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  1. Article ; Online: “Vaai Ganam” - a screening program for early detection of oral potentially malignant disorders and oral cancer among truck drivers in Chennai – a cross-sectional survey

    Parangimalai Diwakar Madan Kumar / Kavitha Loganathan / Ranganathan Kannan / Uma Devi Mohan Das Roa / Aswath Narayanan Mani Bhagiyalakshmi

    International Journal of Occupational Safety and Health, Vol 14, Iss

    2024  Volume 1

    Abstract: Introduction: Truck drivers, though forming an integral part of a vital trade link for the Indian population, lack basic life insurance and health care benefits offered by other organized sectors in Indian Industries. This paper aims to present the ... ...

    Abstract Introduction: Truck drivers, though forming an integral part of a vital trade link for the Indian population, lack basic life insurance and health care benefits offered by other organized sectors in Indian Industries. This paper aims to present the initial findings of the “VaaiGanam” program which proposes to identify tobacco use and the prevalence of Oral potentially malignant disorders (OPMDs) among truck drivers who are stationed or passing via Chennai and provide cessation services by behavioral therapy. Methods: This cross-sectional study was conducted by a dental screening team who were involved in data collection and screening of the 747 truck drivers who fulfilled the inclusion and exclusion criteria between Jan to Oct 2022. After data collection, oral examinations were done and suspicious lesions were sought for expert opinion. A standard punch biopsy was taken from those lesions requiring confirmation. Results: Among the 747 subjects who participated in this program, 704 (94.2%) were current users of various tobacco products, with 235 (31.4%) preferring smoking and the rest 469(62.8%) using smokeless tobacco products. Oral mucosal lesions were recorded in 49 (6.5%) of the study population, mostly among tobacco users. Punch/incisional biopsies were taken among 17 of the 49 subjects and oral dysplasia was histopathologically confirmed in 9 (mild epithelial dysplasia = 5; moderate epithelial dysplasia = 4) subjects. Conclusion: Truck drivers with tobacco and substance abuse are at high risk of developing oral cancer and hence this study emphasizes the importance of periodic oral cancer screening programs for this vulnerable population to identify potentially malignant oral lesions at an early stage.
    Keywords high risk population ; oral cancer ; oral potentially malignant lesions ; Screening ; truck drivers ; Public aspects of medicine ; RA1-1270
    Subject code 610
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher Occupational Health and Safety Society of Nepal
    Document type Article ; Online
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  2. Article ; Online: “Vaai Ganam” - a screening program for early detection of oral potentially malignant disorders and oral cancer among truck drivers in Chennai – a cross-sectional survey

    Parangimalai Diwakar Madan Kumar / Kavitha Loganathan / Ranganathan Kannan / Uma Devi Mohan Das Roa / Aswath Narayanan Mani Bhagiyalakshmi

    International Journal of Occupational Safety and Health, Vol 14, Iss

    2024  Volume 1

    Abstract: Introduction: Truck drivers, though forming an integral part of a vital trade link for the Indian population, lack basic life insurance and health care benefits offered by other organized sectors in Indian Industries. This paper aims to present the ... ...

    Abstract Introduction: Truck drivers, though forming an integral part of a vital trade link for the Indian population, lack basic life insurance and health care benefits offered by other organized sectors in Indian Industries. This paper aims to present the initial findings of the “VaaiGanam” program which proposes to identify tobacco use and the prevalence of Oral potentially malignant disorders (OPMDs) among truck drivers who are stationed or passing via Chennai and provide cessation services by behavioral therapy. Methods: This cross-sectional study was conducted by a dental screening team who were involved in data collection and screening of the 747 truck drivers who fulfilled the inclusion and exclusion criteria between Jan to Oct 2022. After data collection, oral examinations were done and suspicious lesions were sought for expert opinion. A standard punch biopsy was taken from those lesions requiring confirmation. Results: Among the 747 subjects who participated in this program, 704 (94.2%) were current users of various tobacco products, with 235 (31.4%) preferring smoking and the rest 469(62.8%) using smokeless tobacco products. Oral mucosal lesions were recorded in 49 (6.5%) of the study population, mostly among tobacco users. Punch/incisional biopsies were taken among 17 of the 49 subjects and oral dysplasia was histopathologically confirmed in 9 (mild epithelial dysplasia = 5; moderate epithelial dysplasia = 4) subjects. Conclusion: Truck drivers with tobacco and substance abuse are at high risk of developing oral cancer and hence this study emphasizes the importance of periodic oral cancer screening programs for this vulnerable population to identify potentially malignant oral lesions at an early stage.
    Keywords high risk population ; oral cancer ; oral potentially malignant lesions ; Screening ; truck drivers ; Public aspects of medicine ; RA1-1270
    Subject code 610
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher Occupational Health and Safety Society of Nepal
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article: Oral epithelial dysplasia: Classifications and clinical relevance in risk assessment of oral potentially malignant disorders.

    Ranganathan, Kannan / Kavitha, Loganathan

    Journal of oral and maxillofacial pathology : JOMFP

    2019  Volume 23, Issue 1, Page(s) 19–27

    Abstract: After more than a decade, the World Health Organization (WHO) published the revised grading system for oral epithelial dysplasia in 2017. The revised classification has changes reflecting our evolution of understanding of the dysplastic process. Although ...

    Abstract After more than a decade, the World Health Organization (WHO) published the revised grading system for oral epithelial dysplasia in 2017. The revised classification has changes reflecting our evolution of understanding of the dysplastic process. Although the WHO 2017 three-tier grading system is the gold standard for histological diagnosis of oral potentially malignant disorders, it has certain limitations. Suggestions to overcome these limitations include the use of clinical determinants and molecular markers to supplement the grading system. It has also been suggested that a two-tier system may be more reproducible and clinically translatable for better management. These advances in the understanding of epithelial dysplasia are very important globally and for us in the Indian subcontinent, given the prevalence of habits (tobacco/areca nut) and burden of oral cancer in this part of the world. The following review traces the evolution of the grading system of dysplasia, its relevance and clinical utility.
    Language English
    Publishing date 2019-05-02
    Publishing country India
    Document type Journal Article
    ZDB-ID 2390999-7
    ISSN 1998-393X ; 0973-029X
    ISSN (online) 1998-393X
    ISSN 0973-029X
    DOI 10.4103/jomfp.JOMFP_13_19
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  4. Article ; Online: Immunohistochemical biomarkers in oral submucous fibrosis: A scoping review.

    Kavitha, Loganathan / Ranganathan, Kannan / Shyam, Sivasamy / Fathima, Jaffer Hussain Shazia / Umesh, Wadgave / Warnakulasuriya, Saman

    Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology

    2022  Volume 51, Issue 7, Page(s) 594–602

    Abstract: Introduction: This scoping review was done to study the immunohistochemical biomarkers involved in the pathogenesis and malignant transformation of oral submucous fibrosis (OSF), in literature published from 2010 to 2021.: Method: The protocol was ... ...

    Abstract Introduction: This scoping review was done to study the immunohistochemical biomarkers involved in the pathogenesis and malignant transformation of oral submucous fibrosis (OSF), in literature published from 2010 to 2021.
    Method: The protocol was adapted from the Joanna Briggs Institute Reviewer's Manual (2017), and reported according to the PRISMA guidelines for Scoping Reviews.
    Results: Eighty-six studies included in this review reported 84 immunohistochemical (IHC) biomarkers in OSF: 10 epithelial markers, 28 connective tissue markers, 22 proliferative markers, and 24 other biomarkers that are transcription factors, cancer stem cell markers, cell signaling markers, proteins, and enzymes. The commonly reported IHC biomarkers were alpha-smooth muscle actin (α-SMA) and E-cadherin (seven articles each) followed by vascular endothelial growth factor (VEGF) and CD34 (six articles each), p53, p63, and Ki67 (five articles each). α-SMA, Ki67, CD105, and hTERT were significantly increased in oral squamous cell carcinoma arising in a background of OSF (OSCC-OSF) compared with OSF and normal subjects.
    Conclusion: The identified surrogate IHC biomarkers reported in OSF in this scoping review require validation with long-term prospective studies to facilitate early diagnosis, for use in risk assessment, and plan appropriate treatment for OSF in clinical practice. Open Science Framework ID: osf.io/epwra.
    MeSH term(s) Carcinoma, Squamous Cell/diagnosis ; Carcinoma, Squamous Cell/pathology ; Humans ; Ki-67 Antigen ; Mouth Neoplasms/diagnosis ; Mouth Neoplasms/pathology ; Oral Submucous Fibrosis/pathology ; Prospective Studies ; Vascular Endothelial Growth Factor A
    Chemical Substances Ki-67 Antigen ; Vascular Endothelial Growth Factor A
    Language English
    Publishing date 2022-02-22
    Publishing country Denmark
    Document type Journal Article ; Review
    ZDB-ID 1021270-x
    ISSN 1600-0714 ; 0904-2512
    ISSN (online) 1600-0714
    ISSN 0904-2512
    DOI 10.1111/jop.13280
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  5. Article ; Online: Expression of CD44 in Head and Neck Squamous Cell Carcinoma-An

    Kavitha, Loganathan / Vijayashree Priyadharsini, Jayaseelan / Kattula, Deepthi / Rao, Umadevi Krishna Mohan / Balaji Srikanth, Rajabather / Kuzhalmozhi, Manogaran / Ranganathan, Kannan

    Global medical genetics

    2023  Volume 10, Issue 3, Page(s) 221–228

    Abstract: ... ...

    Abstract Introduction
    Language English
    Publishing date 2023-08-16
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 3009997-3
    ISSN 2699-9404 ; 2699-9404
    ISSN (online) 2699-9404
    ISSN 2699-9404
    DOI 10.1055/s-0043-1772459
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  6. Article ; Online: Association among interleukin-6 gene polymorphisms, type 2 diabetes mellitus, and chronic periodontitis: a pilot study.

    Kavitha, Loganathan / Vijayshree Priyadharshini, Jayaseelan / Sivapathasundharam, Balasundaram

    Journal of investigative and clinical dentistry

    2017  Volume 8, Issue 3

    Abstract: Aim: The purpose of this pilot study was to determine the association between single nucleotide polymorphisms (-174 G>C) in the interleukin-6 (IL-6) gene with chronic periodontitis (CP) and type 2 diabetes mellitus (T2DM) in south Indian population.: ... ...

    Abstract Aim: The purpose of this pilot study was to determine the association between single nucleotide polymorphisms (-174 G>C) in the interleukin-6 (IL-6) gene with chronic periodontitis (CP) and type 2 diabetes mellitus (T2DM) in south Indian population.
    Methods: Genomic DNA was obtained from the white blood cells of 30 patients with T2DM, 30 patients with CP, 30 patients with T2DM with CP, and 30 controls. DNA was amplified using polymerase chain reaction with specific primers flanking the locus -174 of the IL-6 gene and further genotyped using the restriction fragment length polymorphism method. The genotype distribution and allele frequencies between the study groups were determined using χ
    Results: The CP group (26.7%) displayed a greater percentage of GC genotype (P = 0.026) when compared to the control group (3.3%). A statistically-significant difference in the allele frequencies was found between the control and CP group with the C-allele frequency being greater (0.13) in the CP group than normal controls (0.02).
    Conclusion: The GC genotype was found to be the risk genotype and the C allele was found to be the risk allele for the development of CP.
    MeSH term(s) Adult ; Aged ; Chronic Periodontitis/genetics ; Cross-Sectional Studies ; Diabetes Mellitus, Type 2/genetics ; Gene Frequency ; Humans ; India ; Interleukin-6/genetics ; Middle Aged ; Pilot Projects ; Polymorphism, Single Nucleotide
    Chemical Substances IL6 protein, human ; Interleukin-6
    Language English
    Publishing date 2017-08
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2625845-6
    ISSN 2041-1626 ; 2041-1618
    ISSN (online) 2041-1626
    ISSN 2041-1618
    DOI 10.1111/jicd.12230
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  7. Article: Expression of CD44 in Head and Neck Squamous Cell Carcinoma—An In-Silico Study

    Kavitha, Loganathan / Vijayashree Priyadharsini, Jayaseelan / Kattula, Deepthi / Rao, Umadevi Krishna Mohan / Balaji Srikanth, Rajabather / Kuzhalmozhi, Manogaran / Ranganathan, Kannan

    Global Medical Genetics

    2023  Volume 10, Issue 03, Page(s) 221–228

    Abstract: Introduction: CD44, a multistructural and multifunctional transmembrane glycoprotein, is a promising cancer stem cell (CSC) marker that regulates the properties of CSCs, including self-renewal, tumor initiation, and metastasis, and confers resistance to ...

    Abstract Introduction: CD44, a multistructural and multifunctional transmembrane glycoprotein, is a promising cancer stem cell (CSC) marker that regulates the properties of CSCs, including self-renewal, tumor initiation, and metastasis, and confers resistance to chemotherapy and radiotherapy. The aim of the present study was to evaluate the gene and protein expression of CD44 and explore its prognostic value in head and neck squamous cell carcinoma (HNSCC).
    Methodology: The present observational study employs computational tools for analysis. The Cancer Genome Atlas Head-Neck Squamous Cell Carcinoma dataset (520 primary HNSCC and 44 normal tissues) from the University of Alabama at Birmingham Cancer platform was used to study the association of CD44 mRNA transcript levels with various clinicopathological characteristics of HNSCC including age, gender, tumor grade, tumor stage, human papillomavirus (HPV) status, p53 mutation status, and overall survival. The CD44 protein expression in HNSCC and normal tissues was ascertained using the National Cancer Institute's Clinical Proteomic Tumor Analysis Consortium Head-and-Neck cancer dataset (108 primary HNSCC and 71 normal tissues).
    Results: CD44 mRNA transcript and protein expression levels were significantly higher in HNSCC tissues than in normal tissues, and high CD44 expression was correlated with poor survival. CD44 was upregulated in Stage 1 and Grade 2 HNSCC compared with other stages and grades. Overexpression of CD44 was observed in HPV-negative and TP53-positive mutant status in HNSCC.
    Conclusion: The pleiotropic roles of CD44 in tumorigenesis urge the need to explore its differential expression in HNSCC. The study concludes that CD44 can be a potential diagnostic and prognostic biomarker for HNSCC and offer new molecular targets for CD44-targeted therapy for cancer management.
    Keywords CD44 ; in-silico ; cancer stem cell ; HNSCC ; UALCAN ; TCGA
    Language English
    Publishing date 2023-08-16
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 3009997-3
    ISSN 2699-9404 ; 2699-9404
    ISSN (online) 2699-9404
    ISSN 2699-9404
    DOI 10.1055/s-0043-1772459
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  8. Article ; Online: Intra-observer and inter-observer variability in two grading systems for oral epithelial dysplasia: A multi-centre study in India.

    Ranganathan, Kannan / Kavitha, Loganathan / Sharada, Prakash / Bavle, Radhika M / Rao, Roopa S / Pattanshetty, Smita M / Hazarey, Vinay K / Madhura, Murittige Gopalakrishna / Nagaraj, Tejavathi / Lingappa, Ashok / Warnakulasuriya, Saman

    Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology

    2020  Volume 49, Issue 9, Page(s) 948–955

    Abstract: Background: The presence and grading of oral epithelial dysplasia (OED) are considered the gold standard for predicting the malignant risk of oral potentially malignant disorders. However, inter-observer and intra-observer agreement in the context of ... ...

    Abstract Background: The presence and grading of oral epithelial dysplasia (OED) are considered the gold standard for predicting the malignant risk of oral potentially malignant disorders. However, inter-observer and intra-observer agreement in the context of reporting on OED grading has been reputedly considered unreliable.
    Methods: We undertook a multi-centre study of six Indian oral pathologists to assess variations in reporting OED using the World Health Organization (WHO; 2005) system and also the recently introduced binary system. The observer variability was assessed with the use of kappa statistics.
    Results: The weighted kappa intra-observer agreement scores improved (κ
    Conclusions: There is considerable room for improvement in the assessment of OED using either system to help in standardised reporting. The professional pathology organisations in India should take steps to provide external quality assessment in reporting OED among oral and general pathologists who are engaged in routine reporting of head and neck specimens.
    MeSH term(s) Carcinoma in Situ ; Humans ; Hyperplasia ; India ; Observer Variation ; Reproducibility of Results
    Language English
    Publishing date 2020-07-09
    Publishing country Denmark
    Document type Journal Article ; Multicenter Study
    ZDB-ID 1021270-x
    ISSN 1600-0714 ; 0904-2512
    ISSN (online) 1600-0714
    ISSN 0904-2512
    DOI 10.1111/jop.13056
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