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  1. Article: Newly innovated system to generate adjustable PEEP with a high-flow nasal cannula.

    Onodera, Yu / Yarimizu, Kenya / Hayasaka, Tatsuya / Kawamae, Kaneyuki / Nakane, Masaki

    Intensive care medicine experimental

    2024  Volume 12, Issue 1, Page(s) 43

    Language English
    Publishing date 2024-04-27
    Publishing country Germany
    Document type Letter
    ZDB-ID 2740385-3
    ISSN 2197-425X
    ISSN 2197-425X
    DOI 10.1186/s40635-024-00627-6
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  2. Article: [Future of anesthesiology in Japan].

    Kawamae, Kaneyuki

    Masui. The Japanese journal of anesthesiology

    2014  Volume 63, Issue 2, Page(s) 127

    MeSH term(s) Anesthesiology/manpower ; Anesthesiology/trends ; Female ; Humans ; Japan ; Male ; Patient Care Team ; Physicians/statistics & numerical data ; Physicians/trends ; Physicians, Women/statistics & numerical data ; Physicians, Women/trends
    Language Japanese
    Publishing date 2014-02
    Publishing country Japan
    Document type Editorial
    ZDB-ID 391878-6
    ISSN 0021-4892
    ISSN 0021-4892
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 360: Show issues Location:
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  3. Article ; Online: Perioperative presepsin as a potential early predictor for postoperative infectious complications in cardiac surgery.

    Suzuki, Hiroto / Narimatsu, Hiroto / Nakane, Masaki / Sadahiro, Mitsuaki / Kawamae, Kaneyuki

    Anaesthesiology intensive therapy

    2022  Volume 53, Issue 3, Page(s) 215–222

    Abstract: Introduction: Postoperative infection remains a serious complication of cardiac surgery; however, no existing biomarkers can detect infection in the early perioperative period. We investigated the usefulness of presepsin, a novel biomarker, in ... ...

    Abstract Introduction: Postoperative infection remains a serious complication of cardiac surgery; however, no existing biomarkers can detect infection in the early perioperative period. We investigated the usefulness of presepsin, a novel biomarker, in predicting postoperative infectious complications in cardiac surgery with cardiopulmonary bypass.
    Material and methods: For patients aged > 18 years who underwent elective cardiac surgery with cardiopulmonary bypass between 2015 and 2017, data of clinical features, perioperative presepsin levels, and infectious complications were collected. We compared the perioperative presepsin levels between the infected and non-infected groups, performed a risk factor analysis for postoperative infection, and calculated the cut-off value of presepsin with postoperative infection.
    Results: Among the 73 included patients, 20 developed postoperative infectious complications. The presepsin levels pre-operatively and on post-operative day (POD) zero were significantly higher in the infected than in the non-infected group (145.2 vs. 93.2, 514.0 vs. 328.1 [pg mL-1], p < 0.05, respectively). The odds ratio (OR) for postoperative infection included pre-operative presepsin (OR; 1.22 [confidence interval; 1.07-1.40]/10 pg mL-1) and presepsin on POD zero (OR; 1.31 [confidence interval; 1.05-1.64] /100 pg mL-1). The cut-off predictive values for postoperative infectious complications of pre-operative presepsin and on POD zero were 132 and 347 [pg mL-1], respectively.
    Conclusions: Perioperative presepsin levels could be an early predictor for postoperative infectious complications in cardiac surgery.
    MeSH term(s) Adolescent ; Biomarkers ; Cardiac Surgical Procedures/adverse effects ; Humans ; Lipopolysaccharide Receptors ; Peptide Fragments ; Postoperative Complications/diagnosis ; Postoperative Complications/epidemiology ; Prospective Studies
    Chemical Substances Biomarkers ; Lipopolysaccharide Receptors ; Peptide Fragments ; presepsin protein, human
    Language English
    Publishing date 2022-02-12
    Publishing country Poland
    Document type Journal Article
    ISSN 1731-2531
    ISSN (online) 1731-2531
    DOI 10.5114/ait.2021.108159
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  4. Article ; Online: Comparison of accuracy between augmented reality/mixed reality techniques and conventional techniques for epidural anesthesia using a practice phantom model kit.

    Hayasaka, Tatsuya / Kawano, Kazuharu / Onodera, Yu / Suzuki, Hiroto / Nakane, Masaki / Kanoto, Masafumi / Kawamae, Kaneyuki

    BMC anesthesiology

    2023  Volume 23, Issue 1, Page(s) 171

    Abstract: Background: This study used an epidural anesthesia practice kit (model) to evaluate the accuracy of epidural anesthesia using standard techniques (blind) and augmented/mixed reality technology and whether visualization using augmented/mixed reality ... ...

    Abstract Background: This study used an epidural anesthesia practice kit (model) to evaluate the accuracy of epidural anesthesia using standard techniques (blind) and augmented/mixed reality technology and whether visualization using augmented/mixed reality technology would facilitate epidural anesthesia.
    Methods: This study was conducted at the Yamagata University Hospital (Yamagata, Japan) between February and June 2022. Thirty medical students with no experience in epidural anesthesia were randomly divided into augmented reality (-), augmented reality (+), and semi-augmented reality groups, with 10 students in each group. Epidural anesthesia was performed using the paramedian approach with an epidural anesthesia practice kit. The augmented reality (-) group performed epidural anesthesia without HoloLens2Ⓡ and the augmented reality (+) group with HoloLens2Ⓡ. The semi-augmented reality group performed epidural anesthesia without HoloLens2Ⓡ after 30 s of image construction of the spine using HoloLens2Ⓡ. The epidural space puncture point distance between the ideal insertion needle and participant's insertion needle was compared.
    Results: Four medical students in the augmented reality (-), zero in the augmented reality (+), and one in the semi-augmented reality groups failed to insert the needle into the epidural space. The epidural space puncture point distance for the augmented reality (-), augmented reality (+), and semi-augmented reality groups were 8.7 (5.7-14.3) mm, 3.5 (1.8-8.0) mm (P = 0.017), and 4.9 (3.2-5.9) mm (P = 0.027), respectively; a significant difference was observed between the two groups.
    Conclusions: Augmented/mixed reality technology has the potential to contribute significantly to the improvement of epidural anesthesia techniques.
    MeSH term(s) Humans ; Augmented Reality ; Anesthesia, Epidural/methods ; Epidural Space ; Spinal Puncture/methods ; Punctures
    Language English
    Publishing date 2023-05-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 2091252-3
    ISSN 1471-2253 ; 1471-2253
    ISSN (online) 1471-2253
    ISSN 1471-2253
    DOI 10.1186/s12871-023-02133-w
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  5. Article ; Online: Perioperative management of a patient undergoing resection of interleukin-6 producing pheochromocytoma.

    Kuroki, Masahiro / Suzuki, Hiroto / Kurota, Misato / Nakane, Masaki / Kawamae, Kaneyuki

    JA clinical reports

    2021  Volume 7, Issue 1, Page(s) 49

    Abstract: Background: Pheochromocytomas produce hormones, cytokines, and catecholamines. We report perioperative anesthetic management of a rare interleukin-6 (IL-6)-producing pheochromocytoma.: Case presentation: A 32-year-old female was scheduled for ... ...

    Abstract Background: Pheochromocytomas produce hormones, cytokines, and catecholamines. We report perioperative anesthetic management of a rare interleukin-6 (IL-6)-producing pheochromocytoma.
    Case presentation: A 32-year-old female was scheduled for laparoscopic adrenalectomy for pheochromocytoma. She had a sustained high fever with elevated serum noradrenaline and IL-6 levels. The persistent high inflammatory state, followed by anemia, malnutrition, and coagulopathy, led us to prepone her date of surgery. During general anesthesia, alpha-blockers allowed hemodynamic fluctuations to be controlled. During surgery, simultaneous increases in noradrenaline and IL-6 levels were observed, which rapidly declined after tumor removal. Her postoperative course was uneventful, without pulmonary edema caused by cytokine storms.
    Conclusions: The conventional pheochromocytoma strategy allowed surgical removal of an IL-6-producing pheochromocytoma under general anesthesia. However, management of high inflammatory states that induce anemia and coagulopathy is necessary.
    Language English
    Publishing date 2021-06-11
    Publishing country Germany
    Document type Journal Article
    ISSN 2363-9024
    ISSN (online) 2363-9024
    DOI 10.1186/s40981-021-00449-5
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  6. Article ; Online: Prediction of return of spontaneous circulation during cardiopulmonary resuscitation by pulse-wave cerebral tissue oxygen saturation: a retrospective observational study.

    Sakaguchi, Kento / Takada, Masayuki / Takahashi, Kazunori / Onodera, Yu / Kobayashi, Tadahiro / Kawamae, Kaneyuki / Nakane, Masaki

    BMC emergency medicine

    2022  Volume 22, Issue 1, Page(s) 30

    Abstract: Background: It is difficult to predict the return of spontaneous circulation (ROSC) during cardiopulmonary resuscitation (CPR). Cerebral tissue oxygen saturation during CPR, as measured by near-infrared spectroscopy (NIRS), is anticipated to predict ... ...

    Abstract Background: It is difficult to predict the return of spontaneous circulation (ROSC) during cardiopulmonary resuscitation (CPR). Cerebral tissue oxygen saturation during CPR, as measured by near-infrared spectroscopy (NIRS), is anticipated to predict ROSC. General markers of cerebral tissue oxygen saturation, such as the tissue oxygenation index (TOI), mainly reflect venous oxygenation, whereas pulse-wave cerebral tissue oxygen saturation (SnO
    Methods: Cardiac arrest patients who presented at the Emergency Department of Yamagata University Hospital in Japan were included in this retrospective, observational study. SnO
    Results: Forty-two patients were included. SnO
    Conclusion: SnO
    MeSH term(s) Cardiopulmonary Resuscitation/methods ; Heart Arrest/therapy ; Humans ; Oxygen Saturation ; Retrospective Studies ; Return of Spontaneous Circulation
    Language English
    Publishing date 2022-02-28
    Publishing country England
    Document type Journal Article ; Observational Study
    ZDB-ID 2050431-7
    ISSN 1471-227X ; 1471-227X
    ISSN (online) 1471-227X
    ISSN 1471-227X
    DOI 10.1186/s12873-022-00586-9
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  7. Article ; Online: Prognostic Value of Antithrombin Activity Levels in the Early Phase of Intensive Care: A 2-Center Retrospective Cohort Study.

    Yarimizu, Kenya / Nakane, Masaki / Onodera, Yu / Matsuuchi, Taro / Suzuki, Hiroto / Yoshioka, Masatomo / Kudo, Masaya / Kawamae, Kaneyuki

    Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis

    2023  Volume 29, Page(s) 10760296231218711

    Abstract: To investigate the relationship between antithrombin (AT) activity level and prognosis in patients requiring intensive care. Patients whose AT activity was measured within 24 h of intensive care unit (ICU) admission were enrolled for analysis. The ... ...

    Abstract To investigate the relationship between antithrombin (AT) activity level and prognosis in patients requiring intensive care. Patients whose AT activity was measured within 24 h of intensive care unit (ICU) admission were enrolled for analysis. The primary endpoint was mortality at discharge. Prognostic accuracy was examined using receiver operating characteristic (ROC) curves and cox hazard regression analysis. Patients were divided into 6 groups based on predicted mortality, and a χ
    MeSH term(s) Humans ; Prognosis ; Antithrombins ; Retrospective Studies ; Critical Care ; Intensive Care Units ; Antithrombin III ; ROC Curve ; Anticoagulants ; Sepsis
    Chemical Substances Antithrombins ; Antithrombin III (9000-94-6) ; Anticoagulants
    Language English
    Publishing date 2023-12-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1237357-6
    ISSN 1938-2723 ; 1076-0296
    ISSN (online) 1938-2723
    ISSN 1076-0296
    DOI 10.1177/10760296231218711
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4370: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  8. Article: Creation of an artificial intelligence model for intubation difficulty classification by deep learning (convolutional neural network) using face images: an observational study.

    Hayasaka, Tatsuya / Kawano, Kazuharu / Kurihara, Kazuki / Suzuki, Hiroto / Nakane, Masaki / Kawamae, Kaneyuki

    Journal of intensive care

    2021  Volume 9, Issue 1, Page(s) 38

    Abstract: Background: Tracheal intubation is the gold standard for securing the airway, and it is not uncommon to encounter intubation difficulties in intensive care units and emergency rooms. Currently, there is a need for an objective measure to assess ... ...

    Abstract Background: Tracheal intubation is the gold standard for securing the airway, and it is not uncommon to encounter intubation difficulties in intensive care units and emergency rooms. Currently, there is a need for an objective measure to assess intubation difficulties in emergency situations by physicians, residents, and paramedics who are unfamiliar with tracheal intubation. Artificial intelligence (AI) is currently used in medical imaging owing to advanced performance. We aimed to create an AI model to classify intubation difficulties from the patient's facial image using a convolutional neural network (CNN), which links the facial image with the actual difficulty of intubation.
    Methods: Patients scheduled for surgery at Yamagata University Hospital between April and August 2020 were enrolled. Patients who underwent surgery with altered facial appearance, surgery with altered range of motion in the neck, or intubation performed by a physician with less than 3 years of anesthesia experience were excluded. Sixteen different facial images were obtained from the patients since the day after surgery. All images were judged as "Easy"/"Difficult" by an anesthesiologist, and an AI classification model was created using deep learning by linking the patient's facial image and the intubation difficulty. Receiver operating characteristic curves of actual intubation difficulty and AI model were developed, and sensitivity, specificity, and area under the curve (AUC) were calculated; median AUC was used as the result. Class activation heat maps were used to visualize how the AI model classifies intubation difficulties.
    Results: The best AI model for classifying intubation difficulties from 16 different images was generated in the supine-side-closed mouth-base position. The accuracy was 80.5%; sensitivity, 81.8%; specificity, 83.3%; AUC, 0.864; and 95% confidence interval, [0.731-0.969], indicating that the class activation heat map was concentrated around the neck regardless of the background; the AI model recognized facial contours and identified intubation difficulties.
    Conclusion: This is the first study to apply deep learning (CNN) to classify intubation difficulties using an AI model. We could create an AI model with an AUC of 0.864. Our AI model may be useful for tracheal intubation performed by inexperienced medical staff in emergency situations or under general anesthesia.
    Language English
    Publishing date 2021-05-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 2739853-5
    ISSN 2052-0492
    ISSN 2052-0492
    DOI 10.1186/s40560-021-00551-x
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  9. Article ; Online: The concerted elevation of conjugation reactions is associated with the aggravation of acetaminophen toxicity in Akr1a-knockout mice with an ascorbate insufficiency.

    Kimura, Soju / Osaki, Tsukasa / Homma, Takujiro / Kimura, Sotai / Kobayashi, Sho / Nakane, Masaki / Miyata, Satoshi / Itoh, Hiroshi / Kawamae, Kaneyuki / Fujii, Junichi

    Life sciences

    2022  Volume 304, Page(s) 120694

    Abstract: Aims: Acetaminophen (APAP) is a relatively safe analgesic drug, but overdosing can cause acute liver failure. Ingested APAP is detoxified by metabolic conversion through conjugation reactions with glucuronate, sulfate, or glutathione (GSH). The ... ...

    Abstract Aims: Acetaminophen (APAP) is a relatively safe analgesic drug, but overdosing can cause acute liver failure. Ingested APAP is detoxified by metabolic conversion through conjugation reactions with glucuronate, sulfate, or glutathione (GSH). The consumption of GSH through conjugation as well as mitochondrial dysfunction is considered to be responsible for the increased susceptibility to APAP-induced hepatotoxicity. Compared to wild-type (WT) mice, Akr1a-knockout (KO) mice are vulnerable to developing hepatotoxicity due to the fact that ascorbate synthesis is attenuated. We used such KO mice to investigate how these conjugation reactions are involved in the hepatotoxicity caused by an overdose of APAP under ascorbate-deficient conditions.
    Main methods: APAP (400 mg/kg) was intraperitoneally administered to WT mice and KO mice. In addition to histological and blood biochemical analyses, metabolites in the liver, blood plasma, and urine were measured at several time points by liquid chromatography-mass spectrometry.
    Key findings: Liver damage occurred earlier in the KO mice than in the WT mice. The levels of APAP-Cys, a final metabolite of GSH-conjugated APAP, as well as glucuronidated APAP and sulfated APAP were all higher in the KO mice compared to the WT mice. Treatment of the APAP-administered KO mice with N-acetylcysteine or supplementation of ascorbate suppressed the conjugation reactions at 6 h after APAP had been administrated, which mitigated the degree of liver damage.
    Significance: An ascorbate deficiency coordinately stimulates conjugation reactions of APAP, which, combined with the mitochondrial damage caused by APAP metabolites, collectively results in the aggravation of the acute liver failure.
    MeSH term(s) Acetaminophen/pharmacokinetics ; Acetaminophen/toxicity ; Aldehyde Reductase/deficiency ; Aldehyde Reductase/metabolism ; Animals ; Chemical and Drug Induced Liver Injury/metabolism ; Chemical and Drug Induced Liver Injury/pathology ; Glutathione/metabolism ; Liver/drug effects ; Liver/metabolism ; Mice ; Mice, Inbred C57BL ; Mice, Knockout
    Chemical Substances Acetaminophen (362O9ITL9D) ; Akr1a1 protein, mouse (EC 1.1.1.2) ; Aldehyde Reductase (EC 1.1.1.21) ; Glutathione (GAN16C9B8O)
    Language English
    Publishing date 2022-06-06
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 3378-9
    ISSN 1879-0631 ; 0024-3205
    ISSN (online) 1879-0631
    ISSN 0024-3205
    DOI 10.1016/j.lfs.2022.120694
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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.368: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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  10. Article: The concerted elevation of conjugation reactions is associated with the aggravation of acetaminophen toxicity in Akr1a-knockout mice with an ascorbate insufficiency

    Kimura, Soju / Osaki, Tsukasa / Homma, Takujiro / Kimura, Sotai / Kobayashi, Sho / Nakane, Masaki / Miyata, Satoshi / Itoh, Hiroshi / Kawamae, Kaneyuki / Fujii, Junichi

    Life sciences. 2022 Sept. 01, v. 304

    2022  

    Abstract: Acetaminophen (APAP) is a relatively safe analgesic drug, but overdosing can cause acute liver failure. Ingested APAP is detoxified by metabolic conversion through conjugation reactions with glucuronate, sulfate, or glutathione (GSH). The consumption of ... ...

    Abstract Acetaminophen (APAP) is a relatively safe analgesic drug, but overdosing can cause acute liver failure. Ingested APAP is detoxified by metabolic conversion through conjugation reactions with glucuronate, sulfate, or glutathione (GSH). The consumption of GSH through conjugation as well as mitochondrial dysfunction is considered to be responsible for the increased susceptibility to APAP-induced hepatotoxicity. Compared to wild-type (WT) mice, Akr1a-knockout (KO) mice are vulnerable to developing hepatotoxicity due to the fact that ascorbate synthesis is attenuated. We used such KO mice to investigate how these conjugation reactions are involved in the hepatotoxicity caused by an overdose of APAP under ascorbate-deficient conditions. APAP (400 mg/kg) was intraperitoneally administered to WT mice and KO mice. In addition to histological and blood biochemical analyses, metabolites in the liver, blood plasma, and urine were measured at several time points by liquid chromatography-mass spectrometry. Liver damage occurred earlier in the KO mice than in the WT mice. The levels of APAP-Cys, a final metabolite of GSH-conjugated APAP, as well as glucuronidated APAP and sulfated APAP were all higher in the KO mice compared to the WT mice. Treatment of the APAP-administered KO mice with N-acetylcysteine or supplementation of ascorbate suppressed the conjugation reactions at 6 h after APAP had been administrated, which mitigated the degree of liver damage. An ascorbate deficiency coordinately stimulates conjugation reactions of APAP, which, combined with the mitochondrial damage caused by APAP metabolites, collectively results in the aggravation of the acute liver failure.
    Keywords acetaminophen ; acetylcysteine ; blood plasma ; glutathione ; hepatotoxicity ; histology ; liquid chromatography ; liver ; liver failure ; mass spectrometry ; metabolites ; mitochondria ; overdose ; sulfates ; urine
    Language English
    Dates of publication 2022-0901
    Publishing place Elsevier Inc.
    Document type Article
    ZDB-ID 3378-9
    ISSN 1879-0631 ; 0024-3205
    ISSN (online) 1879-0631
    ISSN 0024-3205
    DOI 10.1016/j.lfs.2022.120694
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