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Article ; Online: Roller Microneedle Combined with Tranexamic Acid Solution in Treating Melasma.

Zheng, Wenhao / Liu, Sutao / Tian, Liming / Ke, Dan

Journal of visualized experiments : JoVE

2024 , Issue 203

Abstract: Melasma, a common, acquired facial pigmentation skin disorder, presents a straightforward clinical diagnosis but poses challenges in terms of effective management. The precise underlying causes of melasma remain elusive, and the current therapeutic ... ...

Abstract	Melasma, a common, acquired facial pigmentation skin disorder, presents a straightforward clinical diagnosis but poses challenges in terms of effective management. The precise underlying causes of melasma remain elusive, and the current therapeutic approaches predominantly encompass pharmaceutical and laser interventions, with limited efficacy. Transdermal administration stands as a prevalent treatment method for melasma, often facilitated by the application of microneedles. Among these, tranexamic acid emerges as a frequently employed therapeutic agent. A subset of microneedles, known as roller microneedles, plays a significant role in this approach by delicately puncturing the epidermis with multiple fine needles, synergizing with drug delivery. This methodology not only enhances drug absorption but also augments treatment efficacy while minimizing tissue trauma. These attributes forecast promising avenues for the treatment of melasma. This article primarily introduces the combination of roller microneedle and tranexamic acid solution in the treatment of melasma and demonstrates the efficacy of roller microneedle and tranexamic acid solution in the treatment of melasma through clinical cases.
MeSH term(s)	Humans ; Tranexamic Acid/therapeutic use ; Administration, Cutaneous ; Treatment Outcome ; Melanosis/drug therapy ; Administration, Oral
Chemical Substances	Tranexamic Acid (6T84R30KC1)
Language	English
Publishing date	2024-01-19
Publishing country	United States
Document type	Journal Article ; Video-Audio Media
ZDB-ID	2259946-0
ISSN	1940-087X ; 1940-087X
ISSN (online)	1940-087X
ISSN	1940-087X
DOI	10.3791/66015
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Acne Vulgaris is Associated with the Human β-Defensin 1-Gene Polymorphisms in Han Chinese Ethnic Group Patients.

Tian, Li-Ming / Ke, Dan

Clinical, cosmetic and investigational dermatology

2021 Volume 14, Page(s) 123–128

Abstract: Objective: To study the relationship between the single nucleotide polymorphisms (SNPs) of the human β-defensin 1-gene (DEFB1) and the genetic susceptibility of acne vulgaris in the Han Chinese ethnic group.: Methods: A total of 104 patients with ... ...

Abstract	Objective: To study the relationship between the single nucleotide polymorphisms (SNPs) of the human β-defensin 1-gene (DEFB1) and the genetic susceptibility of acne vulgaris in the Han Chinese ethnic group. Methods: A total of 104 patients with acne vulgaris and 126 healthy participants were included in our study. We analyzed the association between acne vulgaris and the polymorphisms in the DEFB1 G-52A, C-44G, and G-20A gene. We then analyzed the relationship between the different genotypes and the susceptibility to acne vulgaris. Results: The frequency of DEFB1 C-44G genetic polymorphisms between the acne vulgaris group and the control group was significantly different (P < 0.05). The frequency of DEFB1 G-20A genetic polymorphisms between the acne vulgaris group and the control group was also significantly different (P < 0.05). Conclusion: The -44G or -20A allele showed a low expression in acne vulgaris, which has already been shown to correlate with the low risk of acne vulgaris among Chinese Han patients. This further supports the contribution of the DEFB1 gene to the pathogenesis of acne.
Language	English
Publishing date	2021-02-04
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2494852-4
ISSN	1178-7015
ISSN	1178-7015
DOI	10.2147/CCID.S292797
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Article ; Online: Type 2 Diabetes Mellitus Easily Develops into Alzheimer's Disease via Hyperglycemia and Insulin Resistance.

Li, Ting / Cao, Hong-Xia / Ke, Dan

Current medical science

2021 Volume 41, Issue 6, Page(s) 1165–1171

Abstract: With the acceleration of population aging, the incidence of type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD) is progressively increasing due to the age-relatedness of these two diseases. The association between T2DM and AD-like dementia is ... ...

Abstract	With the acceleration of population aging, the incidence of type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD) is progressively increasing due to the age-relatedness of these two diseases. The association between T2DM and AD-like dementia is receiving much attention, and T2DM is reported to be a significant risk factor for AD. The aims of this review were to reveal the brain changes caused by T2DM as well as to explore the roles of hyperglycemia and insulin resistance in the development of AD.
MeSH term(s)	Alzheimer Disease/epidemiology ; Brain/metabolism ; Diabetes Mellitus, Type 2/epidemiology ; Humans ; Hyperglycemia/complications ; Insulin Resistance ; Risk Factors
Language	English
Publishing date	2021-12-06
Publishing country	China
Document type	Journal Article ; Review
ZDB-ID	2931065-9
ISSN	2523-899X ; 2096-5230
ISSN (online)	2523-899X
ISSN	2096-5230
DOI	10.1007/s11596-021-2467-2
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Article: Clinical Features and Vitreous Biomarkers of Early-Onset Type 2 Diabetes Mellitus Complicated with Proliferative Diabetic Retinopathy.

Ke, DanDan / Hong, YiYi / Jiang, XinNan / Sun, XuFang

Diabetes, metabolic syndrome and obesity : targets and therapy

2022 Volume 15, Page(s) 1293–1303

Abstract: Purpose: To compare the clinical features and vitreous biomarkers of proliferative diabetic retinopathy (PDR) between patients with early-onset and late-onset type 2 diabetes mellitus (T2DM).: Materials and methods: This case-control study analyzed ... ...

Abstract	Purpose: To compare the clinical features and vitreous biomarkers of proliferative diabetic retinopathy (PDR) between patients with early-onset and late-onset type 2 diabetes mellitus (T2DM). Materials and methods: This case-control study analyzed the clinical data of 74 patients with PDR who underwent vitrectomy. The patients were divided into the early-onset (T2DM diagnosis age ≤ 40 years, n = 39) and late-onset (T2DM diagnosis age > 40 years, n = 35) groups. Thirty-six specimens were collected, and the liquid chip technology was used to detect the content of 27 types of cytokines in the vitreous. Differences in clinical features and cytokine levels between the two groups were evaluated. Bonferroni correction was applied for multiple comparisons. Results: Compared with the late-onset group, the levels of hemoglobin A1c (HbA1c) and total cholesterol were significantly higher in the early-onset group (P < 0.001 and P = 0.009, respectively). Patients with early-onset T2DM PDR had worse visual prognoses and a higher rate of postoperative recurrent vitreous hemorrhage. The results of cytokine detection showed that the levels of interleukin-4 (IL-4), IL-6, IL-8, IL-9, granulocyte colony-stimulating factor, interferon-γ, interferon-inducible 10 kDa, monocyte chemotactic protein 1, macrophage inflammatory protein (MIP)-1α, and MIP-1β in the early-onset group were significantly higher than those in the late-onset group (p < 0.0026). Age at diabetes diagnosis and HbA1c, IL-4, and regulated upon activation, normal T cell expressed and secreted levels were independent risk factors for visual acuity after undergoing vitrectomy. Conclusion: Early-onset T2DM PDR patients had poor blood glucose and lipid metabolism, higher levels of inflammatory factors, and worse visual prognosis. Stricter metabolic management and earlier anti-inflammatory interventions may be required for patients with early-onset T2DM.
Language	English
Publishing date	2022-04-26
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2494854-8
ISSN	1178-7007
ISSN	1178-7007
DOI	10.2147/DMSO.S362074
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Article: Comparison of standard versus modified stenting technique for treatment of tapered coronary artery lesions.

Ke, Dan / He, Xi / Lin, Chaogui / Chen, Lianglong

Reviews in cardiovascular medicine

2021 Volume 22, Issue 3, Page(s) 931–938

Abstract: Tapered coronary artery lesions (TCALs) are often seen clinically, optimal stenting of TCALs remains challengeable. This study sought to compare clinical outcomes between the modified single stenting (MSS) and conventional overlapped stenting (COS) in ... ...

Abstract	Tapered coronary artery lesions (TCALs) are often seen clinically, optimal stenting of TCALs remains challengeable. This study sought to compare clinical outcomes between the modified single stenting (MSS) and conventional overlapped stenting (COS) in treatment of TCALs. 150 patients were treated with MSS (MSS group), another 150 patients were matched with propensity score matching from 5055 patients treated with COS (COS group). Quantitative coronary angiography was performed to measure minimal lumen diameter (MLD), late lumen loss (LLL). The primary endpoint was immediate angiographic success, one-year cumulative major cardiac adverse events (MACEs) composing cardiac death, target vessel myocardial infarction (TVMI), target lesion/vessel revascularization (TLR/TVR) or stent thrombosis (ST). Post-procedural in-stent MLD (2.96 ± 0.34 versus 3.08 ± 0.33,
MeSH term(s)	Angioplasty, Balloon, Coronary ; Coronary Angiography ; Coronary Restenosis ; Coronary Vessels/diagnostic imaging ; Coronary Vessels/surgery ; Humans ; Stents ; Treatment Outcome
Language	English
Publishing date	2021-09-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	2108910-3
ISSN	1530-6550
ISSN	1530-6550
DOI	10.31083/j.rcm2203101
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Zs.A 6410: Show issues

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Article ; Online: Successful application of roxadustat in the treatment of patients with anti-erythropoietin antibody-mediated renal anaemia: a case report and literature review.

Cai, Ke-Dan / Zhu, Bei-Xia / Lin, Hai-Xue / Luo, Qun

The Journal of international medical research

2021 Volume 49, Issue 4, Page(s) 3000605211005984

Abstract: Recombinant human erythropoietin (rHuEPO) has been used worldwide for treatment of renal anaemia due to its good curative effect. However, rHuEPO treatment is associated with a rare but severe complication because of the development of anti-EPO ... ...

Abstract	Recombinant human erythropoietin (rHuEPO) has been used worldwide for treatment of renal anaemia due to its good curative effect. However, rHuEPO treatment is associated with a rare but severe complication because of the development of anti-EPO antibodies, which are difficult to treat. Currently, the main treatments for the anti-EPO antibodies include withdrawing the rHuEPO, providing blood transfusions and administrating steroid-based immunosuppressive agents. Although the above methods can alleviate anti-EPO-related anaemia, there are obvious side-effects such as decreased immunity and an increased risk of infection. Therefore, accurately identifying anti-EPO-related anaemia and effectively treating this complication is worth exploring. This current case report describes a 49-year-old female patient with chronic kidney disease that received rHuEPO subcutaneously and then developed anti-EPO antibody-mediated renal anaemia with her haemoglobin levels dropping to 37 g/l. The patient refused to be treated with steroids, so she received 120 mg roxadustat administered orally every 72 h and her Hb level increased to 110 g/l over a few months. This current case report demonstrates that roxadustat can be used to successfully treat anti-EPO antibody-mediated renal anaemia without the use of steroid-based immunosuppressants.
MeSH term(s)	Anemia/drug therapy ; Erythropoietin/therapeutic use ; Female ; Glycine/analogs & derivatives ; Humans ; Isoquinolines ; Middle Aged ; Recombinant Proteins
Chemical Substances	Isoquinolines ; Recombinant Proteins ; Erythropoietin (11096-26-7) ; Glycine (TE7660XO1C) ; roxadustat (X3O30D9YMX)
Language	English
Publishing date	2021-04-05
Publishing country	England
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	184023-x
ISSN	1473-2300 ; 0300-0605 ; 0142-2596
ISSN (online)	1473-2300
ISSN	0300-0605 ; 0142-2596
DOI	10.1177/03000605211005984
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Zs.A 925: Show issues

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Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article: The relationship between the main leaf traits and photosynthetic physiological characteristics of

Li, Qun / Wen, Jun / Zhao, Cheng-Zhang / Zhao, Lian-Chun / Ke, Dan

AoB PLANTS

2022 Volume 14, Issue 6, Page(s) plac054

Abstract: Plant leaf morphological and photosynthetic physiological characteristics are key functional traits in the adaptability of plants to heterogeneous environments. Analysis of the correlation between leaf morphological traits and photosynthetic ... ...

Abstract	Plant leaf morphological and photosynthetic physiological characteristics are key functional traits in the adaptability of plants to heterogeneous environments. Analysis of the correlation between leaf morphological traits and photosynthetic physiological characteristics of salt marsh plants is helpful to deepen our understanding of how salt marsh plants adjust their leaf structure and function to adapt to their environment. However, there have been few studies on the relationship between leaf morphology and photosynthetic physiological characteristics of plants in inland salt marshes under a habitat gradient. A
Language	English
Publishing date	2022-10-31
Publishing country	England
Document type	Journal Article
ZDB-ID	2555823-7
ISSN	2041-2851
ISSN	2041-2851
DOI	10.1093/aobpla/plac054
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Article ; Online: Dupilumab for the treatment of severe atopic dermatitis in a 19-year-old man with Duchenne muscular dystrophy accompanied by heart failure: A case report.

Ke, Dan / Diao, Qingchun / Zhou, Yanhui / Tao, Xiao / Zhang, Zhongyu / Wen, Yating

Dermatologic therapy

2022 Volume 35, Issue 6, Page(s) e15390

MeSH term(s)	Adult ; Antibodies, Monoclonal, Humanized/therapeutic use ; Dermatitis, Atopic/complications ; Dermatitis, Atopic/diagnosis ; Dermatitis, Atopic/drug therapy ; Heart Failure/diagnosis ; Heart Failure/drug therapy ; Heart Failure/etiology ; Humans ; Male ; Muscular Dystrophy, Duchenne/complications ; Muscular Dystrophy, Duchenne/diagnosis ; Muscular Dystrophy, Duchenne/drug therapy ; Treatment Outcome ; Young Adult
Chemical Substances	Antibodies, Monoclonal, Humanized ; dupilumab (420K487FSG)
Language	English
Publishing date	2022-05-01
Publishing country	United States
Document type	Case Reports ; Letter
ZDB-ID	1354801-3
ISSN	1529-8019 ; 1396-0296
ISSN (online)	1529-8019
ISSN	1396-0296
DOI	10.1111/dth.15390
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Zs.A 5181: Show issues

Location:
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bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: RIPK1 and RIPK3 inhibitors: potential weapons against inflammation to treat diabetic complications.

Ke, Dan / Zhang, Zhen / Liu, Jieting / Chen, Peijian / Dai, Yucen / Sun, Xinhai / Chu, Yanhui / Li, Luxin

Frontiers in immunology

2023 Volume 14, Page(s) 1274654

Abstract: Diabetes mellitus is a metabolic disease that is characterized by chronic hyperglycemia due to a variety of etiological factors. Long-term metabolic stress induces harmful inflammation leading to chronic complications, mainly diabetic ophthalmopathy, ... ...

Abstract	Diabetes mellitus is a metabolic disease that is characterized by chronic hyperglycemia due to a variety of etiological factors. Long-term metabolic stress induces harmful inflammation leading to chronic complications, mainly diabetic ophthalmopathy, diabetic cardiovascular complications and diabetic nephropathy. With diabetes complications being one of the leading causes of disability and death, the use of anti-inflammatories in combination therapy for diabetes is increasing. There has been increasing interest in targeting significant regulators of the inflammatory pathway, notably receptor-interacting serine/threonine-kinase-1 (RIPK1) and receptor-interacting serine/threonine-kinase-3 (RIPK3), as drug targets for managing inflammation in treating diabetes complications. In this review, we aim to provide an up-to-date summary of current research on the mechanism of action and drug development of RIPK1 and RIPK3, which are pivotal in chronic inflammation and immunity, in relation to diabetic complications which may be benefit for explicating the potential of selective RIPK1 and RIPK3 inhibitors as anti-inflammatory therapeutic agents for diabetic complications.
MeSH term(s)	Humans ; Inflammation/drug therapy ; Inflammation/metabolism ; Diabetes Complications/drug therapy ; Receptor-Interacting Protein Serine-Threonine Kinases/metabolism ; Diabetic Nephropathies ; Threonine ; Serine ; Diabetes Mellitus/drug therapy ; Diabetes Mellitus/etiology
Chemical Substances	Receptor-Interacting Protein Serine-Threonine Kinases (EC 2.7.11.1) ; Threonine (2ZD004190S) ; Serine (452VLY9402) ; RIPK1 protein, human (EC 2.7.11.1) ; RIPK3 protein, human (EC 2.7.11.1)
Language	English
Publishing date	2023-10-26
Publishing country	Switzerland
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1274654
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Article: Variation of Ferroptosis-Related Markers in HaCaT Cell Photoaging Models Induced by UVB.

Zhang, Peng-Cheng / Hong, Yi / Zong, Shi-Qin / Chen, Long / Zhang, Chong / Tian, Dai-Zhi / Ke, Dan / Tian, Li-Ming

Clinical, cosmetic and investigational dermatology

2023 Volume 16, Page(s) 3147–3155

Abstract: Objective: To investigate the variation of ferroptosis-related markers in HaCaT cell photoaging models induced by ultraviolet-B (UVB).: Methods: UVB-treated HaCaT cells served as the model (UVB group) for cellular photoaging, whereas untreated HaCaT ... ...

Abstract	Objective: To investigate the variation of ferroptosis-related markers in HaCaT cell photoaging models induced by ultraviolet-B (UVB). Methods: UVB-treated HaCaT cells served as the model (UVB group) for cellular photoaging, whereas untreated HaCaT cells served as the control group. HaCaT cells were exposed to UVB and the ferroptosis inhibitor Ferrostatin-1 (Fer-1) as part of the UVB+Fer-1 group, and co-cultured with the ferroptosis inducer Erastin as part of the UVB+Erastin group. Reactive oxygen species (ROS) detection kit and senescence-related β galactosidase (SA-β-gal) staining were used to evaluate the senescence of HaCaT cells. Lipid reactive oxygen species were detected by C11 BODIPY581/591 probe and mitochondrial morphology was observed by transmission electron microscopy. The mRNA expressions of glutathione peroxidase 4 (GPX4) and ferroptosis-suppressor-protein 1 (FSP1) were detected by real-time reverse transcription-PCR (RT-RCP), and the level of GPX4 protein was measured by immunofluorescence assay. Results: The UVB group had considerably greater levels of ROS, SA-β-gal, and lipid reactive oxygen species than the control group. The UVB group's mitochondrial volume was reduced, the membrane density increased, and the mitochondrial crest decreased or even disappeared. GPX4 and FSP1 expression levels were similarly found to be lower in the UVB group. Furthermore, the positive rate of SA-β-gal and lipid reactive oxygen species in the UVB+Fer-1 group was much lower than in the UVB group, but it was reverse in the UVB+Erastin group. This study showed that induced ferroptosis can aggravate aging, and vice versa. Conclusion: According to the findings, ferroptosis may be linked to UVB-induced skin photoaging, which could be attenuated by inhibition of ferroptosis.
Language	English
Publishing date	2023-11-01
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2494852-4
ISSN	1178-7015
ISSN	1178-7015
DOI	10.2147/CCID.S433071
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