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  1. Book ; Online: Recent Progress in Solid Dispersion Technology

    Kawakami, Kohsaku

    2019  

    Abstract: Amorphous solid dispersion (ASD) is a powerful formulation technology to improve oral absorption of poorly soluble drugs. Despite their being in existence for more than half a century, controlling ASD performance is still regarded as difficult because of ...

    Abstract Amorphous solid dispersion (ASD) is a powerful formulation technology to improve oral absorption of poorly soluble drugs. Despite their being in existence for more than half a century, controlling ASD performance is still regarded as difficult because of ASD's natural non-equilibrium. However, recent significant advances in ASD knowledge and technology may enable a much broader use of ASD technology. This Special Issue, which includes 3 reviews and 6 original articles, focuses on recent progresses in ASD technology in hopes of helping to accelerate developmental studies in the pharmaceutical industry. In striving for a deep understanding of ASD non-equilibrium behavior, the Special issue also delves into and makes progress in the theory of soft-matter dynamics
    Keywords Science (General) ; Biology (General)
    Size 1 electronic resource (204 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Document type Book ; Online
    Note eng ; Open Access
    HBZ-ID HT020324001
    ISBN 9783039215010 ; 9783039215027 ; 3039215019 ; 3039215027
    DOI 10.3390/books978-3-03921-502-7
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Rigid Nuclei and Flexible Nuclei: Appearance and Disappearance of Nuclei in Indomethacin Glass Revealed by a Long-Term Annealing Study.

    Kawakami, Kohsaku

    The journal of physical chemistry. B

    2023  Volume 127, Issue 26, Page(s) 5967–5977

    Abstract: In this study, nucleation/crystallization behaviors of indomethacin glass are discussed with emphasis on the fate of nuclei, which is explained using a notion of "rigid" and "flexible" nuclei. The observation was made mainly by thermal analysis of ... ...

    Abstract In this study, nucleation/crystallization behaviors of indomethacin glass are discussed with emphasis on the fate of nuclei, which is explained using a notion of "rigid" and "flexible" nuclei. The observation was made mainly by thermal analysis of indomethacin glass after long-term annealing at various temperatures. Formation of nuclei was evaluated by observing cold crystallization behaviors of the annealed glasses, as they should be dominated by the "nuclei form" produced in the glass. Nuclei of forms α and γ, which have opposite stability trends, were found to appear over a wide temperature range. The nuclei of form α were stable even in the presence of other crystal forms, whereas those of form γ were likely to be easily integrated into other crystals during their growth, which was explained by a notion of rigid and flexible nuclei. Moreover, unconventionally fast crystallization in the glass-transition region and the finding of a new crystal form are also reported.
    Language English
    Publishing date 2023-06-25
    Publishing country United States
    Document type Journal Article
    ISSN 1520-5207
    ISSN (online) 1520-5207
    DOI 10.1021/acs.jpcb.3c02127
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: [Sharing Patient Safety Management Skills in Oncology Pharmaceutical Outpatient Service].

    Kawakami, Kazuyoshi

    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan

    2023  Volume 143, Issue 3, Page(s) 217–221

    Abstract: Important tasks performed by pharmacists include dispensing medicines based on prescriptions and explaining medication to patients. However, pharmacists are now required not only to perform these tasks but also to provide patients with pharmacotherapy ... ...

    Abstract Important tasks performed by pharmacists include dispensing medicines based on prescriptions and explaining medication to patients. However, pharmacists are now required not only to perform these tasks but also to provide patients with pharmacotherapy that maximises the efficacy of drugs and minimises side effects. In particular, chemotherapy has a wide variety of side effects and a higher incidence of side effects than pharmacotherapy for lifestyle-related diseases. The Cancer Institute Hospital has conducted a oncology pharmacist outpatient clinic for patients undergoing chemotherapy, pharmacists meet with patients on an outpatient basis. The content of these visits includes assessing the severity of side effects and adherence to oral anti-cancer drugs, and proposing supportive therapy to doctors. This symposium will focus on hand-foot syndrome caused by 5-fluorouracil (5-Fu) anticancer drugs and molecular-targeted drugs, and will share information on skills in assessing the severity of these side effects and on side-effect management based on reducing doses of anticancer drugs, taking off drugs and proposing supportive therapy. Furthermore, how the pill counts and Self-report methods are used in clinical practice to assess adherence to oral anti-cancer drugs will be shared. Recently, trainees from insurance dispensing pharmacies have been accepted and training has been provided on the management of adverse effects of chemotherapy and adherence assessment of oral anticancer drugs in the oncology pharmacist outpatient clinic. This symposium will share details of pharmaceutical care practices such as side-effect management in chemotherapy and adherence assessment of oral anticancer drugs, and discuss the skills required for patient safety management.
    MeSH term(s) Humans ; Outpatients ; Pharmaceutical Services ; Ambulatory Care ; Drug-Related Side Effects and Adverse Reactions ; Fluorouracil ; Antineoplastic Agents ; Pharmaceutical Preparations
    Chemical Substances Fluorouracil (U3P01618RT) ; Antineoplastic Agents ; Pharmaceutical Preparations
    Language Japanese
    Publishing date 2023-03-01
    Publishing country Japan
    Document type English Abstract ; Journal Article
    ZDB-ID 200514-1
    ISSN 1347-5231 ; 0031-6903 ; 0372-7750 ; 0919-2085 ; 0919-2131
    ISSN (online) 1347-5231
    ISSN 0031-6903 ; 0372-7750 ; 0919-2085 ; 0919-2131
    DOI 10.1248/yakushi.22-00160-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 643: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Efficacy and side-effect profile of tedizolid in the treatment of streptococcal toxic shock syndrome due to clindamycin-resistant Streptococcus pyogenes: A case report.

    Yokota, Kyoko / Kawakami, Kimihiro

    Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy

    2024  

    Abstract: Oxazolidinones, such as tedizolid and linezolid, are bacteriostatic antibiotics that inhibit protein synthesis. Based on the findings from animal studies and their mechanism of action, these antibiotics are considered for managing toxic shock caused by ... ...

    Abstract Oxazolidinones, such as tedizolid and linezolid, are bacteriostatic antibiotics that inhibit protein synthesis. Based on the findings from animal studies and their mechanism of action, these antibiotics are considered for managing toxic shock caused by clindamycin-resistant Group A Streptococcus (GAS; Streptococcus pyogenes). However, clinical reports on their usage in such cases are limited. Herein, we report a case of a 67-year-old woman with chronic myeloid leukemia who presented with fever, facial swelling, and myalgia. She was diagnosed with cellulitis and empirically treated with meropenem. Blood culture later revealed GAS, and she was diagnosed with streptococcal toxic shock syndrome. The antibiotic regimen was adjusted based on sensitivity results, with clindamycin initially replaced by linezolid and later switched to tedizolid owing to concerns about potential bone marrow suppression. Her condition improved, and she was discharged 15 days after admission. Therefore, tedizolid may be a safer option for managing toxic shock syndrome in patients with comorbidities that include thrombocytopenia.
    Language English
    Publishing date 2024-01-06
    Publishing country Netherlands
    Document type Case Reports
    ZDB-ID 1355399-9
    ISSN 1437-7780 ; 1341-321X
    ISSN (online) 1437-7780
    ISSN 1341-321X
    DOI 10.1016/j.jiac.2024.01.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5236: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Immunohistochemical and Immunoelectron Microscopical Distribution of MEGF8 in the Mouse Central Nervous System.

    Nakadate, Kazuhiko / Kawakami, Kiyoharu

    Cells

    2023  Volume 13, Issue 1

    Abstract: Mutations in multiple epidermal growth factor-like domain 8 (MEGF8), a multidomain transmembrane protein encoded by a gene conserved across species, cause Carpenter's syndrome, which is associated with learning disabilities, mental health issues, and ... ...

    Abstract Mutations in multiple epidermal growth factor-like domain 8 (MEGF8), a multidomain transmembrane protein encoded by a gene conserved across species, cause Carpenter's syndrome, which is associated with learning disabilities, mental health issues, and left-right patterning abnormalities. MEGF8 interacts with MGRN1, a protein that functions as an E3 ubiquitin ligase and is involved in multiple physiological and pathological processes. However, the mechanism underlying the distribution of MEGF8 in the central nervous system (CNS) and its cellular and subcellular locations remain unknown. This study aimed to map MEGF8 in the mouse CNS using a new antibody. We discovered that MEGF8 was distributed in the majority of neuronal cell somata across most CNS regions. High levels of MEGF8 were expressed in the neuropils of the CNS gray matter. Immunoelectron microscopy showed that MEGF8 was present in the synapses and around the outer mitochondrial membrane. These findings show that MEGF8 is uniformly distributed throughout the mouse CNS, and its distribution indicates that it plays a substantial role in synaptic and mitochondrial functions. To the best of our knowledge, this is the first study to document MEGF8 distribution in the CNS.
    MeSH term(s) Animals ; Mice ; Microscopy, Immunoelectron ; Central Nervous System ; Gray Matter ; Antibodies ; Cerebral Cortex ; Membrane Proteins
    Chemical Substances Antibodies ; MEGF8 protein, mouse ; Membrane Proteins
    Language English
    Publishing date 2023-12-28
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells13010063
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Ostwald Ripening of Triacylglycerol Droplets Embedded in Glass-Supported Phospholipid Bilayers.

    Kataoka-Hamai, Chiho / Kawakami, Kohsaku

    Langmuir : the ACS journal of surfaces and colloids

    2023  Volume 39, Issue 29, Page(s) 10001–10010

    Abstract: Lipid droplets are fat storage organelles that consist of a neutral lipid core surrounded by a phospholipid monolayer. Because of their important biological functions, reconstituting model lipid droplets in synthetic phospholipid membranes is of great ... ...

    Abstract Lipid droplets are fat storage organelles that consist of a neutral lipid core surrounded by a phospholipid monolayer. Because of their important biological functions, reconstituting model lipid droplets in synthetic phospholipid membranes is of great interest. In the present study, we investigated the incorporation of triacylglycerol droplets into glass-supported phospholipid bilayers by using fluorescence microscopy. We adsorbed triolein emulsions onto a glass surface that was partially covered with planar bilayers. After adsorption, triolein droplets were found to be immobilized in the bilayer membrane. The volume of each bound droplet varied over time. Large droplets grew, whereas small droplets shrank. Additionally, data on fluorescence recovery after photobleaching obtained for a phospholipid probe indicate that phospholipids on and near triolein droplets were fully mobile. Furthermore, photobleaching data obtained for a triacylglycerol probe indicate that triolein molecules diffused between different droplets along the planar bilayer. These results demonstrate Ostwald ripening, where triolein molecules in a small droplet dissolved in the bilayer, diffused laterally, and eventually bound to the interfaces of larger droplets. We investigated the ripening rate by using the average of the cube root of the fluorescence emission obtained for individual droplets. The ripening slowed after the addition of trilinolein to the triolein phase. Finally, we investigated the time dependence of the size distributions of the triolein droplets. The distribution was initially nearly unimodal and subsequently became bimodal.
    Language English
    Publishing date 2023-07-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2005937-1
    ISSN 1520-5827 ; 0743-7463
    ISSN (online) 1520-5827
    ISSN 0743-7463
    DOI 10.1021/acs.langmuir.3c00835
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Mouse Model of Latent Cryptococcal Infection and Reactivation.

    Sato, Ko / Kawakami, Kazuyoshi

    Methods in molecular biology (Clifton, N.J.)

    2023  Volume 2667, Page(s) 87–98

    Abstract: AbstractCryptococcus neoformans is an opportunistic fungal pathogen that frequently causes fatal meningoencephalitis in patients with impaired immune responses. This fungus, an intracellularly growing microbe, evades host immunity, leading to a latent ... ...

    Abstract AbstractCryptococcus neoformans is an opportunistic fungal pathogen that frequently causes fatal meningoencephalitis in patients with impaired immune responses. This fungus, an intracellularly growing microbe, evades host immunity, leading to a latent infection (latent C. neoformans infection: LCNI), and cryptococcal disease is developed by its reactivation when host immunity is suppressed. Elucidation of the pathophysiology of LCNI is difficult due to the lack of mouse models. Here we show the established methods for LCNI and reactivation.
    MeSH term(s) Animals ; Mice ; Cryptococcus neoformans ; Disease Models, Animal
    Language English
    Publishing date 2023-05-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-3199-7_6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Generation of Transgenic Fish Harboring CRISPR/Cas9-Mediated Somatic Mutations Via a tRNA-Based Multiplex sgRNA Expression.

    Shiraki, Tomoya / Kawakami, Koichi

    Methods in molecular biology (Clifton, N.J.)

    2023  Volume 2707, Page(s) 305–318

    Abstract: The controlled expression of Cas9 and/or sgRNA in transgenic zebrafish made it possible to knock out a gene in a spatially and/or temporally controlled manner. This transgenic approach can be more useful if multiple sgRNAs are efficiently expressed since ...

    Abstract The controlled expression of Cas9 and/or sgRNA in transgenic zebrafish made it possible to knock out a gene in a spatially and/or temporally controlled manner. This transgenic approach can be more useful if multiple sgRNAs are efficiently expressed since we can improve the biallelic frame-shift mutation rate and circumvent the functional redundancy of genes and genetic compensation. We developed the tRNA-based system to express multiple functional sgRNAs from a single transcript in zebrafish and found that it is applicable to the transgenic expression of multiple sgRNAs. In this chapter, we describe a procedure for the generation of plasmids containing multiple sgRNAs flanked by tRNAs and a method to induce multiple CRISPR/Cas9-mediated genome modifications in transgenic zebrafish.
    MeSH term(s) Animals ; RNA, Guide, CRISPR-Cas Systems ; Zebrafish/genetics ; CRISPR-Cas Systems/genetics ; Animals, Genetically Modified/genetics ; Frameshift Mutation
    Chemical Substances RNA, Guide, CRISPR-Cas Systems
    Language English
    Publishing date 2023-09-04
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-3401-1_20
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Molecules Affecting Brain Development and Nervous System.

    Nakadate, Kazuhiko / Kawakami, Kiyoharu

    International journal of molecular sciences

    2023  Volume 24, Issue 10

    Abstract: Brain development is the biological process through which neurons are produced [ ... ]. ...

    Abstract Brain development is the biological process through which neurons are produced [...].
    MeSH term(s) Brain/growth & development ; Brain/metabolism ; Neurons/metabolism ; Neurons/physiology ; Humans ; gamma-Aminobutyric Acid/metabolism ; Neurotransmitter Agents/metabolism
    Chemical Substances gamma-Aminobutyric Acid (56-12-2) ; Neurotransmitter Agents
    Language English
    Publishing date 2023-05-12
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24108691
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: [Considering the Next Generation of Cancer Drug Therapy Delivery by all Pharmacists for Patient Safety Management].

    Kawakami, Kazuyoshi / Hori, Satoko

    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan

    2023  Volume 143, Issue 3, Page(s) 211–212

    MeSH term(s) Humans ; Pharmacists ; Antineoplastic Agents ; Neoplasms
    Chemical Substances Antineoplastic Agents
    Language Japanese
    Publishing date 2023-03-01
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 200514-1
    ISSN 1347-5231 ; 0031-6903 ; 0372-7750 ; 0919-2085 ; 0919-2131
    ISSN (online) 1347-5231
    ISSN 0031-6903 ; 0372-7750 ; 0919-2085 ; 0919-2131
    DOI 10.1248/yakushi.22-00160-F
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 643: Show issues Location:
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