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  1. Article ; Online: Association of baseline electrocardiographic left ventricular hypertrophy with future renal function decline in the general population.

    Ikeda, Shota / Shinohara, Keisuke / Tagawa, Koshiro / Tohyama, Takeshi / Kishimoto, Junji / Kazurayama, Masaya / Tanaka, Shinji / Yamaizumi, Masamitsu / Nagayoshi, Hirokazu / Toyama, Kensuke / Matsushima, Shouji / Tsutsui, Hiroyuki / Kinugawa, Shintaro

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 301

    Abstract: Electrocardiographic left ventricular hypertrophy (LVH) could predict adverse renal outcomes in patients with hypertension. This study aimed to investigate the association between electrocardiographic LVH and future decline in renal function in the ... ...

    Abstract Electrocardiographic left ventricular hypertrophy (LVH) could predict adverse renal outcomes in patients with hypertension. This study aimed to investigate the association between electrocardiographic LVH and future decline in renal function in the general population using a dataset of population-based health checkups from 2010 to 2019 including 19,825 participants. Electrocardiographic LVH was defined according to the Minnesota code. Renal function decline was defined as a decrease of ≥ 25% in the estimated glomerular filtration rate from baseline to < 60 mL/min/1.73 m
    MeSH term(s) Humans ; Hypertrophy, Left Ventricular/diagnosis ; Hypertension ; Kidney ; Blood Pressure ; Incidence ; Electrocardiography ; Risk Factors
    Language English
    Publishing date 2024-01-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-51085-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Low-Normal Platelets and Decreasing Platelets Are Risk Factors for Hearing Impairment Development.

    Abe, Yasunori / Toyama, Kensuke / Kazurayama, Masaya / Tanaka, Shinji / Yamaizumi, Masamitsu / Ueno, Megumi / Spin, Joshua M / Hato, Naohito / Mogi, Masaki

    The Laryngoscope

    2020  Volume 131, Issue 4, Page(s) E1287–E1295

    Abstract: Objective: Identification of undefined risk factors will be crucial for the development of therapeutic strategies in hearing impairment. Platelets are likely to affect the development of sudden sensorineural hearing loss, which is a primary risk factor ... ...

    Abstract Objective: Identification of undefined risk factors will be crucial for the development of therapeutic strategies in hearing impairment. Platelets are likely to affect the development of sudden sensorineural hearing loss, which is a primary risk factor for permanent hearing impairment. This implies that abnormal platelets might contribute to long-term hearing loss. This study investigated the role of platelets in the development of hearing impairment over a 5-year period.
    Methods: This study was a retrospective cohort study and consisted of a population-based survey, which was performed for 1,897 participants in 2014 to 2019. To evaluate the effect of platelet level on hearing ability, the subjects were divided into two groups: a high-normal platelet group (25 ∼ 40 × 10
    Results: Incidence of hearing impairment at low frequencies was significantly higher in the low-normal platelet group than in the high-normal group year over year. Low-normal platelet count associated with low-frequency hearing impairment (LFHI) incidence (odds ratio [OR], 2.34; 95% confidence interval [CI], 1.15-4.76). In the low-normal platelet group, subjects whose counts declined from baseline developed more LFHI than those whose counts increased over time. Further, decreasing platelets appeared to be an independent risk factor contributing to the incidence of LFHI (OR, 2.10; 95%CI, 1.09-4.06) in the low-normal platelet group.
    Conclusion: Both a low-normal platelet and a declining platelet count were independently associated with the incidence of LFHI.
    Level of evidence: 3 Laryngoscope, 131:E1287-E1295, 2021.
    MeSH term(s) Adult ; Female ; Hearing Loss, Sudden/blood ; Hearing Loss, Sudden/epidemiology ; Humans ; Japan/epidemiology ; Male ; Platelet Count ; Prevalence ; Retrospective Studies ; Risk Factors
    Language English
    Publishing date 2020-08-24
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80180-x
    ISSN 1531-4995 ; 0023-852X
    ISSN (online) 1531-4995
    ISSN 0023-852X
    DOI 10.1002/lary.28970
    Database MEDical Literature Analysis and Retrieval System OnLINE

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