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Article ; Online: How can guidelines contribute to reducing "preventable" mortality in patients with upper gastrointestinal bleeding on antithrombotic drugs?

Kawaguchi, Koichiro / Isomoto, Hajime

Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society

2022 Volume 34, Issue 4, Page(s) 738–740

MeSH term(s)	Fibrinolytic Agents/adverse effects ; Gastrointestinal Hemorrhage/chemically induced ; Humans ; Risk Factors
Chemical Substances	Fibrinolytic Agents
Language	English
Publishing date	2022-03-01
Publishing country	Australia
Document type	Editorial ; Comment
ZDB-ID	1171589-3
ISSN	1443-1661 ; 0915-5635
ISSN (online)	1443-1661
ISSN	0915-5635
DOI	10.1111/den.14268
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Article ; Online: Validation of AIMS65 to predict outcomes in acute variceal bleeding: Which risk scoring system outperforms in real practice?

Kawaguchi, Koichiro / Isomoto, Hajime

Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society

2020 Volume 32, Issue 5, Page(s) 739–741

MeSH term(s)	Area Under Curve ; Esophageal and Gastric Varices/diagnosis ; Esophageal and Gastric Varices/therapy ; Gastrointestinal Hemorrhage/diagnosis ; Gastrointestinal Hemorrhage/etiology ; Gastrointestinal Hemorrhage/therapy ; Humans ; Prognosis ; ROC Curve ; Risk Assessment ; Severity of Illness Index
Language	English
Publishing date	2020-03-18
Publishing country	Australia
Document type	Editorial
ZDB-ID	1171589-3
ISSN	1443-1661 ; 0915-5635
ISSN (online)	1443-1661
ISSN	0915-5635
DOI	10.1111/den.13657
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Article ; Online: Gastric neoplasms in familial adenomatous polyposis: Follow-up strategy for patients with or without atrophic gastritis.

Kawaguchi, Koichiro / Isomoto, Hajime

Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society

2020 Volume 32, Issue 4, Page(s) 532–533

MeSH term(s)	Adenomatous Polyposis Coli/complications ; Gastritis, Atrophic/complications ; Humans ; Stomach Neoplasms/diagnosis ; Stomach Neoplasms/etiology ; Stomach Neoplasms/therapy
Language	English
Publishing date	2020-04-20
Publishing country	Australia
Document type	Editorial
ZDB-ID	1171589-3
ISSN	1443-1661 ; 0915-5635
ISSN (online)	1443-1661
ISSN	0915-5635
DOI	10.1111/den.13668
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Article ; Online: The BCL-2 family protein BCL-RAMBO interacts and cooperates with GRP75 to promote its apoptosis signaling pathway.

Xu, Jinghong / Hashino, Takuya / Tanaka, Reiji / Kawaguchi, Koichiro / Yoshida, Hideki / Kataoka, Takao

Scientific reports

2023 Volume 13, Issue 1, Page(s) 14041

Abstract: The BCL-2 family protein BCL-RAMBO, also known as BCL2-like 13, anchors at the outer mitochondrial membrane and regulates apoptosis, mitochondrial fragmentation, and mitophagy. However, the mechanisms underlying the proapoptotic role of BCL-RAMBO remain ... ...

Abstract	The BCL-2 family protein BCL-RAMBO, also known as BCL2-like 13, anchors at the outer mitochondrial membrane and regulates apoptosis, mitochondrial fragmentation, and mitophagy. However, the mechanisms underlying the proapoptotic role of BCL-RAMBO remain unclear. In the present study, we demonstrated that BCL-RAMBO interacted with glucose-regulated protein 75 (GRP75), also known as heat shock protein family A member 9, and mortalin using co-immunoprecipitation and glutathione S-transferase-based pull-down assays. BCL-RAMBO interacted with GRP75 via its No BCL-2 homology domain. The interaction between BCL-RAMBO and GRP75 was confirmed by genetic interactions in Drosophila because a rough eye phenotype caused by the ectopic expression of BCL-RAMBO was partially suppressed by mutations in Hsc70-5, a mammalian GRP75 ortholog. In human embryonic kidney 293T cells, the co-expression of BCL-RAMBO and GRP75 facilitated an elevation in executioner caspase activity and poly (ADP-ribose) polymerase 1 (PARP-1) cleavage. In contrast, the knockdown of GRP75 suppressed elevated executioner caspase activity and PARP-1 cleavage in BCL-RAMBO-transfected cells. The mitochondrial release of cytochrome c induced by BCL-RAMBO was also attenuated by the knockdown of GRP75. These results indicate that GRP75 interacts with BCL-RAMBO and plays a crucial role in the BCL-RAMBO-dependent apoptosis signaling pathway.
MeSH term(s)	Humans ; Animals ; Poly(ADP-ribose) Polymerase Inhibitors ; Apoptosis ; Drosophila ; Signal Transduction ; Caspases ; Mammals
Chemical Substances	glucose-regulated proteins ; Poly(ADP-ribose) Polymerase Inhibitors ; Caspases (EC 3.4.22.-)
Language	English
Publishing date	2023-08-28
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-41196-0
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Article ; Online: An antioxidant suppressed lung cellular senescence and enhanced pulmonary function in aged mice.

Kawaguchi, Koichiro / Hashimoto, Michihiro / Sugimoto, Masataka

Biochemical and biophysical research communications

2021 Volume 541, Page(s) 43–49

Abstract: Oxidative stress is one of the major causes of cellular senescence in mammalian cells. The excess amount of reactive oxygen species generated by oxygen metabolism is pathogenic and facilitates tissue aging. Lung tissue is more susceptible to oxidative ... ...

Abstract	Oxidative stress is one of the major causes of cellular senescence in mammalian cells. The excess amount of reactive oxygen species generated by oxygen metabolism is pathogenic and facilitates tissue aging. Lung tissue is more susceptible to oxidative stress than other organs because it is directly exposed to environmental stresses. The aging of lung tissues increases the risk of chronic diseases. Senescent cells accumulate in tissues during aging and contribute to aging-associated morbidity; however, the roles of cellular senescence in lung aging and diseases have not yet been elucidated in detail. To clarify the physiological role of oxidative stress-induced cellular senescence in aging-associated declines in pulmonary function, we herein investigated the effects of the antioxidant N-acetyl-L-cysteine (NAC) on lung cellular senescence and aging in mice. The administration of NAC to 1-year-old mice reduced the expression of senescence-associated genes in lung tissue. Pulmonary function and lung morphology were partly restored in mice administered NAC. Collectively, these results suggest that oxidative stress is a major inducer of cellular senescence in vivo and that the control of oxidative stress may prevent lung aging and diseases.
MeSH term(s)	Acetylcysteine/pharmacology ; Aging ; Animals ; Antioxidants/pharmacology ; Cells, Cultured ; Cellular Senescence/drug effects ; Cellular Senescence/genetics ; Cyclin-Dependent Kinase Inhibitor p16/genetics ; Down-Regulation/drug effects ; Down-Regulation/genetics ; Female ; Gene Expression Profiling ; Lung/anatomy & histology ; Lung/cytology ; Lung/drug effects ; Lung/physiology ; Mice ; Mice, Inbred C57BL ; Oxidative Stress/drug effects
Chemical Substances	Antioxidants ; Cdkn2a protein, mouse ; Cyclin-Dependent Kinase Inhibitor p16 ; Acetylcysteine (WYQ7N0BPYC)
Language	English
Publishing date	2021-01-16
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	205723-2
ISSN	1090-2104 ; 0006-291X ; 0006-291X
ISSN (online)	1090-2104 ; 0006-291X
ISSN	0006-291X
DOI	10.1016/j.bbrc.2020.12.112
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Article: Gastric Cancer Screening in Japan: A Narrative Review.

Yashima, Kazuo / Shabana, Michiko / Kurumi, Hiroki / Kawaguchi, Koichiro / Isomoto, Hajime

Journal of clinical medicine

2022 Volume 11, Issue 15

Abstract: Gastric cancer is the second leading cause of cancer incidence in Japan, although gastric cancer mortality has decreased over the past few decades. This decrease is attributed to a decline in the prevalence ... ...

Abstract	Gastric cancer is the second leading cause of cancer incidence in Japan, although gastric cancer mortality has decreased over the past few decades. This decrease is attributed to a decline in the prevalence of
Language	English
Publishing date	2022-07-26
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm11154337
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Article ; Online: Age-related changes in lung function in National Center for Geriatrics and Gerontology Aging Farm C57BL/6N mice.

Kawaguchi, Koichiro / Asai, Azusa / Mikawa, Ryuta / Ogiso, Noboru / Sugimoto, Masataka

Experimental animals

2022 Volume 72, Issue 2, Page(s) 173–182

Abstract: Aging is an extremely complex biological process, and various models, from unicellular organisms to mammals, have been used in its research. The mouse is the most widely used model for studying human aging and diseases due to its high homology and well- ... ...

Abstract	Aging is an extremely complex biological process, and various models, from unicellular organisms to mammals, have been used in its research. The mouse is the most widely used model for studying human aging and diseases due to its high homology and well-established strategies for genetic manipulation. Despite these advantages, the maximum lifespan of laboratory mice is nearly three years, which makes it time-consuming to obtain animals of the desired age. To avoid this issue and efficiently conduct aging research, the National Center for Geriatrics and Gerontology operates its "Aging Farm", a system that supplies aged animals in response to researchers' requests. In the present study, as part of the Aging Farm project, we examined changes in the physiological functions of the lungs and gene expression in lung tissues of Aging Farm animals as they aged. A decline in the physiological function of the lungs was already apparent before 6 months of age, and it continued until at least 1 year of age. On the other hand, gene expression profiling by RNA sequencing showed small changes in the early stages of aging but more pronounced changes at 12 and 24 months of age than at 3 months of age. Age-related lung tissue changes are considered to be involved in the pathogenesis of various chronic respiratory diseases, and the characterization of animals as they age will ensure the quality of the Aging Farm as a resource for aging research.
MeSH term(s)	Mice ; Animals ; Humans ; Aged ; Infant ; Farms ; Mice, Inbred C57BL ; Aging ; Geriatrics ; Lung ; Mammals
Language	English
Publishing date	2022-10-26
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2088228-2
ISSN	1881-7122 ; 1341-1357 ; 0007-5124
ISSN (online)	1881-7122
ISSN	1341-1357 ; 0007-5124
DOI	10.1538/expanim.22-0109
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Article ; Online: Novel submucosal injection solution 0.6% sodium alginate: Bench to market for endoscopic submucosal dissection optimization.

Kawaguchi, Koichiro / Isomoto, Hajime

Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society

2019 Volume 31, Issue 4, Page(s) 393–395

MeSH term(s)	Alginates ; Endoscopic Mucosal Resection ; Esophagus ; Gastric Mucosa ; Gastroscopy
Chemical Substances	Alginates
Language	English
Publishing date	2019-06-06
Publishing country	Australia
Document type	Editorial ; Comment
ZDB-ID	1171589-3
ISSN	1443-1661 ; 0915-5635
ISSN (online)	1443-1661
ISSN	0915-5635
DOI	10.1111/den.13426
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Article ; Online: Alantolactone derivatives inhibit the tumor necrosis factor α-induced nuclear factor κB pathway by a different mechanism from alantolactone.

Vu, Quy Van / Baba, Kosuke / Sasaki, Saki / Kawaguchi, Koichiro / Hirano, Hiroyuki / Osada, Hiroyuki / Kataoka, Takao

European journal of pharmacology

2024 Volume 969, Page(s) 176458

Abstract: Alantolactone is a eudesmane-type sesquiterpene lactone that exerts various biological effects, including anti-inflammatory activity. In the present study, screening using the RIKEN Natural Products Depository chemical library identified alantolactone ... ...

Abstract	Alantolactone is a eudesmane-type sesquiterpene lactone that exerts various biological effects, including anti-inflammatory activity. In the present study, screening using the RIKEN Natural Products Depository chemical library identified alantolactone derivatives that inhibited the expression of intercellular adhesion molecule-1 (ICAM-1) on human umbilical vein endothelial cells stimulated with proinflammatory cytokines and Toll-like receptor ligands. In human lung adenocarcinoma A549 cells stimulated with tumor necrosis factor-α (TNF-α), six alantolactone derivatives inhibited ICAM-1 expression in a dose-dependent manner and at IC
MeSH term(s)	Humans ; NF-kappa B/metabolism ; Tumor Necrosis Factor-alpha/pharmacology ; NF-KappaB Inhibitor alpha ; Intercellular Adhesion Molecule-1/metabolism ; Lactones/pharmacology ; Sesquiterpenes, Eudesmane/pharmacology ; Human Umbilical Vein Endothelial Cells ; Lung Neoplasms/metabolism
Chemical Substances	NF-kappa B ; Tumor Necrosis Factor-alpha ; NF-KappaB Inhibitor alpha (139874-52-5) ; alantolactone (M7GSN5Q1M6) ; Intercellular Adhesion Molecule-1 (126547-89-5) ; methylene-lactone ; Lactones ; Sesquiterpenes, Eudesmane
Language	English
Publishing date	2024-02-22
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	80121-5
ISSN	1879-0712 ; 0014-2999
ISSN (online)	1879-0712
ISSN	0014-2999
DOI	10.1016/j.ejphar.2024.176458
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Article ; Online: Aberrant DNA methylation-mediated NF-κB/fatty acid-binding protein 5 (FABP5) feed-forward loop promotes malignancy of colorectal cancer cells

Kawaguchi, Koichiro / Ohashi, Tsubasa / Kobayashi, Narumi / Kanemoto, Kotoya / Nose, Makoto / Shinozaki, Rin / Kataoka, Takao / Fujii, Hiroshi

BBA - Molecular and Cell Biology of Lipids. 2023 Sept., v. 1868, no. 9 p.159362-

2023

Abstract: Fatty acid-binding proteins (FABPs) are intracellular lipid-binding proteins that play roles in fatty acid transport and the regulation of gene expression. Dysregulated FABP expression and/or activity have been associated with cancer pathogenesis; in ... ...

Abstract	Fatty acid-binding proteins (FABPs) are intracellular lipid-binding proteins that play roles in fatty acid transport and the regulation of gene expression. Dysregulated FABP expression and/or activity have been associated with cancer pathogenesis; in particular, epidermal-type FABP (FABP5) is upregulated in many types of cancer. However, the mechanisms regulating FABP5 expression and its involvement in cancer remain largely unknown. Here, we examined the regulation of FABP5 gene expression in non-metastatic and metastatic human colorectal cancer (CRC) cells. We found that FABP5 expression was upregulated in metastatic compared with non-metastatic CRC cells as well as in human CRC tissues compared with adjacent normal tissue. Analysis of the DNA methylation status of the FABP5 promoter showed that hypomethylation correlated with the malignant potential of the CRC cell lines. Moreover, FABP5 promoter hypomethylation also correlated with the expression pattern of splice variants of the DNA methyltransferase DNMT3B. ChIP assays and luciferase reporter assays demonstrated that the transcription factor nuclear factor-kappa B (NF-κB) was involved in regulating FABP5 expression. FABP5 expression could be upregulated in metastatic CRC cells by sequential promotion of DNA demethylation followed by activation of NF-κB. We also found that upregulated FABP5 in turn controlled NF-κB activity through IL-8 production. Collectively, these findings suggest the existence of a DNA methylation-dependent NF-κB /FABP5 positive feed-forward loop that may lead to constitutive activation of NF-κB signaling pathway and play a crucial role in CRC progression.
Keywords	DNA ; DNA demethylation ; DNA methylation ; DNA methyltransferase ; cell biology ; colorectal neoplasms ; fatty acid-binding proteins ; fatty acids ; gene expression ; gene expression regulation ; humans ; interleukin-8 ; luciferase ; metastasis ; transcription factor NF-kappa B ; FABP5 ; NF-κB ; CRC ; PCa ; DNMT ; 5-aza-dC ; PMA ; Colorectal cancer ; Inflammation
Language	English
Dates of publication	2023-09
Publishing place	Elsevier B.V.
Document type	Article ; Online
ISSN	1388-1981
DOI	10.1016/j.bbalip.2023.159362
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