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  1. Article ; Online: Sensitivity of Anguilliformes leptocephali to metamorphosis stimulated by thyroid hormone depends on larval size and metamorphic stage.

    Kawakami, Yutaka

    Comparative biochemistry and physiology. Part A, Molecular & integrative physiology

    2022  Volume 276, Page(s) 111339

    Abstract: Metamorphosis of teleosts including Anguilliformes is well known to be induced by thyroid hormone (TH), although the underlying mechanism is not fully understood. In this study, we investigated the experimental conditions needed to induce normal ... ...

    Abstract Metamorphosis of teleosts including Anguilliformes is well known to be induced by thyroid hormone (TH), although the underlying mechanism is not fully understood. In this study, we investigated the experimental conditions needed to induce normal metamorphosis in artificially spawned Japanese eel (Anguilla japonica), including initial larval size, TH concentration, and timing of TH immersion. Around 37 mm TL was found to be the minimum size of larvae that underwent successful metamorphosis induced by l-thyroxine (T
    MeSH term(s) Animals ; Larva/metabolism ; Thyroid Hormones/pharmacology ; Thyroxine/pharmacology ; Thyroxine/metabolism ; Anguilla/metabolism ; Metamorphosis, Biological/physiology
    Chemical Substances Thyroid Hormones ; Thyroxine (Q51BO43MG4)
    Language English
    Publishing date 2022-11-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 121246-1
    ISSN 1531-4332 ; 0300-9629 ; 1095-6433
    ISSN (online) 1531-4332
    ISSN 0300-9629 ; 1095-6433
    DOI 10.1016/j.cbpa.2022.111339
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  2. Article ; Online: Metabolism of hyaluronic acid during early development of the Japanese eel, Anguilla japonica.

    Kawakami, Yutaka

    Comparative biochemistry and physiology. Part A, Molecular & integrative physiology

    2022  Volume 268, Page(s) 111203

    Abstract: Hyaluronic acids (hyaluronans, HAs) are glycosaminoglycans produced in the bodies of Anguilliforme and Elopiforme leptocephali, and HA is thought to serve as a metabolic energy source during planktonic life-stages. To examine this hypothesis, we ... ...

    Abstract Hyaluronic acids (hyaluronans, HAs) are glycosaminoglycans produced in the bodies of Anguilliforme and Elopiforme leptocephali, and HA is thought to serve as a metabolic energy source during planktonic life-stages. To examine this hypothesis, we investigated the dynamics of HA during early growth of the Japanese eel (Anguilla japonica), including during metamorphosis. From histochemical observations in the fully grown leptocephalus, HA occupied approximately 40-50% of the cross-sectional area and muscle tissue occupied less than 20%. However, the HA and water content are at a maximum during leptocephalus, decreasing during metamorphosis. We found that during leptocephalus, HA is actively accumulated in the body and plays a role in specific density adjustment, facilitating planktonic life. It was thought that after metamorphosis the role of HA in facilitating floating would end, and it would be metabolized to glucose and/or triglyceride.
    MeSH term(s) Anguilla/physiology ; Animals ; Hyaluronic Acid ; Metamorphosis, Biological/physiology ; Muscles
    Chemical Substances Hyaluronic Acid (9004-61-9)
    Language English
    Publishing date 2022-03-23
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 121246-1
    ISSN 1531-4332 ; 0300-9629 ; 1095-6433
    ISSN (online) 1531-4332
    ISSN 0300-9629 ; 1095-6433
    DOI 10.1016/j.cbpa.2022.111203
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  3. Article ; Online: Characterization of triglycerides during early development of the Japanese eel (Anguilla japonica).

    Kawakami, Yutaka

    Comparative biochemistry and physiology. Part A, Molecular & integrative physiology

    2021  Volume 265, Page(s) 111125

    Abstract: Japanese eels store lipids in the peritoneal cavity at the glass eel stage. These lipids are presumed to be consumed as an energy source during migration from oceanic metamorphosing sites to coastal Japan. In this study we investigated the distribution ... ...

    Abstract Japanese eels store lipids in the peritoneal cavity at the glass eel stage. These lipids are presumed to be consumed as an energy source during migration from oceanic metamorphosing sites to coastal Japan. In this study we investigated the distribution and amount of triglyceride in vivo using artificially bred Japanese eel larvae. Triglycerides accumulated in vivo from the early larval stage onward, until they reached a peak volume in fully grown leptocephali, and subsequently gradually decreased during metamorphosis. Furthermore, during the late metamorphic stages of the artificially bred glass eel, triglycerides were stored mainly in the peritoneal cavity, as in wild glass eels. These observations point to a strategy that the Japanese eels use in consuming the triglycerides derived from leptocephali during metamorphosis (when they do not feed) as a source of energy.
    MeSH term(s) Anguilla/physiology ; Animals ; Larva/physiology ; Metamorphosis, Biological/physiology ; Oceans and Seas ; Triglycerides
    Chemical Substances Triglycerides
    Language English
    Publishing date 2021-12-11
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 121246-1
    ISSN 1531-4332 ; 0300-9629 ; 1095-6433
    ISSN (online) 1531-4332
    ISSN 0300-9629 ; 1095-6433
    DOI 10.1016/j.cbpa.2021.111125
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  4. Article: Metabolism of hyaluronic acid during early development of the Japanese eel, Anguilla japonica

    Kawakami, Yutaka

    Comparative biochemistry and physiology. 2022 Mar. 20,

    2022  

    Abstract: Hyaluronic acids (hyaluronans, HAs) are glycosaminoglycans produced in the bodies of Anguilliforme and Elopiforme leptocephali, and HA is thought to serve as a metabolic energy source during planktonic life-stages. To examine this hypothesis, we ... ...

    Abstract Hyaluronic acids (hyaluronans, HAs) are glycosaminoglycans produced in the bodies of Anguilliforme and Elopiforme leptocephali, and HA is thought to serve as a metabolic energy source during planktonic life-stages. To examine this hypothesis, we investigated the dynamics of HA during early growth of the Japanese eel (Anguilla japonica), including during metamorphosis. From histochemical observations in the fully grown leptocephalus, HA occupied approximately 40–50% of the cross-sectional area and muscle tissue occupied less than 20%. However, the HA and water content are at a maximum during leptocephalus, decreasing during metamorphosis. We found that during leptocephalus, HA is actively accumulated in the body and plays a role in specific density adjustment, facilitating planktonic life. It was thought that after metamorphosis the role of HA in facilitating floating would end, and it would be metabolized to glucose and/or triglyceride.
    Keywords Anguilla japonica ; early development ; energy ; glucose ; hyaluronic acid ; leptocephalus larvae ; metabolism ; metamorphosis ; muscle tissues ; plankton ; triacylglycerols ; water content
    Language English
    Dates of publication 2022-0320
    Publishing place Elsevier Inc.
    Document type Article
    Note Pre-press version
    ZDB-ID 121246-1
    ISSN 1531-4332 ; 0300-9629 ; 1095-6433
    ISSN (online) 1531-4332
    ISSN 0300-9629 ; 1095-6433
    DOI 10.1016/j.cbpa.2022.111203
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  5. Article: Characterization of triglycerides during early development of the Japanese eel (Anguilla japonica)

    Kawakami, Yutaka

    Comparative biochemistry and physiology. 2022 Mar., v. 265

    2022  

    Abstract: Japanese eels store lipids in the peritoneal cavity at the glass eel stage. These lipids are presumed to be consumed as an energy source during migration from oceanic metamorphosing sites to coastal Japan. In this study we investigated the distribution ... ...

    Abstract Japanese eels store lipids in the peritoneal cavity at the glass eel stage. These lipids are presumed to be consumed as an energy source during migration from oceanic metamorphosing sites to coastal Japan. In this study we investigated the distribution and amount of triglyceride in vivo using artificially bred Japanese eel larvae. Triglycerides accumulated in vivo from the early larval stage onward, until they reached a peak volume in fully grown leptocephali, and subsequently gradually decreased during metamorphosis. Furthermore, during the late metamorphic stages of the artificially bred glass eel, triglycerides were stored mainly in the peritoneal cavity, as in wild glass eels. These observations point to a strategy that the Japanese eels use in consuming the triglycerides derived from leptocephali during metamorphosis (when they do not feed) as a source of energy.
    Keywords Anguilla japonica ; Japan ; early development ; eel ; energy ; glass ; leptocephalus larvae ; metamorphosis ; triacylglycerols
    Language English
    Dates of publication 2022-03
    Publishing place Elsevier Inc.
    Document type Article
    ZDB-ID 121246-1
    ISSN 1531-4332 ; 0300-9629 ; 1095-6433
    ISSN (online) 1531-4332
    ISSN 0300-9629 ; 1095-6433
    DOI 10.1016/j.cbpa.2021.111125
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  6. Thesis ; Online: Characterization of Metal Accumulation Patterns and Yield Properties in Novel and Existing Iron-Biofortified Rice Lines

    Kawakami, Yuta

    2021  

    Keywords info:eu-repo/classification/ddc/580 ; info:eu-repo/classification/ddc/630 ; Botanical sciences ; Agriculture
    Language English
    Publisher ETH Zurich
    Publishing country ch
    Document type Thesis ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Invisible pancreatic cancer: the cuff sign.

    Nagahata, Ken / Kawakami, Yujiro / Nakase, Hiroshi

    QJM : monthly journal of the Association of Physicians

    2024  

    Language English
    Publishing date 2024-03-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 1199985-8
    ISSN 1460-2393 ; 0033-5622 ; 1460-2725
    ISSN (online) 1460-2393
    ISSN 0033-5622 ; 1460-2725
    DOI 10.1093/qjmed/hcae041
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  8. Article ; Online: Isolated salivary gland extramedullary relapse of Philadelphia chromosome-positive acute lymphoblastic leukemia during blinatumomab treatment.

    Kawakami, Yugo / Imamura, Masaru / Imai, Chihaya

    International journal of hematology

    2024  Volume 119, Issue 5, Page(s) 479–480

    MeSH term(s) Humans ; Male ; Antibodies, Bispecific/adverse effects ; Antibodies, Bispecific/therapeutic use ; Antibodies, Bispecific/administration & dosage ; Antineoplastic Agents/therapeutic use ; Antineoplastic Agents/adverse effects ; Philadelphia Chromosome ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy ; Recurrence ; Salivary Glands/pathology ; Adolescent
    Chemical Substances blinatumomab
    Language English
    Publishing date 2024-03-16
    Publishing country Japan
    Document type Case Reports ; Letter
    ZDB-ID 1076875-0
    ISSN 1865-3774 ; 0917-1258 ; 0925-5710
    ISSN (online) 1865-3774
    ISSN 0917-1258 ; 0925-5710
    DOI 10.1007/s12185-024-03756-6
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  9. Article: Recent progress of cancer immunology and immunotherapy.

    Kawakami, Yutaka

    Nihon rinsho. Japanese journal of clinical medicine

    2018  Volume 75, Issue 2, Page(s) 175–180

    Abstract: Cancer immunotherapy began as a Coley's vaccine, and then, non-specific immuno- modulators, anti-tumor monoclonal antibody, cytokines, cancer vaccine (e.g. tumor antigens, dendritic cells, modified cancer cells), adoptive cell therapy (e.g. TIL, TCR/CAR- ... ...

    Abstract Cancer immunotherapy began as a Coley's vaccine, and then, non-specific immuno- modulators, anti-tumor monoclonal antibody, cytokines, cancer vaccine (e.g. tumor antigens, dendritic cells, modified cancer cells), adoptive cell therapy (e.g. TIL, TCR/CAR-T cells), and immune-checkpoint inhibitors (PD-1/PD-Li, CTLA4 blocking antibody) have been developed and evaluated in clinical trials. The last two immunotherapies have recently shown durable clinical effects even in the patients with advanced cancers. Progress of human cancer immu- nology has been made along with the development of immunotherapy. Particularly, the anal- ysis of clinical trials of the recent immune-checkpoint inhibitors resulted in the understand- ing of human cancer immune-environments. Further investigation with multi-omics and immunological studies will lead to development of more effective cancer immunotherapy.
    MeSH term(s) Humans ; Immunotherapy ; Neoplasms/immunology ; Neoplasms/therapy
    Language Japanese
    Publishing date 2018-12-18
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 390903-7
    ISSN 0047-1852
    ISSN 0047-1852
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  10. Article: [Personalized modulation of tumor microimmune microenvironment for the development of effective combination immunotherapy].

    Kawakami, Yutaka

    Rinsho ketsueki] The Japanese journal of clinical hematology

    2018  Volume 59, Issue 7, Page(s) 939–944

    Abstract: Clinical trials for immune-checkpoint inhibitors and T cell-based adoptive cell therapy have demonstrated robust clinical responses in some patients with advanced cancer of various types, including hematological malignancies. However, response rates to ... ...

    Abstract Clinical trials for immune-checkpoint inhibitors and T cell-based adoptive cell therapy have demonstrated robust clinical responses in some patients with advanced cancer of various types, including hematological malignancies. However, response rates to PD-1/PD-L1 blockade are about 10%-30% in most cancer types. To improve the efficacy of immunotherapy, combination immunotherapy using other standard cancer therapies (e.g., chemotherapy, target therapy, and radiation) and various immune modulators for crucial regulation points in antitumor T-cell responses (e.g., cancer vaccines, immunogenic cancer cell death inducers, adjuvants, T-cell stimulators, and reversal of immune suppression) is under development. In combination immunotherapy, personalization and use of appropriate combined therapies and immune modulators are also critical depending on the immune status of patients (e.g., cancer types, immunological subtypes, and individual differences). Currently, various types of combination immunotherapy, particularly using PD-1/PD-L1 blockade, are being assessed in clinical trials.
    MeSH term(s) B7-H1 Antigen ; Cancer Vaccines ; Humans ; Immunotherapy ; Neoplasms/immunology ; Neoplasms/therapy ; Programmed Cell Death 1 Receptor ; Tumor Microenvironment
    Chemical Substances B7-H1 Antigen ; CD274 protein, human ; Cancer Vaccines ; PDCD1 protein, human ; Programmed Cell Death 1 Receptor
    Language Japanese
    Publishing date 2018-08-02
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 390900-1
    ISSN 0485-1439
    ISSN 0485-1439
    DOI 10.11406/rinketsu.59.939
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