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  1. Book ; Thesis: Beteiligung der Laktatdehydrogenase B an der Troponin I induzierten Autoimmunmyokarditis

    Salbach, Christian / Kaya, Ziya

    2021  

    Institution Universität Heidelberg
    Author's details vorgelegt von Christian Arne Salbach ; Doktorvater: Herr Prof. Dr. med. Ziya Kaya
    Language German
    Size 104 Blätter, Illustrationen, Diagramme, 30 cm
    Publishing place Heidelberg
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Ruprecht-Karls-Universität Heidelberg, 2022
    HBZ-ID HT021740134
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2023 E 459 order for loan Magazin

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  2. Book ; Thesis: Osteoprotegerin und Adiponektin in der Pathogenese der experimentellen Autoimmunmyokarditis

    Stroikova, Vera / Kaya, Ziya

    2019  

    Institution Universität Heidelberg
    Author's details vorgelegt von Vera Stroikova ; Doktorvater: Herr Prof. Dr. med. Ziya Kaya
    Language German
    Size 75 Blätter, Illustrationen, Diagramme, 30 cm
    Publishing place Heidelberg
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Ruprecht-Karls-Universität Heidelberg, 2020
    HBZ-ID HT020632364
    Database Catalogue ZB MED Medicine, Health

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  3. Book ; Thesis: Die Beteiligung des Immunoproteasoms und der Laktatdehydrogenase B an der Pathogenese der Autoimmunmyokarditis

    Bockstahler, Mariella / Fricker, Gert / Kaya, Ziya

    2018  

    Institution Universität Heidelberg
    Author's details vorgelegt von M.Sc. Molekulare Biotechnologie Mariella Alexandra Bockstahler
    Language German
    Size Seite A-N, 110, XX Seiten, Illustrationen, Diagramme, 30 cm
    Publishing place Heidelberg
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Ruprecht-Karls-Universität Heidelberg, 2018
    Note Zusammenfassungen in deutscher und englischer Sprache
    HBZ-ID HT020364079
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

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    2020 E 207 order for loan Magazin

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  4. Article ; Online: Cardiac Troponin I autoantibodies and their potential role in cardiac remodelling.

    Salbach, Christian / Kaya, Ziya

    EBioMedicine

    2019  Volume 48, Page(s) 11–12

    MeSH term(s) Autoantibodies/immunology ; Autoantigens/immunology ; Humans ; Myocardium/immunology ; Myocardium/metabolism ; Troponin I/immunology ; Ventricular Remodeling/immunology
    Chemical Substances Autoantibodies ; Autoantigens ; Troponin I
    Language English
    Publishing date 2019-09-14
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 2851331-9
    ISSN 2352-3964
    ISSN (online) 2352-3964
    DOI 10.1016/j.ebiom.2019.09.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 7090: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  5. Book ; Thesis: Trends bei der Implantation von Herzschrittmachern

    Kaya, Ziya

    Analyse eines 4-Jahres-Zeitraumes an 43865 Patienten

    1998  

    Author's details Ziya Kaya
    Language German
    Size 77 Bl. : graph. Darst.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Ulm, Univ., Diss., 1998
    HBZ-ID HT010406433
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

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  6. Article ; Online: No Evidence for Myocarditis or Other Organ Affection by Induction of an Immune Response against Critical SARS-CoV-2 Protein Epitopes in a Mouse Model Susceptible for Autoimmunity.

    Ignatz, Rebecca Maria / Zirkenbach, Vanessa Antje / Kaya, Mansur / Stroikova, Vera / Öttl, Renate / Frey, Norbert / Kaya, Ziya

    International journal of molecular sciences

    2023  Volume 24, Issue 12

    Abstract: ... ...

    Abstract After
    MeSH term(s) Mice ; Humans ; Animals ; SARS-CoV-2 ; Autoimmunity ; COVID-19 ; Myocarditis/etiology ; Epitopes ; Post-Acute COVID-19 Syndrome ; Peptides ; Autoimmune Diseases/etiology ; Inflammation
    Chemical Substances Epitopes ; Peptides
    Language English
    Publishing date 2023-06-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24129873
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Exploration of Analgesia with Tramadol in the Coxsackievirus B3 Myocarditis Mouse Model

    Pinkert, Sandra / Kespohl, Meike / Kelm, Nicolas / Kaya, Ziya / Heuser, Arnd / Klingel, Karin / Beling, Antje

    Viruses. 2021 June 24, v. 13, no. 7

    2021  

    Abstract: Infection of mice with Coxsackievirus B3 (CVB3) triggers inflammation of the heart and this mouse model is commonly used to investigate underlying mechanisms and therapeutic aspects for viral myocarditis. Virus-triggered cytotoxicity and the activity of ... ...

    Abstract Infection of mice with Coxsackievirus B3 (CVB3) triggers inflammation of the heart and this mouse model is commonly used to investigate underlying mechanisms and therapeutic aspects for viral myocarditis. Virus-triggered cytotoxicity and the activity of infiltrating immune cells contribute to cardiac tissue injury. In addition to cardiac manifestation, CVB3 causes cell death and inflammation in the pancreas. The resulting pancreatitis represents a severe burden and under such experimental conditions, analgesics may be supportive to improve the animals’ well-being. Notably, several known mechanisms exist by which analgesics can interfere with the immune system and thereby compromise the feasibility of the model. We set up a study aiming to improve animal welfare while ensuring model integrity and investigated how tramadol, an opioid, affects virus-induced pathogenicity and immune response in the heart. Tramadol was administered seven days prior to a CVB3 infection in C57BL/6 mice and treatment was continued until the day of analysis. Tramadol had no effect on the virus titer or viral pathogenicity in the heart tissue and the inflammatory response, a hallmark of myocardial injury, was maintained. Our results show that tramadol exerts no disruptive effects on the CVB3 myocarditis mouse model and, therefore, the demonstrated protocol should be considered as a general analgesic strategy for CVB3 infection.
    Keywords analgesia ; analgesics ; animal welfare ; cell death ; cytotoxicity ; heart ; immune response ; immune system ; inflammation ; mice ; myocarditis ; pancreas ; pancreatitis ; pathogenicity ; viral load
    Language English
    Dates of publication 2021-0624
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2516098-9
    ISSN 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v13071222
    Database NAL-Catalogue (AGRICOLA)

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  8. Article ; Online: Exploration of Analgesia with Tramadol in the Coxsackievirus B3 Myocarditis Mouse Model.

    Pinkert, Sandra / Kespohl, Meike / Kelm, Nicolas / Kaya, Ziya / Heuser, Arnd / Klingel, Karin / Beling, Antje

    Viruses

    2021  Volume 13, Issue 7

    Abstract: Infection of mice with Coxsackievirus B3 (CVB3) triggers inflammation of the heart and this mouse model is commonly used to investigate underlying mechanisms and therapeutic aspects for viral myocarditis. Virus-triggered cytotoxicity and the activity of ... ...

    Abstract Infection of mice with Coxsackievirus B3 (CVB3) triggers inflammation of the heart and this mouse model is commonly used to investigate underlying mechanisms and therapeutic aspects for viral myocarditis. Virus-triggered cytotoxicity and the activity of infiltrating immune cells contribute to cardiac tissue injury. In addition to cardiac manifestation, CVB3 causes cell death and inflammation in the pancreas. The resulting pancreatitis represents a severe burden and under such experimental conditions, analgesics may be supportive to improve the animals' well-being. Notably, several known mechanisms exist by which analgesics can interfere with the immune system and thereby compromise the feasibility of the model. We set up a study aiming to improve animal welfare while ensuring model integrity and investigated how tramadol, an opioid, affects virus-induced pathogenicity and immune response in the heart. Tramadol was administered seven days prior to a CVB3 infection in C57BL/6 mice and treatment was continued until the day of analysis. Tramadol had no effect on the virus titer or viral pathogenicity in the heart tissue and the inflammatory response, a hallmark of myocardial injury, was maintained. Our results show that tramadol exerts no disruptive effects on the CVB3 myocarditis mouse model and, therefore, the demonstrated protocol should be considered as a general analgesic strategy for CVB3 infection.
    MeSH term(s) Analgesia/methods ; Animals ; Coxsackievirus Infections/complications ; Disease Models, Animal ; Enterovirus B, Human/pathogenicity ; Heart/drug effects ; Heart/virology ; Male ; Mice ; Mice, Inbred C57BL ; Myocarditis/drug therapy ; Myocarditis/virology ; Tramadol/pharmacology ; Tramadol/therapeutic use ; Viral Load/drug effects ; Virus Replication/drug effects
    Chemical Substances Tramadol (39J1LGJ30J)
    Language English
    Publishing date 2021-06-24
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v13071222
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Effect of SARS-CoV-2 mRNA-Vaccine on the Induction of Myocarditis in Different Murine Animal Models.

    Zirkenbach, Vanessa A / Ignatz, Rebecca M / Öttl, Renate / Cehreli, Zeynep / Stroikova, Vera / Kaya, Mansur / Lehmann, Lorenz H / Preusch, Michael R / Frey, Norbert / Kaya, Ziya

    International journal of molecular sciences

    2023  Volume 24, Issue 5

    Abstract: In the course of the SARS-CoV-2 pandemic, vaccination safety and risk factors of SARS-CoV-2 mRNA-vaccines were under consideration after case reports of vaccine-related side effects, such as myocarditis, which were mostly described in young men. However, ...

    Abstract In the course of the SARS-CoV-2 pandemic, vaccination safety and risk factors of SARS-CoV-2 mRNA-vaccines were under consideration after case reports of vaccine-related side effects, such as myocarditis, which were mostly described in young men. However, there is almost no data on the risk and safety of vaccination, especially in patients who are already diagnosed with acute/chronic (autoimmune) myocarditis from other causes, such as viral infections, or as a side effect of medication and treatment. Thus, the risk and safety of these vaccines, in combination with other therapies that could induce myocarditis (e.g., immune checkpoint inhibitor (ICI) therapy), are still poorly assessable. Therefore, vaccine safety, with respect to worsening myocardial inflammation and myocardial function, was studied in an animal model of experimentally induced autoimmune myocarditis. Furthermore, it is known that ICI treatment (e.g., antibodies (abs) against PD-1, PD-L1, and CTLA-4, or a combination of those) plays an important role in the treatment of oncological patients. However, it is also known that treatment with ICIs can induce severe, life-threatening myocarditis in some patients. Genetically different A/J (most susceptible strain) and C57BL/6 (resistant strain) mice, with diverse susceptibilities for induction of experimental autoimmune myocarditis (EAM) at various age and gender, were vaccinated twice with SARS-CoV-2 mRNA-vaccine. In an additional A/J group, an autoimmune myocarditis was induced. In regard to ICIs, we tested the safety of SARS-CoV-2 vaccination in PD-1
    MeSH term(s) Male ; Animals ; Humans ; Mice ; Mice, Inbred C57BL ; Myocarditis ; COVID-19 Vaccines ; CTLA-4 Antigen ; SARS-CoV-2 ; Programmed Cell Death 1 Receptor ; COVID-19 ; Inflammation ; Drug-Related Side Effects and Adverse Reactions ; Antibodies ; Models, Animal ; RNA, Messenger ; Vaccination
    Chemical Substances COVID-19 Vaccines ; CTLA-4 Antigen ; Programmed Cell Death 1 Receptor ; Antibodies ; RNA, Messenger
    Language English
    Publishing date 2023-03-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24055011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Book: Role of the ubiquitin proteasome system in autoimmune inflammatory heart disease

    Voigt, Antje / Kaya, Ziya

    Schlussbericht ; Laufzeit des Projektes: 01.09.2013 - 31.12.2013

    2014  

    Title variant ubiquitin-proteasome-system
    Author's details [Autoren: Antje Voigt; Ziya Kaya]. Projektleiter: Antje Voigt
    Language German
    Size 3 Bl.
    Publisher Charité Univ.-Medizin
    Publishing place Berlin
    Document type Book
    Note Text dt. ; Förderkennzeichen BMBF 81X2100204
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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