LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 2 of total 2

Search options

  1. Book ; Online ; Thesis: Molecular analysis of death receptors mediated apoptotic and non-apoptotic signalling pathways in human keratinocytes

    Kavuri, Megha Shyam

    2011  

    Author's details von Megha Shyam Kavuri
    Language English
    Size Online-Ressource (PDF-Datei)
    Edition [Online-Ausg.]
    Publisher Universitätsbibl
    Publishing place Magdeburg
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis Univ., Fak. für Naturwiss., Diss.--Magdeburg, 2011
    Database Former special subject collection: coastal and deep sea fishing

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  2. Article ; Online: Endocrine-therapy-resistant ESR1 variants revealed by genomic characterization of breast-cancer-derived xenografts.

    Li, Shunqiang / Shen, Dong / Shao, Jieya / Crowder, Robert / Liu, Wenbin / Prat, Aleix / He, Xiaping / Liu, Shuying / Hoog, Jeremy / Lu, Charles / Ding, Li / Griffith, Obi L / Miller, Christopher / Larson, Dave / Fulton, Robert S / Harrison, Michelle / Mooney, Tom / McMichael, Joshua F / Luo, Jingqin /
    Tao, Yu / Goncalves, Rodrigo / Schlosberg, Christopher / Hiken, Jeffrey F / Saied, Laila / Sanchez, Cesar / Giuntoli, Therese / Bumb, Caroline / Cooper, Crystal / Kitchens, Robert T / Lin, Austin / Phommaly, Chanpheng / Davies, Sherri R / Zhang, Jin / Kavuri, Megha Shyam / McEachern, Donna / Dong, Yi Yu / Ma, Cynthia / Pluard, Timothy / Naughton, Michael / Bose, Ron / Suresh, Rama / McDowell, Reida / Michel, Loren / Aft, Rebecca / Gillanders, William / DeSchryver, Katherine / Wilson, Richard K / Wang, Shaomeng / Mills, Gordon B / Gonzalez-Angulo, Ana / Edwards, John R / Maher, Christopher / Perou, Charles M / Mardis, Elaine R / Ellis, Matthew J

    Cell reports

    2013  Volume 4, Issue 6, Page(s) 1116–1130

    Abstract: To characterize patient-derived xenografts (PDXs) for functional studies, we made whole-genome comparisons with originating breast cancers representative of the major intrinsic subtypes. Structural and copy number aberrations were found to be retained ... ...

    Abstract To characterize patient-derived xenografts (PDXs) for functional studies, we made whole-genome comparisons with originating breast cancers representative of the major intrinsic subtypes. Structural and copy number aberrations were found to be retained with high fidelity. However, at the single-nucleotide level, variable numbers of PDX-specific somatic events were documented, although they were only rarely functionally significant. Variant allele frequencies were often preserved in the PDXs, demonstrating that clonal representation can be transplantable. Estrogen-receptor-positive PDXs were associated with ESR1 ligand-binding-domain mutations, gene amplification, or an ESR1/YAP1 translocation. These events produced different endocrine-therapy-response phenotypes in human, cell line, and PDX endocrine-response studies. Hence, deeply sequenced PDX models are an important resource for the search for genome-forward treatment options and capture endocrine-drug-resistance etiologies that are not observed in standard cell lines. The originating tumor genome provides a benchmark for assessing genetic drift and clonal representation after transplantation.
    MeSH term(s) Adaptor Proteins, Signal Transducing/genetics ; Alleles ; Animals ; Breast Neoplasms/drug therapy ; Breast Neoplasms/genetics ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Drug Resistance, Neoplasm ; Estradiol/pharmacology ; Estrogen Receptor alpha/genetics ; Female ; Gene Amplification ; Genomic Instability ; Heterografts ; Humans ; Mice ; Neoplasm Proteins/biosynthesis ; Neoplasm Proteins/genetics ; Neoplasm Staging ; Phosphoproteins/genetics ; Point Mutation ; RNA, Neoplasm/biosynthesis ; RNA, Neoplasm/genetics ; Transcription Factors ; Translocation, Genetic
    Chemical Substances Adaptor Proteins, Signal Transducing ; ESR1 protein, human ; Estrogen Receptor alpha ; Neoplasm Proteins ; Phosphoproteins ; RNA, Neoplasm ; Transcription Factors ; YAP1 protein, human ; Estradiol (4TI98Z838E)
    Language English
    Publishing date 2013-09-19
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2013.08.022
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top