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Article ; Online: G-protein-coupled estrogen receptor prevents nuclear factor-kappa B promoter activation by Helicobacter pylori cytotoxin-associated gene A in gastric cancer cells.

Okamoto, Mariko / Miura, Atsushi / Ito, Ryota / Kamada, Toshiki / Mizukami, Yoichi / Kawamoto, Keiko

The Journal of veterinary medical science

2023 Volume 85, Issue 12, Page(s) 1348–1354

Abstract: Helicobacter pylori is a well-known pathogen that causes chronic gastritis, leading to the development of gastric cancer. This bacterium has also been detected in dogs, and symptoms similar to those in humans have been reported. The cytotoxin-associated ... ...

Abstract	Helicobacter pylori is a well-known pathogen that causes chronic gastritis, leading to the development of gastric cancer. This bacterium has also been detected in dogs, and symptoms similar to those in humans have been reported. The cytotoxin-associated gene A (CagA) is involved in pathogenesis through aberrant activation of host signal transduction, including the nuclear factor-kappa B (NF-κB) pathway. We have previously shown the anti-inflammatory effect of the G-protein-coupled estrogen receptor (GPER) via inhibiting of NF-κB activation in several cells. Therefore, here, we investigated the effect of GPER on CagA-mediated NF-κB promoter activity and showed that CagA overexpression in gastric cancer cells activated the NF-κB reporter and induced interleukin 8 (il-8) expression, both of which were inhibited by the GPER agonist.
MeSH term(s)	Animals ; Dogs ; Humans ; Cytotoxins/metabolism ; Dog Diseases/metabolism ; Gastric Mucosa/metabolism ; GTP-Binding Proteins/metabolism ; Helicobacter Infections/metabolism ; Helicobacter Infections/veterinary ; Helicobacter pylori/genetics ; Helicobacter pylori/metabolism ; Interleukin-8/genetics ; NF-kappa B/metabolism ; Receptors, Estrogen/genetics ; Receptors, Estrogen/metabolism ; Stomach Neoplasms/genetics ; Stomach Neoplasms/metabolism ; Stomach Neoplasms/veterinary
Chemical Substances	Cytotoxins ; GTP-Binding Proteins (EC 3.6.1.-) ; Interleukin-8 ; NF-kappa B ; Receptors, Estrogen
Language	English
Publishing date	2023-11-13
Publishing country	Japan
Document type	Journal Article
ZDB-ID	1071753-5
ISSN	1347-7439 ; 0916-7250
ISSN (online)	1347-7439
ISSN	0916-7250
DOI	10.1292/jvms.23-0054
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Article ; Online: Polyampholyte-Based Polymer Hydrogels for the Long-Term Storage, Protection and Delivery of Therapeutic Proteins.

Rajan, Robin / Kumar, Nishant / Zhao, Dandan / Dai, Xianda / Kawamoto, Keiko / Matsumura, Kazuaki

Advanced healthcare materials

2023 Volume 12, Issue 17, Page(s) e2203253

Abstract: Protein storage and delivery are crucial for biomedical applications such as protein therapeutics and recombinant proteins. Lack of proper protocols results in the denaturation of proteins, rendering them inactive and manifesting undesired side effects. ... ...

Abstract	Protein storage and delivery are crucial for biomedical applications such as protein therapeutics and recombinant proteins. Lack of proper protocols results in the denaturation of proteins, rendering them inactive and manifesting undesired side effects. In this study, polyampholyte-based (succinylated ε-poly-l-lysine) hydrogels containing polyvinyl alcohol and polyethylene glycol polymer matrices to stabilize proteins are developed. These hydrogels facilitated the loading and release of therapeutic amounts of proteins and withstood thermal and freezing stress (15 freeze-thaw cycles and temperatures of -80 °C and 37 °C), without resulting in protein denaturation and aggregation. To the best of our knowledge, this strategy has not been applied to the design of hydrogels constituting polymers, (in particular, polyampholyte-based polymers) which have inherent efficiency to stabilize proteins and protect them from denaturation. Our findings can open up new avenues in protein biopharmaceutics for the design of materials that can store therapeutic proteins long-term under severe stress and safely deliver them.
MeSH term(s)	Hydrogels ; Polymers ; Polyethylene Glycols ; Freezing ; Polyvinyl Alcohol
Chemical Substances	Hydrogels ; Polymers ; Polyethylene Glycols (3WJQ0SDW1A) ; Polyvinyl Alcohol (9002-89-5)
Language	English
Publishing date	2023-03-01
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2649576-4
ISSN	2192-2659 ; 2192-2640
ISSN (online)	2192-2659
ISSN	2192-2640
DOI	10.1002/adhm.202203253
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Article ; Online: Evaluation of a

Sakuma, Saki / Okamoto, Mariko / Matsushita, Nao / Ukawa, Masami / Tomono, Takumi / Kawamoto, Keiko / Ikeda, Teruo / Sakuma, Shinji

The Journal of veterinary medical science

2022 Volume 84, Issue 4, Page(s) 484–493

Abstract: Poly(N-vinylacetamide-co-acrylic acid) coupled with d-octaarginine (VP-R8) promotes the cellular uptake of peptides/proteins in vitro; however, details of the transfection efficacy of VP-R8, such as the cell types possessing high gene transfer, are not ... ...

Abstract	Poly(N-vinylacetamide-co-acrylic acid) coupled with d-octaarginine (VP-R8) promotes the cellular uptake of peptides/proteins in vitro; however, details of the transfection efficacy of VP-R8, such as the cell types possessing high gene transfer, are not known. Herein, we compared the ability of VP-R8 to induce the cellular uptake of plasmid DNA in mouse and human cell lines from different tissues and organs. A green fluorescent protein (GFP)-expression plasmid was used as model genetic material, and fluorescence as an indicator of uptake and plasmid-derived protein expression. Three mouse and three human cell lines were incubated with a mixture of plasmid and VP-R8, and fluorescence analysis were performed two days after transfection. To confirm stable transgene expression, we performed drug selection three days after transfection. A commercially available polymer-based DNA transfection reagent (PTR) was used as the transfection control and standard for comparing transgene expression efficiency. In the case of transient transgene expression, slight-to-moderate GFP expression was observed in all cell lines transfected with plasmid via VP-R8; however, transfection efficiency was lower than using the PTR for gene delivery. In the case of stable transgene expression, VP-R8 promoted drug-resistance acquisition more efficiently than the PTR did. Cells that developed drug resistance after VP-R8-mediated gene transfection expressed GFP more efficiently than cells that developed drug resistance after transfection with the PTR. Thus, VP-R8 shows potential as an in vitro or ex vivo nonviral transfection tool for generating cell lines with stable transgene expression.
MeSH term(s)	Animals ; Cell Line ; DNA ; Green Fluorescent Proteins/genetics ; Green Fluorescent Proteins/metabolism ; Humans ; Mice ; Oligopeptides ; Plasmids/genetics ; Polymers ; Transfection/veterinary ; Transgenes
Chemical Substances	Oligopeptides ; Polymers ; octaarginine ; Green Fluorescent Proteins (147336-22-9) ; DNA (9007-49-2)
Language	English
Publishing date	2022-02-08
Publishing country	Japan
Document type	Journal Article
ZDB-ID	1071753-5
ISSN	1347-7439 ; 0916-7250
ISSN (online)	1347-7439
ISSN	0916-7250
DOI	10.1292/jvms.21-0647
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Article: Antimicrobial resistance and genotyping of

Elfadadny, Ahmed / Uchiyama, Jumpei / Goto, Kazuyoshi / Imanishi, Ichiro / Ragab, Rokaia F / Nageeb, Wedad M / Iyori, Keita / Toyoda, Yoichi / Tsukui, Toshihiro / Ide, Kaori / Kawamoto, Keiko / Nishifuji, Koji

Frontiers in veterinary science

2023 Volume 10, Page(s) 1074127

Abstract: The strong bond between dogs and their owners creates a close association that could result in the transfer of antibiotic-resistant bacteria from canines to humans, potentially leading to the spread of antimicrobial resistance genes. ...

Abstract	The strong bond between dogs and their owners creates a close association that could result in the transfer of antibiotic-resistant bacteria from canines to humans, potentially leading to the spread of antimicrobial resistance genes.
Language	English
Publishing date	2023-07-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2834243-4
ISSN	2297-1769
ISSN	2297-1769
DOI	10.3389/fvets.2023.1074127
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Article: Whole-Genome Sequences of Eight Campylobacter jejuni Isolates from Wild Birds.

Shyaka, Anselme / Kusumoto, Akiko / Asakura, Hiroshi / Kawamoto, Keiko

Genome announcements

2015 Volume 3, Issue 2

Abstract: We present here the draft genome sequences of 8 Campylobacter jejuni strains isolated from wild birds. The strains were initially isolated from swabs taken from resident wild birds in the Tokachi area of Japan. The genome sizes range from 1.65 to 1.77 ... ...

Abstract	We present here the draft genome sequences of 8 Campylobacter jejuni strains isolated from wild birds. The strains were initially isolated from swabs taken from resident wild birds in the Tokachi area of Japan. The genome sizes range from 1.65 to 1.77 Mbp.
Language	English
Publishing date	2015-04-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	2704277-7
ISSN	2169-8287
ISSN	2169-8287
DOI	10.1128/genomeA.00315-15
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Article: Whole-Genome Sequences of Eight Campylobacter jejuni Isolates from Wild Birds

Shyaka, Anselme / Kusumoto, Akiko / Asakura, Hiroshi / Kawamoto, Keiko

Genome Announcements. 2015 Apr. 30, v. 3, no. 2

2015

Abstract	We present here the draft genome sequences of 8 Campylobacter jejuni strains isolated from wild birds. The strains were initially isolated from swabs taken from resident wild birds in the Tokachi area of Japan. The genome sizes range from 1.65 to 1.77 Mbp.
Keywords	Campylobacter jejuni ; genome ; nucleotide sequences ; wild birds ; Japan
Language	English
Dates of publication	2015-0430
Size	p. e00315-15.
Publishing place	American Society for Microbiology
Document type	Article
ZDB-ID	2704277-7
ISSN	2169-8287
ISSN	2169-8287
DOI	10.1128/genomeA.00315-15
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Article ; Online: Heterogeneous IgE reactivities to Staphylococcus pseudintermedius strains in dogs with atopic dermatitis, and the identification of DM13-domain-containing protein as a bacterial IgE-reactive molecule.

Takemura-Uchiyama, Iyo / Tsurui, Hiroki / Shimakura, Hidekatsu / Nasukawa, Tadahiro / Imanishi, Ichiro / Uchiyama, Jumpei / Fukuyama, Tomoki / Sakamoto, Shuji / Morisawa, Keiko / Fujimura, Masato / Murakami, Hironobu / Kanamaru, Shuji / Kurokawa, Kenji / Kawamoto, Keiko / Iyori, Keita / Sakaguchi, Masahiro

FEMS microbiology letters

2022 Volume 369, Issue 1

Abstract: Staphylococcus pseudintermedius is one of the major pathogens causing canine skin infection. In canine atopic dermatitis (AD), heterogeneous strains of S. pseudintermedius reside on the affected skin site. Because an increase in specific IgE to this ... ...

Abstract	Staphylococcus pseudintermedius is one of the major pathogens causing canine skin infection. In canine atopic dermatitis (AD), heterogeneous strains of S. pseudintermedius reside on the affected skin site. Because an increase in specific IgE to this bacterium has been reported, S. pseudintermedius is likely to exacerbate the severity of canine AD. In this study, the IgE reactivities to various S. pseudintermedius strains and the IgE-reactive molecules of S. pseudintermedius were investigated. First, examining the IgE reactivities to eight strains of S. pseudintermedius using 141 sera of AD dogs, strain variation of S. pseudintermedius showed 10-63% of the IgE reactivities. This is different from the expected result based on the concept of Staphylococcus aureus clonality in AD patients. Moreover, according to the western blot analysis, there were more than four proteins reactive to IgE. Subsequently, the analysis of the common IgE-reactive protein at ∼15 kDa confirmed that the DM13-domain-containing protein was reactive in AD dogs, which is not coincident with any S. aureus IgE-reactive molecules. Considering these, S. pseudintermedius is likely to exacerbate AD severity in dogs, slightly different from the case of S. aureus in human AD.
MeSH term(s)	Animals ; Dermatitis, Atopic/microbiology ; Dermatitis, Atopic/veterinary ; Dogs ; Humans ; Immunoglobulin E/metabolism ; Staphylococcus/genetics ; Staphylococcus aureus/genetics
Chemical Substances	Immunoglobulin E (37341-29-0)
Language	English
Publishing date	2022-02-22
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	752343-9
ISSN	1574-6968 ; 0378-1097
ISSN (online)	1574-6968
ISSN	0378-1097
DOI	10.1093/femsle/fnac019
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Article ; Online: Deletion in the C-terminal domain of ClpX delayed entry of Salmonella enterica into a viable but non-culturable state.

Kusumoto, Akiko / Miyashita, Masayuki / Kawamoto, Keiko

Research in microbiology

2013 Volume 164, Issue 4, Page(s) 335–341

Abstract: Under stressful conditions, bacteria enter a viable but non-culturable (VBNC) state in which they are alive but fail to grow on conventional media. The molecular basis underlying this state is unknown. To identify the key gene responsible for the VBNC ... ...

Abstract	Under stressful conditions, bacteria enter a viable but non-culturable (VBNC) state in which they are alive but fail to grow on conventional media. The molecular basis underlying this state is unknown. To identify the key gene responsible for the VBNC state in Salmonella spp., we examined a S. Typhimurium LT2 VBNC mutant, which shows a characteristic delay in entering the VBNC state. The mutant showed a higher level of expression of general stress sigma factor RpoS than wild-type LT2. The mutant carried a 99-bp in-frame deletion in the clpX gene (clpXΔ323-355). ClpX is known to form a ClpXP protease complex with ClpP, which plays a role in the degradation of RpoS. To investigate the effect of clpXΔ323-355 on VBNC induction, ΔclpX and clpXΔ323-355 strains were generated from LT2 cells. Compared to LT2, the ΔclpX and clpXΔ323-355 strains showed greater amounts of RpoS and required a longer incubation time for induction into the VBNC state. These results suggest that residues 323-355 of ClpX play a major role in the hexameric formation or function of ClpX and in the rate of induction of the VBNC state.
MeSH term(s)	Bacterial Proteins/metabolism ; Endopeptidase Clp/genetics ; Endopeptidase Clp/metabolism ; Gene Expression Regulation, Bacterial ; Mutant Proteins/genetics ; Mutant Proteins/metabolism ; Salmonella typhimurium/genetics ; Salmonella typhimurium/growth & development ; Sequence Deletion ; Sigma Factor/metabolism
Chemical Substances	Bacterial Proteins ; Mutant Proteins ; Sigma Factor ; sigma factor KatF protein, Bacteria ; Endopeptidase Clp (EC 3.4.21.92)
Language	English
Publishing date	2013-05
Publishing country	France
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1004220-9
ISSN	1769-7123 ; 0923-2508
ISSN (online)	1769-7123
ISSN	0923-2508
DOI	10.1016/j.resmic.2013.01.011
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Zs.A 890: Show issues

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Article: Associations of the first occurrence of pathogen-specific clinical mastitis with milk yield and milk composition in dairy cows

Kayano, Mitsunori / Itoh, Megumi / Kusaba, Nobuyuki / Hayashiguchi, Osamu / Kida, Katsuya / Tanaka, Yoshiharu / Kawamoto, Keiko / Gröhn, Yrjö T

Journal of dairy research. 2018 Aug., v. 85, no. 3

2018

Abstract: The aim of this study was to estimate the associations of the first occurrence of pathogen-specific clinical mastitis (CM) with milk yield and milk composition (somatic cell count (SCC), lactose, fat, protein content in milk and milk urea nitrogen (MUN)). ...

Abstract	The aim of this study was to estimate the associations of the first occurrence of pathogen-specific clinical mastitis (CM) with milk yield and milk composition (somatic cell count (SCC), lactose, fat, protein content in milk and milk urea nitrogen (MUN)). We studied 3149 dairy cows in 31 Hokkaido dairy farms in Japan. Five pathogen groups were studied: Streptococcus spp.; Staphylococcus aureus (S. aureus); coagulase-negative staphylococci (CNS); coliforms; and fungi. Test-day milk data and clinical records were collected from June 2011 until February 2014. Mixed models with an autoregressive correlation structure were fitted to quantify the effects of CM and several other control variables (herd, calving season, parity, week of lactation, and other diseases). Primipara (first lactation) and multipara (second and later lactations) were analysed separately. All pathogens, particularly S. aureus and fungi, were associated with significant milk losses in multipara. In this study, S. aureus and CNS infections were not associated with significant milk loss in primipara. All pathogens, in particular S. aureus and fungi, significantly increased SCC in both parity groups. All pathogens, especially CNS (in primipara) and S. aureus (in multipara), decreased lactose content. All pathogen groups except for fungi were associated with significant changes in fat, protein and MUN. Some pathogens such as Streptococcus spp. and coliforms seemed to be associated with long-term fat, protein and MUN changes. These findings provide estimates that could be used to calculate precise costs of CM, and also provide better indicators of pathogen-specific mastitis.
Keywords	Staphylococcus aureus ; Streptococcus ; calving ; coagulase negative staphylococci ; coliform bacteria ; dairy cows ; dairy farming ; fungi ; herds ; lactation ; lactose ; mastitis ; milk ; milk composition ; milk yield ; models ; pathogens ; protein content ; somatic cell count ; urea nitrogen ; Japan
Language	English
Dates of publication	2018-08
Size	p. 309-316.
Publishing place	Cambridge University Press
Document type	Article
ZDB-ID	242089-2
ISSN	1469-7629 ; 0022-0299
ISSN (online)	1469-7629
ISSN	0022-0299
DOI	10.1017/S0022029918000456
Database	NAL-Catalogue (AGRICOLA)

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Z 1073: Show issues

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Article ; Online: General stress sigma factor RpoS influences time required to enter the viable but non-culturable state in Salmonella enterica.

Kusumoto, Akiko / Asakura, Hiroshi / Kawamoto, Keiko

Microbiology and immunology

2012 Volume 56, Issue 4, Page(s) 228–237

Abstract: In stressful conditions, bacteria enter into the viable but non-culturable (VBNC) state; in this state, they are alive but fail to grow on conventional media on which they normally grow and develop into colonies. The molecular basis underlying this state ...

Abstract	In stressful conditions, bacteria enter into the viable but non-culturable (VBNC) state; in this state, they are alive but fail to grow on conventional media on which they normally grow and develop into colonies. The molecular basis underlying this state is unknown. We investigated the role of the alternative sigma factor RpoS (σ(38)) in the VBNC induction using Salmonella Dublin, Salmonella Oranienburg and Salmonella Typhimurium LT2. VBNC was induced by osmotic stress in LT2 and Oranienburg. Dublin also entered the VBNC state, but more slowly than LT2 and Oranienburg did. The LT2 rpoS gene was initiated from an alternative initiation codon, TTG; therefore, LT2 had smaller amounts of RpoS than Dublin and Oranienburg. Oranienburg had a single amino acid substitution (D118N) in RpoS (RpoS(SO)). Disruption of rpoS caused rapid VBNC induction. VBNC induction was significantly delayed by Dublin-type RpoS (RpoS(SD)), but only slightly by RpoS(SO). These results indicate that RpoS delays VBNC induction and that the rapid induction of VBNC in LT2 and Oranienburg may be due to lower levels of RpoS and to the D118N amino acid substitution, respectively. Reduced RpoS intracellular level was observed during VBNC induction. During the VBNC induction, Salmonella might regulate RpoS which is important for maintenance of culturablity under stresses.
MeSH term(s)	Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Gene Expression Regulation, Bacterial ; Gene Knockout Techniques ; Microbial Viability ; Salmonella enterica/genetics ; Salmonella enterica/growth & development ; Salmonella enterica/physiology ; Sigma Factor/genetics ; Sigma Factor/metabolism ; Stress, Physiological
Chemical Substances	Bacterial Proteins ; Sigma Factor ; sigma factor KatF protein, Bacteria
Language	English
Publishing date	2012-04
Publishing country	Australia
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	224792-6
ISSN	1348-0421 ; 0385-5600
ISSN (online)	1348-0421
ISSN	0385-5600
DOI	10.1111/j.1348-0421.2012.00428.x
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