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  1. Article ; Online: Liposome-Nanogel Structures for Future Pharmaceutical Applications: An Updated Review.

    Kazakov, Sergey

    Current pharmaceutical design

    2016  Volume 22, Issue 10, Page(s) 1391–1413

    Abstract: Nature uses combination of lipid bilayers and cross-linked macromolecular networks to achieve workability, multifunctionality, and dynamism in living cells of different types. Despite the concept of liposome-nanogel structures (lipobeads) is known for ... ...

    Abstract Nature uses combination of lipid bilayers and cross-linked macromolecular networks to achieve workability, multifunctionality, and dynamism in living cells of different types. Despite the concept of liposome-nanogel structures (lipobeads) is known for about 30 years, lipobead-based drug delivery systems are still largely experimental. The data available on nano- and giant lipobeads are reviewed to demonstrate technological achievability of lipobeads and to support the expectations that additional expenses on their production will be reimbursed by the potential advantages of their use. Indeed, lipobeads exhibit the properties attractive for the next generation of drug delivery systems: (i) retaining all the important benefits of polymeric and liposomal drug carriers, the hydrogel core brings mechanical stability and environmental responsiveness to the formulation in one construct, (ii) lipobeaddelivered combination therapy shows no toxicity on intravenously administered mice, accumulation of drug-loaded lipobeads both in the area surrounding tumor and within the tumor itself outside the vasculature, high therapeutic activity at the targeted site, and drastically increased survival, (iii) bipartite structure of lipobeads can provide a number of novel and unique options (e.g., consecutive multistep triggering and combined drug delivery systems). In addition, some ideas on the conceptually new drug delivery systems, new mechanisms of lipobead internalization into the cell and new schemes of drug release regulated by specific signaling are discussed.
    MeSH term(s) Animals ; Drug Carriers/chemistry ; Drug Delivery Systems ; Humans ; Liposomes/chemistry ; Mice ; Polyethylene Glycols/chemistry ; Polyethyleneimine/chemistry ; Polymers/chemistry
    Chemical Substances Drug Carriers ; Liposomes ; NanoGel ; Polymers ; Polyethylene Glycols (3WJQ0SDW1A) ; Polyethyleneimine (9002-98-6)
    Language English
    Publishing date 2016-01-22
    Publishing country United Arab Emirates
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1304236-1
    ISSN 1873-4286 ; 1381-6128
    ISSN (online) 1873-4286
    ISSN 1381-6128
    DOI 10.2174/1381612822666160125114733
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4714: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Degradation Kinetics of Disulfide Cross-Linked Microgels: Real-Time Monitoring by Confocal Microscopy.

    Mercer, Iris G / Italiano, Angelina N / Gazaryan, Irina G / Steiner, Aaron B / Kazakov, Sergey V

    Gels (Basel, Switzerland)

    2023  Volume 9, Issue 10

    Abstract: Although biodegradable microgels represent a useful drug delivery system, questions remain regarding the kinetics of gel degradation and subsequent drug release. Spherical microgels (~Ø10-300 µm) were synthesized using an inverse suspension ... ...

    Abstract Although biodegradable microgels represent a useful drug delivery system, questions remain regarding the kinetics of gel degradation and subsequent drug release. Spherical microgels (~Ø10-300 µm) were synthesized using an inverse suspension polymerization method. Specifically, acrylamide and acrylonitrile monomers were thermally co-polymerized with
    Language English
    Publishing date 2023-09-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2813982-3
    ISSN 2310-2861 ; 2310-2861
    ISSN (online) 2310-2861
    ISSN 2310-2861
    DOI 10.3390/gels9100782
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  3. Article ; Online: Hydrogel Micro-/Nanosphere Coated by a Lipid Bilayer: Preparation and Microscopic Probing.

    Rahni, Sarah / Kazakov, Sergey

    Gels (Basel, Switzerland)

    2017  Volume 3, Issue 1

    Abstract: The result of polymeric nanogels and lipid vesicles interaction-lipobeads-can be considered as multipurpose containers for future therapeutic applications, such as targeted anticancer chemotherapy with superior tumor response and minimum side effects. In ...

    Abstract The result of polymeric nanogels and lipid vesicles interaction-lipobeads-can be considered as multipurpose containers for future therapeutic applications, such as targeted anticancer chemotherapy with superior tumor response and minimum side effects. In this work, micrometer sized lipobeads were synthesized by two methods: (i) mixing separately prepared microgels made of poly(N-isopropylacrylamide) (PNIPA) and phospholipid vesicles of micrometer or nanometer size and (ii) polymerization within the lipid vesicles. For the first time, a high vacuum scanning electron microscopy was shown to be suitable for a quick validation of the structural organization of wet lipobeads and their constituents without special sample preparation. In particular, the structural difference of microgels prepared by thermal and UV-polymerization in different solvents was revealed and three types of giant liposomes were recognized under high vacuum in conjunction with their size, composition, and method of preparation. Importantly, the substructure of the hydrogel core and multi- and unilamellar constructions of the peripheral lipid part were explicitly distinguished on the SEM images of lipobeads, justifying the spontaneous formation of a lipid bilayer on the surface of microgels and evidencing an energetically favorable structural organization of the hydrogel/lipid bilayer assembly. This key property can facilitate lipobeads' preparation and decrease technological expenses on their scaled production. The comparison of the SEM imaging with the scanning confocal and atomic force microscopies data are also presented in the discussion.
    Language English
    Publishing date 2017-02-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2813982-3
    ISSN 2310-2861 ; 2310-2861
    ISSN (online) 2310-2861
    ISSN 2310-2861
    DOI 10.3390/gels3010007
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  4. Book ; Thesis: What creates a successful entrepreneur?

    Kazakov, Sergey

    study of determinants of entrepreneurial survival and success

    2012  

    Author's details Sergey Kazakov
    Keywords Entrepreneurship-Ansatz ; Theorie ; USA
    Language English
    Size VIII, 150 S., graph. Darst.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Mass., Clark Univ., Dep. of Economics, Diss.--Worcester, 2012
    Database ECONomics Information System

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  5. Book ; Online: Millikelvin measurements of permittivity and loss tangent of lithium niobate

    Zorzetti, Silvia / Wang, Changqing / Gonin, Ivan / Kazakov, Sergey / Khabiboulline, Timergali / Romanenko, Alexander / Yakovlev, Vyacheslav P / Grassellino, Anna

    2023  

    Abstract: Lithium Niobate is an electro-optic material with many applications in microwave signal processing, communication, quantum sensing, and quantum computing. In this letter, we present findings on evaluating the complex electromagnetic permittivity of ... ...

    Abstract Lithium Niobate is an electro-optic material with many applications in microwave signal processing, communication, quantum sensing, and quantum computing. In this letter, we present findings on evaluating the complex electromagnetic permittivity of lithium niobate at millikelvin temperatures. Measurements are carried out using a resonant-type method with a superconducting radio-frequency (SRF) cavity operating at 7 GHz and designed to characterize anisotropic dielectrics. The relative permittivity tensor and loss tangent are measured at 50 mK with unprecedented accuracy.

    Comment: 5 pages, 4 figures
    Keywords Quantum Physics ; Condensed Matter - Materials Science
    Publishing date 2023-02-24
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Probable Mechanisms of Doxorubicin Antitumor Activity Enhancement by Ginsenoside Rh2.

    Popov, Alexander / Klimovich, Anna / Styshova, Olga / Tsybulsky, Alexander / Hushpulian, Dmitry / Osipyants, Andrey / Khristichenko, Anna / Kazakov, Sergey / Ahuja, Manuj / Kaidery, Navneet / Thomas, Bobby / Tishkov, Vladimir / Brown, Abraham / Gazaryan, Irina / Poloznikov, Andrey

    Molecules (Basel, Switzerland)

    2022  Volume 27, Issue 3

    Abstract: Ginsenoside Rh2 increases the efficacy of doxorubicin (DOX) treatment in murine models of solid and ascites Ehrlich's adenocarcinoma. In a solid tumor model (treatment commencing 7 days after inoculation), DOX + Rh2 co-treatment was significantly more ... ...

    Abstract Ginsenoside Rh2 increases the efficacy of doxorubicin (DOX) treatment in murine models of solid and ascites Ehrlich's adenocarcinoma. In a solid tumor model (treatment commencing 7 days after inoculation), DOX + Rh2 co-treatment was significantly more efficacious than DOX alone. If treatment was started 24 h after inoculation, the inhibition of tumor growth of a solid tumor for the DOX + Rh2 co-treatment group was complete. Furthermore, survival in the ascites model was dramatically higher for the DOX + Rh2 co-treatment group than for DOX alone. Mechanisms underlying the combined DOX and Rh2 effects were studied in primary Ehrlich's adenocarcinoma-derived cells and healthy mice's splenocytes. Despite the previously established Rh2 pro-oxidant activity, DOX + Rh2 co-treatment revealed no increase in ROS compared to DOX treatment alone. However, DOX + Rh2 treatment was more effective in suppressing Ehrlich adenocarcinoma cell adhesion than either treatment alone. We hypothesize that the benefits of DOX + Rh2 combination treatment are due to the suppression of tumor cell attachment/invasion that might be effective in preventing metastatic spread of tumor cells. Ginsenoside Rh2 was found to be a modest activator in a Neh2-luc reporter assay, suggesting that Rh2 can activate the Nrf2-driven antioxidant program. Rh2-induced direct activation of Nrf2 might provide additional benefits by minimizing DOX toxicity towards non-cancerous cells.
    MeSH term(s) Adenocarcinoma ; Animals ; Doxorubicin/pharmacology ; Drugs, Chinese Herbal/pharmacology ; Ginsenosides/pharmacology ; Mice
    Chemical Substances Drugs, Chinese Herbal ; Ginsenosides ; ginsenoside Rh2 (78214-33-2) ; Doxorubicin (80168379AG)
    Language English
    Publishing date 2022-01-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules27030628
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    Zs.MO 81: Show issues

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  7. Article ; Online: Nickel - p-block metal mixed chalcogenides based on AuCu

    Stroganova, Ekaterina A / Kazakov, Sergey M / Efimov, Nikolay N / Khrustalev, Victor N / Keilholz, Simon / Götze, Andre / Kohlmann, Holger / Kuznetsov, Alexey N

    Dalton transactions (Cambridge, England : 2003)

    2020  Volume 49, Issue 42, Page(s) 15081–15094

    Abstract: Two new mixed nickel-gallium chalcogenides, Ni9.39Ga2S2 and Ni5.80GaTe2, and a new mixed nickel-indium telluride, Ni5.78InTe2, have been synthesized by a high-temperature ampoule route with the addition of iodine, and characterized from single-crystal or ...

    Abstract Two new mixed nickel-gallium chalcogenides, Ni9.39Ga2S2 and Ni5.80GaTe2, and a new mixed nickel-indium telluride, Ni5.78InTe2, have been synthesized by a high-temperature ampoule route with the addition of iodine, and characterized from single-crystal or powder diffraction data. They belong to the relatively uncommon Ni7-xMQ2/Ni10-xM2Q2 type of structures (M = Ge, Sn, Sb, In), and are built from p-block metal-centered nickel cuboctahedra, alternating along the c axis with defective Cu2Sb-type nickel-chalcogen ones. Both tellurium-containing compounds show a small degree of orthorhombic distortion with respect to the idealized tetragonal structure, only detectable in the powder diffraction data. No phase transition to the tetragonal structure was detected for Ni5.80GaTe2 by the in situ powder diffraction measurements from room temperature to 550 °C. DFT calculations show close relationships of electronic structures of these ternary compounds to their parent intermetallics, Ni3M (M = Ga, In). Metallic conductivity and paramagnetic properties are predicted for all three with the latter confirmed by magnetic measurements. The bonding patterns, investigated via the ELF topological analysis, show multi-centered nickel - p-block metal bonds in the AuCu3-type fragments and pairwise covalent interactions in the nickel-chalcogen fragments. Both Ni7-xMTe2 compounds showed no structural or compositional changes upon high-temperature mid-pressure hydrogenation.
    Language English
    Publishing date 2020-10-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472887-4
    ISSN 1477-9234 ; 1364-5447 ; 0300-9246 ; 1477-9226
    ISSN (online) 1477-9234 ; 1364-5447
    ISSN 0300-9246 ; 1477-9226
    DOI 10.1039/d0dt03082a
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  8. Article: Draft Genome Sequence of

    Freylikhman, Olga / Kiselev, Artem / Kazakov, Sergey / Sergushichev, Alexey / Panferova, Yulia / Tokarevich, Nikolay / Kostareva, Anna

    Genome announcements

    2018  Volume 6, Issue 3

    Abstract: This is the announcement of a draft genome sequence ... ...

    Abstract This is the announcement of a draft genome sequence of
    Language English
    Publishing date 2018-01-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2704277-7
    ISSN 2169-8287
    ISSN 2169-8287
    DOI 10.1128/genomeA.01464-17
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  9. Article ; Online: Research of wear resistance of piston rings with laser processing on the basis of the accelerated tests

    Kazakov Sergey Sergeevich / Matveev Yury Ivanovich

    Vestnik of Astrakhan State Technical University. Series: Marine Engineering and Technologies, Iss 1, Pp 41-

    2011  Volume 44

    Abstract: Laser hardening of the details of cylinder-piston group is examined. Piston rings were exposed to laser hardening by two variants: on СО2-laser "Comet-2" and on the laser technological complex designed by the authors, which includes solid-state laser LTN- ...

    Abstract Laser hardening of the details of cylinder-piston group is examined. Piston rings were exposed to laser hardening by two variants: on СО2-laser "Comet-2" and on the laser technological complex designed by the authors, which includes solid-state laser LTN-103 and the machine tool with numerical control ТПК-125ВН. It has been stated that laser processing of piston rings both raises wear resistance and reduces deterioration of serial cylinder plugs.
    Keywords wear resistance ; a piston ring ; laser hardening ; microhardness ; a resource ; deterioration. ; Naval Science ; V ; DOAJ:Naval Science
    Language Russian
    Publishing date 2011-04-01T00:00:00Z
    Publisher Astrakhan State Technical University
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article: HIF Prolyl Hydroxylase Inhibitors for COVID-19 Treatment: Pros and Cons.

    Poloznikov, Andrey A / Nersisyan, Stepan A / Hushpulian, Dmitry M / Kazakov, Eliot H / Tonevitsky, Alexander G / Kazakov, Sergey V / Vechorko, Valery I / Nikulin, Sergey V / Makarova, Julia A / Gazaryan, Irina G

    Frontiers in pharmacology

    2021  Volume 11, Page(s) 621054

    Abstract: The review analyzes the potential advantages and problems associated with using HIF prolyl hydroxylase inhibitors as a treatment for COVID-19. HIF prolyl hydroxylase inhibitors are known to boost endogenous erythropoietin (Epo) and activate ... ...

    Abstract The review analyzes the potential advantages and problems associated with using HIF prolyl hydroxylase inhibitors as a treatment for COVID-19. HIF prolyl hydroxylase inhibitors are known to boost endogenous erythropoietin (Epo) and activate erythropoiesis by stabilizing and activating the hypoxia inducible factor (HIF). Recombinant Epo treatment has anti-inflammatory and healing properties, and thus, very likely, will be beneficial for moderate to severe cases of COVID-19. However, HIF PHD inhibition may have a significantly broader effect, in addition to stimulating the endogenous Epo production. The analysis of HIF target genes reveals that some HIF-targets, such as furin, could play a negative role with respect to viral entry. On the other hand, HIF prolyl hydroxylase inhibitors counteract ferroptosis, the process recently implicated in vessel damage during the later stages of COVID-19. Therefore, HIF prolyl hydroxylase inhibitors may serve as a promising treatment of COVID-19 complications, but they are unlikely to aid in the prevention of the initial stages of infection.
    Language English
    Publishing date 2021-01-29
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2020.621054
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