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  1. Article ; Online: COVID-19 and health care workers burnout: A call for global action.

    Kaushik, Dharam

    EClinicalMedicine

    2021  Volume 35, Page(s) 100808

    Language English
    Publishing date 2021-03-22
    Publishing country England
    Document type Journal Article
    ISSN 2589-5370
    ISSN (online) 2589-5370
    DOI 10.1016/j.eclinm.2021.100808
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  2. Article ; Online: Broken Tumor, Intact Courage.

    Kaushik, Dharam

    American journal of kidney diseases : the official journal of the National Kidney Foundation

    2021  Volume 77, Issue 4, Page(s) A14–A15

    MeSH term(s) COVID-19/epidemiology ; COVID-19/prevention & control ; Courage ; Humans ; Kidney Neoplasms/diagnosis ; Kidney Neoplasms/epidemiology ; Kidney Neoplasms/surgery ; Patient Care Team/standards
    Language English
    Publishing date 2021-02-03
    Publishing country United States
    Document type Editorial
    ZDB-ID 604539-x
    ISSN 1523-6838 ; 0272-6386
    ISSN (online) 1523-6838
    ISSN 0272-6386
    DOI 10.1053/j.ajkd.2020.11.009
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    Zs.A 1669: Show issues Location:
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    Zs.MO 468: Show issues

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  3. Article: Mini-Percutaneous Nephrolithotomy With an Endoscopic Surgical Monitoring System for the Management of Renal Stones: A Retrospective Evaluation.

    Gui, Huiming / Wang, Hanzhang / Kaushik, Dharam / Rodriguez, Ronald / Wang, Zhiping

    Frontiers in surgery

    2022  Volume 9, Page(s) 773270

    Abstract: Purpose: To compare the outcomes and postoperative quality of life of patients with renal calculi who underwent standard percutaneous nephrolithotomy (sPNL), mini-invasive percutaneous nephrolithotomy (mPNL) or mPNL with an endoscopic surgical ... ...

    Abstract Purpose: To compare the outcomes and postoperative quality of life of patients with renal calculi who underwent standard percutaneous nephrolithotomy (sPNL), mini-invasive percutaneous nephrolithotomy (mPNL) or mPNL with an endoscopic surgical monitoring system (ESMS) using a retrospective clinical trial.
    Methods: Eighty-six adult patients with renal stones who were treated with sPNL were retrospectively compared to ninety-two patients who were treated with mPNL between July 2014 and December 2017. Next, further studies were retrospectively conducted using a matched paired method. The ninety-two patients treated with mPNL were divided into two groups based on whether the endoscopic surgical monitoring system (ESMS) was used (ESMS-mPNL vs. non-ESMS-mPNL). The ESMS used strain gauge transducers to measure the inflow and outflow of irrigation solution. Bleeding and fluid absorption during endoscopic surgery could be accurately calculated by computer program in ESMS.
    Results: The fluoroscopy time, complication rate, stone-free status and clinically insignificant residual fragment (CIRF) rate were not significantly different between the two groups (sPNL vs. mPNL). The mPNL group had a significantly longer operation time than the sPNL group, and the mPNL group exhibited a markedly reduced 12-h postoperative visual analogue pain scale (VAS) score, mean hospitalization time, and return to work time, had slightly reduced haemoglobin loss, and underwent more tubeless operations. Moreover, among the 92 patients who underwent mPNL, the operation time (
    Conclusions: mPNL is less painful than sPNL in patients undergoing treatment for 20-40 mm renal stones. Similar stone-free rates were achieved by the two procedures, but mPNL was superior to sPNL in terms of blood loss, discomfort, hospitalization time and return to work time. We think that ESMS-mPNL is less painful for patients and more efficacious than non-ESMS-mPNL, and ESMS-mPNL achieves a stone-free rate that is similar to non-ESMS-mPNL in patients receiving treatment for 20-40 mm kidney stones.
    Language English
    Publishing date 2022-07-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2773823-1
    ISSN 2296-875X
    ISSN 2296-875X
    DOI 10.3389/fsurg.2022.773270
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  4. Article: Corrigendum: Mini-percutaneous nephrolithotomy with an endoscopic surgical monitoring system for the management of renal stones: A retrospective evaluation.

    Gui, Huiming / Wang, Hanzhang / Kaushik, Dharam / Rodriguez, Ronald / Wang, Zhiping

    Frontiers in surgery

    2022  Volume 9, Page(s) 999166

    Abstract: This corrects the article DOI: 10.3389/fsurg.2022.773270.]. ...

    Abstract [This corrects the article DOI: 10.3389/fsurg.2022.773270.].
    Language English
    Publishing date 2022-08-10
    Publishing country Switzerland
    Document type Published Erratum
    ZDB-ID 2773823-1
    ISSN 2296-875X
    ISSN 2296-875X
    DOI 10.3389/fsurg.2022.999166
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  5. Article: A comparative analysis of radical cystectomy with perioperative chemotherapy, chemoradiation therapy, or systemic therapy in patients with clinically advanced node-positive bladder cancer (cN2/N3).

    Garg, Harshit / Bhandari, Mukund / Dursun, Furkan / Liss, Michael A / Kaushik, Dharam / Svatek, Robert S / Mansour, Ahmed M

    Frontiers in oncology

    2024  Volume 13, Page(s) 1157880

    Abstract: Introduction: The management of non-metastatic clinically advanced lymph nodal (cN2/N3) bladder cancer (Stage IIIB) could involve radical cystectomy, chemoradiation, or systemic therapy alone. However, a definitive comparison between these approaches is ...

    Abstract Introduction: The management of non-metastatic clinically advanced lymph nodal (cN2/N3) bladder cancer (Stage IIIB) could involve radical cystectomy, chemoradiation, or systemic therapy alone. However, a definitive comparison between these approaches is lacking. This study aims to compare the outcomes of patients undergoing radical cystectomy with pelvic lymph node dissection (RC-PLND), chemoradiation therapy (CRT) or systemic therapy (including immunotherapy) (ST) only in patients with stage IIIB bladder cancer.
    Materials and methods: A retrospective analysis of the National Cancer Database for patients with stage IIIB urothelial bladder cancer was done from 2004-2019. Patients were classified as Group A: Those who received RC-PLND with perioperative chemotherapy, Group B: Those who received CRT, and Group C: Those who received only ST alone. The primary outcome was overall survival (OS). Inverse probability weighting (IPW)-adjusted Kaplan Meier curves were utilized to compare overall survival (OS) and cox multivariate regression analysis was used to identify predictors for OS.
    Results: Overall, 2,575 patients were identified. They were classified into Group A (n=1,278), Group B (n=317) and Group C (n=980). Compared to Group B, patients in Group A were younger (SMD=19.6%), had lower comorbidities (SMD=18.2%), had higher income (SMD=31.5%), had private insurance (SMD= 26.7%), were treated at academic centres (SMD=29.3%) and had higher percentage of N2 disease (SMD=31.1%). Using IPW-adjusted survival analysis, compared to Group C, the median OS was significantly higher in Group A (20.7 vs 14.2 months, p<0.001) and Group B (19.7 vs 14.2 months, p<0.001) but similar between Group A and Group B (20.9 vs 19.7 months, p=0.74). Both surgery (HR=0.72 (0.65-0.80), p<0.001) and CRT (0.70 (0.59-0.82), p<0.001) appeared to be independent predictors for OS on cox-regression analysis. The major limitations include bias due to retrospective analysis and non-assessment of cancer-specific survival.
    Conclusion: In stage IIIB bladder cancer with advanced lymph nodal disease, both RC and CRT offer equivalent survival benefits and are superior to systemic therapy alone.
    Language English
    Publishing date 2024-01-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2023.1157880
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  6. Article ; Online: "Immune-Cell Pawns" Plot Promotion and Corner Kidney Cancer: CheckMate 214.

    Dursun, Furkan / Ramamurthy, Chethan / Kaushik, Dharam

    European urology

    2021  Volume 81, Issue 3, Page(s) 272–273

    MeSH term(s) Female ; Humans ; Kidney Neoplasms ; Male ; Nivolumab
    Chemical Substances Nivolumab (31YO63LBSN)
    Language English
    Publishing date 2021-11-24
    Publishing country Switzerland
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Comment
    ZDB-ID 193790-x
    ISSN 1873-7560 ; 1421-993X ; 0302-2838
    ISSN (online) 1873-7560 ; 1421-993X
    ISSN 0302-2838
    DOI 10.1016/j.eururo.2021.11.006
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    Zs.A 1247: Show issues Location:
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    Zs.MO 294: Show issues

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  7. Article ; Online: Author Reply.

    Mansour, Ahmed M / Kaushik, Dharam

    Urology

    2019  Volume 133, Page(s) 172–173

    Language English
    Publishing date 2019-05-28
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 192062-5
    ISSN 1527-9995 ; 0090-4295
    ISSN (online) 1527-9995
    ISSN 0090-4295
    DOI 10.1016/j.urology.2019.05.064
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    Zs.A 1142: Show issues Location:
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    Zs.MO 275: Show issues

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  8. Article: A case of adrenocortical oncocytic carcinoma arising in ectopic adrenal tissue: a multidisciplinary diagnostic challenge.

    Wadhwani, Nikita / Mais, Daniel / Kaushik, Dharam / Kitano, Mio

    Ecancermedicalscience

    2020  Volume 14, Page(s) 1135

    Abstract: Adrenocortical oncocytic neoplasm arising in ectopic adrenal tissue is a rare finding and presents as a unique diagnostic challenge. We report a case of a 26-year-old female who presented with vague left-sided abdominal pain and a large left ... ...

    Abstract Adrenocortical oncocytic neoplasm arising in ectopic adrenal tissue is a rare finding and presents as a unique diagnostic challenge. We report a case of a 26-year-old female who presented with vague left-sided abdominal pain and a large left retroperitoneal mass. She underwent exploratory laparotomy and resection of the mass and was diagnosed with extra-adrenal adrenocortical oncocytic carcinoma.
    Language English
    Publishing date 2020-11-05
    Publishing country England
    Document type Case Reports
    ISSN 1754-6605
    ISSN 1754-6605
    DOI 10.3332/ecancer.2020.1135
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  9. Article ; Online: Predictors of participants' retention-socioeconomic factors or nonadherence: insights from a urological clinical prospective study.

    Wheeler, Allison J / Garg, Harshit / Kaushik, Dharam / Mansour, Ahmed / Pruthi, Deepak / Liss, Michael A

    Trials

    2022  Volume 23, Issue 1, Page(s) 970

    Abstract: Background: To investigate various patient-level variables, specifically socioeconomic status, as risk factors for withdrawal in a recently completed clinical study. We specifically investigated a non-interventional prospective study assessing the role ... ...

    Abstract Background: To investigate various patient-level variables, specifically socioeconomic status, as risk factors for withdrawal in a recently completed clinical study. We specifically investigated a non-interventional prospective study assessing the role of novel imaging as a biomarker for cancer upgradation in prostate cancer for this objective.
    Methods: In this retrospective analysis, we assessed the association between various patient-level factors including clinic-demographic factors, socioeconomic status, and the number of non-adherences with the participants' retention or withdrawal from the study. For socioeconomic status (SES), we used the zip code-based Economic Innovation Group Distressed Community Index (DCI) which classifies into five even distress tiers: prosperous, comfortable, mid-tier, at-risk, or distressed. Low SES was defined as those with a DCI Distress tier of at-risk or distressed. We compared values between the two retention and withdrawal groups using t-test, chi-square test, and logistic regression analysis.
    Results: Of 273 men screened, 123 men were enrolled. Among them, 86.2% (106/123) retained through the study whereas 13.8% (17/123) withdrew from the study. The mean (SD) age was 64 (6.4) years. Overall, 31.7% (39/123) were Hispanics and 24.3% (30/123) were African Americans. The median (IQR) DCI score was 34 (10.3, 68.1) and 30.8% (38/123) of patients belonged to low SES. The median DCI score in participants who retained in the study was statistically similar to those who withdrew from the study (p=0.4). Neither the DCI tiers (p=0.7) nor the low SES (p=0.9) were associated with participants' retention or withdrawal of the study. In terms of non-adherence, all participants in the withdrawn group had at least one non-adherent event compared to 48.1% in the retained group (p<0.001). Repetitive non-adherence was significantly higher in participants who withdrew from the study vs those who retained in the study [88.2% vs 16.9%, p <0.001]. On multivariate logistic regression analysis, the number of non-adherences (OR=12.5, p<0.001) and not DCI (OR=0.99, p=0.7) appeared to be an independent predictor for participants' retention or withdrawal from the study.
    Conclusions: Expanding diverse inclusion and limiting withdrawal with real-time non-adherence monitoring will lead to more efficient clinical research and greater generalizability of results.
    MeSH term(s) Male ; Humans ; Middle Aged ; Prospective Studies ; Retrospective Studies ; Socioeconomic Factors ; Income
    Language English
    Publishing date 2022-12-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 2040523-6
    ISSN 1745-6215 ; 1468-6694 ; 1745-6215
    ISSN (online) 1745-6215
    ISSN 1468-6694 ; 1745-6215
    DOI 10.1186/s13063-022-06901-w
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  10. Article ; Online: Impact of rural residence on the presentation, management and survival of patients with non-metastatic muscle-invasive bladder carcinoma.

    Dursun, Furkan / Elshabrawy, Ahmed / Wang, Hanzhang / Kaushik, Dharam / Liss, Michael A / Svatek, Robert S / Gore, John L / Mansour, Ahmed M

    Investigative and clinical urology

    2023  Volume 64, Issue 6, Page(s) 561–571

    Abstract: Purpose: To assess the impact of rural and remote residence on the receipt of guidelines-recommended treatment, quality of treatment and overall survival (OS) in patients with non-metastatic muscle-invasive bladder cancer (MIBC).: Materials and ... ...

    Abstract Purpose: To assess the impact of rural and remote residence on the receipt of guidelines-recommended treatment, quality of treatment and overall survival (OS) in patients with non-metastatic muscle-invasive bladder cancer (MIBC).
    Materials and methods: Patients with MIBC were identified using National Cancer Database. Patients were classified into three residential areas. Logistic regression models were used to assess associations between geographic residence and receipt of radical cystectomy (RC) or chemoradiation therapy (CRT). Models were fitted to assess quality benchmarks of RC and CRT.
    Results: We identified 71,395 patients. Of those 58,874 (82.5%) were living in Metro areas, 8,534 (11.9%) in urban-rural adjacent (URA), and 3,987 (5.6%) in urban-rural remote to metro area (URR). URR residence was significantly associated with poor OS compared to URA and Metro residence (HR 0.87, 95% CI 0.81-0.94 and HR 0.90, 95% CI 0.87-0.93, p<0.001). There was no difference in the likelihood of receiving RC and CRT among different residential areas. Among patients who underwent RC; individuals living in URR were less likely to receive neoadjuvant chemotherapy and adequate lymph node dissection, and had a higher probability of positive surgical margin than those living in metro areas. For those who received CRT; individuals living in Metro areas were more likely to receive concomitant systemic therapy compared to URR.
    Conclusions: Rural residence is associated with lower OS for MIBC patients and less likelihood of meeting quality benchmarks for RC and CRT. This data should be used to guide further health policy and allocation of resources for rural population.
    MeSH term(s) Humans ; Urinary Bladder/pathology ; Rural Population ; Urinary Bladder Neoplasms/pathology ; Cystectomy ; Muscles/pathology ; Carcinoma/surgery ; Retrospective Studies
    Language English
    Publishing date 2023-11-06
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2923014-7
    ISSN 2466-054X ; 2466-0493
    ISSN (online) 2466-054X
    ISSN 2466-0493
    DOI 10.4111/icu.20230125
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