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Article ; Online: Evaluation of fibrosis with noninvasive biochemical tests in chronic viral hepatitis B.

Kaya, Adem / Barutcu, Sezgin / Gulsen, Murat Taner

Hepatology forum

2023 Volume 4, Issue 1, Page(s) 25–29

Abstract: Background and aim: Early diagnosis and treatment of chronic hepatitis B (CHB) disease are important for the prevention of complications such as cirrhosis and hepatocellular cancer. Liver biopsy is an invasive, complicated, and expensive diagnostic ... ...

Abstract	Background and aim: Early diagnosis and treatment of chronic hepatitis B (CHB) disease are important for the prevention of complications such as cirrhosis and hepatocellular cancer. Liver biopsy is an invasive, complicated, and expensive diagnostic method, which is the gold standard for detecting fibrosis. The aim of this study was to investigate the role of these tests in predicting liver fibrosis and treatment decision. Materials and methods: A total of 1051 patients diagnosed with CHB between 2010 and 2020 in the Gaziantep University Gastroenterology Department were retrospectively evaluated. AAR, API, APRI, FIB-4, KING score, and FIBROQ score were calculated at the time of onset diagnosis. In addition, the Zeugma score, a new formula that is thought to be more sensitive and specific, was determined. Noninvasive fibrosis scores were compared according to the biopsy results of the patients. Results: In this study, the area values under the curve were 0.648 for the API score, 0.711 for the APRI score, 0.716 for the FIB-4 score, 0.723 for the KING score, 0.595 for the FIBROQ score, and 0.701 for the Zeugma score (p<0.05). No statistically significant difference was obtained for the AAR score. The KING, FIB-4, APRI, and Zeugma scores were the best indicators for detecting advanced fibrosis. For KING, FIB-4, APRI, and Zeugma scores, the cutoff value for the prediction of advanced fibrosis were ≥8.67, ≥0.94, ≥16.24, and ≥9.63 with a sensitivity of 50.52%, 56.77%, 59.64%, and 52.34%, specificity of 87.26%, 74.96%, 73.61%, and 78.11%, respectively (p<0.05). In our study, we compared the globulin and GGT parameters with fibrosis, which we used in the Zeugma score formula. Globulin and GGT mean values were significantly higher in the fibrosis group (p<0.05). There was a statistically significant correlation between fibrosis and globulin and GGT values (p<0.05, r=0.230 and p<0.05, r=0.305, respectively). Conclusion: The KING score was found to be the most reliable method for the noninvasive detection of hepatic fibrosis in patients with chronic HBV. The FIB-4, APRI, and Zeugma scores were also shown to be effective in determining liver fibrosis. It was shown that the AAR score was not sufficient for detecting hepatic fibrosis. The Zeugma score, a novel noninvasive test, is a useful and easy tool to evaluate liver fibrosis in patients with chronic HBV and has better accuracy than AAR, API, and FIBROQ.
Language	English
Publishing date	2023-01-17
Publishing country	Turkey
Document type	Journal Article
ISSN	2757-7392
ISSN (online)	2757-7392
DOI	10.14744/hf.2022.2022.0025
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Article: Ecofriendly Usability of Mushroom Cultivation Substrate as a Ruminant Feed: Anaerobic Digestion Using Gas Production Techniques

Palangi, Valiollah / Kaya, Adem / Kaya, Ali / Giannenas, Ilias

Animals. 2022 June 19, v. 12, no. 12

2022

Abstract: The current study was carried out to evaluate the nutritive value of mushroom-uncultivated and -cultivated substrates, and their in vitro gas and methane production. The experiment was conducted in a completely randomized design, and analyzed with GLM ... ...

Abstract	The current study was carried out to evaluate the nutritive value of mushroom-uncultivated and -cultivated substrates, and their in vitro gas and methane production. The experiment was conducted in a completely randomized design, and analyzed with GLM using SAS 9.4. Analysis of the structural morphology of mushroom-cultivated substrate was performed using a scanning electron microscope. Mushroom cultivation led to lower ether extract, acid detergent fiber, and crude fiber level of substrate (p < 0.05). Mushroom-cultivated substrate showed higher in vitro cumulative gas production (p < 0.05). Moreover, mushroom cultivation led to a higher sample surface, and improved the microorganisms’ access to feed materials, thus stimulating rumen fermentation and increasing methane production (p < 0.05). The organic matter digestibility, metabolizable energy, and net energy lactation values were higher for mushroom-cultivated substrate than uncultivated substrate. The results demonstrate that mushroom-cultivation not only increases the contact surface of cellulose, leading to higher ruminal microorganisms’ access to feedstuff, but could also had higher nutritive value; this material might be used in ruminant ration formulation, to reduce environmental pollution and feed costs.
Keywords	acid detergent fiber ; anaerobic digestion ; cellulose ; crude fiber ; digestible organic matter ; energy ; feeds ; fermentation ; lactation ; metabolizable energy ; methane production ; mushroom growing ; pollution ; ruminants
Language	English
Dates of publication	2022-0619
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2606558-7
ISSN	2076-2615
ISSN	2076-2615
DOI	10.3390/ani12121583
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Article ; Online: Prediction of prognosis and outcome of patients with pulmonary embolism in the emergency department using early warning scores and qSOFA score.

Yolcu, Sadiye / Kaya, Adem / Yilmaz, Nurettin

The Journal of international medical research

2022 Volume 50, Issue 10, Page(s) 3000605221129915

Abstract: Objective: To determine the prediction ability of the National Early Warning Score (NEWS), National Early Warning Score 2 (NEWS2), and quick Sequential Organ Failure Assessment (qSOFA) score for the prognosis of pulmonary embolism (PE) in the emergency ... ...

Abstract	Objective: To determine the prediction ability of the National Early Warning Score (NEWS), National Early Warning Score 2 (NEWS2), and quick Sequential Organ Failure Assessment (qSOFA) score for the prognosis of pulmonary embolism (PE) in the emergency department. Methods: This retrospective study involved 245 patients with PE. The NEWS, NEWS2, and qSOFA scores were compared according to the hospitalization clinic (ward vs. intensive care unit), hospitalization length (<10 vs. >10 days), severity of embolism (massive vs. submassive), and outcome (discharged vs. died). Results: The areas under the curve of the NEWS, NEWS2, and qSOFA score for 1-week mortality were 0.854 (sensitivity, 78%; specificity, 73%; cutoff, 7.5; confidence interval, 0.807-0.902), 0.870 (sensitivity, 83%; specificity, 73%; cutoff, 5.5; confidence interval, 0.825-0.915), and 0.789 (sensitivity, 83%; specificity, 51%; cutoff, 0.5; confidence interval, 0.720-0.858), respectively. Conclusion: The NEWS2 more accurately predicts 1-week mortality than do the NEWS and qSOFA score in patients with PE.
MeSH term(s)	Early Warning Score ; Emergency Service, Hospital ; Hospital Mortality ; Humans ; Organ Dysfunction Scores ; Prognosis ; Pulmonary Embolism/diagnosis ; ROC Curve ; Retrospective Studies ; Sepsis
Language	English
Publishing date	2022-10-11
Publishing country	England
Document type	Journal Article
ZDB-ID	184023-x
ISSN	1473-2300 ; 0300-0605 ; 0142-2596
ISSN (online)	1473-2300
ISSN	0300-0605 ; 0142-2596
DOI	10.1177/03000605221129915
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Article: Ecofriendly Usability of Mushroom Cultivation Substrate as a Ruminant Feed: Anaerobic Digestion Using Gas Production Techniques.

Palangi, Valiollah / Kaya, Adem / Kaya, Ali / Giannenas, Ilias

Animals : an open access journal from MDPI

2022 Volume 12, Issue 12

Abstract	The current study was carried out to evaluate the nutritive value of mushroom-uncultivated and -cultivated substrates, and their in vitro gas and methane production. The experiment was conducted in a completely randomized design, and analyzed with GLM using SAS 9.4. Analysis of the structural morphology of mushroom-cultivated substrate was performed using a scanning electron microscope. Mushroom cultivation led to lower ether extract, acid detergent fiber, and crude fiber level of substrate (p < 0.05). Mushroom-cultivated substrate showed higher in vitro cumulative gas production (p < 0.05). Moreover, mushroom cultivation led to a higher sample surface, and improved the microorganisms’ access to feed materials, thus stimulating rumen fermentation and increasing methane production (p < 0.05). The organic matter digestibility, metabolizable energy, and net energy lactation values were higher for mushroom-cultivated substrate than uncultivated substrate. The results demonstrate that mushroom-cultivation not only increases the contact surface of cellulose, leading to higher ruminal microorganisms’ access to feedstuff, but could also had higher nutritive value; this material might be used in ruminant ration formulation, to reduce environmental pollution and feed costs.
Language	English
Publishing date	2022-06-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606558-7
ISSN	2076-2615
ISSN	2076-2615
DOI	10.3390/ani12121583
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Article: Comparison of Black Tea Waste and Legume Roughages: Methane Mitigation and Rumen Fermentation Parameters.

Sezmis, Gurkan / Kaya, Adem / Kaya, Hatice / Macit, Muhlis / Erten, Kadir / Palangi, Valiollah / Lackner, Maximilian

Metabolites

2023 Volume 13, Issue 6

Abstract: The chemical composition, in vitro total gas and ... ...

Abstract	The chemical composition, in vitro total gas and CH
Language	English
Publishing date	2023-06-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662251-8
ISSN	2218-1989
ISSN	2218-1989
DOI	10.3390/metabo13060731
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Article ; Online: Comparison of national early warning score-2 and qSOFA in predicting the prognosis of older adults with altered mental status.

Tapsiz, Hatice / Yolcu, Sadiye / Yilmaz, Nurettin / Tunc, Mehmet / Kaya, Adem / Avci, Akkan

Irish journal of medical science

2022 Volume 192, Issue 3, Page(s) 1355–1359

Abstract: Background: Altered mental status occurs in one in four older adults, and the risk increases with age. Numerous scoring systems have been improved to predict mortality, but data are limited for these scoring systems to interpret older adult patients.: ...

Abstract	Background: Altered mental status occurs in one in four older adults, and the risk increases with age. Numerous scoring systems have been improved to predict mortality, but data are limited for these scoring systems to interpret older adult patients. Aim: We aimed to compare qSOFA and National Early Warning Score-2 (NEWS2) scores in predicting the prognosis of older adults with altered mental status. Method: We included 500 older adults with altered mental status. We noted the qSOFA and NEWS2 scores of the patients. We compared the qSOFA and NEWS2 scores for the prediction of 30-day mortality, 48-h mortality, hospitalization clinic, outcome, and hospitalization length. Results: The mean NEWS2 score was 6.4, and the mean qSOFA score was 1.3. For 30-day mortality, the sensitivity and specificity of the NEWS2 score ≥ 5 were 68.29% and 69.6%, respectively, and those of qSOFA score > 1 were 47.14% and 78.75%, respectively. AUC values for 30-day mortality prediction were 0,725 (CI: 0.683-0.763) and 0.631 (CI: 0.587-0.673). For intensive care unit hospitalization prediction, the sensitivity and specificity of the NEWS2 score ≥ 5 were 52.73% and 77.67%, respectively, and those of qSOFA score > 1 were 35.32% and 81.55%, respectively. In patients with a NEWS2 score > 10 points, the predicted 48-h mortality had a specificity of 80.6%, which was higher than the qSOFA score. Conclusion: NEWS2 score can be used to predict 48-h mortality, 30-day mortality, and intensive care unit hospitalization compared with qSOFA in older adults with altered mental status.
MeSH term(s)	Humans ; Aged ; Early Warning Score ; Organ Dysfunction Scores ; Retrospective Studies ; Hospital Mortality ; Prognosis ; ROC Curve ; Sepsis
Language	English
Publishing date	2022-07-18
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	390895-1
ISSN	1863-4362 ; 0021-1265
ISSN (online)	1863-4362
ISSN	0021-1265
DOI	10.1007/s11845-022-03102-x
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Article ; Online: Adding eosinophil count to EMERALD rules predicts subarachnoid haemorrhage better in emergency department.

Kaya, Adem / Satar, Salim / Gulen, Muge / Acehan, Selen / Afser, Kemal Alper / Demirhindi, Hakan

Irish journal of medical science

2022 Volume 192, Issue 3, Page(s) 1453–1462

Abstract: Background: Subarachnoid haemorrhage (SAH) clinical decision rules can provide successful results in the differential diagnosis of non-traumatic headache.: Aim: The aim of this study is to investigate whether a laboratory parameter that can be added ... ...

Abstract	Background: Subarachnoid haemorrhage (SAH) clinical decision rules can provide successful results in the differential diagnosis of non-traumatic headache. Aim: The aim of this study is to investigate whether a laboratory parameter that can be added to clinical decision-making rules can better predict subarachnoid haemorrhages in patients presenting to the emergency department with headache. Methods: We conducted a retrospective cohort study between March 2017 and March 2019. Patients over the age of 18 who admitted to the emergency department with non-traumatic, acute headache last 14 days before admission and evaluated by imaging and laboratory studies were included in the study. Results: A total of 867 patients were included and 141 of them had SAH. In detecting the SAH, Ottawa SAH rule sensitivity (85.1%), specificity (47.1%), positive predictive value (PPV) (23.8%) and negative predictive value (NPV) (94.2%), and for EMERALD SAH, rule sensitivity (96.4%), specificity (43.2%), PPV (24.8%) and NPV (98.4%). In the regression analysis, statistically significant result was obtained to exclude the diagnosis of SAH with the decrease in the eosinophil value (cutoff < 0.085 10^3/µL, OR: 0.011, 95% CI: 0.001-0.213, p = 0.003). When eosinophil value was added to EMERALD SAH rule, it provided a 100% of sensitivity, a 38.4% of specificity, a 24% of PPV and a 100% of NPV in detecting the SAH. Conclusions: EMERALD SAH rule plus eosinophil, which offers 100% sensitivity and NPV for predicting SAH in adult non-traumatic headaches, may be recommended as a successful and practical decision rule for clinical use according to the Ottawa and EMERALD SAH rule.
MeSH term(s)	Adult ; Humans ; Middle Aged ; Retrospective Studies ; Subarachnoid Hemorrhage/diagnostic imaging ; Eosinophils ; Sensitivity and Specificity ; Acute Disease ; Headache/diagnosis ; Headache/etiology ; Emergency Service, Hospital
Language	English
Publishing date	2022-07-25
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	390895-1
ISSN	1863-4362 ; 0021-1265
ISSN (online)	1863-4362
ISSN	0021-1265
DOI	10.1007/s11845-022-03106-7
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Article: Effects of supplementation of dietary humate, probiotic, and their combination on performance, egg quality, and yolk fatty acid composition of laying hens

Macit, Muhlis / Karaoglu, Mevlut / Celebi, Saban / Esenbuga, Nurinisa / Yoruk, M. Akif / Kaya, Adem

Tropical animal health and production. 2021 Mar., v. 53, no. 1

2021

Abstract: This study was carried out to determine the effects of addition of humate, probiotic, and their combination into diets on performance, egg quality, and yolk fatty acid composition of hens during the second laying period. Lohmann LSL white layers (n = 192) ...

Abstract	This study was carried out to determine the effects of addition of humate, probiotic, and their combination into diets on performance, egg quality, and yolk fatty acid composition of hens during the second laying period. Lohmann LSL white layers (n = 192), 46 weeks of age, were randomly divided into 4 groups and fed with basal diet (control, C), 0.3% humate (H), 0.3% probiotic (P), 0.15% humate + 0.15% probiotic (HP) for 18 weeks. Feed consumption and egg production were determined daily, egg weight was measured biweekly, and body weights were recorded at the beginning and the end of the experiment. Also, 12 egg samples from each group were randomly collected to determine the egg quality every 30 days. Laying performance, yolk color, and fatty acid composition were significantly (P < 0.05 and P < 0.01) affected by addition of humate, probiotic, and their combination into diets of layers. The HP group had higher cracked egg yield and feed conversion ratio values than control and H and P groups. Except for egg yolk color, the other egg quality parameters such as shape index, shell strength, shell thickness, albumen index, yolk index, and Haught unit were not affected by treatment (P < 0.05 and P < 0.01). The egg yolks of treatment groups had less stearic acid than those of control group. In conclusion, supplementation of humate and probiotic into the diets of laying hens increased monounsaturated fatty acids in yolk and improved feed conversion ratio and egg yolk color.
Keywords	animal health ; color ; dietary supplements ; egg production ; egg weight ; egg yolk color ; eggs ; fatty acid composition ; feed conversion ; feed intake ; probiotics ; stearic acid
Language	English
Dates of publication	2021-03
Size	p. 63.
Publishing place	Springer Netherlands
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	603363-5
ISSN	1573-7438 ; 0049-4747
ISSN (online)	1573-7438
ISSN	0049-4747
DOI	10.1007/s11250-020-02546-6
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Article: Determination of fatty acids and vitamins A, D and E intake through fish consumption

Yerlikaya, Pinar / Alp, Ali Can / Tokay, Fahrettin Gokhun / Aygun, Tugce / Kaya, Adem / Topuz, Osman Kadir / Yatmaz, Hanife Aydan

International journal of food science & technology. 2022 Jan., v. 57, no. 1

2022

Abstract: PUFA consumption, especially the balance among fatty acids and vitamins present in seafood, is important for a healthy life. Marine‐derived organisms are good sources of recommended high EPA+DHA, vitamins A, D and E, UI, and balanced n‐3/n‐6 ratio ... ...

Abstract	PUFA consumption, especially the balance among fatty acids and vitamins present in seafood, is important for a healthy life. Marine‐derived organisms are good sources of recommended high EPA+DHA, vitamins A, D and E, UI, and balanced n‐3/n‐6 ratio whether wild or cultured. The aim of this study was to reveal the fatty acid profile related to recommended health aspects and the presence of such vitamins of commonly consumed fish species (anchovy, mackerel, sea bream, sea bass, salmon and trout) in the north‐eastern Mediterranean. It was found that despite its high lipid content (15.31 ± 1.16%), salmon remained poor in terms of PUFA; meanwhile, anchovy and mackerel had remarkable EPA and DHA. The highest PUFA content (47.25 ± 1.69%) was determined in sea bream owing to respectable linoleic acid content. PUFA/SFA value was found nearly three times higher than the recommended value of 0.4. The highest n‐3/n‐6 ratio was found in anchovy (13.19 ± 0.28). The advised lower AI and TI values were obtained in salmon. Meanwhile, higher UI values were recorded in anchovy and mackerel samples. Alpha‐tocopherol was 25.50 μg g⁻¹ in salmon, followed by sea bream, mackerel and trout. Cholecalciferol was not determined in any of the samples. Retinyl palmitate was ranged between 5.65 and 6.60 μg g⁻¹.
Keywords	Sparidae ; alpha-tocopherol ; anchovies ; bass ; cholecalciferol ; fatty acid composition ; fish consumption ; food science ; linoleic acid ; lipid content ; mackerel ; retinyl palmitate ; salmon ; seafoods ; technology ; trout
Language	English
Dates of publication	2022-01
Size	p. 653-661.
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	JOURNAL ARTICLE
ZDB-ID	883561-5
ISSN	0950-5423
ISSN	0950-5423
DOI	10.1111/ijfs.15435
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Activated Charcoal and Poisoning: Is It Really Effective?

Aksay, Erdem / Kaya, Adem / Gulen, Muge / Acehan, Selen / Isıkber, Cem / Sahin, Gonca / Satar, Salim

American journal of therapeutics

2021 Volume 29, Issue 2, Page(s) e182–e192

Abstract: Background: This study aims to compare the poisoned patients who could not be administered activated charcoal because of its unavailability with the poisoned patients who were administered charcoal in the later period and to reveal the results about its ...

Abstract	Background: This study aims to compare the poisoned patients who could not be administered activated charcoal because of its unavailability with the poisoned patients who were administered charcoal in the later period and to reveal the results about its effectiveness. Study question: Is the use of activated charcoal effective against poisoning caused by oral medication? Study design: This retrospective cohort study with historical control was planned at a tertiary hospital. Patients older than 18 years were admitted to the emergency department because of oral drug poisoning during the study periods. A total of 1159 patients who were not given activated charcoal and 877 patients who were given activated charcoal were included in this study. Measures and outcomes: The frequency of clinical findings secondary to the drug taken, the frequency of antidote use, the frequency of intubation, and the hospitalization length were determined as clinical outcome parameters. Results: There was no statistically significant difference in the development of central nervous system findings, cardiovascular system findings, frequency of intubation, and blood gas disorders, as well as the length of hospitalization periods according to the activated charcoal application. Hepatobiliary system findings and electrolyte disturbances were found to be less common in patients given activated charcoal. The frequency of tachycardia, speech impairment, coma, and respiratory acidosis was found to be statistically higher in patients who were administered activated charcoal. The hospitalization period of the patients who were given activated charcoal was longer in patients with drug findings; however, there was no difference in the hospitalization periods of the patients who were given an antidote. Conclusions: The use of activated charcoal in poisoned patients may not provide sufficient clinical benefits. However, clinical studies with strong evidence levels are needed to determine activated charcoal's clinical efficacy, which is still used as a universal antidote.
MeSH term(s)	Antidotes ; Charcoal ; Humans ; Poisoning/drug therapy ; Poisoning/epidemiology ; Poisons ; Retrospective Studies
Chemical Substances	Antidotes ; Poisons ; Charcoal (16291-96-6)
Language	English
Publishing date	2021-08-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	1280786-2
ISSN	1536-3686 ; 1075-2765
ISSN (online)	1536-3686
ISSN	1075-2765
DOI	10.1097/MJT.0000000000001422
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