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Article ; Online: Impact of a digital web-based asthma platform, a real-life study.

Genberg, Emma M / Viitanen, Hilkka T / Mäkelä, Mika J / Kautiainen, Hannu J / Kauppi, Paula M

2023 Volume 23, Issue 1, Page(s) 165

Abstract: Background: Digital health technology (DHT) is a growing area in the treatment of chronic diseases. Study results on DHT's effect on asthma control have been mixed, but benefits have been seen for adherence, self-management, symptoms, and quality of ... ...

Abstract	Background: Digital health technology (DHT) is a growing area in the treatment of chronic diseases. Study results on DHT's effect on asthma control have been mixed, but benefits have been seen for adherence, self-management, symptoms, and quality of life. The aim was to evaluate the impact of an interactive web-based asthma treatment platform on asthma exacerbations and health care visits. Methods: In this real-life study, we retrospectively collected data on adult patients registered on a web-based interactive asthma treatment platform between December 2018 and May 2021. Patients who activated their accounts were active users, and patients who did not were inactive users and considered as controls. We compared the number of exacerbations, total number of exacerbation events defined as the sum of oral corticosteroid (OCS) and antimicrobial courses, emergency room visits, hospitalizations, and asthma-related health care visits before and one year after the registration on the platform. Statistical tests used included the t-test, Pearson's chi-square test and Poisson regression models. Results: Of 147 patients registered on the platform, 106 activated their accounts and 41 did not. The active users had significantly fewer total number of exacerbation events (2.56 per person years, relative decline 0.78, 95% CI 0.6 to 1.0) and asthma-related health care visits (2.38 per person years, relative decline 0.84, 95% CI 0.74 to 0.96) than before registration to the platform, whereas the reductions in health care visits and the total number of exacerbation events were not significant in the inactive users. Conclusions: An interactive web-based asthma platform can reduce asthma-related health care visits and exacerbations when used actively.
MeSH term(s)	Adult ; Humans ; Quality of Life ; Retrospective Studies ; Asthma/drug therapy ; Adrenal Cortex Hormones/therapeutic use ; Internet ; Anti-Asthmatic Agents/therapeutic use
Chemical Substances	Adrenal Cortex Hormones ; Anti-Asthmatic Agents
Language	English
Publishing date	2023-05-12
Publishing country	England
Document type	Journal Article
ZDB-ID	2059871-3
ISSN	1471-2466 ; 1471-2466
ISSN (online)	1471-2466
ISSN	1471-2466
DOI	10.1186/s12890-023-02467-8
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Article ; Online: Decreasing muscle performance associated with increasing disease activity in patients with rheumatoid arthritis.

Uutela, Toini I / Kautiainen, Hannu J / Häkkinen, Arja H

PloS one

2018 Volume 13, Issue 4, Page(s) e0194917

Abstract: Objectives: Increasing evidence suggests that inflammation has a detrimental effect on muscle strength. Our objective was to analyse the association between muscle performance and different disease activity levels in patients with rheumatoid arthritis ( ... ...

Abstract	Objectives: Increasing evidence suggests that inflammation has a detrimental effect on muscle strength. Our objective was to analyse the association between muscle performance and different disease activity levels in patients with rheumatoid arthritis (RA). Method: A total of 199 consecutive outpatients were subject to cross-sectional assessment. Measurements of grip strength, endurance of the upper and lower limbs and trunk strength were combined as a muscle performance composite score (MPCS), using a standardised method. The disease activity for 28 joints (DAS28), radiographs of small joints (Larsen score), rheumatoid factor, body mass index (BMI), comorbidities and anti-rheumatic drugs were verified. Patients' questionnaires included sociodemographic information, pain level, global disease activity, the Beck Depression Inventory, the mental and physical component scores of Short Form-36 and physical activity level. Results: Of the 199 patients, 36%, 17% and 47% patients had remission, low/moderate and high DAS28, respectively. The patients in remission had significantly shorter disease duration, better parameters in terms of pain, physician's assessment, Larsen, Beck or physical component score of Short Form-36, and they were more physically active than other patients. After adjustments for age, sex, RA duration, radiographs and BMI, the decreasing MPCS associated linearly with the increasing DAS28 activity levels (linearity, P <0.001). Conclusion: Poorer MPCS is clearly associated with higher disease activity in patients with RA. Muscle performance is a modifiable risk factor. The findings suggest evaluating muscle performance in clinical practice as a part of patient care.
MeSH term(s)	Arthritis, Rheumatoid/physiopathology ; Comorbidity ; Cross-Sectional Studies ; Female ; Humans ; Male ; Middle Aged ; Muscle Strength/physiology ; Muscle, Skeletal/physiology ; Pain Measurement ; Physical Endurance ; Risk Factors ; Severity of Illness Index
Language	English
Publishing date	2018-04-09
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0194917
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Article ; Online: Temporal Trends Over Two Decades in the Use of Anticholinergic Drugs Among Older Community-Dwelling People in Helsinki, Finland.

Rinkinen, Mikko-Oskari / Roitto, Hanna-Maria / Öhman, Hanna R / Kautiainen, Hannu J / Tilvis, Reijo S / Strandberg, Timo E / Pitkala, Kaisu H / Aalto, Ulla L

Drugs & aging

2022 Volume 39, Issue 9, Page(s) 705–713

Abstract: Background: Knowledge of the adverse effects of drugs with anticholinergic properties (DAPs) has increased in recent decades. However, research on the temporal trends of the clinical use of DAPs is still sparse.: Objectives: The aim of this study was ...

Abstract	Background: Knowledge of the adverse effects of drugs with anticholinergic properties (DAPs) has increased in recent decades. However, research on the temporal trends of the clinical use of DAPs is still sparse. Objectives: The aim of this study was to investigate the temporal trends of DAP use over two decades in the older community-dwelling population and to explore the medication classes contributing to the use of DAPs. Methods: The study involved random samples of ≥ 75-year-old community-dwelling Helsinki citizens in 1999, 2009, and 2019 from the Helsinki Ageing Study. A postal questionnaire inquired about their health, functioning, and medications. The medications were categorized as DAPs according to Duran's list. In addition, we grouped DAPs into various medication groups. Results: The prevalence and burden of DAPs on Duran's list showed a decreasing trend over the years. In 1999 the prevalence was 20% and the burden 0.35, in 2009 they were 22% and 0.35, respectively, and in 2019 they were 16% and 0.23, respectively. There were no differences in how the 75- and 80-year-olds used DAPs compared with those aged 85 years and older. The proportion of typical antipsychotics, benzodiazepines, hypnotics, urinary antispasmodics, and asthma/chronic obstructive pulmonary disease medications decreased, whereas the proportion of atypical antipsychotics, antidepressants, strong opioids, and antihistamines increased. In particular the use of mirtazapine increased-to 3.9% in 2019. In 2019 the three most prevalent groups of DAPs were antidepressants (7.4%), opioids (2.7%), and antihistamines (2.4%). Conclusions: The decrease in the use of DAPs on Duran's list is a welcome change. Although the use of old, strong DAPs has decreased, new DAPs have simultaneously emerged. Physicians need continuous education in prescribing DAPs and more recent information on the use and effects of DAPs is needed in order to decrease their exposure among the rapidly growing older population.
MeSH term(s)	Aged ; Analgesics, Opioid ; Antipsychotic Agents ; Cholinergic Antagonists/adverse effects ; Finland/epidemiology ; Humans ; Hypnotics and Sedatives ; Independent Living ; Prevalence
Chemical Substances	Analgesics, Opioid ; Antipsychotic Agents ; Cholinergic Antagonists ; Hypnotics and Sedatives
Language	English
Publishing date	2022-08-01
Publishing country	New Zealand
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1075770-3
ISSN	1179-1969 ; 1170-229X
ISSN (online)	1179-1969
ISSN	1170-229X
DOI	10.1007/s40266-022-00968-5
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Article ; Online: Comparison of active, manual, and instrumental straight leg raise in measuring hamstring extensibility.

Ylinen, Jari J / Kautiainen, Hannu J / Häkkinen, Arja H

Journal of strength and conditioning research

2010 Volume 24, Issue 4, Page(s) 972–977

Abstract: The active manual straight leg raise (ASLR) and passive manual straight leg raise (MSLR) tests are commonly used in clinical settings to assess hamstring tightness. However, to our knowledge, the validity and sensitivity of these tests have not been ... ...

Abstract	The active manual straight leg raise (ASLR) and passive manual straight leg raise (MSLR) tests are commonly used in clinical settings to assess hamstring tightness. However, to our knowledge, the validity and sensitivity of these tests have not been compared with the instrumental straight leg raise (ISLR). The aim of the present study was to assess the intrarater reproducibility of the ISLR and compare the sensitivity of the ASLR, MSLR, and ISLR to change. Twelve men with hamstring tightness underwent the ASLR, MSLR, and ISLR tests at baseline and after a 4-week home-based right leg stretching program with the left leg serving as a control. The ISLR measurements were repeated consecutively at baseline to assess reproducibility. The intraclass correlation coefficient for the ISLR was 0.94, and the coefficient of reproducibility was 6. Significant differences in the range of motion emerged between all testing methods (p < 0.05). In the stretched legs, the mean +/- SD increases were 17 +/- 5 degrees for ISLR, 10 +/- 8 degrees for ASLR, and 6 +/- 5 degrees for MSLR, whereas the control legs showed a significant mean change only for ASLR (5 +/- 4 degrees ). The mean standard response with the ASLR and MSLR tests did not differentiate between the treated and control legs, but it was almost 10-fold higher in the treated leg than the control leg for the ISLR, clearly differentiating between them. The ISLR had good reproducibility and sensitivity to changes, whereas ASLR and MSLR showed a poor ability to detect changes. Thus, the ISLR test is recommended for use in research evaluating the effectiveness of stretching.
MeSH term(s)	Biomechanical Phenomena ; Confidence Intervals ; Exercise Test/methods ; Humans ; Leg/physiology ; Male ; Movement ; Muscle Contraction/physiology ; Muscle Relaxation/physiology ; Muscle Stretching Exercises ; Muscle, Skeletal/physiology ; Observer Variation ; Probability ; Range of Motion, Articular/physiology ; Reproducibility of Results
Language	English
Publishing date	2010-04
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1156349-7
ISSN	1533-4287 ; 1064-8011
ISSN (online)	1533-4287
ISSN	1064-8011
DOI	10.1519/JSC.0b013e3181d0a55f
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Article ; Online: Short- and long-term outcome following laparoscopic versus open resection for carcinoma of the rectum in the multimodal setting.

Kellokumpu, Ilmo H / Kairaluoma, Matti I / Nuorva, Kyösti P / Kautiainen, Hannu J / Jantunen, Ismo T

Diseases of the colon and rectum

2012 Volume 55, Issue 8, Page(s) 854–863

Abstract: Background: Laparoscopic resection for rectal cancer has remained controversial because of the lack of level 1 evidence regarding oncologic safety and long-term survival.: Objectives: The aim of this study was to assess the impact of laparoscopic ... ...

Abstract	Background: Laparoscopic resection for rectal cancer has remained controversial because of the lack of level 1 evidence regarding oncologic safety and long-term survival. Objectives: The aim of this study was to assess the impact of laparoscopic versus open resection for rectal cancer on clinical and oncologic outcome in the multimodal setting. Design: This is a review of prospectively gathered data from a single-institution rectal cancer database. Settings: This study was conducted in the Central Hospital of Central Finland. Patients: From January 1999 to December 2006, 191 selected patients were included. Interventions: One hundred patients underwent laparoscopic resection, and 91 patients, also suitable for laparoscopic surgery, underwent open major rectal resection in the multimodal setting. Main outcome measures: The main measures of outcome were early recovery and short- and long-term morbidity; local recurrence and survival were secondary outcomes. Limitations: This is not a randomized study. Results: The study groups were balanced for baseline characteristics. Conversion rate to open surgery was 22%. Laparoscopic surgery resulted in significantly less bleeding (175 mL vs 500 mL, p < 0.001), 1 day earlier recovery of normal diet (3 days vs 4 days, p = 0.001), and shorter postoperative hospital stay (7 days vs 9 days, p < 0.001). Postoperative 30-day mortality (1% vs 3%), morbidity (31% vs 43%), readmission (11% vs 15%), and reoperation (6% vs 9%) rates were similar in the 2 groups, but significantly fewer patients in the laparoscopic group had long-term complications (19% vs 36%, p = 0.033). The 5-year disease-free survival (78% vs 80%, p = 0.74) and local recurrence (5% vs 6%, p = 0.66) rates were similar in the laparoscopic and open group for those 175 patients treated for cure. Conclusion: Laparoscopic surgery resulted in faster postoperative recovery and fewer long-term complications than open surgery without apparently compromising the long-term oncologic outcome. Our results indicate that laparoscopic rectal resection is an acceptable alternative to open surgery in selected patients with rectal cancer.
MeSH term(s)	Aged ; Chemoradiotherapy, Adjuvant ; Female ; Follow-Up Studies ; Humans ; Laparoscopy ; Length of Stay/statistics & numerical data ; Male ; Middle Aged ; Neoadjuvant Therapy ; Neoplasm Recurrence, Local ; Neoplasm Staging ; Patient Readmission/statistics & numerical data ; Postoperative Complications/epidemiology ; Recovery of Function ; Rectal Neoplasms/mortality ; Rectal Neoplasms/pathology ; Rectal Neoplasms/surgery ; Rectal Neoplasms/therapy ; Rectum/surgery ; Reoperation/statistics & numerical data ; Survival Analysis ; Treatment Outcome
Language	English
Publishing date	2012-08
Publishing country	United States
Document type	Comparative Study ; Evaluation Studies ; Journal Article
ZDB-ID	212581-x
ISSN	1530-0358 ; 0012-3706
ISSN (online)	1530-0358
ISSN	0012-3706
DOI	10.1097/DCR.0b013e31825b9052
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Article: The non-use of hearing aids in people aged 75 years and over in the city of Kuopio in Finland.

Lupsakko, Taina A / Kautiainen, Hannu J / Sulkava, Raimo

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

2005 Volume 262, Issue 3, Page(s) 165–169

Abstract: Hearing loss is one of the most prevalent chronic conditions affecting the health of the aged. It is typically medically non-treatable, and hearing aid (HA) use remains the treatment of choice. However, only 15-30% of older adults with hearing impairment ...

Abstract	Hearing loss is one of the most prevalent chronic conditions affecting the health of the aged. It is typically medically non-treatable, and hearing aid (HA) use remains the treatment of choice. However, only 15-30% of older adults with hearing impairment possess an HA. Many of them never use it. The purpose of our study was to investigate the use of provided HAs and reasons for the non-use of HAs. This population-based survey was set in the city of Kuopio in eastern Finland. A total of 601 people aged 75 years or older participated in this study. A geriatrician and a trained nurse examined the subjects. Their functional and cognitive capacity was evaluated. A questionnaire about participants' socioeconomic characteristics and the use of HAs were included in the study protocol. The subjects who had an HA were assigned to three groups on the basis of HA use: full-time users, part-time users and non-users. Inquiries were made about the subjective reasons for the non-use of HAs. An HA had been prescribed earlier to 16.6% of the study group. Fourteen percent of the females and 23% of the males had been provided with an HA. The HA owners were older than persons who had not been provided with an HA. Twenty-five percent of the HA owners were non-users, and 55% were full-time users. A decline in cognitive or functional capacity and low income explained the non-use of HAs. The most common subjective reasons for the non-use of HAs were that the use did not help at all (10/24), the HA was broken (4/24) or it was too complicated to use (5/24). The non-use of HAs is still common among the aged. Elderly people who have been provided with an HA and who have a cognitive or functional decline are at risk to be a non-user of an HA. Therefore, they need special attention in counseling.
MeSH term(s)	Aged ; Aged, 80 and over ; Cognition ; Counseling ; Demography ; Female ; Finland/epidemiology ; Hearing Aids/utilization ; Humans ; Male ; Mass Screening/methods ; Presbycusis/epidemiology ; Presbycusis/therapy ; Socioeconomic Factors ; Surveys and Questionnaires ; Treatment Refusal/statistics & numerical data
Language	English
Publishing date	2005-03
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1017359-6
ISSN	0937-4477
ISSN	0937-4477
DOI	10.1007/s00405-004-0789-x
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Article ; Online: Body size modifies the relationship between maternal serum 25-hydroxyvitamin D concentrations and gestational diabetes in high-risk women.

Valkama, Anita J / Meinilä, Jelena M / Koivusalo, Saila B / Lindström, Jaana / Rönö, Kristiina / Tiitinen, Aila E / Stach-Lempinen, Beata / Kautiainen, Hannu J / Viljakainen, Heli / Andersson, Sture / Eriksson, Johan G

European journal of clinical nutrition

2017 Volume 72, Issue 3, Page(s) 460–463

Abstract: Obesity increases the risk of low 25-hydroxyvitamin D (25(OH)D) concentrations and gestational diabetes (GDM). We explored whether the association between GDM and change in 25(OH)D concentrations measured in the first (7-18 wk) and second (20-27 wk) ... ...

Abstract	Obesity increases the risk of low 25-hydroxyvitamin D (25(OH)D) concentrations and gestational diabetes (GDM). We explored whether the association between GDM and change in 25(OH)D concentrations measured in the first (7-18 wk) and second (20-27 wk) trimesters of pregnancy is dependent on maternal BMI. The study was a prospective study of 219 women with BMI of ≥30 kg/m
MeSH term(s)	Adult ; Body Size/physiology ; Diabetes, Gestational/blood ; Diabetes, Gestational/epidemiology ; Female ; Humans ; Pregnancy ; Prospective Studies ; Vitamin D/analogs & derivatives ; Vitamin D/blood
Chemical Substances	Vitamin D (1406-16-2) ; 25-hydroxyvitamin D (A288AR3C9H)
Language	English
Publishing date	2017-11-06
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	639358-5
ISSN	1476-5640 ; 0954-3007
ISSN (online)	1476-5640
ISSN	0954-3007
DOI	10.1038/s41430-017-0010-0
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Zs.A 1045: Show issues

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Article ; Online: Outcome after temporary physeal stapling for knee valgus deformity in children with JIA.

Skyttä, Eerik T / Savolainen, Anneli / Kautiainen, Hannu J / Belt, Eero A

Archives of orthopaedic and trauma surgery

2008 Volume 128, Issue 10, Page(s) 1213–1216

Abstract: Introduction: Majority of children with secondary knee valgus deformity due to juvenile idiopathic arthritis (JIA) are affected by the polyarthritic disease subtype. Progressive rheumatoid knee destruction in patients with JIA and valgus deformity may ... ...

Abstract	Introduction: Majority of children with secondary knee valgus deformity due to juvenile idiopathic arthritis (JIA) are affected by the polyarthritic disease subtype. Progressive rheumatoid knee destruction in patients with JIA and valgus deformity may necessitate total knee replacement (TKR) at a young age. Temporary physeal arrest is a safe and effective method for correction of knee valgus malalignment prior to closure of the epiphyseal growth plates even during active arthritis. Results: Most of the angular correction achieved in the stapled knees (n = 103) in the present cohort remained the same through the long-term follow-up though in some patients the deformity did recur. The advantages of angular correction prior to possible future TKR include easier soft tissue balancing, diminished bony deformity and less deranged collateral ligaments reducing the need for expensive custom and constrained implants. Conclusion: However, the effect of the correction on postponing the early need for TKR is limited.
MeSH term(s)	Adolescent ; Arthritis, Juvenile/complications ; Child ; Child, Preschool ; Epiphyses/surgery ; Female ; Femur ; Humans ; Joint Deformities, Acquired/etiology ; Joint Deformities, Acquired/surgery ; Knee Joint ; Male ; Surgical Stapling ; Treatment Outcome
Language	English
Publishing date	2008-10
Publishing country	Germany
Document type	Journal Article
ZDB-ID	80407-1
ISSN	1434-3916 ; 0003-9330 ; 0344-8444
ISSN (online)	1434-3916
ISSN	0003-9330 ; 0344-8444
DOI	10.1007/s00402-008-0605-y
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Article ; Online: Core muscle activation during dynamic upper limb exercises in women.

Tarnanen, Sami P / Siekkinen, Kirsti M / Häkkinen, Arja H / Mälkiä, Esko A / Kautiainen, Hannu J / Ylinen, Jari J

Journal of strength and conditioning research

2012 Volume 26, Issue 12, Page(s) 3217–3224

Abstract: Although several everyday functions and sporting activities demand controlled use of the abdominal and back muscles while working with the upper limbs, the activity of core muscles during dynamic upper limb exercises in the standing position has not been ...

Abstract	Although several everyday functions and sporting activities demand controlled use of the abdominal and back muscles while working with the upper limbs, the activity of core muscles during dynamic upper limb exercises in the standing position has not been studied extensively. The purpose of this cross-sectional study was to examine abdominal and back muscle activity during dynamic upper limb exercises while standing and to evaluate whether dynamic exercises are appropriate for strengthening muscles. The activation of the rectus abdominis, obliquus externus abdominis, longissimus, and multifidus muscles during dynamic bilateral or unilateral shoulder exercises with or without fixation of the pelvis was measured in 20 healthy women using surface electromyography. Trunk muscle activation during isometric maximum contraction was used as a comparative reference. With bilateral shoulder extension and unilateral shoulder horizontal adduction, abdominal muscle activity was >60% of activity during reference exercises. With unilateral shoulder horizontal abduction and shoulder extension exercises, back muscle activity was >60% of the activity level reference exercise. Muscle activation levels were 35-64% lower during shoulder horizontal adduction and abduction without fixation compared with exercises with fixation. The results indicate that upper limb exercises performed in the standing position are effective for activating core muscles. Bilateral and unilateral shoulder extension and unilateral shoulder horizontal abduction and adduction with the pelvis fixed elicited the greatest activity of the core muscles.
MeSH term(s)	Abdominal Muscles/physiology ; Adult ; Analysis of Variance ; Back/physiology ; Biomechanical Phenomena ; Cross-Sectional Studies ; Electromyography ; Exercise/physiology ; Female ; Humans ; Isometric Contraction/physiology ; Muscle Strength/physiology ; Muscle, Skeletal/physiology ; Upper Extremity/physiology
Language	English
Publishing date	2012-12
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1156349-7
ISSN	1533-4287 ; 1064-8011
ISSN (online)	1533-4287
ISSN	1064-8011
DOI	10.1519/JSC.0b013e318248ad54
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Article ; Online: Gender difference among smoking, adiponectin, and high-sensitivity C-reactive protein.

Ahonen, Tiina M / Kautiainen, Hannu J / Keinänen-Kiukaanniemi, Sirkka M / Kumpusalo, Esko A / Vanhala, Mauno J

American journal of preventive medicine

2008 Volume 35, Issue 6, Page(s) 598–601

Abstract: Background: Subclinical inflammation is a novel risk factor of cardiovascular diseases and type 2 diabetes. An inverse association between plasma adiponectin and insulin resistance has been previously shown. Elevated levels of high-sensitivity C- ... ...

Abstract	Background: Subclinical inflammation is a novel risk factor of cardiovascular diseases and type 2 diabetes. An inverse association between plasma adiponectin and insulin resistance has been previously shown. Elevated levels of high-sensitivity C-reactive protein (hs-CRP) predict future cardiovascular events. Smoking has been proven to connect with inflammatory markers. There is also evidence of a difference between genders in pro-inflammation. This study aimed to examine the connections among adiponectin, hs-CRP, and smoking and to determine possible gender differences in these associations. Methods: Included were 365 men and 476 women; all were nondiabetic and middle-aged. Daily smoking subjects were considered to be smokers. Adiponectin and hs-CRP were analyzed. Data were collected in 1997-1998, and cytokines were analyzed in 2003. Results: Thirty-five percent of the men and 22% of the women were smokers. In women, the adiponectin level was significantly lower in smokers (6.94+/-3.27 microg/ml) compared to nonsmokers (8.27+/-4.72 microg/ml, p=0.0017). This association remained significant after adjustment for age and BMI (p=0.0061). The hs-CRP level was significantly higher in smoking men (1.59+/-1.71 pg/ml) compared to nonsmoking men (1.17+/-1.41 pg/ml, p=0.018). This result remained after adjustment for age and BMI (p=0.0056). When smokers were compared to nonsmokers, there was no difference in adiponectin among men or in hs-CRP among women. Conclusions: In the nondiabetic population, smoking associates differently with subclinical inflammation between genders, with a decreased adiponectin level in women and with an increased hs-CRP level in men.
MeSH term(s)	Adiponectin/blood ; Adult ; Biomarkers/blood ; Body Mass Index ; C-Reactive Protein/metabolism ; Female ; Finland ; Humans ; Inflammation/blood ; Inflammation/etiology ; Insulin Resistance ; Male ; Metabolic Syndrome/complications ; Middle Aged ; Risk Factors ; Sex Factors ; Smoking/adverse effects ; Smoking/blood
Chemical Substances	Adiponectin ; Biomarkers ; C-Reactive Protein (9007-41-4)
Language	English
Publishing date	2008-12
Publishing country	Netherlands
Document type	Comparative Study ; Journal Article
ZDB-ID	632646-8
ISSN	1873-2607 ; 0749-3797
ISSN (online)	1873-2607
ISSN	0749-3797
DOI	10.1016/j.amepre.2008.09.011
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In stock of ZB MED Cologne/Königswinter

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In stock of ZB MED Cologne/Königswinter

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In stock of ZB MED Cologne/Königswinter

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In stock of ZB MED Cologne/Königswinter

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