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Article ; Online: The diagnostic accuracy of two-dimensional strain imaging echocardiography to detect the severity of coronary artery disease in non-ST segment elevation acute coronary syndrome.

Goswami, Sourabh / Choudhary, Rahul / Deora, Surender / Kaushik, Atul

2023 Volume 75, Issue 6, Page(s) 409–415

Abstract: Objective: Strain imaging by two-dimensional speckle tracking echocardiography can detect severe coronary artery disease (CAD). This study aims to assess the diagnostic accuracy of various strain parameters in patients with non-ST segment acute coronary ...

Abstract	Objective: Strain imaging by two-dimensional speckle tracking echocardiography can detect severe coronary artery disease (CAD). This study aims to assess the diagnostic accuracy of various strain parameters in patients with non-ST segment acute coronary syndrome to detect the angiographic severity of CAD and also to compare among them. Methods: This hospital-based observational study was conducted on 178 patients with NSTEACS and preserved left ventricular ejection fraction who presented in emergency or outdoor from July 2021 to December 2022. We excluded patients with prior coronary revascularization, heart failure, arrhythmia, more than trivial valvular heart disease, or poor acoustic window. Global longitudinal strain (GLS), peak systolic strain (SS), post systolic index (PSI), and systolic strain rate (SR) were calculated by speckle tracking with automated function imaging. Coronary angiography was done in all patients, and the syntax score was calculated. Results: The strain parameters showed a significant correlation with the syntax score. There was a statistically significant difference in strain parameters between patients with left main (LM) or triple vessel disease (TVD) and others. Receiver operating characteristic (ROC) curve analysis showed that GLS had a better diagnostic accuracy for detecting LM or TVD than other strain parameters. GLS with a cut-off value of -11.2% had a sensitivity of 85.7% and specificity of 53.5% for detecting LM or TVD. Conclusion: Strain imaging can be a helpful bedside adjunct to conventional investigations for detecting severe CAD in patients with NSTEACS.
MeSH term(s)	Humans ; Coronary Artery Disease/diagnosis ; Stroke Volume ; Acute Coronary Syndrome/diagnosis ; Ventricular Function, Left ; Electrocardiography/methods ; Reproducibility of Results ; Echocardiography/methods ; Coronary Angiography ; ROC Curve
Language	English
Publishing date	2023-09-28
Publishing country	India
Document type	Observational Study ; Journal Article
ZDB-ID	604366-5
ISSN	2213-3763 ; 0019-4832
ISSN (online)	2213-3763
ISSN	0019-4832
DOI	10.1016/j.ihj.2023.09.003
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Zs.A 616: Show issues

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Article ; Online: Is it Worthy Enough to Revascularize Chronically Occluded Coronaries?

Sahu, Ankit Kumar / Kazmi, Danish Hasan / Kaushik, Atul

Cardiology in review

2023

Abstract: Chronic total occlusions (CTOs) represent the "final frontier" of coronary interventions with the lowest procedural success rates and the most common reason for incomplete revascularization and referral to coronary artery bypass graft surgery (CABG). CTO ...

Abstract	Chronic total occlusions (CTOs) represent the "final frontier" of coronary interventions with the lowest procedural success rates and the most common reason for incomplete revascularization and referral to coronary artery bypass graft surgery (CABG). CTO lesions are not an infrequent finding during coronary angiography. They are often responsible for enhancing the complexity of the coronary disease burden thereby affecting the final interventional decision in the process. Notwithstanding the modest technical success of CTO-PCI, most of the earlier observational data demonstrated a clear survival benefit free of major cardiovascular events (MACE) in patients undergoing successful CTO revascularization. However, data from recent randomized trials fail to uphold the same survival advantage albeit, showing some trend toward improvement in left ventricular function, quality of life indicators and freedom from fatal ventricular arrythmia. Various guidance statements propose a well-defined role for CTO intervention in specific situations provided criterions for patient selection, appreciable inducible ischemia, myocardial viability and cost-risk-benefit analysis are met.
Language	English
Publishing date	2023-03-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	1294965-6
ISSN	1538-4683 ; 1061-5377
ISSN (online)	1538-4683
ISSN	1061-5377
DOI	10.1097/CRD.0000000000000509
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Article: Origin of all Three Coronaries from Single Ostium: A Rare Case Report.

Deora, Surender / Sharma, Jai Bharat / Kaushik, Atul / Choudhary, Rahul

Heart views : the official journal of the Gulf Heart Association

2023 Volume 24, Issue 1, Page(s) 59–62

Abstract: Origin of coronary arteries from the opposite sinus of Valsalva is rare and origin from a single ostium is extremely rare. Patients with these anomalies may have myocardial ischemia because of altered ostial configuration, exit angulation from the aorta, ...

Abstract	Origin of coronary arteries from the opposite sinus of Valsalva is rare and origin from a single ostium is extremely rare. Patients with these anomalies may have myocardial ischemia because of altered ostial configuration, exit angulation from the aorta, the course between great arteries, and atherosclerosis. Usually, these anomalies are diagnosed during coronary angiography either by computed tomography or catheter-based. Management depends upon the coronary anomaly and associated clinical condition.
Language	English
Publishing date	2023-02-23
Publishing country	India
Document type	Case Reports
ZDB-ID	2575257-1
ISSN	0976-5123 ; 1995-705X
ISSN (online)	0976-5123
ISSN	1995-705X
DOI	10.4103/heartviews.heartviews_81_22
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Article ; Online: Impending myocardial ischaemia during thyroid storm diagnosed through Wellens' syndrome.

Patra, Shinjan / Kaliyappan, Anupriya / Kaushik, Atul / Roy, Ayan

BMJ case reports

2022 Volume 15, Issue 8

Abstract: We present a case of thyroid storm precipitated by discontinuation of antithyroid drugs. The patient developed a concurrent acute coronary event during the resolution period of the thyroid storm. After 48 hours of prudent management of thyroid storm, the ...

Abstract	We present a case of thyroid storm precipitated by discontinuation of antithyroid drugs. The patient developed a concurrent acute coronary event during the resolution period of the thyroid storm. After 48 hours of prudent management of thyroid storm, the patient's sensorium and haemodynamics were stabilised but he had persistent mild chest discomfort and developed new-onset jaw pain. On admission, ECG showed sinus tachycardia. In consideration of persistent mild chest discomfort and new-onset jaw pain, serial ECGs were performed which revealed biphasic T waves in V2-V3 suggestive of Wellens' syndrome type A. This indicated a critical stenosis of the left anterior descending (LAD) coronary artery and impending myocardial ischaemia. The patient underwent urgent coronary catheterisation, which revealed 80% stenosis of proximal LAD and was subsequently revascularised resolving his symptoms. This case underscores the significance of serial ECG monitoring even after the acute phase of thyroid crisis, which helped in timely identification of Wellens' syndrome.
MeSH term(s)	Constriction, Pathologic ; Coronary Artery Disease ; Coronary Stenosis ; Electrocardiography ; Humans ; Male ; Pain ; Syndrome ; Thyroid Crisis
Language	English
Publishing date	2022-08-26
Publishing country	England
Document type	Case Reports ; Journal Article
ISSN	1757-790X
ISSN (online)	1757-790X
DOI	10.1136/bcr-2022-250488
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Article: Role of Itolizumab in the Treatment of COVID-19 Patients, Admitted to ICU at a Tertiary Care Hospital.

Kurri, Nalini / Tyagi, Bhumesh / Kaushik, Atul / Gupta, Nikhil / Agarwal, A K / Singh, B M

The Journal of the Association of Physicians of India

2023 Volume 70, Issue 10, Page(s) 11–12

Abstract: Background: Clinical studies have correlated severe deterioration of COVID-19 patients due to excessive and uncontrolled production of cytokines. There is a pressing need to explore therapies, which could prevent the cytokine storm rather than ... ...

Abstract	Background: Clinical studies have correlated severe deterioration of COVID-19 patients due to excessive and uncontrolled production of cytokines. There is a pressing need to explore therapies, which could prevent the cytokine storm rather than terminating it. Aims and objectives: The aim of the study is to evaluate the effect of itolizumab on clinical outcomes of patients with moderate-severe COVID-19 disease admitted to ICU. The primary aim of the current study is to find out any mortality benefit in 14 days. The secondary aim is to assess the morbidity outcomes in terms of reduction in inflammatory markers and also the duration of hospital stays to assess the prognostication. Materials and methods: It is a retrospective case-control study in which laboratory-confirmed COVID-19 patients admitted to ICU were taken. A total of 62 patients were recruited, 31 patients received itolizumab (cases/treatment group) and 31 patients didn't receive itolizumab (designated as controls). Results: Among the total patients recruited, 68% of the study population was male and 32% were female. A total of 12 patients expired among cases and 13 expired among controls. Overall mortality in both groups was noted to be almost similar. The control group showed mortality at lower computed tomography (CT) scores compared to the cases. There is a significant reduction in inflammatory markers, like interleukins-6 (IL-6) and D-dimer in cases compared to the control group. Conclusion: In conclusion, treating patients with cytokine storms before they require intubation/mechanical ventilation is crucial to preventing deaths. Itolizumab has shown no clinical benefit in critically ill COVID-19 patients, however, timely initiation of itolizumab therapy may serve as a key therapeutic option in preventing the mortality and morbidity outcomes in moderate-severe COVID-19 patients.
MeSH term(s)	Humans ; Male ; Female ; COVID-19 ; SARS-CoV-2 ; Case-Control Studies ; Retrospective Studies ; Tertiary Care Centers ; Intensive Care Units
Chemical Substances	itolizumab (XQQ2RHV14N)
Language	English
Publishing date	2023-06-25
Publishing country	India
Document type	Journal Article
ZDB-ID	800766-4
ISSN	0004-5772
ISSN	0004-5772
DOI	10.5005/japi-11001-0114
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Article: Takotsubo cardiomyopathy following head and neck surgery: Can the fear of disfigurement be blamed?

Rathod, Darshana KirtiKumar / Sharma, Ankur / Sharma, Nivedita / Kaushik, Atul / Karmakar, Shilpi

Saudi journal of anaesthesia

2023 Volume 17, Issue 3, Page(s) 419–422

Abstract: Takotsubo cardiomyopathy is accompanied by transitory left ventricular dysfunction without substantial coronary artery disease. A history of acute physical or mental stress typically precedes such a presentation. We want to highlight a case of Takotsubo ... ...

Abstract	Takotsubo cardiomyopathy is accompanied by transitory left ventricular dysfunction without substantial coronary artery disease. A history of acute physical or mental stress typically precedes such a presentation. We want to highlight a case of Takotsubo cardiomyopathy in the early postoperative period in a young female patient who underwent extensive surgery for buccal mucosal carcinoma. The onset of this cardiomyopathy can be ascribed to a fear of disfigurement and prolonged surgical stress.
Language	English
Publishing date	2023-06-22
Publishing country	India
Document type	Case Reports
ZDB-ID	2562174-9
ISSN	0975-3125 ; 1658-354X
ISSN (online)	0975-3125
ISSN	1658-354X
DOI	10.4103/sja.sja_906_22
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Article ; Online: Comment: Comparison of radial versus femoral access using hemostatic devices following percutaneous coronary intervention.

Deora, Surender / Choudhary, Rahul / Kaushik, Atul

Indian heart journal

2021 Volume 73, Issue 4, Page(s) 525–526

MeSH term(s)	Femoral Artery/surgery ; Hemostatics ; Humans ; Percutaneous Coronary Intervention ; Radial Artery
Chemical Substances	Hemostatics
Language	English
Publishing date	2021-07-06
Publishing country	India
Document type	Letter ; Comment
ZDB-ID	604366-5
ISSN	2213-3763 ; 0019-4832
ISSN (online)	2213-3763
ISSN	0019-4832
DOI	10.1016/j.ihj.2021.06.015
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Zs.A 616: Show issues

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Article ; Online: Noninvasive assessment of pulmonary congestion in heart failure: Need of the hour.

Deora, Surender / Choudhary, Rahul / Kaushik, Atul / Singh, Satyajeet / Singh, Bhupinder / Kumar, Barun

Indian heart journal

2023 Volume 75, Issue 4, Page(s) 224–228

Abstract: Early pulmonary congestion detection and surveillance in acute heart failure patients can prevent decompensation, minimize hospitalizations, and improve prognosis. In India, the warm and wet types of HF are still the most common types and residual ... ...

Abstract	Early pulmonary congestion detection and surveillance in acute heart failure patients can prevent decompensation, minimize hospitalizations, and improve prognosis. In India, the warm and wet types of HF are still the most common types and residual congestion at discharge is still a significant concern. Thus, there is an urgent need for a reliable and sensitive means of identifying residual and subclinical congestion. Two such monitoring systems are available and approved by US FDA. These include CardioMEMS HF System (Abbott, Sylmar, California) and ReDS System (Sensible Medical Innovations, Ltd., Nanya, Israel). CardioMEMS is a wireless pressure-sensitive implantable device, while ReDS is a wearable noninvasive device for measurement of the lung fluid and hence direct detection of PC. This review discusses the role of noninvasive assessment in PC monitoring in patients with heart failure and its implications from an Indian perspective.
MeSH term(s)	Humans ; Lung ; Pulmonary Edema/diagnosis ; Pulmonary Edema/etiology ; Hospitalization ; Monitoring, Physiologic ; Heart Failure/complications ; Heart Failure/diagnosis
Language	English
Publishing date	2023-05-17
Publishing country	India
Document type	Journal Article ; Review
ZDB-ID	604366-5
ISSN	2213-3763 ; 0019-4832
ISSN (online)	2213-3763
ISSN	0019-4832
DOI	10.1016/j.ihj.2023.05.004
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Zs.A 616: Show issues

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Article: Evaluation of larvicidal potential of Eritrean medicinal plants against

Kaushik, Jeevan Jyoti / Kaushik, Atul / Mebrahtu, Dawit / Bereket, Efrem / Eyob, Elen / Kelifa, Hana / Weldemichael, Kokob / Andebrhan, Rahwa

Journal of parasitic diseases : official organ of the Indian Society for Parasitology

2024 Volume 48, Issue 1, Page(s) 150–156

Abstract: Larvicidal activity of three Eritrean medicinal plants was evaluated ... ...

Abstract	Larvicidal activity of three Eritrean medicinal plants was evaluated against
Language	English
Publishing date	2024-02-22
Publishing country	India
Document type	Journal Article
ZDB-ID	2548456-4
ISSN	0975-0703 ; 0971-7196
ISSN (online)	0975-0703
ISSN	0971-7196
DOI	10.1007/s12639-024-01653-7
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Article: COVID-19 pandemic and stent thrombosis in a post percutaneous coronary intervention patient-a case report highlighting the selection of P2Y12 inhibitor.

Choudhary, Rahul / Kaushik, Atul / Sharma, Jai Bharat

Cardiovascular diagnosis and therapy

2020 Volume 10, Issue 4, Page(s) 898–901

Abstract: The current pandemic of novel coronavirus disease 2019 (COVID-19) has posed a great threat to people's health worldwide, with specific implications on patients with underlying heart diseases. During this challenging period, nearly all major societies ... ...

Abstract	The current pandemic of novel coronavirus disease 2019 (COVID-19) has posed a great threat to people's health worldwide, with specific implications on patients with underlying heart diseases. During this challenging period, nearly all major societies have recommended for conservative approach, even for patients with relatively stable acute cardiovascular diseases. Selection of specific antiplatelet therapy in an uncomplicated post percutaneous coronary intervention (PCI) patient can, at times, be crucial issue in such strained circumstances. We report a case of 64-year-old male, who was taken for urgent coronary angiogram (CAG) in view of non ST elevation acute coronary syndrome. Successful PCI with implantation of drug eluting stent was done for right coronary artery (RCA) and left anterior descending (LAD) artery lesions. On day 5th post-PCI, he developed acute inferior wall STEMI due to subacute stent thrombosis (ST), and despite all efforts, patient could not be saved as he didn't receive timely intervention. Increased travel time to emergency department due to lockdown because of COVID-19 and along with extra time required for donning of personal protection equipment (PPE) and other COVID-19 related safety measures prolonged the ischemic time. Potent P2Y12 inhibitor based dual antiplatelet therapy might have prevented this subacute ST, and thus mortality, as the patient was discharged on clopidogrel after PCI. While selecting specific P2Y12 inhibitor in a post PCI patient, apart from clinical condition of patient and complexity of procedure, we should also consider current COVID-19 pandemic. Current circumstances may favour ticagrelor over other P2Y12 inhibitors in view of its potent, rapid, and reversible antiplatelet action along with its optimistic effect in pneumonia.
Keywords	covid19
Language	English
Publishing date	2020-09-14
Publishing country	China (Republic : 1949- )
Document type	Case Reports
ZDB-ID	2685043-6
ISSN	2223-3660 ; 2223-3652
ISSN (online)	2223-3660
ISSN	2223-3652
DOI	10.21037/cdt-20-485
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