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  1. AU="Kavishe, Bazil Baltazar"
  2. AU=Muench Ricardo AU=Muench Ricardo
  3. AU="Guler, Emrah"
  4. AU="Kim, Kyeong Bae"
  5. AU="Birindelli, S"
  6. AU="Monguió-Tortajada, Marta"
  7. AU="Kumta, Nikhil A"
  8. AU="Wu, Wenli"
  9. AU="Curland, Nele"
  10. AU="Redish, A David"
  11. AU="Patterson, Bradley"
  12. AU="Lombardi, Gianmarco"
  13. AU="Rassl, Doris"
  14. AU="Román, Pablo"

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  1. Artikel ; Online: Measurement of and training for NCD guideline implementation in LMICs: a scoping review protocol.

    Faro, Elissa / Adeagbo, Oluwafemi / Mpinganjira, Mafuno Grace / Chirwa, Tobias / Matanje, Beatrice / Mayige, Mary / Kavishe, Bazil Baltazar / Mmbaga, Blandina / Francis, Joel M

    BMJ open

    2023  Band 13, Heft 7, Seite(n) e073550

    Abstract: Introduction: Globally, non-communicable diseases (NCDs) are the leading causes of morbidity and mortality with an estimated 41 million deaths (74% of all global deaths) annually. Despite the WHO's Global Action Plan for the Prevention and Control of ... ...

    Abstract Introduction: Globally, non-communicable diseases (NCDs) are the leading causes of morbidity and mortality with an estimated 41 million deaths (74% of all global deaths) annually. Despite the WHO's Global Action Plan for the Prevention and Control of NCDs since 2013, progress on implementation of the guidelines has been slow. Although research has shown success of some NCD prevention and treatment interventions, there is a dearth of research on NCD care delivery approaches, cost-effectiveness and larger implementation research, especially in low/middle-income countries (LMICs). The objective of this scoping review is to identify the existing variation in how, why and by whom implementation of NCD guidelines is measured as part of implementation research or non-research programme improvement.
    Methods and analysis: Using the methods established by Arksey and O'Malley, the search strategy was developed in consultation with a research librarian together with stakeholder feedback from content experts. We will apply the search to multiple electronic databases and grey literature sources. Two reviewers will independently screen title and abstract for inclusion followed by a full-text screening and all included records will be abstracted using a standardised tool that will be piloted with a sample of articles before application to all records. We will conduct a narrative synthesis of abstracted data and simple quantitative descriptive statistics.
    Dissemination: The results will enable stakeholders in LMICs to leverage existing tools and resources for implementation and ongoing evaluation of NCD guidelines, to improve education and capacity building, and ultimately NCD care across the lifespan.
    Mesh-Begriff(e) Humans ; Developing Countries ; Noncommunicable Diseases/prevention & control ; Delivery of Health Care/methods ; Review Literature as Topic
    Sprache Englisch
    Erscheinungsdatum 2023-07-04
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2023-073550
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Perceptions, facilitators and barriers of physical activity among people living with HIV: a qualitative study.

    Kitilya, Brenda / Sanga, Erica / PrayGod, George / Kavishe, Bazil Baltazar / Ditlevsen, Kia / Peck, Robert / Olsen, Mette Frahm

    BMC public health

    2023  Band 23, Heft 1, Seite(n) 360

    Abstract: Background: People living with HIV (PLWH) have low levels of physical activity. Using the social ecological model to understand perceptions, facilitators and barriers of physical activity in this population is of importance for developing contextualised ...

    Abstract Background: People living with HIV (PLWH) have low levels of physical activity. Using the social ecological model to understand perceptions, facilitators and barriers of physical activity in this population is of importance for developing contextualised interventions to improve physical activity in PLWH.
    Method: This was a qualitative sub-study conducted between august and November 2019 as part of a cohort study on diabetes and associated complications in HIV infected in Mwanza, Tanzania. Sixteen in-depth interviews and three focus groups with nine participants in each were conducted. The interviews and focus groups were audio recorded, transcribed and translated into English. The social ecological model was considered during the coding and interpretation of the results. Transcripts were discussed, coded and analyzed using deductive content analysis.
    Results: Forty-three PLWH aged 23-61 years participated in this study. The findings showed that most PLWH perceived physical activity as beneficial to their health. However, their perceptions of physical activity were rooted within existing gender stereotypes and roles in the community. Running and playing football were perceived as activities for men while household chores activities were for women. Further, men were perceived to do more physical activity than women. For women, household chores and income-generating activities were perceived as sufficient physical activity. Social support and engagement of family members and friends in physical activity were reported as facilitators of physical activity. Reported barriers of physical activity were lack of time, money, availability of physical activity facilities and social support groups, and poor information on physical activity from health care providers in HIV clinics. Human-immunodeficiency virus (HIV) HIV infection was not perceived by PLWH as a barrier for doing physical activity but most family members did not support them to do physical activity, fearing that it might worsen their condition.
    Conclusion: The findings demonstrated differing perceptions, facilitators and barriers of physical activity among PLWH. Interventions addressing awareness, gender stereotypes and roles related to physical activity from individual to community level are needed. Supportive environment and infrastructures are needed to improve physical activity levels in PLWH in Tanzania.
    Mesh-Begriff(e) Male ; Humans ; Female ; HIV ; Cohort Studies ; Tanzania/epidemiology ; HIV Infections/complications ; Qualitative Research ; Exercise
    Sprache Englisch
    Erscheinungsdatum 2023-02-18
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2041338-5
    ISSN 1471-2458 ; 1471-2458
    ISSN (online) 1471-2458
    ISSN 1471-2458
    DOI 10.1186/s12889-023-15052-9
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Brief Report: Changes in Nocturnal Heart Rate Variability in People Living With HIV During the First Year of Antiretroviral Therapy Compared With HIV-Uninfected Community Controls.

    Kavishe, Bazil Baltazar / PrayGod, George / Brage, Soren / Kitilya, Brenda Wilfred / Faurholt-Jepsen, Daniel / Todd, Jim / Jeremiah, Kidola / Filteau, Suzanne / Olsen, Mette Frahm / Peck, Robert

    Journal of acquired immune deficiency syndromes (1999)

    2023  Band 93, Heft 3, Seite(n) 208–212

    Abstract: Background: Higher nocturnal heart rate and lower nocturnal heart rate variability (HRV) is associated with increased cardiovascular disease mortality. Longitudinal studies on nocturnal HRV in people living with HIV (PLWH) are lacking.: Methods: We ... ...

    Abstract Background: Higher nocturnal heart rate and lower nocturnal heart rate variability (HRV) is associated with increased cardiovascular disease mortality. Longitudinal studies on nocturnal HRV in people living with HIV (PLWH) are lacking.
    Methods: We conducted a 1-year prospective cohort study of adult PLWH and HIV-uninfected community controls in northwestern Tanzania. At enrollment, we collected data on cardiovascular risk factors and tested blood samples for hemoglobin, insulin, CD4 cell count, and C-reactive protein. We measured nocturnal HRV and heart rate at baseline and first-year follow-up. Mixed effect linear regression was used to determine predictors of lower HRV.
    Results: Of the 111 enrolled participants (74 PLWH and 37 HIV-uninfected adults), 57.7% were female and the median age was 40 years. Over 1 year of follow-up, the average nocturnal heart rate was 4.5 beats/minute higher in PLWH ( P = 0.006). In the fully adjusted model (with age, sex, nocturnal heart rate, and diabetes), average nocturnal HRV was 10.5 milliseconds lower in PLWH compared with HIV-uninfected adults ( P = 0.03). Unlike with nocturnal heart rate, nocturnal HRV did not improve after 1 year of ART in PLWH or HIV-uninfected adults (fully adjusted change = -2.5 milliseconds, P = 0.45). Lower educational attainment, lesser pancreatic β-cell function, and anemia were associated with higher HRV.
    Conclusions: Nocturnal parasympathetic nervous system function was persistently lower in PLWH compared with HIV-uninfected adults even after antiretroviral therapy initiation. Improving nocturnal autonomic nervous system function could be a target for cardiovascular disease prevention in PLWH.
    Mesh-Begriff(e) Adult ; Humans ; Female ; Male ; HIV Infections/complications ; Heart Rate ; Prospective Studies ; Cardiovascular Diseases/complications ; Longitudinal Studies
    Sprache Englisch
    Erscheinungsdatum 2023-03-24
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 645053-2
    ISSN 1944-7884 ; 1077-9450 ; 0897-5965 ; 0894-9255 ; 1525-4135
    ISSN (online) 1944-7884 ; 1077-9450
    ISSN 0897-5965 ; 0894-9255 ; 1525-4135
    DOI 10.1097/QAI.0000000000003191
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Levels and correlates of physical activity and capacity among HIV-infected compared to HIV-uninfected individuals.

    Kitilya, Brenda / PrayGod, George / Peck, Robert / Changalucha, John / Jeremiah, Kidola / Kavishe, Bazil Baltazar / Friis, Henrik / Filteau, Suzanne / Faurholt-Jepsen, Daniel / Krogh-Madsen, Rikke / Brage, Soren / Olsen, Mette F

    PloS one

    2022  Band 17, Heft 1, Seite(n) e0262298

    Abstract: Introduction: In the HIV-infected individuals, physical activity improves physical strength, quality of life and reduces the risk of developing non-communicable diseases. In Sub-Saharan Africa, HIV-infected patients report being less active compared to ... ...

    Abstract Introduction: In the HIV-infected individuals, physical activity improves physical strength, quality of life and reduces the risk of developing non-communicable diseases. In Sub-Saharan Africa, HIV-infected patients report being less active compared to HIV-uninfected individuals. We assessed the levels and correlates of objectively measured physical activity and capacity among HIV-infected antiretroviral therapy (ART)-naive individuals compared to HIV-uninfected individuals in Mwanza, Tanzania.
    Method: We conducted a cross-sectional study among newly diagnosed HIV-infected ART-naive individuals and HIV-uninfected individuals frequency-matched for age and sex. Socio-demographic data, anthropometrics, CD4 counts, haemoglobin level, and C-reactive protein (CRP) were collected. Physical activity energy expenditure (PAEE) was assessed as measure of physical activity whereas sleeping heart rate (SHR) and grip strength were assessed as measures of physical capacity. Multivariable linear regression was used to assess the correlates associated with physical activity and capacity.
    Results: A total of 272 HIV-infected and 119 HIV-uninfected individuals, mean age 39 years and 60% women participated in the study. Compared to HIV-uninfected individuals, HIV-infected had poorer physical activity and capacity: lower PAEE (-7.3 kj/kg/day, 95% CI: -11.2, -3.3), elevated SHR (7.7 beats/min, 95%CI: 10.1, 5.3) and reduced grip strength (-4.7 kg, 95%CI: -6.8, -2.8). In HIV-infected individuals, low body mass index, moderate-severe anaemia, low CD4 counts and high CRP were associated with lower physical activity and capacity. In HIV-uninfected individuals, abdominal obesity and moderate anaemia were associated with lower physical activity and capacity.
    Conclusion: HIV-infected participants had lower levels of physical activity and capacity than HIV-uninfected participants. Correlates of physical activity and capacity differed by HIV status. Management of HIV and related conditions needs to be provided effectively in health care facilities. Interventions promoting physical activity in these populations will be of importance to improve their health and reduce the risk of non-communicable diseases.
    Mesh-Begriff(e) Adult ; Africa South of the Sahara/epidemiology ; Anthropometry ; Anti-Retroviral Agents/therapeutic use ; Body Mass Index ; CD4 Lymphocyte Count ; Cross-Sectional Studies ; Exercise/physiology ; Female ; HIV/pathogenicity ; HIV Infections/physiopathology ; HIV Infections/psychology ; Humans ; Male ; Middle Aged ; Obesity ; Quality of Life ; Tanzania/epidemiology
    Chemische Substanzen Anti-Retroviral Agents
    Sprache Englisch
    Erscheinungsdatum 2022-01-21
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0262298
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Blood Pressure and Body Composition During First Year of Antiretroviral Therapy in People With HIV Compared With HIV-Uninfected Community Controls.

    Kavishe, Bazil Baltazar / Olsen, Mette Frahm / Filteau, Suzanne / Kitilya, Brenda W / Jeremiah, Kidola / Krogh-Madsen, Rikke / Todd, Jim / Friis, Henrik / Faurholt-Jepsen, Daniel / PrayGod, George / Peck, Robert

    American journal of hypertension

    2022  Band 35, Heft 11, Seite(n) 929–937

    Abstract: Background: Body composition changes may explain the rapid increase in blood pressure (BP) in people with HIV (PWH) during the first year of antiretroviral therapy.: Methods: We analyzed data from a cohort of PWH and HIV-uninfected adults from the ... ...

    Abstract Background: Body composition changes may explain the rapid increase in blood pressure (BP) in people with HIV (PWH) during the first year of antiretroviral therapy.
    Methods: We analyzed data from a cohort of PWH and HIV-uninfected adults from the same communities in Mwanza, Tanzania. Blood pressure (BP, mm Hg) and body composition data were collected at baseline and 12-month follow-up. We used multivariable linear regression to compare BP changes in PWH and HIV-uninfected adults, and the relationship between changes in body composition and changes in BP.
    Results: BP data were available for 640 PWH and 299 HIV-uninfected adults. Sixty-four percent were women and the mean age was 38 years. In PWH, systolic BP (SBP) increased (114-118) whereas SBP decreased (125-123) in HIV-uninfected participants. Fat mass increased by 1.6 kg on average in PWH and was strongly associated with the change in BP (P < 0.001). The greater increase in SBP in PWH was partly explained by the lower baseline SBP but PWH still experienced a 2.2 (95% CI: 0.3-4.2) greater increase in SBP after adjustment. Weight gain partially mediated the relationship between HIV and SBP increase in PWH; a 1-kg increase in fat mass accounted for 0.8 (95% CI: 0.6-1.1) increase in SBP.
    Conclusions: Weight and fat mass increase rapidly in PWH during the first 12 months of antiretroviral therapy and contribute to a rapid increase in SBP. Interventions to prevent excessive increase in fat mass are needed for PWH.
    Mesh-Begriff(e) Adult ; Humans ; Female ; Male ; Blood Pressure ; Tanzania ; HIV Infections ; Body Composition ; Cohort Studies
    Sprache Englisch
    Erscheinungsdatum 2022-08-09
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 639383-4
    ISSN 1941-7225 ; 1879-1905 ; 0895-7061
    ISSN (online) 1941-7225 ; 1879-1905
    ISSN 0895-7061
    DOI 10.1093/ajh/hpac085
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Volltext online

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    Zs.A 2329: Hefte anzeigen Standort:
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  6. Artikel ; Online: Risk factors for impaired renal function in HIV-infected and HIV-uninfected adults: cross-sectional study in North-Western Tanzania.

    Kavishe, Bazil Baltazar / Kweka, Belinda V / Nitsch, Dorothea / PrayGod, George / Jeremiah, Kidola / Faurholt-Jepsen, Daniel / Filteau, Suzanne / Olsen, Mette Frahm / Kitilya, Brenda W / Krogh-Madsen, Rikke / Friis, Henrik / Peck, Robert

    BMC nephrology

    2021  Band 22, Heft 1, Seite(n) 355

    Abstract: Background: Although the burden of impaired renal function is rising in sub-Saharan Africa (SSA), little is known about correlates of impaired renal function in the region. We determined factors associated with estimated glomerular filtration rate (eGFR) ...

    Abstract Background: Although the burden of impaired renal function is rising in sub-Saharan Africa (SSA), little is known about correlates of impaired renal function in the region. We determined factors associated with estimated glomerular filtration rate (eGFR) and impaired renal function in HIV-infected and HIV-uninfected adults.
    Methods: We undertook cross-sectional analysis of data from 1947 adults at enrolment for a cohort study on diabetes and associated complications in HIV patients in Mwanza, north-western Tanzania. A structured questionnaire was used to collect data on sociodemography, smoking, alcohol, physical activity, antiretroviral therapy (ART) and anthropometry. We measured blood pressure, tested blood samples for creatinine, glucose and HIV, and performed Kato Katz for Schistosoma mansoni. Correlates of eGFR (mL/min/1.73 m
    Results: 655 (34%) participants were HIV-uninfected, 956 (49%) were ART-naive HIV-infected and 336 (17%) were HIV-infected adults on ART. The mean age was 41 years (SD12) and majority (59%) were females. Overall, the mean eGFR was 113.6 mL/min/1.73 m
    Conclusion: Impaired renal function is prevalent in this middle-aged study population. Interventions for prevention of impaired renal function are needed in the study population with special focus in HIV-infected adults and those with high socioeconomic status. Interventions targeting modifiable risk factors such as alcohol and weight reduction are warranted.
    Mesh-Begriff(e) Adolescent ; Adult ; Cross-Sectional Studies ; Female ; HIV Infections/complications ; Humans ; Male ; Middle Aged ; Renal Insufficiency/epidemiology ; Renal Insufficiency/etiology ; Risk Factors ; Tanzania/epidemiology ; Young Adult
    Sprache Englisch
    Erscheinungsdatum 2021-10-29
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2041348-8
    ISSN 1471-2369 ; 1471-2369
    ISSN (online) 1471-2369
    ISSN 1471-2369
    DOI 10.1186/s12882-021-02563-z
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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