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Article ; Online: Vancomycin-resistant

Tokano, Mieko / Tarumoto, Norihito / Sakai, Jun / Imai, Kazuo / Kodana, Masahiro / Kawamura, Toru / Maeda, Takuya / Maesaki, Shigefumi

Microbiology spectrum

2023 Volume 12, Issue 1, Page(s) e0244423

Abstract: Importance: Our study emphasizes the efficacy of whole-genome sequencing (WGS) in addressing outbreaks of vancomycin-resistant enterococci. WGS enables the identification and tracking of resistant bacterial strains, early detection and management of ... ...

Abstract	Importance: Our study emphasizes the efficacy of whole-genome sequencing (WGS) in addressing outbreaks of vancomycin-resistant enterococci. WGS enables the identification and tracking of resistant bacterial strains, early detection and management of novel infectious disease outbreaks, and the appropriate selection and use of antibiotics. Furthermore, our approach deepens our understanding of how resistant bacteria transfer genes and adapt to their environments or hosts. For modern medicine, these insights have significant implications for controlling infections and effectively managing antibiotic use in the current era, where antibiotic resistance is progressing.
MeSH term(s)	Humans ; Vancomycin-Resistant Enterococci/genetics ; Molecular Epidemiology ; Vancomycin/pharmacology ; Vancomycin/therapeutic use ; Enterococcus faecium/genetics ; Japan/epidemiology ; Multilocus Sequence Typing ; Anti-Bacterial Agents/pharmacology ; Gram-Positive Bacterial Infections/epidemiology ; Gram-Positive Bacterial Infections/microbiology ; Bacterial Proteins/genetics
Chemical Substances	Vancomycin (6Q205EH1VU) ; Anti-Bacterial Agents ; Bacterial Proteins
Language	English
Publishing date	2023-12-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2807133-5
ISSN	2165-0497 ; 2165-0497
ISSN (online)	2165-0497
ISSN	2165-0497
DOI	10.1128/spectrum.02444-23
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Article ; Online: Adherence and Effectiveness of MoviPrep

Asayama, Naoki / Oka, Shiro / Nagata, Shinji / Matsuo, Taiji / Aoyama, Taiki / Kawamura, Toru / Kuroda, Tsuyoshi / Hiraga, Yuko / Nakadoi, Koichi / Kunihiro, Masaki / Ohnishi, Mayu / Tanaka, Shinji

Journal of the anus, rectum and colon

2024 Volume 8, Issue 1, Page(s) 9–17

Abstract: Objectives: Bowel preparation is burdensome because of long cleansing times and large dose volumes of conventional polyethylene glycol (PEG) lavage solution Niflec: Methods: This multicenter, randomized, open-label, parallel-group comparative study, ... ...

Abstract	Objectives: Bowel preparation is burdensome because of long cleansing times and large dose volumes of conventional polyethylene glycol (PEG) lavage solution Niflec Methods: This multicenter, randomized, open-label, parallel-group comparative study, conducted at Hiroshima University Hospital and 7 affiliated hospitals in May 2015-March 2016, evaluated adherence to and effectiveness of Mov in bowel preparation. Participants (n=380) were allocated to receive 1 of 3 pre-colonoscopy regimens: Nif+Modified Brown Method (Group A), Mov+Modified Brown Method (Group B), or Mov+Laxative (Group C). Results: Total intake volume showed no significant difference among the groups. Bowel preparation time was significantly shorter in Group B (112.4±44.8 min, n=118) than in Groups A (131.3±59 min, n=105) and C (122.6±48.1 min, n=115). Sleep disturbance (37%) was significantly higher in Group B than Group A; distension (11%) was significantly lower in Group C than in Groups A and B (p<0.05, respectively). No severe adverse events occurred in any group. Conclusions: Mov+Modified Brown method provided significantly shorter bowel preparation time, with no significant difference in total intake volume among the regimens. Mov+Laxative yielded significantly less distension than the other groups, with bowel preparation equivalent to that of the Nif+Modified Brown method.
Language	English
Publishing date	2024-01-25
Publishing country	Japan
Document type	Journal Article
ISSN	2432-3853
ISSN (online)	2432-3853
DOI	10.23922/jarc.2023-030
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Article: Diagnostic Accuracy of

Quach, Duc Trong / Aoki, Rika / Iga, Akiko / Le, Quang Dinh / Kawamura, Toru / Yamashita, Ken / Tanaka, Shinji / Yoshihara, Masaharu / Hiyama, Toru

Frontiers in medicine

2022 Volume 8, Page(s) 830730

Abstract: Aim: To assess the time trend of diagnostic accuracy of pre- and post-eradication : Methods: A series 100 of conventional endoscopic image sets taken from subjects undergoing gastric cancer screening at a polyclinic were evaluated by 5 experienced ... ...

Abstract	Aim: To assess the time trend of diagnostic accuracy of pre- and post-eradication Methods: A series 100 of conventional endoscopic image sets taken from subjects undergoing gastric cancer screening at a polyclinic were evaluated by 5 experienced assessors. Each assessor independently examined endoscopic findings according to the Kyoto classification and then determined the Results: The overall diagnostic accuracy of Conclusions: Diagnostic accuracy of
Language	English
Publishing date	2022-01-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2775999-4
ISSN	2296-858X
ISSN	2296-858X
DOI	10.3389/fmed.2021.830730
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Article ; Online: Bacterial Meningitis Caused by Bacillus subtilis var. natto.

Tokano, Mieko / Tarumoto, Norihito / Imai, Kazuo / Sakai, Jun / Maeda, Takuya / Kawamura, Toru / Seo, Kazuhide / Takahashi, Kazushi / Yamamoto, Toshimasa / Maesaki, Shigefumi

Internal medicine (Tokyo, Japan)

2022 Volume 62, Issue 13, Page(s) 1989–1993

Abstract: A 67-year-old woman with a 2-day history of a fever, headache and disturbed consciousness was admitted to our hospital. Bacillus subtilis was isolated from both the cerebrospinal fluid and blood. She was cured by the administration of vancomycin. Next- ... ...

Abstract	A 67-year-old woman with a 2-day history of a fever, headache and disturbed consciousness was admitted to our hospital. Bacillus subtilis was isolated from both the cerebrospinal fluid and blood. She was cured by the administration of vancomycin. Next-generation sequencing identified the strain as B. subtilis var. natto, the same strain found in natto, which this patient ate daily. We suspected that some of the B. subtilis that caused the infection may have actually been B. subtilis var. natto.
MeSH term(s)	Female ; Humans ; Aged ; Bacillus subtilis/genetics ; High-Throughput Nucleotide Sequencing ; Meningitis, Bacterial/complications ; Meningitis, Bacterial/diagnosis ; Meningitis, Bacterial/drug therapy
Language	English
Publishing date	2022-11-23
Publishing country	Japan
Document type	Case Reports ; Journal Article
ZDB-ID	32371-8
ISSN	1349-7235 ; 0021-5120 ; 0918-2918
ISSN (online)	1349-7235
ISSN	0021-5120 ; 0918-2918
DOI	10.2169/internalmedicine.0768-22
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Article ; Online: Impaired diffuse noxious inhibitory controls in specific alternation of rhythm in temperature-stressed rats.

Itomi, Yasuo / Tsukimi, Yasuhiro / Kawamura, Toru

European journal of pharmacology

2016 Volume 784, Page(s) 61–68

Abstract: Fibromyalgia is characterized by chronic widespread musculoskeletal pain. A hypofunction in descending pain inhibitory systems is considered to be involved in the chronic pain of fibromyalgia. We examined functional changes in descending pain inhibitory ... ...

Abstract	Fibromyalgia is characterized by chronic widespread musculoskeletal pain. A hypofunction in descending pain inhibitory systems is considered to be involved in the chronic pain of fibromyalgia. We examined functional changes in descending pain inhibitory systems in rats with specific alternation of rhythm in temperature (SART) stress, by measuring the strength of diffuse noxious inhibitory controls (DNIC). Hindpaw withdrawal thresholds to mechanical von Frey filament or fiber-specific electrical stimuli by the Neurometer system were used to measure the pain response. To induce DNIC, capsaicin was injected into the intraplantar of the forepaw. SART-stressed rats were established by exposure to repeated cold stress for 4 days. In the control rats, heterotopic intraplantar capsaicin injection increased withdrawal threshold, indicative of analgesia by DNIC. The strength of DNIC was reduced by naloxone (μ-opioid receptor antagonist, intraperitoneally and intracerebroventricularly), yohimbine (α2-adrenoceptor antagonist, intrathecally), and WAY-100635 (5-HT1A receptor antagonist, intrathecally) in the von Frey test. In SART-stressed rats, capsaicin injection did not increase withdrawal threshold in the von Frey test, indicating deficits in DNIC. In the Neurometer test, deficient DNIC in SART-stressed rats were observed only for Aδ- and C-fibers, but not Aβ-fibers stimulation. Analgesic effect of intracerebroventricular morphine was markedly reduced in SART-stressed rats compared with the control rats. Taken together, in SART-stressed rats, capsaicin-induced DNIC were deficient, and a hypofunction of opioid-mediated central pain modulation system may cause the DNIC deficit.
MeSH term(s)	Animals ; Capsaicin/pharmacology ; Diffuse Noxious Inhibitory Control/drug effects ; Heat-Shock Response/drug effects ; Hyperalgesia/physiopathology ; Male ; Morphine/pharmacology ; Pain/physiopathology ; Rats ; Rats, Sprague-Dawley
Chemical Substances	Morphine (76I7G6D29C) ; Capsaicin (S07O44R1ZM)
Language	English
Publishing date	2016-05-10
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	80121-5
ISSN	1879-0712 ; 0014-2999
ISSN (online)	1879-0712
ISSN	0014-2999
DOI	10.1016/j.ejphar.2016.05.011
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Zs.A 522: Show issues

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Article ; Online: Correction to: Clinical characteristics in blood stream infections caused by Klebsiella pneumoniae, Klebsiella variicola, and Klebsiella quasipneumoniae: a comparative study, Japan, 2014-2017.

Imai, Kazuo / Ishibashi, Noriomi / Kodana, Masahiro / Tarumoto, Norihito / Sakai, Jun / Kawamura, Toru / Takeuchi, Shinichi / Taji, Yoshitada / Ebihara, Yasuhiro / Ikebuchi, Kenji / Murakami, Takashi / Maeda, Takuya / Mitsutake, Kotaro / Maesaki, Shigefumi

BMC infectious diseases

2022 Volume 22, Issue 1, Page(s) 425

Language	English
Publishing date	2022-05-04
Publishing country	England
Document type	Published Erratum
ZDB-ID	2041550-3
ISSN	1471-2334 ; 1471-2334
ISSN (online)	1471-2334
ISSN	1471-2334
DOI	10.1186/s12879-022-07384-5
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Article ; Online: Specific alteration of rhythm in temperature-stressed rats possess features of abdominal pain in IBS patients.

Itomi, Yasuo / Kawamura, Toru / Tsukimi, Yasuhiro

Journal of pharmacological sciences

2015 Volume 129, Issue 1, Page(s) 26–30

Abstract: It is known that specific alteration of rhythm in temperature (SART) stress produces somatic pain. However, it remains to be investigated whether SART stress induces visceral pain. In this study, we investigated the visceral hypersensitivity in the SART ... ...

Abstract	It is known that specific alteration of rhythm in temperature (SART) stress produces somatic pain. However, it remains to be investigated whether SART stress induces visceral pain. In this study, we investigated the visceral hypersensitivity in the SART stress model by pharmacological tools and heterotopical nociception. Four-week-old Sprague-Dawley rats were exposed to repeated cold stress. Visceral pain was measured by visceromotor response to colorectal distension, and the effects of alosetron and duloxetine on visceral pain were investigated in SART rats. Heterotopical nociception was given by capsaicin injection into the left forepaw to induce diffuse noxious inhibitory controls (DNIC). SART stress induced visceral hypersensitivity that was sustained at minimum for one week. In pharmacological analysis, alosetron and duloxetine improved SART stress-induced visceral hypersensitivity. Heterotopical nociception induced DNIC in normal conditions, but was disrupted in SART rats. On the other hand, RMCP-II mRNA in distal colon was not affected by SART stress. In conclusion, SART rats exhibit several features of visceral pain in IBS, and may be a useful model for investigating the central modification of pain control in IBS.
MeSH term(s)	Abdominal Pain/etiology ; Abdominal Pain/prevention & control ; Animals ; Carbolines/pharmacology ; Cold Temperature/adverse effects ; Disease Models, Animal ; Duloxetine Hydrochloride/pharmacology ; Irritable Bowel Syndrome/complications ; Irritable Bowel Syndrome/physiopathology ; Male ; Nociception/drug effects ; Nociception/physiology ; Rats, Sprague-Dawley ; Stress, Physiological/physiology ; Temperature ; Visceral Pain/etiology ; Visceral Pain/prevention & control
Chemical Substances	Carbolines ; alosetron (13Z9HTH115) ; Duloxetine Hydrochloride (9044SC542W)
Language	English
Publishing date	2015-09
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2104264-0
ISSN	1347-8648 ; 1347-8613
ISSN (online)	1347-8648
ISSN	1347-8613
DOI	10.1016/j.jphs.2015.07.044
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Article ; Online: Pharmacological evaluation of a novel corticotropin-releasing factor 1 receptor antagonist T-3047928 in stress-induced animal models in a comparison with alosetron.

Itomi, Yasuo / Tanaka, Takahiro / Matsushita, Kozo / Kawamura, Toru / Kojima, Takuto / Aso, Kazuyoshi / Matsumoto-Okano, Shiho / Tsukimi, Yasuhiro

Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society

2020 Volume 32, Issue 5, Page(s) e13795

Abstract: Background: The major symptoms of irritable bowel syndrome (IBS) are changes in bowel habits and abdominal pain. Psychological stress is the major pathophysiological components of IBS. Corticotropin-releasing factor (CRF) is a well-known integrator in ... ...

Abstract	Background: The major symptoms of irritable bowel syndrome (IBS) are changes in bowel habits and abdominal pain. Psychological stress is the major pathophysiological components of IBS. Corticotropin-releasing factor (CRF) is a well-known integrator in response to psychological stress. In this study, a novel CRF1 receptor antagonist T-3047928 was evaluated in stress-induced IBS models of rats to explore its potency for IBS. Methods: Plasma adrenocorticotropic hormone (ACTH) levels after intravenous oCRH challenge were measured as a pharmacodynamic marker. Efficacies of oral T-3047928 were compared with oral alosetron, a 5-HT3 antagonist, on conditioning fear stress (CFS)-induced defecation, restraint stress (RS)-induced acute visceral pain, specific alteration of rhythm in temperature (SART) stress-induced chronic visceral pain, and normal defecation. Results: T-3047928 (1-10 mg/kg, p.o.) demonstrated a dose-dependent inhibition on oCRH-induced ACTH secretion. In disease models, T-3047928 suppressed fecal pellet output induced by CFS and improved both acute and chronic visceral hypersensitivity induced by RS and SART stress, respectively. Alosetron was also efficacious in stress-induced defecation and visceral pain models at 1 and 10 mg/kg, respectively. Alosetron, however, also suppressed normal defecation at lower those. On the other hand, T-3047928 did not change normal defecation even at higher dose than those in disease models. Conclusion: T-3047928 is an orally active CRF1 antagonist that demonstrated potent inhibitory effects in stress-associated IBS models with no effect on normal defecation. Therefore, it is suggested that T-3047928 may have a potency as a novel option for IBS-D therapy with minimal constipation risk.
MeSH term(s)	Adrenocorticotropic Hormone/blood ; Animals ; Carbolines/administration & dosage ; Conditioning, Classical ; Defecation/drug effects ; Disease Models, Animal ; Fear ; Irritable Bowel Syndrome/blood ; Irritable Bowel Syndrome/complications ; Male ; Pain Threshold/drug effects ; Rats, Sprague-Dawley ; Receptors, Corticotropin-Releasing Hormone/antagonists & inhibitors ; Restraint, Physical ; Serotonin 5-HT3 Receptor Agonists/administration & dosage ; Stress, Psychological/blood ; Stress, Psychological/complications ; Stress, Psychological/prevention & control
Chemical Substances	Carbolines ; Receptors, Corticotropin-Releasing Hormone ; Serotonin 5-HT3 Receptor Agonists ; alosetron (13Z9HTH115) ; CRF receptor type 1 (5CLY6W2H1M) ; Adrenocorticotropic Hormone (9002-60-2)
Language	English
Publishing date	2020-01-22
Publishing country	England
Document type	Journal Article
ZDB-ID	1186328-6
ISSN	1365-2982 ; 1350-1925
ISSN (online)	1365-2982
ISSN	1350-1925
DOI	10.1111/nmo.13795
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Zs.A 2979: Show issues

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Article: Antimicrobial susceptibility and prevalence of resistance genes in Bacteroides fragilis isolated from blood culture bottles in two tertiary care hospitals in Japan

Ogane, Kana / Tarumoto, Norihito / Kodana, Masahiro / Onodera, Azusa / Imai, Kazuo / Sakai, Jun / Kawamura, Toru / Takeuchi, Shinichi / Murakami, Takashi / Mitsutake, Kotaro / Ikebuchi, Kenji / Maesaki, Shigefumi / Maeda, Takuya

Anaerobe. 2020 Aug., v. 64

2020

Abstract: The in vitro susceptibilities of Bacteroides fragilis to antimicrobial agents, especially to carbapenem, are a major concern in the treatment of patients with bloodstream infections. In this study, 50 isolates of B. fragilis were obtained from positive ... ...

Abstract	The in vitro susceptibilities of Bacteroides fragilis to antimicrobial agents, especially to carbapenem, are a major concern in the treatment of patients with bloodstream infections. In this study, 50 isolates of B. fragilis were obtained from positive blood bottles from 2014 to 2019 in Saitama, Japan. Their susceptibility to ampicillin/sulbactam was reduced to 70.0% compared with a previous report, whereas they were still sufficiently susceptible to piperacillin/tazobactam (94.0%). Five cfiA-positive isolates (5/50, 10.0%) were identified that were resistant to doripenem and meropenem, and two of them carried an insertion sequence located upstream of the cfiA-coding region. In particular, imipenem should be considered as a first-line carbapenem for the empirical treatment of B. fragilis infection because only insertion sequence and cfiA double-positive strains showed resistance to imipenem. Thirty-six percent of the isolates had a reduced minimum inhibitory concentration for moxifloxacin. In addition, metronidazole should still be considered as an active agent for B. fragilis because all isolates were susceptible to this antibiotic and the prevalence of the nim gene was low in Japan.
Keywords	Bacteroides fragilis ; antibiotic resistance ; blood ; blood flow ; bottles ; doripenem ; hospitals ; imipenem ; meropenem ; metronidazole ; minimum inhibitory concentration ; moxifloxacin ; patients ; piperacillin ; resistance genes ; sulbactam ; transposons ; Japan
Language	English
Dates of publication	2020-08
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	1237621-8
ISSN	1075-9964
ISSN	1075-9964
DOI	10.1016/j.anaerobe.2020.102215
Database	NAL-Catalogue (AGRICOLA)

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Article: [A Case of GIST in the Small Intestine Diagnosed via CT after Repeated Melena and Removed by Laparoscopy-Assisted Surgery].

Notani, Hiroyuki / Asano, Daisuke / Fujiwara, Naoto / Kawamura, Toru / Sato, Yasushi / Nakashima, Akira

Gan to kagaku ryoho. Cancer & chemotherapy

2016 Volume 43, Issue 12, Page(s) 1851–1853

Abstract: A 63-year-old man visited an emergency outpatient unit with the chief complaints of melena and lightheadedness. At the time of the visit, blood tests showed Hb of 4.3 g/dL, suggesting severe anemia, and he exhibited repeated melena, even after ... ...

Abstract	A 63-year-old man visited an emergency outpatient unit with the chief complaints of melena and lightheadedness. At the time of the visit, blood tests showed Hb of 4.3 g/dL, suggesting severe anemia, and he exhibited repeated melena, even after hospitalization. Small intestinal bleeding was suspected during endoscopic examination of the lower gastrointestinal tract, and abdominalCT examination suggested a 3.5 cm tumor-like lesion in the jejunum. He was diagnosed as having bleeding of a tumor in the small intestine and consequently underwent laparoscopic surgery. Based on intraabdominal observation, Meckel 's diverticulum was confirmed in the jejunum, 100 cm from the ileocecal region, along with a 4 cm tumor in the upper jejunum, located 50 cm from Treitz's ligament. The tumor was visually confirmed to be sarcomatoid with no direct invasion to the surrounding tissues and no disseminated node, showing favorable mobility. These lesions were exteriorized from the abdominal cavity for resection and anastomosis, and the surgery was completed with no severe complications. It was diagnosed histopathologically as a gastrointestinal stromal tumor(GIST)in the small intestine, and no postoperative adjunctive chemotherapy was administered because the case was considered low risk based on the tumor diameter and the number of mitosis events. At present, 1 year after the surgery, the patient is under follow-up observation on an outpatient basis with no findings to suggest recurrence or metastasis.
MeSH term(s)	Gastrointestinal Stromal Tumors/complications ; Gastrointestinal Stromal Tumors/diagnostic imaging ; Gastrointestinal Stromal Tumors/surgery ; Humans ; Jejunal Neoplasms/complications ; Jejunal Neoplasms/diagnostic imaging ; Jejunal Neoplasms/pathology ; Jejunal Neoplasms/surgery ; Laparoscopy ; Male ; Melena/etiology ; Middle Aged ; Tomography, X-Ray Computed ; Treatment Outcome
Language	Japanese
Publishing date	2016-11
Publishing country	Japan
Document type	Case Reports ; Journal Article
ZDB-ID	604842-0
ISSN	0385-0684
ISSN	0385-0684
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