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  1. Article ; Online: On the importance of birth weight in relation to disease risk in later life.

    Kavousi, Maryam / Snieder, Harold

    European heart journal

    2024  Volume 45, Issue 6, Page(s) 455–457

    MeSH term(s) Humans ; Birth Weight ; Blood Pressure ; Risk Factors
    Language English
    Publishing date 2024-02-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehad785
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  2. Article: Recognising and addressing social determinants of health: an important step toward centring equity in cardiovascular care.

    Ginos, Bigina N R / Kavousi, Maryam

    Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation

    2024  Volume 32, Issue 3, Page(s) 104–105

    Language English
    Publishing date 2024-02-16
    Publishing country Netherlands
    Document type Editorial
    ZDB-ID 2211468-3
    ISSN 1876-6250 ; 1568-5888 ; 0929-7456
    ISSN (online) 1876-6250
    ISSN 1568-5888 ; 0929-7456
    DOI 10.1007/s12471-024-01857-9
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  3. Article: Differences in Epidemiology and Risk Factors for Atrial Fibrillation Between Women and Men.

    Kavousi, Maryam

    Frontiers in cardiovascular medicine

    2020  Volume 7, Page(s) 3

    Abstract: Atrial fibrillation (AF), the most common sustained cardiac arrhythmia, is one of the most frequent cardiovascular diseases among both women and men. Although age-adjusted AF incidence and prevalence is larger among men, women are older at the time of AF ...

    Abstract Atrial fibrillation (AF), the most common sustained cardiac arrhythmia, is one of the most frequent cardiovascular diseases among both women and men. Although age-adjusted AF incidence and prevalence is larger among men, women are older at the time of AF diagnosis and have larger risk for AF-associated adverse outcomes such as morality and stroke. Based on evidence from epidemiological studies, elevated body mass index seems to confer a higher risk of AF among men. However, evidence regarding sex differences in the association between diabetes mellitus, elevated blood pressure, and dysglycemia with AF remains conflicting. While men with AF have larger burden of coronary artery disease, women with AF tend to have a larger prevalence of heart failure and valvular heart disease. Recently, several women-specific risk factors including pregnancy and its complications and number of children have been associated with AF. Earlier age at menopause, despite being a strong marker of adverse cardiometabolic risk, does not seem to be associated with increased risk of AF. To reduce the AF burden in both genders, better understanding of the differences between women and men with regard to AF is central. Large-scale studies are needed to separately investigate and report on women and men. Besides observations from epidemiological and clinical studies, to improve our understanding of sexual dimorphism in AF, sufficiently large genome-wide association studies as well as well-powered Mendelian randomization studies are essential to shed light on the sex-specific nature of the associations of risk factors with AF.
    Language English
    Publishing date 2020-01-31
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2020.00003
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  4. Article ; Online: Polygenic risk score: a tool ready for clinical use?

    Kavousi, Maryam / Schunkert, Heribert

    European heart journal

    2022  Volume 43, Issue 18, Page(s) 1712–1714

    MeSH term(s) Causality ; Genetic Predisposition to Disease/genetics ; Genome-Wide Association Study ; Humans ; Pituitary ACTH Hypersecretion ; Risk Factors
    Language English
    Publishing date 2022-02-21
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehab923
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  5. Article: Integration of sex and gender in cardiovascular medicine: a scientific and clinical imperative.

    Kavousi, Maryam / van Lennep, Jeanine Roeters

    Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation

    2023  Volume 31, Issue 10, Page(s) 369–370

    Language English
    Publishing date 2023-09-08
    Publishing country Netherlands
    Document type Editorial
    ZDB-ID 2211468-3
    ISSN 1876-6250 ; 1568-5888 ; 0929-7456
    ISSN (online) 1876-6250
    ISSN 1568-5888 ; 0929-7456
    DOI 10.1007/s12471-023-01817-9
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  6. Article ; Online: Tools and Techniques - Statistical. Confounding and effect measure modification: analysing sex in cardiovascular research.

    Kavousi, Maryam

    EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology

    2016  Volume 12, Issue 3, Page(s) 404–407

    MeSH term(s) Cardiovascular Diseases/therapy ; Humans ; Research ; Research Design ; Risk Factors ; Sex Factors
    Language English
    Publishing date 2016-06-20
    Publishing country France
    Document type Journal Article ; Review
    ZDB-ID 2457174-X
    ISSN 1969-6213 ; 1774-024X
    ISSN (online) 1969-6213
    ISSN 1774-024X
    DOI 10.4244/EIJV12I3A68
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    Zs.MO 571: Show issues

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  7. Article ; Online: Progression of arterial calcifications: what, where, and in whom?

    van der Toorn, Janine E / Vernooij, Meike W / Ikram, M Arfan / Kavousi, Maryam / Bos, Daniel

    European radiology

    2024  

    Abstract: Objectives: There is a lack of information on the development of arteriosclerosis over time. This study aims to assess long-term sex-specific changes in arterial calcifications in five arteries, and the influence of cardiovascular risk factors hereon.!## ...

    Abstract Objectives: There is a lack of information on the development of arteriosclerosis over time. This study aims to assess long-term sex-specific changes in arterial calcifications in five arteries, and the influence of cardiovascular risk factors hereon.
    Methods: From a population-based cohort, 807 participants (mean baseline age, 65.8; SD, 4.2) underwent a non-contrast computed tomography (CT) examination between 2003 and 2006, and after a median follow-up of 14 years. We assessed incidences and changes in volumes of coronary artery calcification (CAC), aortic arch calcification (AAC), extracranial (ECAC) and intracranial carotid artery calcification (ICAC), and vertebrobasilar artery calcification (VBAC). We investigated the simultaneous presence of severe progression (upper quartile of percentual change volumes). Associations of cardiovascular risk factors with changes in calcification volumes were assessed using multivariate linear regression models.
    Results: The difference in AAC was most substantial; the median volume (mm
    Conclusions: We found a considerable incidence and increase in volumes of calcifications in different arteries, over a 14-year time interval. Cardiovascular risk factors were associated with increase of calcifications with sex-specific differential effects across arteries.
    Clinical relevance statement: There is a considerable incidence and increase in volumes of calcifications in different arteries, over a 14-year time interval. Cardiovascular risk factors are associated with increase of calcifications with sex-specific differential effects across arteries; thus, assessing changes in only one artery may thus not provide a good reflection of the systemic development of arteriosclerosis.
    Key points: • Assessing change in arterial calcification in only one artery does not reflect the systemic development of arterial calcification. • Cardiovascular risk factors are associated with progression of arterial calcifications. • Progression of arterial calcification is sex and artery-specific.
    Language English
    Publishing date 2024-01-15
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1085366-2
    ISSN 1432-1084 ; 0938-7994 ; 1613-3749
    ISSN (online) 1432-1084
    ISSN 0938-7994 ; 1613-3749
    DOI 10.1007/s00330-023-10566-7
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  8. Article ; Online: Autoimmunity-related atrial fibrillation incidence: an emerging conundrum meriting further investigation: authors' reply.

    Tilly, Martijn J / de Groot, Natasja M S / Kavousi, Maryam

    Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology

    2023  Volume 25, Issue 5

    MeSH term(s) Humans ; Atrial Fibrillation/diagnosis ; Atrial Fibrillation/epidemiology ; Autoimmunity ; Biological Specimen Banks ; Autoimmune Diseases ; United Kingdom
    Language English
    Publishing date 2023-03-24
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 1449879-0
    ISSN 1532-2092 ; 1099-5129
    ISSN (online) 1532-2092
    ISSN 1099-5129
    DOI 10.1093/europace/euad081
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    Zs.A 5434: Show issues Location:
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  9. Article ; Online: Aortic Valve Calcium in Relation to Subclinical Cardiac Dysfunction and Risk of Heart Failure.

    Zhu, Fang / Kaiser, Yannick / Boersma, Eric / Bos, Daniel / Kavousi, Maryam

    Circulation. Cardiovascular imaging

    2023  Volume 16, Issue 3, Page(s) e014323

    Abstract: Background: The link between (mild) aortic valve calcium (AVC) with subclinical cardiac dysfunction and with risk of heart failure (HF) remains unclear. This research aims to determine the association of computed tomography-assessed AVC with ... ...

    Abstract Background: The link between (mild) aortic valve calcium (AVC) with subclinical cardiac dysfunction and with risk of heart failure (HF) remains unclear. This research aims to determine the association of computed tomography-assessed AVC with echocardiographic measurements of cardiac dysfunction, and with HF in the general population.
    Methods: We included 2348 participants of the Rotterdam Study cohort (mean age 68.5 years, 52% women), who had AVC measurement between 2003 and 2006, and without history of HF at baseline. Linear regression models were used to explore relationship between AVC and echocardiographic measures at baseline. Participants were followed until December 2016. Fine and Gray subdistribution hazard models were used to assess the association of AVC with incident HF, accounting for death as a competing risk.
    Results: The presence of AVC or greater AVC were associated with larger mean left ventricular mass and larger mean left atrial size. In particular, AVC ≥800 showed a strong association (body surface area indexed left ventricular mass, β coefficient: 22.01; left atrium diameter, β coefficient: 0.17). During a median of 9.8 years follow-up, 182 incident HF cases were identified. After accounting for death events and adjusting for cardiovascular risk factors, one-unit larger log (AVC+1) was associated with a 10% increase in the subdistribution hazard of HF (subdistribution hazard ratio, 1.10 [95% CI, 1.03-1.18]), but the presence of AVC was not significantly associated with HF risk in fully adjusted models. Compared with the AVC=0, AVC between 300 and 799 (subdistribution hazard ratio, 2.36 [95% CI, 1.32-4.19]) and AVC ≥800 (subdistribution hazard ratio, 2.54 [95% CI, 1.31-4.90]) were associated with a high risk of HF.
    Conclusions: Presence and high levels of AVC were associated with markers of left ventricular structure, independent of traditional cardiovascular risk factors. Larger computed tomography-assessed AVC is an indicative of increased risk for the development of HF.
    MeSH term(s) Humans ; Female ; Aged ; Male ; Aortic Valve/diagnostic imaging ; Calcium ; Calcinosis/epidemiology ; Heart Failure/diagnostic imaging ; Heart Failure/epidemiology ; Aortic Valve Stenosis/diagnostic imaging ; Aortic Valve Stenosis/epidemiology ; Risk Factors
    Chemical Substances Calcium (SY7Q814VUP)
    Language English
    Publishing date 2023-03-07
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2435045-X
    ISSN 1942-0080 ; 1941-9651
    ISSN (online) 1942-0080
    ISSN 1941-9651
    DOI 10.1161/CIRCIMAGING.122.014323
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  10. Article ; Online: Female Reproductive Factors and Risk of New-Onset Heart Failure: Findings From UK Biobank.

    Zhu, Fang / Qi, Hongchao / Bos, Maxime / Boersma, Eric / Kavousi, Maryam

    JACC. Heart failure

    2023  Volume 11, Issue 9, Page(s) 1203–1212

    Abstract: Background: A comprehensive evaluation of woman-specific risk factors in relation to incident heart failure (HF) is limited.: Objectives: This study sought to investigate the association of multiple female reproductive factors with the risk of HF.: ...

    Abstract Background: A comprehensive evaluation of woman-specific risk factors in relation to incident heart failure (HF) is limited.
    Objectives: This study sought to investigate the association of multiple female reproductive factors with the risk of HF.
    Methods: Between 2007 and 2010, 229,026 women (mean age: 56.5 years) without prevalent HF from the UK Biobank cohort were included and followed until December 2020. The relation between (self-reported) reproductive factors and HF was analyzed using Cox proportional hazards models with adjustment for potential confounding.
    Results: Menarche at age <12 years, compared to age 12-13 years, carried a 9% larger risk of HF (HR: 1.09 [95% CI: 1.01-1.18]). Younger age at menopause was associated with a higher risk of HF (HR
    Conclusions: The findings emphasize the importance of female reproductive history in the assessment of HF risk.
    MeSH term(s) Child ; Humans ; Female ; Middle Aged ; Adolescent ; Young Adult ; Adult ; Heart Failure/epidemiology ; Prospective Studies ; Reproductive History ; Biological Specimen Banks ; Risk Factors ; United Kingdom/epidemiology
    Language English
    Publishing date 2023-04-19
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2705621-1
    ISSN 2213-1787 ; 2213-1779
    ISSN (online) 2213-1787
    ISSN 2213-1779
    DOI 10.1016/j.jchf.2023.02.019
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