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  1. Article ; Online: Complement factor I: Regulatory nexus, driver of immunopathology, and therapeutic.

    Hallam, T M / Sharp, S J / Andreadi, A / Kavanagh, D

    Immunobiology

    2023  Volume 228, Issue 5, Page(s) 152410

    Abstract: Complement factor I (FI) is the nexus for classical, lectin and alternative pathway complement regulation. FI is an 88 kDa plasma protein that circulates in an inactive configuration until it forms a trimolecular complex with its cofactor and substrate ... ...

    Abstract Complement factor I (FI) is the nexus for classical, lectin and alternative pathway complement regulation. FI is an 88 kDa plasma protein that circulates in an inactive configuration until it forms a trimolecular complex with its cofactor and substrate whereupon a structural reorganization allows the catalytic triad to cleave its substrates, C3b and C4b. In keeping with its role as the master complement regulatory enzyme, deficiency has been linked to immunopathology. In the setting of complete FI deficiency, a consumptive C3 deficiency results in recurrent infections with encapsulated microorganisms. Aseptic cerebral inflammation and vasculitic presentations are also less commonly observed. Heterozygous mutations in the factor I gene (CFI) have been demonstrated to be enriched in atypical haemolytic uraemic syndrome, albeit with a very low penetrance. Haploinsufficiency of CFI has also been associated with decreased retinal thickness and is a strong risk factor for the development of age-related macular degeneration. Supplementation of FI using plasma purified or recombinant protein has long been postulated, however, technical difficulties prevented progression into clinical trials. It is only using gene therapy that CFI supplementation has reached the clinic with GT005 in phase I/II clinical trials for geographic atrophy.
    MeSH term(s) Humans ; Complement Factor I/chemistry ; Complement C3/genetics ; Atypical Hemolytic Uremic Syndrome ; Mutation ; Inflammation ; Complement C3b
    Chemical Substances Complement Factor I (EC 3.4.21.45) ; Complement C3 ; Complement C3b (80295-43-8)
    Language English
    Publishing date 2023-06-05
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 563292-4
    ISSN 1878-3279 ; 0171-2985
    ISSN (online) 1878-3279
    ISSN 0171-2985
    DOI 10.1016/j.imbio.2023.152410
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Transferability of Technical Skills Across Robotic Surgery Platforms: A Scoping Review.

    Devine, Michael / Morris, Marie / Kavanagh, Dara

    Cureus

    2024  Volume 16, Issue 3, Page(s) e56429

    Abstract: As the application of robotic approaches to surgery continues to broaden, new consoles have been introduced to the market. Due to the global utilization of a single platform, previously validated curricula have not been assessed on new robotic systems. ... ...

    Abstract As the application of robotic approaches to surgery continues to broaden, new consoles have been introduced to the market. Due to the global utilization of a single platform, previously validated curricula have not been assessed on new robotic systems. Surgery by its nature occurs in a high-stakes environment, potentially exacerbated by non-standardized robotic systems. The aim of this review is to critique the evidence available regarding the transferability of technical skills across robotic platforms. A scoping review utilizing the Medline (Pubmed) and Cochrane Databases was conducted. Full texts were reviewed and appraised. Selected articles were eligible for inclusion if they investigated the ability or implications of the transfer of skill across robotic platforms. Data was extracted, coded inductively, and themes synthesized. NVIVO software was used as an adjunct for this qualitative analysis. Following the removal of duplicates a total of 278 papers were screened according to the eligibility criteria. Fifty full-text articles were reviewed and four met the criterion for inclusion. Novices' performance across platforms was comparable. Increasing levels of prior robotic experience revealed an improvement in technical performance on a novel robotic platform. Safety metrics appear comparable across systems. Quantifying learning curves across robotic platforms and their implications for the robotic surgeon in training remains to be determined. Future research needs to address the gaps in the literature by clearly defining the extent of technical skills transfer between robotic platforms. These factors will guide the next iteration of surgical training curriculums and regulations for robotic surgery.
    Language English
    Publishing date 2024-03-19
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.56429
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Diagnosis and treatment of thrombotic microangiopathy.

    Thompson, Gemma L / Kavanagh, David

    International journal of laboratory hematology

    2022  Volume 44 Suppl 1, Page(s) 101–113

    Abstract: Thrombotic microangiopathy (TMA) is characterized by thrombocytopenia, microangiopathic haemolytic anaemia and end organ damage. TMAs have varying underlying pathophysiology and can therefore present with an array of clinical presentations. Renal ... ...

    Abstract Thrombotic microangiopathy (TMA) is characterized by thrombocytopenia, microangiopathic haemolytic anaemia and end organ damage. TMAs have varying underlying pathophysiology and can therefore present with an array of clinical presentations. Renal involvement is common as the kidney is particularly susceptible to the endothelial damage and microvascular occlusion. TMAs require rapid assessment, diagnosis, and commencement of appropriate treatment due to the high morbidity and mortality associated with them. Ground-breaking research into the pathogenesis of TMAs over the past 20 years has driven the successful development of targeted therapeutics revolutionizing patient outcomes. This review outlines the clinical presentations, pathogenesis, diagnostic tests and treatments for TMAs.
    MeSH term(s) Humans ; Thrombotic Microangiopathies/diagnosis ; Thrombotic Microangiopathies/therapy
    Language English
    Publishing date 2022-09-08
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2268590-X
    ISSN 1751-553X ; 1751-5521 ; 0141-9854
    ISSN (online) 1751-553X
    ISSN 1751-5521 ; 0141-9854
    DOI 10.1111/ijlh.13954
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Jg. 1995 - 2021: Lesesall (1.OG)
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  4. Book ; Online: Chief Dental Officer letter to registrants, 20/03/2020

    Kavanagh, Dympna

    2020  

    Keywords Covid-19 ; Coronavirus ; Dentists ; covid19
    Language English
    Publishing date 2020-03-20
    Publisher Health Protection Surveillance Centre
    Publishing country ie
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: XXIX International Complement Workshop Newcastle 2023.

    Marchbank, Kevin J / Kavanagh, David / Harris, Claire L

    Immunobiology

    2023  Volume 228, Issue 5, Page(s) 152729

    Language English
    Publishing date 2023-08-10
    Publishing country Netherlands
    Document type Editorial
    ZDB-ID 563292-4
    ISSN 1878-3279 ; 0171-2985
    ISSN (online) 1878-3279
    ISSN 0171-2985
    DOI 10.1016/j.imbio.2023.152729
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ud II Zs.32: Show issues Location:
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  6. Article ; Online: Use of a B-cell depleting regimen for antifactor H autoantibody-mediated membranoproliferative glomerulonephritis in a paediatric patient.

    Henderson, Sarah / Ardill, Rosalyn / Reynolds, Ben / Kavanagh, David

    BMJ case reports

    2022  Volume 15, Issue 4

    Abstract: A male child presented initially well with a mixed nephrotic-nephritic syndrome and was commenced on standard high-dose oral corticosteroids. Clinical deterioration occurred 3 weeks later with rapidly progressing renal dysfunction, seizures and ... ...

    Abstract A male child presented initially well with a mixed nephrotic-nephritic syndrome and was commenced on standard high-dose oral corticosteroids. Clinical deterioration occurred 3 weeks later with rapidly progressing renal dysfunction, seizures and diminished urinary output, requiring renal replacement therapy. Once stabilised, renal biopsy demonstrated mesangial and capillary C3, minimal IgG deposition, with mesangial electron dense deposits felt consistent with postinfectious glomerulonephritis or C3 glomerulopathy. Further investigations identified circulating autoantibody directed against factor H, as a plausible aetiology of the membranoproliferative glomerulonephritis (MPGN). Treatment with rituximab and mycophenolate mofetil was associated with a reduction in antibody titres and a concurrent reduction in proteinuria and normalisation of renal function.Subsequent monitoring of antibody titres prompted further administrations of rituximab, with reduction in titres demonstrated after repeat doses. Atypical presentations or complications of nephrotic syndrome or MPGN should prompt detailed investigations for the cause with consideration of antifactor H antibodies.
    MeSH term(s) Autoantibodies ; Child ; Female ; Glomerulonephritis/drug therapy ; Glomerulonephritis/etiology ; Glomerulonephritis, Membranoproliferative/pathology ; Humans ; Male ; Nephrotic Syndrome/drug therapy ; Nephrotic Syndrome/etiology ; Rituximab/therapeutic use
    Chemical Substances Autoantibodies ; Rituximab (4F4X42SYQ6)
    Language English
    Publishing date 2022-04-20
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2021-246281
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Policy planner. Interview by Paul O'Grady.

    Kavanagh, Dympna

    Journal of the Irish Dental Association

    2014  Volume 60, Issue 2, Page(s) 82–83

    MeSH term(s) Dental Care ; Dentists/supply & distribution ; Health Planning ; Health Policy ; Health Priorities ; Health Services Needs and Demand ; Humans ; Ireland ; Oral Health ; State Dentistry/organization & administration
    Language English
    Publishing date 2014-04
    Publishing country Ireland
    Document type Interview
    ZDB-ID 603659-4
    ISSN 0021-1133
    ISSN 0021-1133
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1038: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  8. Article ; Online: Validation of deep learning-based markerless 3D pose estimation.

    Kosourikhina, Veronika / Kavanagh, Diarmuid / Richardson, Michael J / Kaplan, David M

    PloS one

    2022  Volume 17, Issue 10, Page(s) e0276258

    Abstract: Deep learning-based approaches to markerless 3D pose estimation are being adopted by researchers in psychology and neuroscience at an unprecedented rate. Yet many of these tools remain unvalidated. Here, we report on the validation of one increasingly ... ...

    Abstract Deep learning-based approaches to markerless 3D pose estimation are being adopted by researchers in psychology and neuroscience at an unprecedented rate. Yet many of these tools remain unvalidated. Here, we report on the validation of one increasingly popular tool (DeepLabCut) against simultaneous measurements obtained from a reference measurement system (Fastrak) with well-known performance characteristics. Our results confirm close (mm range) agreement between the two, indicating that under specific circumstances deep learning-based approaches can match more traditional motion tracking methods. Although more work needs to be done to determine their specific performance characteristics and limitations, this study should help build confidence within the research community using these new tools.
    MeSH term(s) Deep Learning ; Motion
    Language English
    Publishing date 2022-10-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0276258
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: A Pragmatic Informatics Approach to Develop Knowledge Tools for Supporting Cardiac Surgical Patients' Mental Health Needs.

    Smith, Susan / Strodl, Esben / Varnfield, Marlien / Kavanagh, David / Rolls, Tricia / Gurunathan, Usha / Janoschka, Bo / Naidoo, Rishendran

    Studies in health technology and informatics

    2024  Volume 310, Page(s) 1410–1411

    Abstract: A pragmatic informatics approach was developed to create knowledge tools for co-design of a new model of mental healthcare in cardiac surgery The real-world evidence generation leverages existing technological platforms and routine data collections plus ... ...

    Abstract A pragmatic informatics approach was developed to create knowledge tools for co-design of a new model of mental healthcare in cardiac surgery The real-world evidence generation leverages existing technological platforms and routine data collections plus tailored brief tools, surveys and qualitative data.
    MeSH term(s) Humans ; Mental Health ; Cardiac Surgical Procedures ; Heart ; Patients ; Informatics
    Language English
    Publishing date 2024-01-25
    Publishing country Netherlands
    Document type Journal Article
    ISSN 1879-8365
    ISSN (online) 1879-8365
    DOI 10.3233/SHTI231219
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Perceptions and experiences of simulation-based assessment of technical skill in surgery: A scoping review.

    Toale, Conor / Morris, Marie / Kavanagh, Dara

    American journal of surgery

    2021  Volume 222, Issue 4, Page(s) 723–730

    Abstract: Introduction: The introduction of simulation-based assessment raises questions as to its role in trainee selection, progression, certification and credentialing. This study sought to review and critique the available research regarding the perceptions ... ...

    Abstract Introduction: The introduction of simulation-based assessment raises questions as to its role in trainee selection, progression, certification and credentialing. This study sought to review and critique the available research regarding the perceptions and experiences of residents and their trainers towards simulation-based assessment of technical skills in surgery.
    Methods: A comprehensive literature review of the Medline (PubMed), Embase, Cochrane and Web of Science databases was performed in accordance with the Joanna Briggs Institute 2020 protocol for scoping reviews in July 2020, for all original research articles, abstracts and conference proceedings assessing the attitudes, perceptions, opinions and experiences of residents and surgical trainers toward simulation-based assessment of technical or operative skill.
    Results: A total of 1869 studies were identified on database searching. Quantitative, qualitative and mixed-methodology publications reporting the attitudes and experiences of surgical trainers and residents were identified, with 21 articles ultimately meeting the inclusion criteria for (qualitative) thematic analysis. Results were charted and categorized into broad themes: 1) Perceptions of simulation-based assessment in principle, 2) Entrustment, 3) Credentialing and certification, and 4) Resident selection and recruitment, identifying both positive perceptions and key areas of concern from residents and trainers alike regarding the current and future application of simulation-based assessment.
    Conclusion: There is broadly positive agreement amongst residents and surgical trainers in the published literature regarding the validity of simulation-based assessment. Perceptions of the broader application and implications of simulation-based skill assessment has been identified as a gap in the literature. Future studies should aim to record comprehensive data from key stakeholders prior to implementation of a simulation-based assessment curriculum to ensure acceptability.
    MeSH term(s) Certification ; Clinical Competence ; Humans ; Internship and Residency ; Simulation Training ; Surgical Procedures, Operative/education ; Surgical Procedures, Operative/standards
    Language English
    Publishing date 2021-04-06
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2953-1
    ISSN 1879-1883 ; 0002-9610
    ISSN (online) 1879-1883
    ISSN 0002-9610
    DOI 10.1016/j.amjsurg.2021.03.035
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