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Book ; Online: Kollektivierung als Herausforderung für das Strafrecht : Normentheoretische Betrachtungen

Papathanasiou, Katharina / Schumann, Kay H. / Schneider, Anne / Fernandes Godinho, Inês

2021

Keywords	LNF ; Norms theory ; collectivisation ; Protection of legal interests ; Attribution
Size	1 electronic resource (155 pages)
Publisher	Nomos Verlagsgesellschaft mbH and Company KG
Publishing place	Baden-Baden
Document type	Book ; Online
Note	German ; Open Access
HBZ-ID	HT021048619
ISBN	978-3-8487-6765-6 ; 3-8487-6765-1
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Clearing the Smoke: Underreporting of Smoking Status in Food and Drug Administration-Approved Bladder Cancer Therapeutic Trials.

Kay, Hannah / Matulewicz, Richard S / Bjurlin, Marc A

The Journal of urology

2024 Volume 211, Issue 4, Page(s) 611–613

MeSH term(s)	Humans ; Smoking/epidemiology ; United States/epidemiology ; United States Food and Drug Administration ; Urinary Bladder Neoplasms/drug therapy ; Urinary Bladder Neoplasms/epidemiology ; Clinical Trials as Topic
Language	English
Publishing date	2024-02-01
Publishing country	United States
Document type	Editorial
ZDB-ID	3176-8
ISSN	1527-3792 ; 0022-5347
ISSN (online)	1527-3792
ISSN	0022-5347
DOI	10.1097/JU.0000000000003853
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Ui VI Zs.91: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 331: Show issues

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Book ; Online: Rebalancing and Sustaining Growth in China

McKay, Huw / Song, Ligang

2012

Abstract: The idea that China's economy needs to rebalance is no longer controversial inside or outside the country. Whether it be the increasing recognition of ... ...

Abstract	The idea that China's economy needs to rebalance is no longer controversial inside or outside the country. Whether it be the increasing recognition of income
Keywords	Economic theory. Demography
Size	1 electronic resource ( p.)
Publisher	ANU Press
Document type	Book ; Online
Note	English ; Open Access
HBZ-ID	HT020088398
ISBN	9781921862793 ; 1921862793
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article: A case report on the development of sacroiliitis post laparoscopic appendicectomy for acute appendicitis: a rare cause of sacroiliitis in an adult.

McKay, Hannah / Suwanwalaikorn, Varit / Hassan, Mekki / Whelan, Maria

International journal of surgery case reports

2024 Volume 115, Page(s) 109305

Abstract: Introduction and importance: Acute appendicitis is the most common abdominal surgical emergency in the world and often requires surgical intervention. One of the complications of appendicitis is abscess formation. In rare cases, a localised abscess can ... ...

Abstract	Introduction and importance: Acute appendicitis is the most common abdominal surgical emergency in the world and often requires surgical intervention. One of the complications of appendicitis is abscess formation. In rare cases, a localised abscess can occur in the adjacent organs, such as the iliac and psoas muscles. Sacroiliitis occurring secondary to, or concomitant with, acute appendicitis is extremely rare. However, a missed diagnosis of either or both conditions can lead to serious complications, including mortality. Case presentation: A 27-year-old male patient presented to the emergency department with a history of acute severe right hip pain that was aggravated by movement and associated with nausea and vomiting. CT suggested acute uncomplicated appendicitis with no localised contamination. He underwent an emergent laparoscopy which showed mild appendiceal inflammation and appendicectomy was performed. He became septic a few hours after the operation, resulting in admission to the high dependency care unit for close observation. On review the following day, he reported ongoing right hip pain and lower back pain with a new onset inability to weight-bear. An MRI scan was performed which showed features of infection around the right sacroiliac joint and Staphylococcus aureus grew in his blood culture. A diagnosis of acute pyogenic sacroiliitis was then made. The patient was treated with IV antibiotics for a total of four weeks, followed by two weeks of oral antibiotics. Clinical discussion: Acute pyogenic sacroiliitis is one of the rarer conditions seen that can mimic the acute abdomen, in this case acute appendicitis. MRI is the best diagnostic modality in sacroiliitis, in comparison to CT for appendicitis. In most cases of acute appendicitis, mixed bacteria including aerobes and anaerobes are seen in the blood culture while staphylococcus aureus is seen mostly in acute pyogenic sacroiliitis. Staphylococcus aureus-induced appendicitis is reported in less than 3.7 % of cases. An early diagnosis of either or both conditions can significantly reduce complications and, more importantly, expedite implementation of appropriate treatment. Conclusion: In our case we present a combination acute appendicitis, acute sacroiliitis and staphylococcus aureus septicaemia and provide proof that acute pyogenic sacroiliitis can be a rare complication of acute appendicitis. Thus, a high clinical index of suspicion should be considered in the appropriate clinical scenario.
Language	English
Publishing date	2024-01-26
Publishing country	Netherlands
Document type	Case Reports
ISSN	2210-2612
ISSN	2210-2612
DOI	10.1016/j.ijscr.2024.109305
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Kinase-Catalyzed Biotinylation to Identify Phosphatase Substrates (K-BIPS).

Bremer, Hannah J / Pflum, Mary Kay H

Methods in molecular biology (Clifton, N.J.)

2023 Volume 2743, Page(s) 135–152

Abstract: Phosphorylation is a reversible post-translational modification that alters the functions of proteins to govern various cellular events, including cell signaling. Kinases catalyze the transfer of a phosphoryl group onto the hydroxyl residue of serine, ... ...

Abstract	Phosphorylation is a reversible post-translational modification that alters the functions of proteins to govern various cellular events, including cell signaling. Kinases catalyze the transfer of a phosphoryl group onto the hydroxyl residue of serine, threonine, and tyrosine, while phosphatases catalyze the removal. Unregulated kinase and phosphatase activity have been observed in various cancers and neurodegenerative diseases. Despite their importance in cell biology, the role of phosphatases in cellular events has yet to be fully characterized, partly due to the lack of tools to identify phosphatase-substrate pairs in a biological context. The method called kinase-catalyzed biotinylation to identify phosphatase substrates (K-BIPS) was developed to remedy the lack of information surrounding phosphatase biology, particularly focused on substrate identification. In the K-BIPS method, the γ-phosphoryl modified adenosine 5'-triphosphate (ATP) analog, ATP-biotin, is used by kinases to biotin-label phosphoproteins. Because phosphatases must initially remove a phosphoryl group for subsequent biotinylation by ATP-biotin, phosphatase substrates are identified in K-BIPS by comparing biotinylated proteins in the presence and absence of active phosphatases. K-BIPS has been used to discover novel substrates of both serine/threonine and tyrosine phosphatases. This chapter describes the K-BIPS method to enable the identification of substrates to any phosphatases of interest, which will augment studies of phosphatase biology.
MeSH term(s)	Biotinylation ; Phosphoric Monoester Hydrolases ; Adenosine Triphosphate ; Biotin ; Catalysis ; Serine ; Threonine ; Tyrosine
Chemical Substances	Phosphoric Monoester Hydrolases (EC 3.1.3.2) ; Adenosine Triphosphate (8L70Q75FXE) ; Biotin (6SO6U10H04) ; Serine (452VLY9402) ; Threonine (2ZD004190S) ; Tyrosine (42HK56048U)
Language	English
Publishing date	2023-12-26
Publishing country	United States
Document type	Journal Article
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-0716-3569-8_9
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Kinase-catalyzed Biotinylation with Inactivated Lysates for Discovery of Substrates (K-BILDS).

Gary, Chelsea R / Pflum, Mary Kay H

Current protocols

2023 Volume 3, Issue 8, Page(s) e851

Abstract: Protein phosphorylation is catalyzed by kinases to regulate a large variety of cellular activities, including growth and signal transduction. Methods to identify kinase substrates are crucial to fully understand phosphorylation-mediated cellular events ... ...

Abstract	Protein phosphorylation is catalyzed by kinases to regulate a large variety of cellular activities, including growth and signal transduction. Methods to identify kinase substrates are crucial to fully understand phosphorylation-mediated cellular events and disease states. Here, we report a set of protocols to identify substrates of a target kinase using Kinase-catalyzed Biotinylation with Inactivated Lysates for Discovery of Substrates (K-BILDS). As described in these protocols, K-BILDS involves inactivation of endogenous kinases in lysates, followed by addition of an active exogenous kinase and the γ-phosphate-modified ATP analog ATP-biotin for kinase-catalyzed biotinylation of cellular substrates. Avidin enrichment isolates biotinylated substrates of the active kinase, which can be monitored by western blot. Substrates of the target kinase can also be discovered using mass spectrometry analysis. Key advantages of K-BILDS include compatibility with any lysate, tissue homogenate, or complex mixture of biological relevance and any active kinase of interest. K-BILDS is a versatile method for studying or discovering substrates of a kinase of interest to characterize biological pathways thoroughly. © 2023 Wiley Periodicals LLC. Basic Protocol 1: FSBA treatment of lysates to inactivate kinases Basic Protocol 2: Kinase-catalyzed Biotinylation with Inactivated Lysates for Discovery of Substrates (K-BILDS).
MeSH term(s)	Biotinylation ; Phosphorylation ; Protein Kinases/chemistry ; Protein Kinases/metabolism ; Signal Transduction ; Catalysis
Chemical Substances	Protein Kinases (EC 2.7.-)
Language	English
Publishing date	2023-07-10
Publishing country	United States
Document type	Journal Article
ISSN	2691-1299
ISSN (online)	2691-1299
DOI	10.1002/cpz1.851
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Environmental and Circadian Regulation Combine to Shape the Rhythmic Selenoproteome.

Kay, Holly / Taylor, Harry / van Ooijen, Gerben

Cells

2022 Volume 11, Issue 3

Abstract: The circadian clock orchestrates an organism's endogenous processes with environmental 24 h cycles. Redox homeostasis and the circadian clock regulate one another to negate the potential effects of our planet's light/dark cycle on the generation of ... ...

Abstract	The circadian clock orchestrates an organism's endogenous processes with environmental 24 h cycles. Redox homeostasis and the circadian clock regulate one another to negate the potential effects of our planet's light/dark cycle on the generation of reactive oxygen species (ROS) and attain homeostasis. Selenoproteins are an important class of redox-related enzymes that have a selenocysteine residue in the active site. This study reports functional understanding of how environmental and endogenous circadian rhythms integrate to shape the selenoproteome in a model eukaryotic cell. We mined quantitative proteomic data for the 24 selenoproteins of the picoeukaryote
MeSH term(s)	Circadian Clocks/physiology ; Photoperiod ; Proteomics ; Reactive Oxygen Species ; Selenium
Chemical Substances	Reactive Oxygen Species ; Selenium (H6241UJ22B)
Language	English
Publishing date	2022-01-20
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells11030340
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Article ; Online: Kinase-Catalyzed Crosslinking and Immunoprecipitation (K-CLIP) to Explore Kinase-Substrate Pairs.

Beltman, Rachel J / Pflum, Mary Kay H

Current protocols

2022 Volume 2, Issue 9, Page(s) e539

Abstract: Kinases are responsible for phosphorylation of proteins and are involved in many biological processes, including cell signaling. Identifying the kinases that phosphorylate specific phosphoproteins is critical to augment the current understanding of ... ...

Abstract	Kinases are responsible for phosphorylation of proteins and are involved in many biological processes, including cell signaling. Identifying the kinases that phosphorylate specific phosphoproteins is critical to augment the current understanding of cellular events. Herein, we report a general protocol to study the kinases of a target substrate phosphoprotein using kinase-catalyzed crosslinking and immunoprecipitation (K-CLIP). K-CLIP uses a photocrosslinking γ-phosphoryl-modified ATP analog, such as ATP-arylazide, to covalently crosslink substrates to kinases with UV irradiation. Crosslinked kinase-substrate complexes can then be enriched by immunoprecipitating the target substrate phosphoprotein, with bound kinase(s) identified using Western blot or mass spectrometry analysis. K-CLIP is an adaptable chemical tool to investigate and discover kinase-substrate pairs, which will promote characterization of complex phosphorylation-mediated cell biology. © 2022 Wiley Periodicals LLC. Basic Protocol 1: Kinase-catalyzed crosslinking of lysates Basic Protocol 2: Kinase-catalyzed crosslinking and immunoprecipitation (K-CLIP).
MeSH term(s)	Adenosine Triphosphate ; Catalysis ; Immunoprecipitation ; Phosphoproteins/metabolism ; Phosphorylation
Chemical Substances	Phosphoproteins ; Adenosine Triphosphate (8L70Q75FXE)
Language	English
Publishing date	2022-12-06
Publishing country	United States
Document type	Journal Article
ISSN	2691-1299
ISSN (online)	2691-1299
DOI	10.1002/cpz1.539
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Unique contributions of perceptual and conceptual humanness to object representations in the human brain.

Grootswagers, Tijl / McKay, Harriet / Varlet, Manuel

NeuroImage

2022 Volume 257, Page(s) 119350

Abstract: The human brain is able to quickly and accurately identify objects in a dynamic visual world. Objects evoke different patterns of neural activity in the visual system, which reflect object category memberships. However, the underlying dimensions of ... ...

Abstract	The human brain is able to quickly and accurately identify objects in a dynamic visual world. Objects evoke different patterns of neural activity in the visual system, which reflect object category memberships. However, the underlying dimensions of object representations in the brain remain unclear. Recent research suggests that objects similarity to humans is one of the main dimensions used by the brain to organise objects, but the nature of the human-similarity features driving this organisation are still unknown. Here, we investigate the relative contributions of perceptual and conceptual features of humanness to the representational organisation of objects in the human visual system. We collected behavioural judgements of human-similarity of various objects, which were compared with time-resolved neuroimaging responses to the same objects. The behavioural judgement tasks targeted either perceptual or conceptual humanness features to determine their respective contribution to perceived human-similarity. Behavioural and neuroimaging data revealed significant and unique contributions of both perceptual and conceptual features of humanness, each explaining unique variance in neuroimaging data. Furthermore, our results showed distinct spatio-temporal dynamics in the processing of conceptual and perceptual humanness features, with later and more lateralised brain responses to conceptual features. This study highlights the critical importance of social requirements in information processing and organisation in the human brain.
MeSH term(s)	Brain/physiology ; Brain Mapping/methods ; Humans ; Judgment/physiology ; Magnetic Resonance Imaging ; Pattern Recognition, Visual/physiology ; Photic Stimulation
Language	English
Publishing date	2022-06-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1147767-2
ISSN	1095-9572 ; 1053-8119
ISSN (online)	1095-9572
ISSN	1053-8119
DOI	10.1016/j.neuroimage.2022.119350
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Zs.A 3664: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 7: Show issues

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Book ; Online ; Thesis: The role of the receptor kinase STRUBBELIG in the cell wall stress response

Lesniewska, Barbara [Verfasser] / Schneitz, Kay H. [Akademischer Betreuer] / Schneitz, Kay H. [Gutachter] / Poppenberger-Sieberer, Brigitte [Gutachter]

2023

Author's details	Barbara Lesniewska ; Gutachter: Kay H. Schneitz, Brigitte Poppenberger-Sieberer ; Betreuer: Kay H. Schneitz
Keywords	Naturwissenschaften ; Science
Subject code	sg500
Language	English
Publisher	Universitätsbibliothek der TU München
Publishing place	München
Document type	Book ; Online ; Thesis
Database	Digital theses on the web

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