract: Introduction: Diabetes is a global public health challenge with rising prevalence. This review explores current diabetes understanding, diagnostic and management guidelines, economic impact, and lifestyle modifications as the primary approach.: Areas ... ...
| Abstract | Introduction: Diabetes is a global public health challenge with rising prevalence. This review explores current diabetes understanding, diagnostic and management guidelines, economic impact, and lifestyle modifications as the primary approach. Areas covered: Focusing on pharmacological interventions, we discuss the roles of GLP-1 agonists and GLP/GIP agonists in diabetes management and cardiovascular risk reduction. Tirzepatide, a novel medication, is highlighted for its unique mechanism of action. Clinical trials demonstrate its effectiveness in glucose control, weight reduction, and its potential impact on diabetes, obesity, NASH, and cardiovascular risks. Expert opinion: Tirzepatide shows promise in diabetes treatment, offering glucose control and weight loss. It also holds potential for addressing comorbidities. However, cautious use is vital due to potential adverse effects and contraindications, including hypersensitivity reactions, pregnancy, and breastfeeding precautions. This review underscores tirzepatide as a valuable addition to diabetes therapies, with evolving prospects for enhanced patient outcomes as research advances. |
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| MeSH term(s) | Female ; Pregnancy ; Humans ; Glycemic Control ; Blood Glucose ; Diabetes Mellitus/drug therapy ; Gastric Inhibitory Polypeptide ; Diabetes Mellitus, Type 2/drug therapy ; Glucagon-Like Peptide-1 Receptor ; Hypoglycemic Agents/adverse effects ; Glucagon-Like Peptide-2 Receptor |
| Chemical Substances | tirzepatide (OYN3CCI6QE) ; Blood Glucose ; Gastric Inhibitory Polypeptide (59392-49-3) ; Glucagon-Like Peptide-1 Receptor ; Hypoglycemic Agents ; Glucagon-Like Peptide-2 Receptor |
| Language | English |
| Publishing date | 2024-01-31 |
| Publishing country | England |
| Document type | Journal Article ; Review |
| ISSN | 1751-2441 |
| ISSN (online) | 1751-2441 |
| DOI | 10.1080/17512433.2024.2310070 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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